7-Hydroxyflavanone

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  • Identifiers

    CAS number
    6515-36-2

    Molecular formula
    C15H12O3

    SMILES
    C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 66.72%
    Phenolic 52.67%
    Coumarinic 47.71%
    Spicy 47.31%
    Vanilla 41.4%
    Coconut 40.89%
    Balsamic 35.81%
    Hay 33.58%
    Aromatic 31.92%
    Nutty 31.71%

     

    Flavor
    Bitter 90.21%
    Herbal 27.11%
    Tonka 25.44%
    Lovage 21.47%
    Balsam 20.84%
    Cedarleaf 19.62%
    Sweet 19.51%
    Naphthalic 19.46%
    Parsley 19.2%
    Ripe apricot 19.16%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    9.55 (weak base)

    Molecular weight
    240.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    462°C

    Flash point

    • 192.4 ˚C est.

  • Synonyms

    • 7-Hydroxyflavanone
    • 6515-36-2
    • 7-hydroxy-2-phenyl-2,3-dihydrochromen-4-one
    • DTXSID0022430
    • 2,3-dihydro-7-hydroxy-2-phenyl-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-phenyl-
    • CC64495H41
    • J502.873F
    • CHEBI:34483
    • RefChem:546584
    • GlyTouCan:G46738CU
    • DTXCID902430
    • G46738CU
    • 624-686-1
    • 7-Hydroxy-2-phenylchroman-4-one
    • MFCD00017487
    • 7-hydroxy-2-phenyl-chroman-4-one
    • 7-hydroxy-2-phenyl-4-chromanone
    • CHEMBL97542
    • 2H-1-Benzopyran-7-yloxy
    • 7-hydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
    • 7-hydroxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • UNII-CC64495H41
    • 7-hydroxy-flavanone
    • 7-hydroxydihydroflavone
    • 7-Hydroxyflavanone, 98%
    • Oprea1_401356
    • MLS001181922
    • SCHEMBL130266
    • FLAVANONE, 7-HYDROXY-
    • orb1299311
    • SCHEMBL11383085
    • SCHEMBL29843931
    • HMS1664L06
    • HMS2865F07
    • EX-A7837
    • BDBM50104887
    • LMPK12140018
    • AKOS015856572
    • EBC-466096
    • FH67345
    • NCGC00246641-01
    • AS-60587
    • PD039777
    • SMR000567707
    • ST079153
    • SY049415
    • DB-054767
    • CS-0128374
    • H1006
    • D90988
    • Q27116101
    • 7-Hydroxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
    • 6515-36-2

  • Applications

    7-Hydroxyflavanone (CAS 6515-36-2) is primarily used as an organic-synthesis intermediate, providing a flavanone scaffold for the preparation of flavonoid derivatives and related heterocycles. It is commonly employed in pharmaceutical and biomedical research as a building block for target compounds and for library generation in medicinal chemistry. In industrial and academic settings, it supports method development and the exploration of new synthetic routes within flavonoid chemistry. The material may also be evaluated as a fragrance intermediate or precursor to aroma compounds in cosmetics, and as a precursor in dye and colorant chemistry for coatings and inks, depending on formulation goals and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.45
    methanol 31.47
    isopropanol 16.82
    water 0.21
    ethyl acetate 63.5
    n-propanol 12.98
    acetone 132.32
    n-butanol 12.66
    acetonitrile 108.27
    DMF 196.87
    toluene 12.98
    isobutanol 12.65
    1,4-dioxane 268.99
    methyl acetate 104.12
    THF 270.18
    2-butanone 97.06
    n-pentanol 15.49
    sec-butanol 11.91
    n-hexane 0.08
    ethylene glycol 26.67
    NMP 89.22
    cyclohexane 0.28
    DMSO 560.97
    n-butyl acetate 41.54
    n-octanol 9.4
    chloroform 50.53
    n-propyl acetate 50.19
    acetic acid 68.27
    dichloromethane 48.18
    cyclohexanone 99.77
    propylene glycol 29.97
    isopropyl acetate 42.03
    DMAc 295.3
    2-ethoxyethanol 83.61
    isopentanol 19.57
    n-heptane 0.46
    ethyl formate 42.5
    1,2-dichloroethane 61.02
    n-hexanol 13.52
    2-methoxyethanol 133.38
    isobutyl acetate 33.49
    tetrachloromethane 2.59
    n-pentyl acetate 20.48
    transcutol 714.7
    n-heptanol 8.92
    ethylbenzene 7.41
    MIBK 42.29
    2-propoxyethanol 78.81
    tert-butanol 39.36
    MTBE 25.33
    2-butoxyethanol 39.49
    propionic acid 40.35
    o-xylene 10.52
    formic acid 33.35
    diethyl ether 19.68
    m-xylene 10.45
    p-xylene 11.81
    chlorobenzene 25.18
    dimethyl carbonate 74.57
    n-octane 0.25
    formamide 104.98
    cyclopentanone 146.69
    2-pentanone 52.32
    anisole 53.15
    cyclopentyl methyl ether 45.45
    gamma-butyrolactone 171.42
    1-methoxy-2-propanol 99.85
    pyridine 85.4
    3-pentanone 51.64
    furfural 153.22
    n-dodecane 0.73
    diethylene glycol 109.16
    diisopropyl ether 7.78
    tert-amyl alcohol 21.23
    acetylacetone 137.71
    n-hexadecane 0.87
    acetophenone 54.73
    methyl propionate 64.06
    isopentyl acetate 41.08
    trichloroethylene 137.77
    n-nonanol 10.68
    cyclohexanol 19.66
    benzyl alcohol 42.28
    2-ethylhexanol 12.63
    isooctanol 9.73
    dipropyl ether 21.02
    1,2-dichlorobenzene 26.24
    ethyl lactate 40.0
    propylene carbonate 76.68
    n-methylformamide 85.5
    2-pentanol 10.81
    n-pentane 0.08
    1-propoxy-2-propanol 55.81
    1-methoxy-2-propyl acetate 79.35
    2-(2-methoxypropoxy) propanol 84.78
    mesitylene 7.41
    ε-caprolactone 77.08
    p-cymene 9.26
    epichlorohydrin 213.01
    1,1,1-trichloroethane 31.37
    2-aminoethanol 29.25
    morpholine-4-carbaldehyde 209.07
    sulfolane 199.03
    2,2,4-trimethylpentane 0.5
    2-methyltetrahydrofuran 65.4
    n-hexyl acetate 33.08
    isooctane 0.48
    2-(2-butoxyethoxy)ethanol 117.08
    sec-butyl acetate 35.06
    tert-butyl acetate 50.73
    decalin 0.88
    glycerin 71.1
    diglyme 268.66
    acrylic acid 54.26
    isopropyl myristate 18.88
    n-butyric acid 39.36
    acetyl acetate 60.49
    di(2-ethylhexyl) phthalate 22.38
    ethyl propionate 46.59
    nitromethane 264.54
    1,2-diethoxyethane 112.61
    benzonitrile 51.59
    trioctyl phosphate 14.36
    1-bromopropane 8.64
    gamma-valerolactone 204.58
    n-decanol 9.29
    triethyl phosphate 29.82
    4-methyl-2-pentanol 11.66
    propionitrile 53.95
    vinylene carbonate 81.7
    1,1,2-trichlorotrifluoroethane 137.54
    DMS 70.8
    cumene 6.75
    2-octanol 5.71
    2-hexanone 47.32
    octyl acetate 21.38
    limonene 10.8
    1,2-dimethoxyethane 190.12
    ethyl orthosilicate 25.61
    tributyl phosphate 21.57
    diacetone alcohol 75.6
    N,N-dimethylaniline 29.41
    acrylonitrile 93.66
    aniline 34.19
    1,3-propanediol 45.11
    bromobenzene 20.95
    dibromomethane 17.08
    1,1,2,2-tetrachloroethane 99.16
    2-methyl-cyclohexyl acetate 34.96
    tetrabutyl urea 29.65
    diisobutyl methanol 11.56
    2-phenylethanol 33.88
    styrene 10.7
    dioctyl adipate 36.08
    dimethyl sulfate 119.44
    ethyl butyrate 38.65
    methyl lactate 62.87
    butyl lactate 29.44
    diethyl carbonate 36.63
    propanediol butyl ether 48.97
    triethyl orthoformate 36.37
    p-tert-butyltoluene 8.57
    methyl 4-tert-butylbenzoate 46.45
    morpholine 186.71
    tert-butylamine 12.18
    n-dodecanol 7.95
    dimethoxymethane 165.46
    ethylene carbonate 68.94
    cyrene 71.29
    2-ethoxyethyl acetate 60.26
    2-ethylhexyl acetate 30.68
    1,2,4-trichlorobenzene 39.52
    4-methylpyridine 61.28
    dibutyl ether 22.13
    2,6-dimethyl-4-heptanol 11.56
    DEF 66.77
    dimethyl isosorbide 129.98
    tetrachloroethylene 41.69
    eugenol 48.02
    triacetin 78.06
    span 80 45.46
    1,4-butanediol 20.45
    1,1-dichloroethane 32.12
    2-methyl-1-pentanol 18.33
    methyl formate 89.93
    2-methyl-1-butanol 13.89
    n-decane 0.89
    butyronitrile 29.5
    3,7-dimethyl-1-octanol 15.09
    1-chlorooctane 5.64
    1-chlorotetradecane 3.49
    n-nonane 0.6
    undecane 0.82
    tert-butylcyclohexane 0.89
    cyclooctane 0.19
    cyclopentanol 23.09
    tetrahydropyran 68.52
    tert-amyl methyl ether 19.23
    2,5,8-trioxanonane 186.87
    1-hexene 0.82
    2-isopropoxyethanol 58.87
    2,2,2-trifluoroethanol 38.37
    methyl butyrate 54.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction