7-Methylquinoline

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  • Identifiers

    CAS number
    612-60-2

    Molecular formula
    C10H9N

    SMILES
    CC1=CC2=C(C=CC=N2)C=C1

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 69.98%
    Animal 69.68%
    Sweet 69.2%
    Tobacco 58.05%
    Herbal 53.45%
    Leathery 51.56%
    Green 48.27%
    Woody 47.03%
    Earthy 45.26%
    Oily 41.95%

     

    Flavor
    Tobacco 44.64%
    Nutty 39.09%
    Fecal 38.96%
    Leather 34.49%
    Musty 31.79%
    Animal 31.55%
    Coffee 31.31%
    Phenolic 31.08%
    Medicinal 29.46%
    Civet 28.66%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    4.75 (weak acid)

    Molecular weight
    143.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 95 to 100 °F (NTP, 1992)

    Boiling point

    • 484.7 to 486.5 °F at 760 mmHg (NTP, 1992)

    Flash point

    • 99.33 ˚C est.
    • 230 °F (NTP, 1992)

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)

  • Synonyms

    • 7-METHYLQUINOLINE
    • 612-60-2
    • m-Toluquinoline
    • Quinoline, 7-methyl-
    • 7-methyl-Quinoline
    • CCRIS 2895
    • EINECS 210-316-2
    • UNII-EOW995K43C
    • NSC 65665
    • BRN 0110317
    • EOW995K43C
    • DTXSID5025657
    • AI3-00850
    • MFCD00006805
    • NSC-65665
    • METHYLQUINOLINE, 7-
    • DTXCID005657
    • 5-20-07-00402 (Beilstein Handbook Reference)
    • NSC 65665; m-Toluquinoline
    • 7-methyl quinoline
    • mToluquinoline
    • NSC65665
    • Quinoline, 7methyl
    • 7-Methylquinoline, 97%
    • NCIOpen2_000315
    • SCHEMBL12361
    • CHEMBL1322524
    • BCP32568
    • Tox21_201146
    • BBL102502
    • STL556305
    • AKOS005206837
    • FM40554
    • NCGC00091608-01
    • NCGC00091608-02
    • NCGC00258698-01
    • AS-12675
    • CAS-612-60-2
    • DB-012212
    • M0417
    • M1180
    • NS00034624
    • EN300-97214
    • I11486
    • A833132
    • Q27277283
    • F0001-2460
    • m-Toluquinoline;Quinoline, 7-methyl-;7-methyl-Quinoline
    • 210-316-2

  • Applications

    7-Methylquinoline (CAS 612-60-2) is primarily used as an intermediate and building block in pharmaceutical and agrochemical synthesis, and serves as a scaffold for the preparation of more complex quinoline derivatives. It is also a precursor for dye and pigment chemistries and can be channeled into functionalized derivatives for specialty polymers, coatings, or inks. In organic chemistry, it may act as a ligand in metal-catalysis systems, or be employed as a high-boiling solvent in certain industrial processes. Additionally, due to its quinoline scaffold, it is often evaluated for electronic or optoelectronic material applications, including as a building block for luminescent materials and hole-transport components.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 126.18
    methanol 41.0
    isopropanol 112.44
    water 0.36
    ethyl acetate 280.27
    n-propanol 136.9
    acetone 380.82
    n-butanol 137.52
    acetonitrile 279.08
    DMF 487.37
    toluene 243.2
    isobutanol 117.52
    1,4-dioxane 547.28
    methyl acetate 289.02
    THF 628.87
    2-butanone 360.52
    n-pentanol 113.12
    sec-butanol 120.45
    n-hexane 83.16
    ethylene glycol 15.94
    NMP 288.32
    cyclohexane 92.49
    DMSO 367.03
    n-butyl acetate 522.2
    n-octanol 143.8
    chloroform 743.27
    n-propyl acetate 267.39
    acetic acid 117.37
    dichloromethane 1021.14
    cyclohexanone 518.17
    propylene glycol 21.19
    isopropyl acetate 157.35
    DMAc 291.06
    2-ethoxyethanol 114.73
    isopentanol 119.27
    n-heptane 165.71
    ethyl formate 277.31
    1,2-dichloroethane 622.91
    n-hexanol 276.13
    2-methoxyethanol 154.82
    isobutyl acetate 175.4
    tetrachloromethane 140.85
    n-pentyl acetate 204.9
    transcutol 407.82
    n-heptanol 132.18
    ethylbenzene 168.03
    MIBK 168.15
    2-propoxyethanol 245.8
    tert-butanol 133.06
    MTBE 162.16
    2-butoxyethanol 148.49
    propionic acid 127.52
    o-xylene 152.97
    formic acid 15.64
    diethyl ether 260.8
    m-xylene 162.24
    p-xylene 218.0
    chlorobenzene 264.04
    dimethyl carbonate 113.96
    n-octane 56.05
    formamide 48.91
    cyclopentanone 548.52
    2-pentanone 297.69
    anisole 217.6
    cyclopentyl methyl ether 319.83
    gamma-butyrolactone 562.26
    1-methoxy-2-propanol 125.27
    pyridine 493.53
    3-pentanone 253.41
    furfural 386.5
    n-dodecane 38.1
    diethylene glycol 99.58
    diisopropyl ether 88.69
    tert-amyl alcohol 120.53
    acetylacetone 262.01
    n-hexadecane 43.4
    acetophenone 195.48
    methyl propionate 234.4
    isopentyl acetate 330.64
    trichloroethylene 888.92
    n-nonanol 124.05
    cyclohexanol 146.88
    benzyl alcohol 126.74
    2-ethylhexanol 214.04
    isooctanol 100.74
    dipropyl ether 391.48
    1,2-dichlorobenzene 219.01
    ethyl lactate 80.29
    propylene carbonate 312.73
    n-methylformamide 182.63
    2-pentanol 100.17
    n-pentane 58.73
    1-propoxy-2-propanol 218.13
    1-methoxy-2-propyl acetate 224.12
    2-(2-methoxypropoxy) propanol 140.63
    mesitylene 103.78
    ε-caprolactone 397.67
    p-cymene 143.93
    epichlorohydrin 614.31
    1,1,1-trichloroethane 447.66
    2-aminoethanol 36.01
    morpholine-4-carbaldehyde 335.59
    sulfolane 428.72
    2,2,4-trimethylpentane 26.38
    2-methyltetrahydrofuran 457.2
    n-hexyl acetate 251.91
    isooctane 22.24
    2-(2-butoxyethoxy)ethanol 182.94
    sec-butyl acetate 143.73
    tert-butyl acetate 142.17
    decalin 57.11
    glycerin 28.57
    diglyme 389.56
    acrylic acid 96.76
    isopropyl myristate 114.21
    n-butyric acid 187.07
    acetyl acetate 154.49
    di(2-ethylhexyl) phthalate 81.53
    ethyl propionate 217.81
    nitromethane 289.66
    1,2-diethoxyethane 344.11
    benzonitrile 238.79
    trioctyl phosphate 71.32
    1-bromopropane 398.45
    gamma-valerolactone 494.99
    n-decanol 102.73
    triethyl phosphate 102.63
    4-methyl-2-pentanol 67.18
    propionitrile 262.59
    vinylene carbonate 299.96
    1,1,2-trichlorotrifluoroethane 174.14
    DMS 178.58
    cumene 126.46
    2-octanol 103.5
    2-hexanone 264.7
    octyl acetate 140.86
    limonene 195.04
    1,2-dimethoxyethane 385.23
    ethyl orthosilicate 94.68
    tributyl phosphate 88.15
    diacetone alcohol 134.33
    N,N-dimethylaniline 165.81
    acrylonitrile 282.19
    aniline 164.61
    1,3-propanediol 68.42
    bromobenzene 313.07
    dibromomethane 694.62
    1,1,2,2-tetrachloroethane 535.21
    2-methyl-cyclohexyl acetate 164.87
    tetrabutyl urea 127.78
    diisobutyl methanol 109.84
    2-phenylethanol 172.48
    styrene 178.29
    dioctyl adipate 136.67
    dimethyl sulfate 149.59
    ethyl butyrate 305.38
    methyl lactate 63.2
    butyl lactate 106.18
    diethyl carbonate 187.72
    propanediol butyl ether 96.72
    triethyl orthoformate 155.98
    p-tert-butyltoluene 119.43
    methyl 4-tert-butylbenzoate 161.68
    morpholine 465.55
    tert-butylamine 104.14
    n-dodecanol 87.15
    dimethoxymethane 290.17
    ethylene carbonate 268.6
    cyrene 120.59
    2-ethoxyethyl acetate 221.37
    2-ethylhexyl acetate 296.1
    1,2,4-trichlorobenzene 228.19
    4-methylpyridine 434.53
    dibutyl ether 274.52
    2,6-dimethyl-4-heptanol 109.84
    DEF 306.71
    dimethyl isosorbide 252.8
    tetrachloroethylene 356.24
    eugenol 143.18
    triacetin 173.74
    span 80 117.4
    1,4-butanediol 35.91
    1,1-dichloroethane 531.5
    2-methyl-1-pentanol 106.23
    methyl formate 189.92
    2-methyl-1-butanol 116.17
    n-decane 63.35
    butyronitrile 288.92
    3,7-dimethyl-1-octanol 118.75
    1-chlorooctane 172.69
    1-chlorotetradecane 72.62
    n-nonane 69.99
    undecane 48.34
    tert-butylcyclohexane 51.53
    cyclooctane 41.6
    cyclopentanol 169.95
    tetrahydropyran 528.89
    tert-amyl methyl ether 136.74
    2,5,8-trioxanonane 237.14
    1-hexene 234.15
    2-isopropoxyethanol 104.87
    2,2,2-trifluoroethanol 50.37
    methyl butyrate 304.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction