8-Acetyl-6-hydroxy-7-methoxycoumarin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    202288-19-5

    Molecular formula
    C12H10O5

    SMILES
    CC(=O)C1=C2C(=CC(=C1OC)O)C=CC(=O)O2

    Safety labels

  • Odor profile

    Fragrance
    Sweet 51.58%
    Vanilla 44.33%
    Fruity 43.96%
    Caramellic 43.79%
    Burnt 36.95%
    Phenolic 36.39%
    Creamy 36.13%
    Powdery 33.96%
    Balsamic 31.68%
    Dry 30.73%

     

    Flavor
    Bitter 57.66%
    Sweet 31.25%
    Odorless 24.69%
    Heliotropin 21.87%
    Powdery 21.57%
    Eugenol 20.95%
    Parsley 20.86%
    Vanilla 20.68%
    Seedy 20.66%
    Ham 20.65%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    7.63 (neutral)

    Molecular weight
    234.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    426°C

    Flash point

    • 178.82 ˚C est.

  • Synonyms

    • 8-acetyl-6-hydroxy-7-methoxycoumarin
    • 202288-19-5
    • 8-ACETYL-6-HYDROXY-7-METHOXYCHROMEN-2-ONE
    • SCHEMBL5427865
    • DTXSID901355570
    • 8-acetyl-6-hydroxy-7-methoxy-2-oxochromene
    • ST50331448
    • 202288-19-5

  • Applications

    Chemical name: 8-Acetyl-6-hydroxy-7-methoxycoumarin; CAS number: 202288-19-5. 8-Acetyl-6-hydroxy-7-methoxycoumarin is primarily used as an intermediate in the synthesis of fragrance ingredients and odorants, leveraging the coumarin core with hydroxy and methoxy substitutions to enable further derivatization for perfumery and related flavor applications under regulatory controls. It is also evaluated as a starting material for cosmetics and personal care actives, owing to its aromatic scaffold and functional groups. In industrial manufacturing it can serve as a precursor for specialty dyes or pigments used in coatings, inks, and plastics, and as a building block for polymer additives and potential UV-stable components in formulations. In research settings, the coumarin framework may provide fluorescence or UV-absorbing properties for analytical probes and photophysical studies. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.97
    methanol 6.4
    isopropanol 2.63
    water 0.02
    ethyl acetate 12.83
    n-propanol 3.2
    acetone 26.14
    n-butanol 3.26
    acetonitrile 13.04
    DMF 86.44
    toluene 2.38
    isobutanol 2.94
    1,4-dioxane 26.0
    methyl acetate 19.69
    THF 79.73
    2-butanone 21.97
    n-pentanol 3.33
    sec-butanol 3.18
    n-hexane 0.21
    ethylene glycol 3.91
    NMP 67.78
    cyclohexane 0.22
    DMSO 171.83
    n-butyl acetate 14.9
    n-octanol 4.83
    chloroform 7.37
    n-propyl acetate 12.68
    acetic acid 7.57
    dichloromethane 19.17
    cyclohexanone 30.79
    propylene glycol 1.51
    isopropyl acetate 7.34
    DMAc 86.47
    2-ethoxyethanol 15.78
    isopentanol 4.17
    n-heptane 0.31
    ethyl formate 12.75
    1,2-dichloroethane 21.03
    n-hexanol 5.44
    2-methoxyethanol 28.49
    isobutyl acetate 6.27
    tetrachloromethane 1.29
    n-pentyl acetate 10.28
    transcutol 18.63
    n-heptanol 4.61
    ethylbenzene 2.99
    MIBK 9.7
    2-propoxyethanol 23.17
    tert-butanol 6.05
    MTBE 4.27
    2-butoxyethanol 13.45
    propionic acid 5.33
    o-xylene 3.18
    formic acid 7.52
    diethyl ether 5.15
    m-xylene 2.54
    p-xylene 4.32
    chlorobenzene 5.64
    dimethyl carbonate 15.43
    n-octane 0.22
    formamide 18.75
    cyclopentanone 56.83
    2-pentanone 14.55
    anisole 9.48
    cyclopentyl methyl ether 14.42
    gamma-butyrolactone 60.72
    1-methoxy-2-propanol 14.45
    pyridine 20.85
    3-pentanone 13.8
    furfural 49.46
    n-dodecane 0.3
    diethylene glycol 26.7
    diisopropyl ether 1.38
    tert-amyl alcohol 5.58
    acetylacetone 25.42
    n-hexadecane 0.36
    acetophenone 14.57
    methyl propionate 16.42
    isopentyl acetate 12.79
    trichloroethylene 27.38
    n-nonanol 4.91
    cyclohexanol 4.39
    benzyl alcohol 8.44
    2-ethylhexanol 5.47
    isooctanol 4.07
    dipropyl ether 5.6
    1,2-dichlorobenzene 7.6
    ethyl lactate 9.15
    propylene carbonate 19.85
    n-methylformamide 26.78
    2-pentanol 2.09
    n-pentane 0.12
    1-propoxy-2-propanol 13.32
    1-methoxy-2-propyl acetate 17.29
    2-(2-methoxypropoxy) propanol 15.83
    mesitylene 1.64
    ε-caprolactone 24.72
    p-cymene 3.5
    epichlorohydrin 69.67
    1,1,1-trichloroethane 7.21
    2-aminoethanol 4.17
    morpholine-4-carbaldehyde 58.16
    sulfolane 94.69
    2,2,4-trimethylpentane 0.17
    2-methyltetrahydrofuran 23.58
    n-hexyl acetate 12.31
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 15.5
    sec-butyl acetate 6.81
    tert-butyl acetate 9.76
    decalin 0.43
    glycerin 7.0
    diglyme 35.82
    acrylic acid 6.3
    isopropyl myristate 5.13
    n-butyric acid 6.17
    acetyl acetate 7.6
    di(2-ethylhexyl) phthalate 7.01
    ethyl propionate 13.53
    nitromethane 43.3
    1,2-diethoxyethane 8.98
    benzonitrile 13.07
    trioctyl phosphate 5.94
    1-bromopropane 5.91
    gamma-valerolactone 61.73
    n-decanol 3.87
    triethyl phosphate 9.61
    4-methyl-2-pentanol 2.12
    propionitrile 9.56
    vinylene carbonate 18.16
    1,1,2-trichlorotrifluoroethane 31.3
    DMS 14.77
    cumene 2.54
    2-octanol 3.36
    2-hexanone 14.64
    octyl acetate 7.38
    limonene 4.34
    1,2-dimethoxyethane 48.79
    ethyl orthosilicate 7.95
    tributyl phosphate 6.85
    diacetone alcohol 16.03
    N,N-dimethylaniline 8.57
    acrylonitrile 16.16
    aniline 5.32
    1,3-propanediol 7.14
    bromobenzene 4.72
    dibromomethane 9.36
    1,1,2,2-tetrachloroethane 19.39
    2-methyl-cyclohexyl acetate 11.71
    tetrabutyl urea 11.11
    diisobutyl methanol 3.23
    2-phenylethanol 11.08
    styrene 2.69
    dioctyl adipate 8.23
    dimethyl sulfate 39.24
    ethyl butyrate 11.27
    methyl lactate 11.34
    butyl lactate 8.05
    diethyl carbonate 9.03
    propanediol butyl ether 8.77
    triethyl orthoformate 8.76
    p-tert-butyltoluene 2.89
    methyl 4-tert-butylbenzoate 15.57
    morpholine 26.86
    tert-butylamine 2.33
    n-dodecanol 2.91
    dimethoxymethane 41.03
    ethylene carbonate 15.18
    cyrene 20.5
    2-ethoxyethyl acetate 14.19
    2-ethylhexyl acetate 10.95
    1,2,4-trichlorobenzene 9.4
    4-methylpyridine 18.9
    dibutyl ether 4.68
    2,6-dimethyl-4-heptanol 3.23
    DEF 25.87
    dimethyl isosorbide 32.06
    tetrachloroethylene 13.03
    eugenol 15.86
    triacetin 11.37
    span 80 8.91
    1,4-butanediol 3.28
    1,1-dichloroethane 7.34
    2-methyl-1-pentanol 4.45
    methyl formate 29.3
    2-methyl-1-butanol 3.85
    n-decane 0.48
    butyronitrile 8.57
    3,7-dimethyl-1-octanol 4.55
    1-chlorooctane 2.76
    1-chlorotetradecane 1.27
    n-nonane 0.38
    undecane 0.38
    tert-butylcyclohexane 0.37
    cyclooctane 0.11
    cyclopentanol 6.72
    tetrahydropyran 12.98
    tert-amyl methyl ether 4.97
    2,5,8-trioxanonane 25.71
    1-hexene 1.28
    2-isopropoxyethanol 10.36
    2,2,2-trifluoroethanol 7.29
    methyl butyrate 19.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction