7-Methoxy-4-methylcoumarin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    2555-28-4

    Molecular formula
    C11H10O3

    SMILES
    CC1=CC(=O)OC2=C1C=CC(=C2)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 66.84%
    Phenolic 44.94%
    Coumarinic 43.23%
    Nutty 42.51%
    Powdery 38.6%
    Vanilla 36.63%
    Hay 36.61%
    Coconut 34.87%
    Tobacco 32.98%
    Creamy 32.2%

     

    Flavor
    Bitter 56.5%
    Sweet 40.02%
    Tonka 30.5%
    Balsam 28.65%
    Woody 25.52%
    Spice 24.17%
    Balsamic 22.61%
    Vanilla 22.47%
    Tobacco 21.4%
    Creamy 21.08%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.54 (neutral)

    Molecular weight
    190.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    342°C

    Flash point

    • 146.84 ˚C est.

  • Synonyms

    • 7-Methoxy-4-methylcoumarin
    • 2555-28-4
    • 7-Methoxy-4-methyl-2H-chromen-2-one
    • 4-Methylherniarin
    • 2H-1-Benzopyran-2-one, 7-methoxy-4-methyl-
    • HYMECROMONE METHYL ETHER
    • 7-methoxy-4-methylchromen-2-one
    • 4-Methyl-7-methoxycoumarin
    • 7-Methoxy-4-methyl-2H-1-benzopyran-2-one
    • MFCD00009773
    • NSC 688805
    • 39JDG776HP
    • 7-Methoxy-4-methyl-chromen-2-one
    • NSC688805
    • UNII-39JDG776HP
    • DTXSID70180242
    • NSC-688805
    • Herniarin, 4-methyl-
    • coumarin,4-methyl-7-methoxy
    • Coumarin, 7-methoxy-4-methyl-
    • Spectrum_000788
    • ST060441
    • SpecPlus_000316
    • Spectrum2_001769
    • Spectrum3_001256
    • Spectrum4_001475
    • Spectrum5_000149
    • 2(1H)-Benzopyran-2-one, 7-methoxy-4-methyl
    • BSPBio_002792
    • KBioGR_002049
    • KBioSS_001268
    • SPECTRUM300540
    • 7-Methoxy-4-Methyl coumarin
    • MLS002207059
    • CHEMBL12636
    • DivK1c_006412
    • SCHEMBL314248
    • SPBio_001637
    • KBio1_001356
    • KBio2_001268
    • KBio2_003836
    • KBio2_006404
    • KBio3_002292
    • DTXCID80102733
    • Methyl 4-methylumbelliferyl ether
    • CHEBI:107662
    • ALBB-023165
    • HY-D0128
    • CCG-38419
    • GEO-02734
    • s4780
    • STK392110
    • AKOS001086638
    • FM25254
    • SDCCGMLS-0066546.P001
    • 7-methoxy-4-methyl-1-benzopyran-2-one
    • NCGC00095600-01
    • NCGC00095600-02
    • NCGC00178467-01
    • 7-Methoxy-4-methyl-2H-chromen-2-one #
    • AS-17835
    • SMR001306707
    • SY048371
    • 1ST164145
    • DB-029378
    • CS-0010038
    • M1393
    • NS00027916
    • F16417
    • EN300-6734931
    • SR-05000002424
    • SR-05000002424-1
    • BRD-K55766625-001-02-6
    • BRD-K55766625-001-04-2
    • Q27185984
    • Z53836589
    • 607-744-0
    • 7-Methoxy-4-methyl-2H-1-benzopyran-2-one;4-Methyl-herniarin;4-Methylumbelliferone methyl ether

  • Applications

    7-Methoxy-4-methylcoumarin is commonly used as a fragrance ingredient and odor fixative in perfumery and cosmetics, and serves as an intermediate for the synthesis of other coumarin derivatives used in pharmaceuticals and dyes. It is also explored as a fluorescent dye or probe for analytical and sensing applications, and may be used as a UV-absorbing or functional additive in coatings, inks, and polymer formulations. In industrial manufacturing, it can act as a building block for specialty monomers and other coumarin-containing intermediates. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.03
    methanol 9.55
    isopropanol 4.47
    water 0.05
    ethyl acetate 21.42
    n-propanol 6.5
    acetone 24.16
    n-butanol 6.47
    acetonitrile 14.34
    DMF 106.26
    toluene 8.07
    isobutanol 5.63
    1,4-dioxane 62.49
    methyl acetate 27.9
    THF 101.0
    2-butanone 24.86
    n-pentanol 4.93
    sec-butanol 4.9
    n-hexane 0.26
    ethylene glycol 5.54
    NMP 151.35
    cyclohexane 0.44
    DMSO 110.93
    n-butyl acetate 17.61
    n-octanol 2.06
    chloroform 43.58
    n-propyl acetate 15.36
    acetic acid 29.1
    dichloromethane 59.65
    cyclohexanone 46.36
    propylene glycol 3.82
    isopropyl acetate 13.96
    DMAc 117.8
    2-ethoxyethanol 22.11
    isopentanol 8.41
    n-heptane 0.29
    ethyl formate 12.59
    1,2-dichloroethane 52.38
    n-hexanol 5.51
    2-methoxyethanol 47.01
    isobutyl acetate 10.68
    tetrachloromethane 3.41
    n-pentyl acetate 7.69
    transcutol 129.81
    n-heptanol 3.07
    ethylbenzene 4.98
    MIBK 14.39
    2-propoxyethanol 29.94
    tert-butanol 11.06
    MTBE 11.63
    2-butoxyethanol 13.8
    propionic acid 14.85
    o-xylene 7.52
    formic acid 18.31
    diethyl ether 10.94
    m-xylene 6.76
    p-xylene 6.99
    chlorobenzene 18.49
    dimethyl carbonate 26.17
    n-octane 0.1
    formamide 41.94
    cyclopentanone 71.9
    2-pentanone 18.29
    anisole 23.6
    cyclopentyl methyl ether 33.38
    gamma-butyrolactone 98.41
    1-methoxy-2-propanol 27.39
    pyridine 45.58
    3-pentanone 18.49
    furfural 97.93
    n-dodecane 0.13
    diethylene glycol 33.96
    diisopropyl ether 3.78
    tert-amyl alcohol 9.78
    acetylacetone 40.38
    n-hexadecane 0.16
    acetophenone 25.59
    methyl propionate 25.53
    isopentyl acetate 18.56
    trichloroethylene 114.09
    n-nonanol 2.35
    cyclohexanol 8.88
    benzyl alcohol 16.03
    2-ethylhexanol 5.03
    isooctanol 3.22
    dipropyl ether 7.81
    1,2-dichlorobenzene 22.77
    ethyl lactate 10.79
    propylene carbonate 38.66
    n-methylformamide 33.65
    2-pentanol 3.9
    n-pentane 0.21
    1-propoxy-2-propanol 17.66
    1-methoxy-2-propyl acetate 32.71
    2-(2-methoxypropoxy) propanol 28.04
    mesitylene 4.01
    ε-caprolactone 44.14
    p-cymene 5.12
    epichlorohydrin 138.3
    1,1,1-trichloroethane 25.47
    2-aminoethanol 8.54
    morpholine-4-carbaldehyde 129.49
    sulfolane 137.75
    2,2,4-trimethylpentane 0.51
    2-methyltetrahydrofuran 51.31
    n-hexyl acetate 10.46
    isooctane 0.32
    2-(2-butoxyethoxy)ethanol 28.83
    sec-butyl acetate 11.93
    tert-butyl acetate 22.88
    decalin 0.83
    glycerin 15.74
    diglyme 78.24
    acrylic acid 21.47
    isopropyl myristate 5.45
    n-butyric acid 16.27
    acetyl acetate 21.75
    di(2-ethylhexyl) phthalate 9.41
    ethyl propionate 17.51
    nitromethane 83.24
    1,2-diethoxyethane 22.62
    benzonitrile 17.16
    trioctyl phosphate 4.81
    1-bromopropane 11.63
    gamma-valerolactone 115.33
    n-decanol 1.84
    triethyl phosphate 15.7
    4-methyl-2-pentanol 4.07
    propionitrile 11.73
    vinylene carbonate 38.91
    1,1,2-trichlorotrifluoroethane 72.53
    DMS 28.39
    cumene 4.46
    2-octanol 1.7
    2-hexanone 14.85
    octyl acetate 6.23
    limonene 6.49
    1,2-dimethoxyethane 58.12
    ethyl orthosilicate 13.81
    tributyl phosphate 7.85
    diacetone alcohol 29.27
    N,N-dimethylaniline 17.89
    acrylonitrile 22.27
    aniline 20.04
    1,3-propanediol 13.98
    bromobenzene 15.83
    dibromomethane 25.87
    1,1,2,2-tetrachloroethane 72.83
    2-methyl-cyclohexyl acetate 18.54
    tetrabutyl urea 10.99
    diisobutyl methanol 4.14
    2-phenylethanol 17.03
    styrene 6.04
    dioctyl adipate 12.44
    dimethyl sulfate 61.11
    ethyl butyrate 16.89
    methyl lactate 16.96
    butyl lactate 8.61
    diethyl carbonate 16.77
    propanediol butyl ether 10.11
    triethyl orthoformate 16.07
    p-tert-butyltoluene 4.94
    methyl 4-tert-butylbenzoate 22.38
    morpholine 67.23
    tert-butylamine 5.52
    n-dodecanol 1.46
    dimethoxymethane 58.3
    ethylene carbonate 28.56
    cyrene 37.16
    2-ethoxyethyl acetate 20.2
    2-ethylhexyl acetate 15.32
    1,2,4-trichlorobenzene 32.07
    4-methylpyridine 39.76
    dibutyl ether 4.4
    2,6-dimethyl-4-heptanol 4.14
    DEF 35.09
    dimethyl isosorbide 66.02
    tetrachloroethylene 40.36
    eugenol 22.36
    triacetin 21.02
    span 80 14.89
    1,4-butanediol 4.34
    1,1-dichloroethane 21.91
    2-methyl-1-pentanol 7.25
    methyl formate 28.9
    2-methyl-1-butanol 7.71
    n-decane 0.2
    butyronitrile 9.36
    3,7-dimethyl-1-octanol 3.85
    1-chlorooctane 1.45
    1-chlorotetradecane 0.81
    n-nonane 0.15
    undecane 0.16
    tert-butylcyclohexane 0.77
    cyclooctane 0.18
    cyclopentanol 11.76
    tetrahydropyran 28.89
    tert-amyl methyl ether 12.24
    2,5,8-trioxanonane 59.19
    1-hexene 1.72
    2-isopropoxyethanol 15.18
    2,2,2-trifluoroethanol 19.09
    methyl butyrate 20.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction