8-Hydroxygalangin

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  • Identifiers

    CAS number
    74693-69-9

    Molecular formula
    C15H10O6

    SMILES
    C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 56.86%
    Phenolic 52.36%
    Burnt 40.07%
    Smoky 25.17%
    Medicinal 22.87%
    Spicy 22.17%
    Balsamic 19.0%
    Savory 18.4%
    Bitter 17.91%
    Dry 17.62%

     

    Flavor
    Bitter 92.63%
    Odorless 22.93%
    Sweet-like 21.21%
    Very strong 20.36%
    Eugenol 20.28%
    Cedarleaf 20.21%
    Indole 20.18%
    Nitrile 20.06%
    Curry 19.85%
    Lovage 19.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    9.73 (weak base)

    Molecular weight
    286.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1098°C

    Flash point

    • 221.11 ˚C est.

  • Synonyms

    • 8-Hydroxygalangin
    • 3,5,7,8-Tetrahydroxyflavone
    • BRN 0295943
    • 2-Phenyl-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one
    • FLAVONE, 3,5,7,8-TETRAHYDROXY-
    • 4H-1-Benzopyran-4-one, 2-phenyl-3,5,7,8-tetrahydroxy-
    • DTXSID00225670
    • 4-18-00-03279 (Beilstein Handbook Reference)
    • RefChem:107174
    • 3,5,7,8-tetrahydroxy-2-phenylchromen-4-one
    • DTXCID30148161
    • 4H-1-Benzopyran-4-one, 2-phenyl-3,5,7,8-tetrahydroxy-(9CI)
    • 74693-69-9
    • 4H-1-Benzopyran-4-one, 2-phenyl-3,5,7,8-tetrahydroxy- (9CI)
    • LMPK12113088
    • 3,5,7,8-Tetrahydroxy-2-phenyl-4H-1-benzopyran-4-one
    • 74693-69-9

  • Applications

    8-Hydroxygalangin (CAS 74693-69-9) is a flavonoid commonly used as an intermediate in the synthesis of flavonoid derivatives for pharmaceutical and agrochemical research. In formulations, it can serve as an antioxidant and stabilizer, supporting cosmetic and personal care products by reducing oxidation. It is also evaluated as a metal-chelating agent, informing potential use as a stabilizer in polymer systems and coatings. In analytical chemistry, it is used as a ligand in metal-ion complexation studies and as a reference compound. As a synthetic building block, it enables the preparation of additional flavonoid derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.78
    methanol 3.15
    isopropanol 4.44
    water 0.0
    ethyl acetate 3.64
    n-propanol 6.15
    acetone 0.99
    n-butanol 5.83
    acetonitrile 0.54
    DMF 27.97
    toluene 0.55
    isobutanol 3.43
    1,4-dioxane 5.14
    methyl acetate 3.27
    THF 46.52
    2-butanone 6.28
    n-pentanol 2.65
    sec-butanol 7.48
    n-hexane 0.01
    ethylene glycol 5.29
    NMP 32.21
    cyclohexane 0.02
    DMSO 61.83
    n-butyl acetate 2.84
    n-octanol 4.22
    chloroform 0.0
    n-propyl acetate 2.01
    acetic acid 3.2
    dichloromethane 0.01
    cyclohexanone 7.3
    propylene glycol 6.02
    isopropyl acetate 3.39
    DMAc 49.62
    2-ethoxyethanol 13.78
    isopentanol 5.46
    n-heptane 0.05
    ethyl formate 1.37
    1,2-dichloroethane 0.1
    n-hexanol 3.65
    2-methoxyethanol 48.19
    isobutyl acetate 0.75
    tetrachloromethane 0.01
    n-pentyl acetate 3.95
    transcutol 32.44
    n-heptanol 4.17
    ethylbenzene 0.32
    MIBK 3.48
    2-propoxyethanol 19.25
    tert-butanol 7.67
    MTBE 3.57
    2-butoxyethanol 12.77
    propionic acid 4.21
    o-xylene 0.69
    formic acid 3.57
    diethyl ether 1.95
    m-xylene 0.56
    p-xylene 0.22
    chlorobenzene 0.09
    dimethyl carbonate 4.07
    n-octane 0.04
    formamide 8.74
    cyclopentanone 15.39
    2-pentanone 4.66
    anisole 1.74
    cyclopentyl methyl ether 9.34
    gamma-butyrolactone 15.44
    1-methoxy-2-propanol 38.28
    pyridine 4.96
    3-pentanone 2.9
    furfural 8.5
    n-dodecane 0.08
    diethylene glycol 19.16
    diisopropyl ether 0.62
    tert-amyl alcohol 10.6
    acetylacetone 5.86
    n-hexadecane 0.09
    acetophenone 2.65
    methyl propionate 6.75
    isopentyl acetate 3.19
    trichloroethylene 0.14
    n-nonanol 4.57
    cyclohexanol 5.43
    benzyl alcohol 2.89
    2-ethylhexanol 2.42
    isooctanol 3.3
    dipropyl ether 2.37
    1,2-dichlorobenzene 0.14
    ethyl lactate 3.93
    propylene carbonate 3.65
    n-methylformamide 8.01
    2-pentanol 5.02
    n-pentane 0.02
    1-propoxy-2-propanol 14.88
    1-methoxy-2-propyl acetate 9.93
    2-(2-methoxypropoxy) propanol 12.18
    mesitylene 0.27
    ε-caprolactone 8.99
    p-cymene 0.74
    epichlorohydrin 12.53
    1,1,1-trichloroethane 0.03
    2-aminoethanol 9.2
    morpholine-4-carbaldehyde 23.58
    sulfolane 36.83
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 13.66
    n-hexyl acetate 5.7
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 17.73
    sec-butyl acetate 1.88
    tert-butyl acetate 5.53
    decalin 0.03
    glycerin 22.14
    diglyme 26.38
    acrylic acid 4.26
    isopropyl myristate 2.3
    n-butyric acid 4.98
    acetyl acetate 1.19
    di(2-ethylhexyl) phthalate 2.06
    ethyl propionate 2.74
    nitromethane 5.71
    1,2-diethoxyethane 5.85
    benzonitrile 1.16
    trioctyl phosphate 2.12
    1-bromopropane 0.11
    gamma-valerolactone 21.44
    n-decanol 3.18
    triethyl phosphate 1.88
    4-methyl-2-pentanol 2.88
    propionitrile 1.71
    vinylene carbonate 1.96
    1,1,2-trichlorotrifluoroethane 11.92
    DMS 3.96
    cumene 0.26
    2-octanol 3.52
    2-hexanone 2.55
    octyl acetate 3.26
    limonene 1.02
    1,2-dimethoxyethane 14.99
    ethyl orthosilicate 1.8
    tributyl phosphate 1.9
    diacetone alcohol 18.86
    N,N-dimethylaniline 1.72
    acrylonitrile 2.85
    aniline 3.04
    1,3-propanediol 16.07
    bromobenzene 0.05
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.24
    2-methyl-cyclohexyl acetate 2.19
    tetrabutyl urea 3.43
    diisobutyl methanol 1.96
    2-phenylethanol 4.04
    styrene 0.23
    dioctyl adipate 3.01
    dimethyl sulfate 9.59
    ethyl butyrate 2.59
    methyl lactate 12.68
    butyl lactate 5.45
    diethyl carbonate 1.36
    propanediol butyl ether 12.22
    triethyl orthoformate 2.84
    p-tert-butyltoluene 0.81
    methyl 4-tert-butylbenzoate 6.18
    morpholine 17.63
    tert-butylamine 2.01
    n-dodecanol 2.11
    dimethoxymethane 17.01
    ethylene carbonate 1.62
    cyrene 10.3
    2-ethoxyethyl acetate 6.62
    2-ethylhexyl acetate 2.05
    1,2,4-trichlorobenzene 0.35
    4-methylpyridine 3.68
    dibutyl ether 2.68
    2,6-dimethyl-4-heptanol 1.96
    DEF 12.0
    dimethyl isosorbide 16.0
    tetrachloroethylene 0.16
    eugenol 6.61
    triacetin 5.05
    span 80 8.82
    1,4-butanediol 2.74
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 3.12
    methyl formate 3.26
    2-methyl-1-butanol 6.27
    n-decane 0.13
    butyronitrile 1.37
    3,7-dimethyl-1-octanol 3.2
    1-chlorooctane 0.78
    1-chlorotetradecane 0.31
    n-nonane 0.08
    undecane 0.1
    tert-butylcyclohexane 0.03
    cyclooctane 0.01
    cyclopentanol 6.43
    tetrahydropyran 4.7
    tert-amyl methyl ether 5.82
    2,5,8-trioxanonane 18.57
    1-hexene 0.08
    2-isopropoxyethanol 7.51
    2,2,2-trifluoroethanol 1.4
    methyl butyrate 3.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction