8-Hydroxy-p-menthan-3-one

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    3304-24-3

    Molecular formula
    C10H18O2

    SMILES
    CC1CCC(C(=O)C1)C(C)(C)O

    Retention indicies (RI)

    • Carbowax: 1770.0

  • Odor profile

    Herbal 78.41%
    Mint 72.01%
    Camphoreous 59.56%
    Woody 59.23%
    Cooling 52.17%
    Fresh 47.26%
    Pine 43.77%
    Floral 40.48%
    Earthy 38.25%
    Sweet 32.74%

    Scent© AI

  • Properties

    XLogP3-AA
    1.9

    Molecular weight
    170.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    257°C

    Flash point est.
    107.63 ˚C

  • Synonyms

    • 8-hydroxy-p-menthan-3-one
    • 3304-24-3
    • Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-5-methyl-
    • 2-(1-Hydroxy-1-methylethyl)-5-methylcyclohexanone
    • 2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-one
    • 8-Hydroxy-p-menth-3-on
    • SCHEMBL6902851
    • DTXSID20954657
    • QNZZGEDTDYWNFN-UHFFFAOYSA-N

  • Applications

    8‑Hydroxy‑p‑menthan‑3‑one (CAS 3304‑24‑3) is a menthane‑type monoterpenoid bearing both ketone and alcohol functions, used as a flavor and fragrance ingredient and as a synthetic intermediate; in foods, beverages, and oral‑care products it reinforces minty, fresh, slightly camphoraceous facets, softens the harshness of menthol/menthone, and imparts a clean cooling impression, while in fine fragrance, personal care, and deodorants it builds transparent freshness, boosts top‑note lift, and improves freshness longevity; in aroma chemistry it also serves as a building block for other p‑menthane derivatives (esters, ethers, cooling amides) and as an analytical reference in menthol/menthone metabolism studies, sensory work, and formulation development; its typical monoterpenoid attributes (clean odor, deodorizing support) make it useful in household cleaners and air‑care at low dosage subject to matrix and regulatory constraints, with formulators considering compatibility with other mint terpenes, susceptibility to oxidation, and compliance with safety and regional regulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 714.71
    methanol 1189.11
    isopropanol 593.22
    water 7.79
    ethyl acetate 268.47
    n-propanol 467.31
    acetone 411.43
    n-butanol 400.83
    acetonitrile 500.68
    DMF 466.23
    toluene 138.81
    isobutanol 335.7
    1,4-dioxane 935.94
    methyl acetate 263.67
    THF 1288.38
    2-butanone 258.62
    n-pentanol 236.17
    sec-butanol 351.98
    n-hexane 50.69
    ethylene glycol 166.83
    NMP 426.09
    cyclohexane 108.64
    DMSO 334.45
    n-butyl acetate 219.15
    n-octanol 207.08
    chloroform 882.95
    n-propyl acetate 151.63
    acetic acid 558.5
    dichloromethane 534.37
    cyclohexanone 495.05
    propylene glycol 273.68
    isopropyl acetate 178.67
    DMAc 293.72
    2-ethoxyethanol 240.69
    isopentanol 294.65
    n-heptane 46.89
    ethyl formate 252.85
    1,2-dichloroethane 245.36
    n-hexanol 474.24
    2-methoxyethanol 573.23
    isobutyl acetate 116.08
    tetrachloromethane 121.58
    n-pentyl acetate 142.33
    transcutol 767.58
    n-heptanol 177.89
    ethylbenzene 79.0
    MIBK 170.09
    2-propoxyethanol 526.49
    tert-butanol 604.19
    MTBE 273.97
    2-butoxyethanol 227.82
    propionic acid 333.12
    o-xylene 103.62
    formic acid 257.19
    diethyl ether 287.89
    m-xylene 119.48
    p-xylene 116.23
    chlorobenzene 197.35
    dimethyl carbonate 92.84
    n-octane 17.36
    formamide 224.71
    cyclopentanone 519.19
    2-pentanone 234.75
    anisole 154.25
    cyclopentyl methyl ether 356.29
    gamma-butyrolactone 649.64
    1-methoxy-2-propanol 438.8
    pyridine 336.4
    3-pentanone 156.24
    furfural 462.02
    n-dodecane 18.09
    diethylene glycol 410.47
    diisopropyl ether 96.1
    tert-amyl alcohol 341.53
    acetylacetone 261.04
    n-hexadecane 20.25
    acetophenone 138.89
    methyl propionate 196.16
    isopentyl acetate 195.41
    trichloroethylene 465.3
    n-nonanol 164.71
    cyclohexanol 404.43
    benzyl alcohol 163.22
    2-ethylhexanol 190.02
    isooctanol 127.13
    dipropyl ether 167.61
    1,2-dichlorobenzene 167.21
    ethyl lactate 103.7
    propylene carbonate 376.01
    n-methylformamide 299.29
    2-pentanol 255.36
    n-pentane 60.12
    1-propoxy-2-propanol 333.0
    1-methoxy-2-propyl acetate 239.96
    2-(2-methoxypropoxy) propanol 220.71
    mesitylene 85.33
    ε-caprolactone 417.18
    p-cymene 76.69
    epichlorohydrin 497.4
    1,1,1-trichloroethane 314.24
    2-aminoethanol 326.97
    morpholine-4-carbaldehyde 487.59
    sulfolane 474.28
    2,2,4-trimethylpentane 27.23
    2-methyltetrahydrofuran 613.38
    n-hexyl acetate 252.12
    isooctane 26.24
    2-(2-butoxyethoxy)ethanol 329.13
    sec-butyl acetate 107.41
    tert-butyl acetate 197.44
    decalin 38.89
    glycerin 319.16
    diglyme 465.79
    acrylic acid 270.93
    isopropyl myristate 100.53
    n-butyric acid 461.47
    acetyl acetate 200.17
    di(2-ethylhexyl) phthalate 106.89
    ethyl propionate 131.88
    nitromethane 562.52
    1,2-diethoxyethane 210.67
    benzonitrile 235.96
    trioctyl phosphate 87.51
    1-bromopropane 194.01
    gamma-valerolactone 632.45
    n-decanol 120.64
    triethyl phosphate 83.77
    4-methyl-2-pentanol 152.43
    propionitrile 329.76
    vinylene carbonate 332.46
    1,1,2-trichlorotrifluoroethane 372.2
    DMS 161.77
    cumene 65.69
    2-octanol 131.08
    2-hexanone 167.65
    octyl acetate 129.15
    limonene 115.32
    1,2-dimethoxyethane 424.18
    ethyl orthosilicate 82.86
    tributyl phosphate 98.06
    diacetone alcohol 249.57
    N,N-dimethylaniline 107.85
    acrylonitrile 334.52
    aniline 211.39
    1,3-propanediol 407.67
    bromobenzene 175.22
    dibromomethane 363.71
    1,1,2,2-tetrachloroethane 408.57
    2-methyl-cyclohexyl acetate 148.29
    tetrabutyl urea 115.83
    diisobutyl methanol 106.65
    2-phenylethanol 216.3
    styrene 85.92
    dioctyl adipate 133.14
    dimethyl sulfate 131.46
    ethyl butyrate 145.5
    methyl lactate 147.92
    butyl lactate 146.81
    diethyl carbonate 109.48
    propanediol butyl ether 273.06
    triethyl orthoformate 118.05
    p-tert-butyltoluene 81.9
    methyl 4-tert-butylbenzoate 176.09
    morpholine 855.67
    tert-butylamine 380.79
    n-dodecanol 92.11
    dimethoxymethane 324.99
    ethylene carbonate 288.34
    cyrene 193.8
    2-ethoxyethyl acetate 177.64
    2-ethylhexyl acetate 149.8
    1,2,4-trichlorobenzene 201.25
    4-methylpyridine 328.98
    dibutyl ether 141.18
    2,6-dimethyl-4-heptanol 106.65
    DEF 215.54
    dimethyl isosorbide 343.43
    tetrachloroethylene 253.42
    eugenol 165.49
    triacetin 199.92
    span 80 247.88
    1,4-butanediol 136.7
    1,1-dichloroethane 341.72
    2-methyl-1-pentanol 176.99
    methyl formate 259.54
    2-methyl-1-butanol 261.06
    n-decane 30.22
    butyronitrile 361.24
    3,7-dimethyl-1-octanol 166.73
    1-chlorooctane 99.1
    1-chlorotetradecane 41.64
    n-nonane 28.62
    undecane 22.71
    tert-butylcyclohexane 36.22
    cyclooctane 32.81
    cyclopentanol 443.79
    tetrahydropyran 713.11
    tert-amyl methyl ether 176.1
    2,5,8-trioxanonane 339.1
    1-hexene 133.88
    2-isopropoxyethanol 172.74
    2,2,2-trifluoroethanol 179.11
    methyl butyrate 169.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Hesperozygis ringens (Brazil) Hesperozygis ringens (Benth.) Epling, fam. Lamiaceae (Labiatae) 1.3%
Buchu leaf (South Africa) 1a 84649-93-4 Agathosma betulina (Berg.) Pillans (Barosma betulina Bertl.), fam. Rutacea 0.12%
Buchu leaf (South Africa) 1b (species) 84649-93-4 Agathosma crenulata Pillans, fam. Rutaceae 4.67%