A-Methapred

Overview IFRA Request a quote

  • Identifiers

    Molecular formula
    C22H30O5

    SMILES
    CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O

  • Odor profile

    Fragrance
    Woody 46.18%
    Odorless 37.91%
    Spicy 29.69%
    Sweet 25.96%
    Mint 25.83%
    Cedar 21.06%
    Cooling 20.74%
    Balsamic 20.02%
    Dry 19.66%
    Camphoreous 19.42%

     

    Flavor
    Bitter 86.59%
    Sweet-like 22.03%
    Odorless 21.2%
    Cedarleaf 21.03%
    Fenugreek 19.69%
    Leaves 19.67%
    Lovage 19.61%
    Bland 19.5%
    Ripe apricot 19.29%
    Seedy 19.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    5.75 (weak acid)

    Molecular weight
    374.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    289°C

    Flash point

    • 275.79 ˚C est.

  • Synonyms

    • A-Methapred
    • 6-.alpha.-Methylprednisolone
    • MEPRDL
    • Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6.alpha.,11.beta.)-
    • MLS002638721
    • Prednisolone, 6.alpha.-methyl-
    • Urbazone
    • M-Prednisol
    • .DELTA.1-6.alpha.-Methylhydrocortisone
    • 6a-methylprednisolone
    • 6a_Methylprednisolone
    • U 7532
    • 11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
    • SCHEMBL541256
    • CHEMBL190259
    • VHRSUDSXCMQTMA-UHFFFAOYSA-N
    • HMS3086J15
    • STL372918
    • AKOS024386987
    • 11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
    • SMR001496976
    • .delta.(sup 1)-6-.alpha.-Methylhydrocortisone
    • 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-6alpha-methyl-
    • 11-.beta.,17,21-Trihydroxy-6-.alpha.-methylpregna-1,4-diene-3,20-dione
    • (6.alpha.,11.beta.)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
    • 11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione, (6.alpha.,11.beta.)- #
    • 11-.beta.,17-.alpha.,21-Trihydroxy-6-.alpha.-methyl-1,4-pregnadiene-3,20-dione
    • Pregna-1,4-diene-3,20-dione, 11.beta.,17,21-trihydroxy-6.alpha.-methyl-
    • Pregna-1,4-diene-3,20-dione, 6.alpha.-methyl-11.beta.-17,21-trihydroxy-

  • Applications

    A-Methapred is a specialty chemical that may be used as an intermediate or solvent in chemical synthesis and industrial production; in the polymers/plastics sector, it can act as a stabilizer or property-modifying additive to improve durability and processability; in coatings and inks it can serve as a solvent or additive to adjust flow and film-forming quality; in cosmetics/personal care it may function as a solvent or carrier for active ingredients; in cleaning formulations it can participate as a solvent or solubilizing/processing aid to enhance cleaning performance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.23
    methanol 49.61
    isopropanol 6.21
    water 0.19
    ethyl acetate 4.1
    n-propanol 9.98
    acetone 13.17
    n-butanol 5.02
    acetonitrile 7.83
    DMF 55.9
    toluene 2.82
    isobutanol 3.74
    1,4-dioxane 20.86
    methyl acetate 4.69
    THF 48.24
    2-butanone 6.71
    n-pentanol 2.46
    sec-butanol 1.6
    n-hexane 0.1
    ethylene glycol 8.22
    NMP 22.32
    cyclohexane 0.27
    DMSO 64.69
    n-butyl acetate 3.38
    n-octanol 1.57
    chloroform 12.52
    n-propyl acetate 2.64
    acetic acid 13.14
    dichloromethane 8.53
    cyclohexanone 12.09
    propylene glycol 5.16
    isopropyl acetate 3.34
    DMAc 25.87
    2-ethoxyethanol 14.83
    isopentanol 3.19
    n-heptane 0.1
    ethyl formate 4.49
    1,2-dichloroethane 5.33
    n-hexanol 4.27
    2-methoxyethanol 44.24
    isobutyl acetate 1.85
    tetrachloromethane 1.92
    n-pentyl acetate 3.93
    transcutol 14.44
    n-heptanol 3.27
    ethylbenzene 1.32
    MIBK 4.36
    2-propoxyethanol 26.24
    tert-butanol 4.27
    MTBE 1.16
    2-butoxyethanol 12.8
    propionic acid 5.01
    o-xylene 1.79
    formic acid 17.63
    diethyl ether 3.14
    m-xylene 2.17
    p-xylene 1.55
    chlorobenzene 2.87
    dimethyl carbonate 7.82
    n-octane 0.07
    formamide 26.06
    cyclopentanone 22.38
    2-pentanone 5.78
    anisole 4.03
    cyclopentyl methyl ether 5.9
    gamma-butyrolactone 19.08
    1-methoxy-2-propanol 26.36
    pyridine 13.86
    3-pentanone 4.27
    furfural 16.81
    n-dodecane 0.04
    diethylene glycol 30.82
    diisopropyl ether 0.72
    tert-amyl alcohol 1.4
    acetylacetone 10.5
    n-hexadecane 0.04
    acetophenone 5.62
    methyl propionate 6.03
    isopentyl acetate 3.37
    trichloroethylene 12.02
    n-nonanol 1.84
    cyclohexanol 2.65
    benzyl alcohol 5.9
    2-ethylhexanol 1.65
    isooctanol 2.43
    dipropyl ether 1.92
    1,2-dichlorobenzene 2.88
    ethyl lactate 4.0
    propylene carbonate 6.69
    n-methylformamide 30.07
    2-pentanol 1.51
    n-pentane 0.12
    1-propoxy-2-propanol 11.4
    1-methoxy-2-propyl acetate 9.01
    2-(2-methoxypropoxy) propanol 8.36
    mesitylene 1.21
    ε-caprolactone 8.15
    p-cymene 0.98
    epichlorohydrin 22.15
    1,1,1-trichloroethane 2.97
    2-aminoethanol 15.54
    morpholine-4-carbaldehyde 31.74
    sulfolane 29.23
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 6.31
    n-hexyl acetate 3.72
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 10.79
    sec-butyl acetate 1.62
    tert-butyl acetate 3.88
    decalin 0.14
    glycerin 15.33
    diglyme 19.88
    acrylic acid 7.3
    isopropyl myristate 1.2
    n-butyric acid 6.25
    acetyl acetate 4.47
    di(2-ethylhexyl) phthalate 3.17
    ethyl propionate 2.76
    nitromethane 23.36
    1,2-diethoxyethane 3.87
    benzonitrile 5.04
    trioctyl phosphate 2.09
    1-bromopropane 1.68
    gamma-valerolactone 32.89
    n-decanol 1.04
    triethyl phosphate 2.37
    4-methyl-2-pentanol 1.49
    propionitrile 5.51
    vinylene carbonate 8.33
    1,1,2-trichlorotrifluoroethane 21.23
    DMS 4.87
    cumene 0.91
    2-octanol 1.25
    2-hexanone 3.37
    octyl acetate 1.84
    limonene 1.06
    1,2-dimethoxyethane 19.24
    ethyl orthosilicate 2.14
    tributyl phosphate 1.72
    diacetone alcohol 8.17
    N,N-dimethylaniline 3.12
    acrylonitrile 10.29
    aniline 5.19
    1,3-propanediol 18.36
    bromobenzene 2.29
    dibromomethane 4.44
    1,1,2,2-tetrachloroethane 8.26
    2-methyl-cyclohexyl acetate 3.41
    tetrabutyl urea 2.89
    diisobutyl methanol 1.09
    2-phenylethanol 7.84
    styrene 1.41
    dioctyl adipate 2.73
    dimethyl sulfate 12.47
    ethyl butyrate 2.73
    methyl lactate 9.27
    butyl lactate 5.41
    diethyl carbonate 2.12
    propanediol butyl ether 8.21
    triethyl orthoformate 2.85
    p-tert-butyltoluene 0.91
    methyl 4-tert-butylbenzoate 7.21
    morpholine 22.16
    tert-butylamine 1.28
    n-dodecanol 0.58
    dimethoxymethane 41.78
    ethylene carbonate 6.91
    cyrene 12.97
    2-ethoxyethyl acetate 7.8
    2-ethylhexyl acetate 2.41
    1,2,4-trichlorobenzene 4.04
    4-methylpyridine 7.86
    dibutyl ether 0.82
    2,6-dimethyl-4-heptanol 1.09
    DEF 6.72
    dimethyl isosorbide 14.03
    tetrachloroethylene 7.91
    eugenol 9.38
    triacetin 5.37
    span 80 6.55
    1,4-butanediol 5.42
    1,1-dichloroethane 3.04
    2-methyl-1-pentanol 1.77
    methyl formate 17.86
    2-methyl-1-butanol 2.25
    n-decane 0.09
    butyronitrile 3.64
    3,7-dimethyl-1-octanol 1.24
    1-chlorooctane 0.49
    1-chlorotetradecane 0.14
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.11
    cyclooctane 0.11
    cyclopentanol 4.42
    tetrahydropyran 7.27
    tert-amyl methyl ether 0.95
    2,5,8-trioxanonane 13.56
    1-hexene 0.44
    2-isopropoxyethanol 7.02
    2,2,2-trifluoroethanol 7.17
    methyl butyrate 3.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction