7-Methoxyflavonol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    7478-60-6

    Molecular formula
    C16H12O4

    SMILES
    COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=CC=C3)O

    Safety labels

  • Odor profile

    Fragrance
    Fruity 60.58%
    Sweet 54.14%
    Phenolic 45.82%
    Vanilla 38.33%
    Berry 34.09%
    Powdery 33.45%
    Burnt 32.79%
    Balsamic 30.46%
    Spicy 29.54%
    Floral 29.5%

     

    Flavor
    Bitter 92.62%
    Lovage 20.0%
    Very strong 19.88%
    Parsley 19.57%
    Indole 19.42%
    Cedarleaf 19.36%
    Naphthalic 19.2%
    Tarragon 19.16%
    Curry 19.16%
    Eugenol 19.04%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    8.49 (weak base)

    Molecular weight
    268.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    572°C

    Flash point

    • 181.63 ˚C est.

  • Synonyms

    • 7-Methoxyflavonol
    • 3-Hydroxy-7-methoxyflavone
    • 3-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one
    • Flavone, 3-hydroxy-7-methoxy-
    • 0ZT4X5SA77
    • UNII-0ZT4X5SA77
    • NSC 401510
    • NSC-401510
    • 3-HYDROXY-7-METHOXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE
    • DTXSID90225760
    • RefChem:106308
    • DTXCID20148251
    • IPRIGHIBTRMTDP-UHFFFAOYSA-N
    • 7478-60-6
    • 3-hydroxy-7-methoxy-2-phenylchromen-4-one
    • 4H-1-Benzopyran-4-one,3-hydroxy-7-methoxy-2-phenyl-
    • 4H-1-Benzopyran-4-one, 3-hydroxy-7-methoxy-2-phenyl-
    • NSC401510
    • MFCD00017640
    • 3-hydroxy-7-methoxy-2-phenyl-chromen-4-one
    • Oprea1_220260
    • Oprea1_593689
    • CHEMBL483836
    • MEGxp0_001708
    • orb1683326
    • SCHEMBL4650060
    • ACon1_002420
    • CHEBI:190987
    • HY-N9241
    • AKOS000600302
    • FM67881
    • NCGC00169865-01
    • PD210359
    • ST086116
    • DB-055910
    • CS-0159052
    • NS00116172
    • H36311
    • 3-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one #
    • Q63408918
    • 3-Hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one; 3-Hydroxy-7-methoxyflavone
    • 7478-60-6

  • Applications

    7-Methoxyflavonol (CAS 7478-60-6) is regarded as a starting material in the synthesis of flavonoid derivatives for pharmaceutical research and the development of bioactive compounds, commonly used as a building block in organic synthesis and in structure–activity relationship (SAR) studies. In cosmetics and personal care, it is evaluated as an antioxidant and may serve as a platform for flavonoid-derived actives in formulations. In industrial manufacturing and polymers, it can be used as a synthetic precursor with potential antioxidant/stabilizing roles for polymers; in coatings/inks it may serve as a precursor for colorants or pigment-like additives based on flavonoids. These applications depend on local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.76
    methanol 0.63
    isopropanol 0.71
    water 0.0
    ethyl acetate 3.7
    n-propanol 0.99
    acetone 5.04
    n-butanol 0.98
    acetonitrile 1.64
    DMF 13.64
    toluene 4.49
    isobutanol 0.88
    1,4-dioxane 9.49
    methyl acetate 5.23
    THF 30.7
    2-butanone 7.29
    n-pentanol 0.97
    sec-butanol 1.07
    n-hexane 0.07
    ethylene glycol 0.66
    NMP 12.32
    cyclohexane 0.17
    DMSO 20.98
    n-butyl acetate 4.14
    n-octanol 0.84
    chloroform 8.28
    n-propyl acetate 3.79
    acetic acid 4.22
    dichloromethane 14.53
    cyclohexanone 10.64
    propylene glycol 0.69
    isopropyl acetate 4.25
    DMAc 24.97
    2-ethoxyethanol 4.5
    isopentanol 1.67
    n-heptane 0.15
    ethyl formate 1.99
    1,2-dichloroethane 14.7
    n-hexanol 1.58
    2-methoxyethanol 7.76
    isobutyl acetate 2.94
    tetrachloromethane 0.39
    n-pentyl acetate 3.41
    transcutol 42.0
    n-heptanol 1.26
    ethylbenzene 2.05
    MIBK 4.61
    2-propoxyethanol 7.52
    tert-butanol 2.07
    MTBE 3.15
    2-butoxyethanol 5.16
    propionic acid 2.34
    o-xylene 2.86
    formic acid 1.35
    diethyl ether 2.65
    m-xylene 2.21
    p-xylene 2.51
    chlorobenzene 4.09
    dimethyl carbonate 5.21
    n-octane 0.08
    formamide 3.87
    cyclopentanone 16.1
    2-pentanone 4.22
    anisole 5.59
    cyclopentyl methyl ether 6.97
    gamma-butyrolactone 16.06
    1-methoxy-2-propanol 6.0
    pyridine 15.05
    3-pentanone 5.19
    furfural 18.38
    n-dodecane 0.12
    diethylene glycol 7.07
    diisopropyl ether 1.2
    tert-amyl alcohol 2.31
    acetylacetone 10.74
    n-hexadecane 0.14
    acetophenone 6.93
    methyl propionate 4.57
    isopentyl acetate 5.4
    trichloroethylene 31.89
    n-nonanol 1.19
    cyclohexanol 1.95
    benzyl alcohol 4.14
    2-ethylhexanol 1.95
    isooctanol 1.49
    dipropyl ether 2.95
    1,2-dichlorobenzene 4.7
    ethyl lactate 2.98
    propylene carbonate 6.19
    n-methylformamide 3.2
    2-pentanol 0.9
    n-pentane 0.06
    1-propoxy-2-propanol 5.75
    1-methoxy-2-propyl acetate 9.65
    2-(2-methoxypropoxy) propanol 9.87
    mesitylene 1.32
    ε-caprolactone 8.15
    p-cymene 2.09
    epichlorohydrin 34.8
    1,1,1-trichloroethane 4.82
    2-aminoethanol 1.08
    morpholine-4-carbaldehyde 18.18
    sulfolane 25.88
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 9.08
    n-hexyl acetate 3.76
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 11.04
    sec-butyl acetate 3.54
    tert-butyl acetate 6.81
    decalin 0.24
    glycerin 2.93
    diglyme 29.7
    acrylic acid 3.62
    isopropyl myristate 2.46
    n-butyric acid 2.85
    acetyl acetate 4.12
    di(2-ethylhexyl) phthalate 3.16
    ethyl propionate 4.25
    nitromethane 11.24
    1,2-diethoxyethane 9.74
    benzonitrile 4.39
    trioctyl phosphate 1.79
    1-bromopropane 3.3
    gamma-valerolactone 22.18
    n-decanol 1.01
    triethyl phosphate 4.08
    4-methyl-2-pentanol 1.24
    propionitrile 2.48
    vinylene carbonate 6.55
    1,1,2-trichlorotrifluoroethane 17.88
    DMS 8.79
    cumene 1.52
    2-octanol 0.84
    2-hexanone 4.39
    octyl acetate 2.61
    limonene 2.4
    1,2-dimethoxyethane 14.74
    ethyl orthosilicate 3.83
    tributyl phosphate 2.59
    diacetone alcohol 9.83
    N,N-dimethylaniline 4.46
    acrylonitrile 4.77
    aniline 4.86
    1,3-propanediol 2.21
    bromobenzene 4.27
    dibromomethane 5.7
    1,1,2,2-tetrachloroethane 18.66
    2-methyl-cyclohexyl acetate 4.99
    tetrabutyl urea 4.07
    diisobutyl methanol 1.92
    2-phenylethanol 5.63
    styrene 2.38
    dioctyl adipate 4.61
    dimethyl sulfate 10.82
    ethyl butyrate 4.27
    methyl lactate 4.39
    butyl lactate 3.68
    diethyl carbonate 3.68
    propanediol butyl ether 3.55
    triethyl orthoformate 4.52
    p-tert-butyltoluene 1.91
    methyl 4-tert-butylbenzoate 8.16
    morpholine 10.48
    tert-butylamine 1.1
    n-dodecanol 0.86
    dimethoxymethane 12.19
    ethylene carbonate 4.47
    cyrene 8.3
    2-ethoxyethyl acetate 7.94
    2-ethylhexyl acetate 4.09
    1,2,4-trichlorobenzene 7.53
    4-methylpyridine 8.12
    dibutyl ether 2.75
    2,6-dimethyl-4-heptanol 1.92
    DEF 6.6
    dimethyl isosorbide 21.57
    tetrachloroethylene 9.88
    eugenol 8.11
    triacetin 7.44
    span 80 5.6
    1,4-butanediol 0.68
    1,1-dichloroethane 4.38
    2-methyl-1-pentanol 1.84
    methyl formate 3.44
    2-methyl-1-butanol 1.47
    n-decane 0.17
    butyronitrile 1.74
    3,7-dimethyl-1-octanol 1.65
    1-chlorooctane 0.89
    1-chlorotetradecane 0.52
    n-nonane 0.12
    undecane 0.14
    tert-butylcyclohexane 0.21
    cyclooctane 0.07
    cyclopentanol 2.11
    tetrahydropyran 6.54
    tert-amyl methyl ether 3.59
    2,5,8-trioxanonane 21.39
    1-hexene 0.57
    2-isopropoxyethanol 3.85
    2,2,2-trifluoroethanol 1.87
    methyl butyrate 5.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction