(7S)-6,7-Dihydro-4,7-dimethyl-5H-cyclopenta(c)pyridine

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  • Identifiers

    CAS number
    524-03-8

    Molecular formula
    C10H13N

    SMILES
    C[C@H]1CCC2=C1C=NC=C2C

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Earthy 53.31%
    Animal 45.86%
    Sweet 42.75%
    Nutty 39.79%
    Leathery 38.26%
    Musty 37.23%
    Tobacco 32.89%
    Roasted 32.6%
    Woody 31.32%
    Burnt 29.61%

     

    Flavor
    Earthy 45.12%
    Woody 41.62%
    Musty 37.89%
    Bitter 26.32%
    Wood 25.8%
    Camphor 25.56%
    Earth 25.35%
    Spicy 24.85%
    Tobacco 24.41%
    Nutty 24.08%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.36 (neutral)

    Molecular weight
    147.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    248°C

    Flash point

    • 89.38 ˚C est.

  • Synonyms

    • Actinidine
    • 524-03-8
    • (-)-Actinidine
    • (7S)-4,7-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridine
    • VWU976C78Y
    • CHEBI:2443
    • 5H-2-Pyrindine, 6,7-dihydro-4,7-dimethyl-, (S)-
    • (7S)-4,7-dimethyl-6,7-dihydro-5H-cyclopenta(c)pyridine
    • (7S)-6,7-Dihydro-4,7-dimethyl-5H-cyclopenta(c)pyridine
    • (7S)-6,7-Dihydro-4,7-dimethyl-5H-cyclopenta[c]pyridine
    • RefChem:906288
    • L-(-)-Actinidine
    • 5H-Cyclopenta[c]pyridine, 6,7-dihydro-4,7-dimethyl-, (7S)-
    • (S)-(-)-actidine
    • DTXSID70894115
    • UNII-VWU976C78Y
    • (S)-6,7-Dihydro-4,7-dimethyl-5H-2-pyrindine
    • SCHEMBL692365
    • (7S)-4,7-dimethyl-5H,6H,7H-cyclopenta[c]pyridine
    • AKOS028108983
    • NS00094379
    • C09910
    • Q343309
    • (S)-4,7-Dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridine
    • 524-03-8

  • Applications

    The compound (7S)-6,7-Dihydro-4,7-dimethyl-5H-cyclopenta(c)pyridine (CAS 524-03-8) is primarily used as an intermediate in the synthesis of chiral heterocycles and pharmaceutical lead compounds; it is commonly evaluated as a building block in medicinal chemistry to access substituted cyclopenta[c]pyridine frameworks. It is also assessed as a precursor in agrochemical and specialty chemical research, and may serve as a chiral scaffold for asymmetric synthesis and catalyst development. Additionally, it can be used as a research chemical in drug discovery programs and as a starting material for materials science investigations involving nitrogen-containing bicyclic motifs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 650.93
    methanol 676.08
    isopropanol 502.03
    water 5.24
    ethyl acetate 750.76
    n-propanol 569.62
    acetone 796.12
    n-butanol 488.38
    acetonitrile 1111.23
    DMF 644.27
    toluene 599.66
    isobutanol 449.08
    1,4-dioxane 1739.61
    methyl acetate 792.36
    THF 1384.36
    2-butanone 657.19
    n-pentanol 327.28
    sec-butanol 380.2
    n-hexane 99.39
    ethylene glycol 123.47
    NMP 523.94
    cyclohexane 156.3
    DMSO 503.66
    n-butyl acetate 743.78
    n-octanol 238.99
    chloroform 2339.01
    n-propyl acetate 444.55
    acetic acid 470.34
    dichloromethane 2250.02
    cyclohexanone 908.45
    propylene glycol 131.66
    isopropyl acetate 433.69
    DMAc 359.82
    2-ethoxyethanol 453.83
    isopentanol 417.28
    n-heptane 81.68
    ethyl formate 560.86
    1,2-dichloroethane 1206.31
    n-hexanol 543.92
    2-methoxyethanol 742.89
    isobutyl acetate 309.94
    tetrachloromethane 548.71
    n-pentyl acetate 375.96
    transcutol 1289.65
    n-heptanol 261.53
    ethylbenzene 237.94
    MIBK 374.23
    2-propoxyethanol 757.8
    tert-butanol 467.64
    MTBE 596.98
    2-butoxyethanol 403.64
    propionic acid 411.37
    o-xylene 281.82
    formic acid 180.09
    diethyl ether 861.04
    m-xylene 356.91
    p-xylene 303.44
    chlorobenzene 732.76
    dimethyl carbonate 268.51
    n-octane 49.53
    formamide 276.52
    cyclopentanone 902.57
    2-pentanone 543.69
    anisole 402.26
    cyclopentyl methyl ether 695.61
    gamma-butyrolactone 1082.53
    1-methoxy-2-propanol 482.95
    pyridine 1165.76
    3-pentanone 457.33
    furfural 826.74
    n-dodecane 39.96
    diethylene glycol 490.84
    diisopropyl ether 242.46
    tert-amyl alcohol 351.15
    acetylacetone 543.66
    n-hexadecane 45.56
    acetophenone 309.43
    methyl propionate 517.68
    isopentyl acetate 613.5
    trichloroethylene 1812.06
    n-nonanol 205.37
    cyclohexanol 411.17
    benzyl alcohol 299.14
    2-ethylhexanol 317.15
    isooctanol 217.78
    dipropyl ether 365.5
    1,2-dichlorobenzene 575.43
    ethyl lactate 155.24
    propylene carbonate 577.83
    n-methylformamide 562.01
    2-pentanol 313.26
    n-pentane 111.16
    1-propoxy-2-propanol 502.42
    1-methoxy-2-propyl acetate 522.5
    2-(2-methoxypropoxy) propanol 290.63
    mesitylene 221.97
    ε-caprolactone 744.4
    p-cymene 161.19
    epichlorohydrin 1335.46
    1,1,1-trichloroethane 1150.69
    2-aminoethanol 238.29
    morpholine-4-carbaldehyde 722.59
    sulfolane 782.99
    2,2,4-trimethylpentane 59.5
    2-methyltetrahydrofuran 1053.21
    n-hexyl acetate 472.67
    isooctane 61.31
    2-(2-butoxyethoxy)ethanol 455.1
    sec-butyl acetate 275.32
    tert-butyl acetate 405.65
    decalin 78.2
    glycerin 181.52
    diglyme 822.4
    acrylic acid 337.94
    isopropyl myristate 180.05
    n-butyric acid 556.75
    acetyl acetate 390.41
    di(2-ethylhexyl) phthalate 161.83
    ethyl propionate 341.15
    nitromethane 900.83
    1,2-diethoxyethane 718.97
    benzonitrile 557.1
    trioctyl phosphate 125.94
    1-bromopropane 772.13
    gamma-valerolactone 1123.69
    n-decanol 156.67
    triethyl phosphate 148.51
    4-methyl-2-pentanol 214.62
    propionitrile 784.94
    vinylene carbonate 608.36
    1,1,2-trichlorotrifluoroethane 504.88
    DMS 379.14
    cumene 163.09
    2-octanol 187.84
    2-hexanone 383.2
    octyl acetate 222.93
    limonene 208.5
    1,2-dimethoxyethane 765.09
    ethyl orthosilicate 150.45
    tributyl phosphate 158.14
    diacetone alcohol 347.96
    N,N-dimethylaniline 225.09
    acrylonitrile 870.87
    aniline 502.19
    1,3-propanediol 399.27
    bromobenzene 815.29
    dibromomethane 1449.29
    1,1,2,2-tetrachloroethane 1113.74
    2-methyl-cyclohexyl acetate 266.12
    tetrabutyl urea 179.07
    diisobutyl methanol 169.94
    2-phenylethanol 424.0
    styrene 295.45
    dioctyl adipate 207.81
    dimethyl sulfate 270.58
    ethyl butyrate 385.5
    methyl lactate 187.78
    butyl lactate 224.12
    diethyl carbonate 244.77
    propanediol butyl ether 275.67
    triethyl orthoformate 252.22
    p-tert-butyltoluene 154.54
    methyl 4-tert-butylbenzoate 282.31
    morpholine 1358.81
    tert-butylamine 343.29
    n-dodecanol 125.43
    dimethoxymethane 712.5
    ethylene carbonate 563.98
    cyrene 237.92
    2-ethoxyethyl acetate 531.65
    2-ethylhexyl acetate 483.82
    1,2,4-trichlorobenzene 579.67
    4-methylpyridine 984.74
    dibutyl ether 335.89
    2,6-dimethyl-4-heptanol 169.94
    DEF 500.07
    dimethyl isosorbide 467.27
    tetrachloroethylene 886.74
    eugenol 287.82
    triacetin 290.62
    span 80 265.5
    1,4-butanediol 159.64
    1,1-dichloroethane 1301.19
    2-methyl-1-pentanol 299.43
    methyl formate 527.6
    2-methyl-1-butanol 379.19
    n-decane 62.44
    butyronitrile 767.73
    3,7-dimethyl-1-octanol 220.95
    1-chlorooctane 217.05
    1-chlorotetradecane 94.53
    n-nonane 63.24
    undecane 48.19
    tert-butylcyclohexane 78.01
    cyclooctane 70.52
    cyclopentanol 408.01
    tetrahydropyran 1181.65
    tert-amyl methyl ether 345.05
    2,5,8-trioxanonane 459.65
    1-hexene 287.0
    2-isopropoxyethanol 337.73
    2,2,2-trifluoroethanol 220.01
    methyl butyrate 430.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction