7,2',4',5'-Tetramethoxyflavone

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  • Identifiers

    CAS number
    4253-02-5

    Molecular formula
    C19H18O6

    SMILES
    COC1=CC2=C(C=C1)C(=O)C=C(O2)C3=CC(=C(C=C3OC)OC)OC

    Safety labels

  • Odor profile

    Fragrance
    Sweet 62.44%
    Vanilla 52.28%
    Phenolic 47.92%
    Spicy 46.89%
    Powdery 40.6%
    Fruity 38.71%
    Floral 37.99%
    Balsamic 34.51%
    Woody 34.01%
    Smoky 33.11%

     

    Flavor
    Bitter 85.66%
    Parsley 21.76%
    Bland 20.33%
    Eugenol 20.07%
    Cedarleaf 19.59%
    Lovage 19.45%
    Ripe apricot 19.04%
    Aniseed 18.99%
    Sweet-like 18.96%
    Tarragon 18.65%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    6.62 (neutral)

    Molecular weight
    342.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    564°C

    Flash point

    • 194.49 ˚C est.

  • Synonyms

    • 7-methoxy-2-(2,4,5-trimethoxyphenyl)chromen-4-one
    • RefChem:914126
    • DTXCID00117809
    • 4253-02-5
    • 7,2',4',5'-Tetramethoxyflavone
    • DTXSID90195318
    • CHEMBL460229
    • LMPK12110054
    • 4253-02-5

  • Applications

    7,2',4',5'-Tetramethoxyflavone (CAS 4253-02-5) is primarily used as an intermediate and structural building block in organic synthesis, with applications in pharmaceutical and agrochemical manufacture; it is also evaluated as a potential component in fragrances and cosmetics, and as a supporting matrix or additive for coatings, inks, and specialty polymers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.68
    methanol 0.55
    isopropanol 0.84
    water 0.0
    ethyl acetate 7.34
    n-propanol 1.07
    acetone 6.82
    n-butanol 0.83
    acetonitrile 6.49
    DMF 19.38
    toluene 1.5
    isobutanol 1.06
    1,4-dioxane 12.72
    methyl acetate 11.41
    THF 31.53
    2-butanone 7.62
    n-pentanol 0.96
    sec-butanol 1.09
    n-hexane 0.16
    ethylene glycol 0.83
    NMP 40.04
    cyclohexane 0.33
    DMSO 41.23
    n-butyl acetate 4.65
    n-octanol 0.68
    chloroform 40.56
    n-propyl acetate 5.63
    acetic acid 9.94
    dichloromethane 57.18
    cyclohexanone 13.89
    propylene glycol 0.52
    isopropyl acetate 4.72
    DMAc 48.33
    2-ethoxyethanol 5.08
    isopentanol 1.2
    n-heptane 0.23
    ethyl formate 3.85
    1,2-dichloroethane 28.78
    n-hexanol 0.88
    2-methoxyethanol 5.94
    isobutyl acetate 3.57
    tetrachloromethane 2.73
    n-pentyl acetate 2.9
    transcutol 16.13
    n-heptanol 0.86
    ethylbenzene 1.33
    MIBK 3.4
    2-propoxyethanol 6.63
    tert-butanol 1.79
    MTBE 2.79
    2-butoxyethanol 3.94
    propionic acid 5.11
    o-xylene 1.78
    formic acid 3.28
    diethyl ether 3.13
    m-xylene 1.12
    p-xylene 2.23
    chlorobenzene 4.65
    dimethyl carbonate 10.21
    n-octane 0.1
    formamide 7.71
    cyclopentanone 22.06
    2-pentanone 4.09
    anisole 4.84
    cyclopentyl methyl ether 7.81
    gamma-butyrolactone 37.83
    1-methoxy-2-propanol 3.91
    pyridine 13.06
    3-pentanone 6.92
    furfural 28.54
    n-dodecane 0.11
    diethylene glycol 6.95
    diisopropyl ether 1.18
    tert-amyl alcohol 1.88
    acetylacetone 11.76
    n-hexadecane 0.14
    acetophenone 7.8
    methyl propionate 9.57
    isopentyl acetate 5.39
    trichloroethylene 62.05
    n-nonanol 0.93
    cyclohexanol 2.14
    benzyl alcohol 3.58
    2-ethylhexanol 1.33
    isooctanol 1.02
    dipropyl ether 3.56
    1,2-dichlorobenzene 7.39
    ethyl lactate 3.86
    propylene carbonate 13.19
    n-methylformamide 6.47
    2-pentanol 0.71
    n-pentane 0.1
    1-propoxy-2-propanol 4.61
    1-methoxy-2-propyl acetate 9.52
    2-(2-methoxypropoxy) propanol 7.66
    mesitylene 0.85
    ε-caprolactone 13.68
    p-cymene 1.63
    epichlorohydrin 48.0
    1,1,1-trichloroethane 15.76
    2-aminoethanol 1.07
    morpholine-4-carbaldehyde 31.02
    sulfolane 55.94
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 12.18
    n-hexyl acetate 2.85
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 6.52
    sec-butyl acetate 4.25
    tert-butyl acetate 6.17
    decalin 0.36
    glycerin 2.39
    diglyme 20.92
    acrylic acid 7.61
    isopropyl myristate 1.93
    n-butyric acid 3.91
    acetyl acetate 8.73
    di(2-ethylhexyl) phthalate 2.79
    ethyl propionate 7.32
    nitromethane 35.8
    1,2-diethoxyethane 6.4
    benzonitrile 4.98
    trioctyl phosphate 1.48
    1-bromopropane 5.6
    gamma-valerolactone 29.69
    n-decanol 0.75
    triethyl phosphate 6.77
    4-methyl-2-pentanol 0.76
    propionitrile 4.75
    vinylene carbonate 13.59
    1,1,2-trichlorotrifluoroethane 36.88
    DMS 9.63
    cumene 1.23
    2-octanol 0.59
    2-hexanone 4.54
    octyl acetate 2.12
    limonene 2.03
    1,2-dimethoxyethane 14.81
    ethyl orthosilicate 5.82
    tributyl phosphate 2.46
    diacetone alcohol 6.23
    N,N-dimethylaniline 4.69
    acrylonitrile 8.87
    aniline 3.4
    1,3-propanediol 1.7
    bromobenzene 5.03
    dibromomethane 21.15
    1,1,2,2-tetrachloroethane 41.83
    2-methyl-cyclohexyl acetate 6.82
    tetrabutyl urea 3.77
    diisobutyl methanol 1.32
    2-phenylethanol 3.58
    styrene 1.49
    dioctyl adipate 4.45
    dimethyl sulfate 28.49
    ethyl butyrate 6.27
    methyl lactate 5.36
    butyl lactate 2.78
    diethyl carbonate 6.53
    propanediol butyl ether 2.03
    triethyl orthoformate 6.56
    p-tert-butyltoluene 1.43
    methyl 4-tert-butylbenzoate 7.61
    morpholine 13.1
    tert-butylamine 0.95
    n-dodecanol 0.64
    dimethoxymethane 12.32
    ethylene carbonate 10.5
    cyrene 12.07
    2-ethoxyethyl acetate 6.96
    2-ethylhexyl acetate 4.67
    1,2,4-trichlorobenzene 11.04
    4-methylpyridine 8.29
    dibutyl ether 2.15
    2,6-dimethyl-4-heptanol 1.32
    DEF 10.79
    dimethyl isosorbide 20.96
    tetrachloroethylene 24.13
    eugenol 6.72
    triacetin 8.18
    span 80 4.14
    1,4-butanediol 0.88
    1,1-dichloroethane 11.45
    2-methyl-1-pentanol 1.51
    methyl formate 6.9
    2-methyl-1-butanol 1.2
    n-decane 0.18
    butyronitrile 2.56
    3,7-dimethyl-1-octanol 1.12
    1-chlorooctane 0.83
    1-chlorotetradecane 0.47
    n-nonane 0.13
    undecane 0.14
    tert-butylcyclohexane 0.26
    cyclooctane 0.11
    cyclopentanol 3.22
    tetrahydropyran 6.96
    tert-amyl methyl ether 2.94
    2,5,8-trioxanonane 15.88
    1-hexene 0.66
    2-isopropoxyethanol 4.25
    2,2,2-trifluoroethanol 9.24
    methyl butyrate 7.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction