7-Methoxy-1-methyl-2-phenyl-4(1H)-quinolinone

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  • Identifiers

    CAS number
    483-51-2

    Molecular formula
    C17H15NO2

    SMILES
    CN1C(=CC(=O)C2=C1C=C(C=C2)OC)C3=CC=CC=C3

    Safety labels

  • Odor profile

    Fragrance
    Floral 60.54%
    Sweet 51.13%
    Fruity 48.65%
    Neroli 43.82%
    Grape 39.28%
    Powdery 37.29%
    Animal 36.33%
    Orange 34.02%
    Phenolic 31.76%
    Honey 27.56%

     

    Flavor
    Bitter 93.08%
    Very strong 20.51%
    Indole 20.21%
    Lovage 19.78%
    Nitrile 19.65%
    Cedarleaf 19.48%
    Parsley 18.98%
    Moth ball 18.89%
    Naphthelene 18.88%
    Broom 18.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    6.43 (neutral)

    Molecular weight
    265.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    511°C

    Melting point expt.

    • 200 - 201 °C

    Flash point

    • 203.93 ˚C est.

  • Synonyms

    • EDULEINE
    • 483-51-2
    • 7-methoxy-1-methyl-2-phenyl-4(1H)-quinolinone
    • KY2D9CAQ7P
    • NSC-77150
    • 7-methoxy-1-methyl-2-phenyl-1,4-dihydroquinolin-4-one
    • RefChem:1074458
    • 7-methoxy-1-methyl-2-phenylquinolin-4(1h)-one
    • 7-methoxy-1-methyl-2-phenylquinolin-4-one
    • 7-methoxy-1-methyl-2-phenyl-quinolin-4-one
    • MLS000549198
    • SMR000113846
    • 4(1H)-Quinolone, 7-methoxy-1-methyl-2-phenyl-
    • 4(1H)-Quinolinone, 7-methoxy-1-methyl-2-phenyl-
    • NSC77150
    • UNII-KY2D9CAQ7P
    • Oprea1_614141
    • cid_253834
    • orb3023920
    • SCHEMBL7912617
    • CHEMBL1721520
    • BDBM32704
    • DTXSID50291683
    • HMS2318A12
    • 7-methoxy-1-methyl-2-phenyl-4-quinolone
    • 7-methoxy-1-methyl-2-phenyl-4-quinolinone
    • DS-009230
    • AB00464856-08
    • AE-562/12222921
    • 483-51-2

  • Applications

    7-Methoxy-1-methyl-2-phenyl-4(1H)-quinolinone (CAS 483-51-2) is primarily used as an advanced synthetic intermediate and scaffold for quinolinone and other heterocyclic compounds in pharmaceutical development; it is commonly employed as a building block in drug synthesis and serves as a basis for medicinal chemistry programs aiming to develop heterocyclic pharmacophores. In industrial and academic settings, it can function as a modular precursor for assembling polycyclic heterocycles and may be used as a reagent in aromatic coupling or ring-formation transformations to access more complex structures. The compound may also be explored as a precursor for dye or optoelectronic materials and as a ligand precursor for coordination chemistry and catalytic applications. Depending on local regulations and formulation constraints, it can be considered a research intermediate for polymer and coating-related investigations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.24
    methanol 10.17
    isopropanol 6.13
    water 0.02
    ethyl acetate 23.4
    n-propanol 11.11
    acetone 26.91
    n-butanol 9.01
    acetonitrile 23.58
    DMF 69.04
    toluene 19.57
    isobutanol 8.17
    1,4-dioxane 74.78
    methyl acetate 30.45
    THF 114.17
    2-butanone 33.96
    n-pentanol 8.51
    sec-butanol 6.1
    n-hexane 0.28
    ethylene glycol 6.37
    NMP 45.55
    cyclohexane 0.88
    DMSO 109.28
    n-butyl acetate 15.84
    n-octanol 2.03
    chloroform 202.97
    n-propyl acetate 19.96
    acetic acid 32.03
    dichloromethane 307.85
    cyclohexanone 52.92
    propylene glycol 3.8
    isopropyl acetate 13.33
    DMAc 78.36
    2-ethoxyethanol 32.64
    isopentanol 9.42
    n-heptane 0.41
    ethyl formate 20.63
    1,2-dichloroethane 214.15
    n-hexanol 7.67
    2-methoxyethanol 47.23
    isobutyl acetate 13.89
    tetrachloromethane 9.07
    n-pentyl acetate 8.53
    transcutol 92.08
    n-heptanol 3.92
    ethylbenzene 8.63
    MIBK 13.85
    2-propoxyethanol 30.55
    tert-butanol 8.82
    MTBE 7.42
    2-butoxyethanol 15.97
    propionic acid 16.44
    o-xylene 10.07
    formic acid 17.72
    diethyl ether 14.13
    m-xylene 9.08
    p-xylene 11.85
    chlorobenzene 39.28
    dimethyl carbonate 19.76
    n-octane 0.18
    formamide 43.12
    cyclopentanone 73.19
    2-pentanone 19.24
    anisole 25.14
    cyclopentyl methyl ether 27.06
    gamma-butyrolactone 87.82
    1-methoxy-2-propanol 21.38
    pyridine 91.78
    3-pentanone 20.44
    furfural 105.41
    n-dodecane 0.21
    diethylene glycol 36.01
    diisopropyl ether 3.09
    tert-amyl alcohol 7.05
    acetylacetone 33.66
    n-hexadecane 0.26
    acetophenone 27.96
    methyl propionate 22.61
    isopentyl acetate 17.04
    trichloroethylene 340.35
    n-nonanol 2.55
    cyclohexanol 10.63
    benzyl alcohol 23.65
    2-ethylhexanol 6.2
    isooctanol 4.07
    dipropyl ether 8.68
    1,2-dichlorobenzene 36.47
    ethyl lactate 10.49
    propylene carbonate 34.0
    n-methylformamide 33.06
    2-pentanol 4.0
    n-pentane 0.23
    1-propoxy-2-propanol 14.96
    1-methoxy-2-propyl acetate 24.3
    2-(2-methoxypropoxy) propanol 19.92
    mesitylene 4.41
    ε-caprolactone 39.69
    p-cymene 6.2
    epichlorohydrin 216.98
    1,1,1-trichloroethane 58.91
    2-aminoethanol 10.14
    morpholine-4-carbaldehyde 72.49
    sulfolane 88.94
    2,2,4-trimethylpentane 0.36
    2-methyltetrahydrofuran 45.24
    n-hexyl acetate 8.41
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 24.26
    sec-butyl acetate 13.0
    tert-butyl acetate 14.81
    decalin 0.88
    glycerin 13.5
    diglyme 67.98
    acrylic acid 22.07
    isopropyl myristate 4.83
    n-butyric acid 18.89
    acetyl acetate 18.94
    di(2-ethylhexyl) phthalate 8.39
    ethyl propionate 17.81
    nitromethane 82.28
    1,2-diethoxyethane 24.32
    benzonitrile 27.95
    trioctyl phosphate 4.26
    1-bromopropane 34.86
    gamma-valerolactone 102.2
    n-decanol 2.1
    triethyl phosphate 13.49
    4-methyl-2-pentanol 3.86
    propionitrile 21.1
    vinylene carbonate 40.62
    1,1,2-trichlorotrifluoroethane 91.88
    DMS 19.51
    cumene 6.35
    2-octanol 2.05
    2-hexanone 20.46
    octyl acetate 5.58
    limonene 6.39
    1,2-dimethoxyethane 65.53
    ethyl orthosilicate 12.25
    tributyl phosphate 6.29
    diacetone alcohol 18.97
    N,N-dimethylaniline 15.5
    acrylonitrile 36.92
    aniline 27.99
    1,3-propanediol 17.41
    bromobenzene 39.82
    dibromomethane 133.52
    1,1,2,2-tetrachloroethane 188.96
    2-methyl-cyclohexyl acetate 17.33
    tetrabutyl urea 9.08
    diisobutyl methanol 4.62
    2-phenylethanol 20.8
    styrene 11.1
    dioctyl adipate 10.21
    dimethyl sulfate 36.04
    ethyl butyrate 16.15
    methyl lactate 12.2
    butyl lactate 8.59
    diethyl carbonate 15.64
    propanediol butyl ether 7.82
    triethyl orthoformate 13.95
    p-tert-butyltoluene 5.02
    methyl 4-tert-butylbenzoate 18.39
    morpholine 75.2
    tert-butylamine 4.26
    n-dodecanol 1.8
    dimethoxymethane 47.78
    ethylene carbonate 30.29
    cyrene 27.25
    2-ethoxyethyl acetate 22.11
    2-ethylhexyl acetate 13.82
    1,2,4-trichlorobenzene 46.58
    4-methylpyridine 52.55
    dibutyl ether 4.97
    2,6-dimethyl-4-heptanol 4.62
    DEF 26.6
    dimethyl isosorbide 45.18
    tetrachloroethylene 114.18
    eugenol 21.95
    triacetin 16.68
    span 80 11.9
    1,4-butanediol 6.96
    1,1-dichloroethane 72.42
    2-methyl-1-pentanol 10.12
    methyl formate 28.85
    2-methyl-1-butanol 8.29
    n-decane 0.31
    butyronitrile 17.13
    3,7-dimethyl-1-octanol 3.69
    1-chlorooctane 2.14
    1-chlorotetradecane 1.15
    n-nonane 0.22
    undecane 0.25
    tert-butylcyclohexane 0.72
    cyclooctane 0.24
    cyclopentanol 13.66
    tetrahydropyran 44.92
    tert-amyl methyl ether 6.85
    2,5,8-trioxanonane 45.82
    1-hexene 2.71
    2-isopropoxyethanol 20.79
    2,2,2-trifluoroethanol 20.94
    methyl butyrate 23.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction