9(11)-Dehydroglycyrrhetic acid

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  • Identifiers

    CAS number
    14884-88-9

    Molecular formula
    C30H46O3

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC=C4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O

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  • Odor profile

    Fragrance
    Woody 83.45%
    Amber 57.87%
    Dry 50.9%
    Cedar 47.15%
    Musk 46.78%
    Sandalwood 42.14%
    Vetiver 35.77%
    Balsamic 35.27%
    Animal 32.97%
    Powdery 32.85%

     

    Flavor
    Woody 62.49%
    Camphor 48.18%
    Pine 42.09%
    Sweet 39.59%
    Balsam 38.59%
    Herbal 33.74%
    Dry 32.31%
    Earthy 31.77%
    Bitter 30.94%
    Spicy 29.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.2

    pKa est.
    6.55 (neutral)

    Molecular weight
    454.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    452°C

    Flash point

    • 266.56 ˚C est.

  • Synonyms

    • 9(11)-Dehydroglycyrrhetic acid
    • 3beta-Hydroxy-9(11),12-oleandien-30-oic acid
    • 14884-88-9
    • CHEMBL2334574
    • CHEBI:168538
    • DTXSID901228791
    • AKOS016036393
    • LMPR0106150021
    • 3beta-Hydroxyoleana-9(11),12-dien-30-oic acid
    • (3I(2),20I(2))-3-Hydroxyoleana-9(11),12-dien-29-oic acid
    • (2S,4aS,6aR,6bS,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,14b-dodecahydropicene-2-carboxylic acid
    • 14884-88-9

  • Applications

    9(11)-Dehydroglycyrrhetic acid (CAS 14884-88-9) is a triterpenoid related to glycyrrhetinic acid and is typically used as an intermediate or building block in the synthesis of glycyrrhetinic acid derivatives. In pharmaceuticals and medicinal chemistry, it is commonly evaluated for the preparation of glycyrrhetinic acid–based compounds and related scaffolds. In cosmetics and personal care, it may serve as a starting material for derivatized, skin‑active compounds or conditioning agents after appropriate functionalization. In industrial manufacturing, it is used as a precursor for laboratory-scale synthesis of specialty chemicals and as a chiral building block for further transformations. Use in final products depends on purity, regulatory status, and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.38
    methanol 6.49
    isopropanol 8.96
    water 0.0
    ethyl acetate 6.29
    n-propanol 17.05
    acetone 5.66
    n-butanol 15.09
    acetonitrile 1.51
    DMF 64.9
    toluene 9.72
    isobutanol 10.2
    1,4-dioxane 37.32
    methyl acetate 5.04
    THF 61.08
    2-butanone 10.53
    n-pentanol 10.18
    sec-butanol 8.36
    n-hexane 0.49
    ethylene glycol 0.74
    NMP 31.82
    cyclohexane 0.41
    DMSO 8.69
    n-butyl acetate 7.37
    n-octanol 4.57
    chloroform 19.87
    n-propyl acetate 4.68
    acetic acid 3.64
    dichloromethane 9.42
    cyclohexanone 15.14
    propylene glycol 2.5
    isopropyl acetate 6.88
    DMAc 38.07
    2-ethoxyethanol 17.63
    isopentanol 9.29
    n-heptane 0.42
    ethyl formate 2.5
    1,2-dichloroethane 6.02
    n-hexanol 11.77
    2-methoxyethanol 27.04
    isobutyl acetate 4.97
    tetrachloromethane 2.61
    n-pentyl acetate 10.62
    transcutol 43.95
    n-heptanol 8.83
    ethylbenzene 4.59
    MIBK 7.49
    2-propoxyethanol 50.97
    tert-butanol 6.48
    MTBE 8.37
    2-butoxyethanol 27.8
    propionic acid 4.39
    o-xylene 4.79
    formic acid 1.59
    diethyl ether 11.69
    m-xylene 6.19
    p-xylene 4.23
    chlorobenzene 6.63
    dimethyl carbonate 6.54
    n-octane 0.16
    formamide 2.6
    cyclopentanone 21.9
    2-pentanone 10.33
    anisole 12.21
    cyclopentyl methyl ether 18.82
    gamma-butyrolactone 16.58
    1-methoxy-2-propanol 36.91
    pyridine 23.7
    3-pentanone 8.26
    furfural 14.06
    n-dodecane 0.06
    diethylene glycol 14.82
    diisopropyl ether 2.8
    tert-amyl alcohol 6.17
    acetylacetone 9.43
    n-hexadecane 0.08
    acetophenone 8.61
    methyl propionate 9.7
    isopentyl acetate 8.7
    trichloroethylene 16.45
    n-nonanol 5.49
    cyclohexanol 7.04
    benzyl alcohol 10.34
    2-ethylhexanol 5.02
    isooctanol 6.73
    dipropyl ether 8.17
    1,2-dichlorobenzene 5.86
    ethyl lactate 4.3
    propylene carbonate 6.53
    n-methylformamide 9.87
    2-pentanol 7.58
    n-pentane 0.51
    1-propoxy-2-propanol 32.6
    1-methoxy-2-propyl acetate 19.54
    2-(2-methoxypropoxy) propanol 16.77
    mesitylene 3.13
    ε-caprolactone 14.35
    p-cymene 2.72
    epichlorohydrin 24.92
    1,1,1-trichloroethane 5.62
    2-aminoethanol 4.69
    morpholine-4-carbaldehyde 55.65
    sulfolane 18.53
    2,2,4-trimethylpentane 0.36
    2-methyltetrahydrofuran 18.64
    n-hexyl acetate 10.81
    isooctane 0.32
    2-(2-butoxyethoxy)ethanol 25.27
    sec-butyl acetate 4.43
    tert-butyl acetate 8.43
    decalin 0.42
    glycerin 4.34
    diglyme 39.82
    acrylic acid 3.6
    isopropyl myristate 3.13
    n-butyric acid 8.69
    acetyl acetate 3.83
    di(2-ethylhexyl) phthalate 5.76
    ethyl propionate 5.08
    nitromethane 6.0
    1,2-diethoxyethane 13.07
    benzonitrile 5.11
    trioctyl phosphate 3.72
    1-bromopropane 4.72
    gamma-valerolactone 44.02
    n-decanol 2.85
    triethyl phosphate 3.86
    4-methyl-2-pentanol 4.89
    propionitrile 3.9
    vinylene carbonate 7.31
    1,1,2-trichlorotrifluoroethane 16.94
    DMS 8.74
    cumene 2.85
    2-octanol 4.11
    2-hexanone 7.07
    octyl acetate 4.57
    limonene 2.94
    1,2-dimethoxyethane 26.57
    ethyl orthosilicate 4.66
    tributyl phosphate 3.06
    diacetone alcohol 11.85
    N,N-dimethylaniline 10.3
    acrylonitrile 4.28
    aniline 11.29
    1,3-propanediol 9.0
    bromobenzene 6.36
    dibromomethane 6.54
    1,1,2,2-tetrachloroethane 15.24
    2-methyl-cyclohexyl acetate 6.88
    tetrabutyl urea 5.0
    diisobutyl methanol 3.13
    2-phenylethanol 14.27
    styrene 4.88
    dioctyl adipate 5.81
    dimethyl sulfate 9.33
    ethyl butyrate 5.56
    methyl lactate 7.93
    butyl lactate 12.07
    diethyl carbonate 3.2
    propanediol butyl ether 17.16
    triethyl orthoformate 7.27
    p-tert-butyltoluene 3.03
    methyl 4-tert-butylbenzoate 15.6
    morpholine 59.86
    tert-butylamine 3.65
    n-dodecanol 1.41
    dimethoxymethane 47.35
    ethylene carbonate 5.73
    cyrene 16.38
    2-ethoxyethyl acetate 17.42
    2-ethylhexyl acetate 6.72
    1,2,4-trichlorobenzene 9.01
    4-methylpyridine 18.77
    dibutyl ether 3.13
    2,6-dimethyl-4-heptanol 3.13
    DEF 15.36
    dimethyl isosorbide 28.28
    tetrachloroethylene 10.04
    eugenol 17.18
    triacetin 10.4
    span 80 14.96
    1,4-butanediol 3.02
    1,1-dichloroethane 5.74
    2-methyl-1-pentanol 6.59
    methyl formate 4.76
    2-methyl-1-butanol 9.53
    n-decane 0.2
    butyronitrile 4.45
    3,7-dimethyl-1-octanol 3.93
    1-chlorooctane 1.39
    1-chlorotetradecane 0.3
    n-nonane 0.17
    undecane 0.11
    tert-butylcyclohexane 0.46
    cyclooctane 0.25
    cyclopentanol 8.15
    tetrahydropyran 25.26
    tert-amyl methyl ether 6.42
    2,5,8-trioxanonane 22.67
    1-hexene 2.24
    2-isopropoxyethanol 12.22
    2,2,2-trifluoroethanol 1.6
    methyl butyrate 5.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction