7-Hydroxy-5-methylflavone

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  • Identifiers

    CAS number
    15235-99-1

    Molecular formula
    C16H12O3

    SMILES
    CC1=CC(=CC2=C1C(=O)C=C(O2)C3=CC=CC=C3)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 51.81%
    Fruity 36.27%
    Animal 31.85%
    Burnt 31.45%
    Sweet 31.25%
    Odorless 27.0%
    Powdery 26.92%
    Woody 26.88%
    Dry 26.45%
    Medicinal 25.73%

     

    Flavor
    Bitter 90.78%
    Very strong 21.41%
    Indole 21.1%
    Cedarleaf 20.59%
    Nitrile 20.57%
    Lovage 20.42%
    Parsley 20.09%
    Moth ball 20.08%
    Naphthelene 19.9%
    Ripe apricot 19.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    8.98 (weak base)

    Molecular weight
    252.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    562°C

    Flash point

    • 181.21 ˚C est.

  • Synonyms

    • 7-Hydroxy-5-methylflavone
    • 7-hydroxy-5-methyl-2-phenylchromen-4-one
    • Flavone, 7-hydroxy-5-methyl-
    • WEM49N23AB
    • HYDROXY-5-METHYLFLAVONE, 7-
    • 7-Hydroxy-5-methyl-2-phenyl-4H-1-benzopyran-4-one
    • DTXSID10934483
    • 4H-1-Benzopyran-4-one, 7-hydroxy-5-methyl-2-phenyl-
    • RefChem:106171
    • DTXCID001363130
    • QGHXBJKZPBTQQL-UHFFFAOYSA-N
    • 15235-99-1
    • 7-hydroxy-5-methyl-2-phenyl-4H-chromen-4-one
    • MFCD00017601
    • METHOXYVONE_met006
    • 7-Hydroxy-5-methylflavon
    • UNII-WEM49N23AB
    • 4H-1-Benzopyran-4-one,7-hydroxy-5-methyl-2-phenyl-
    • orb1683331
    • SCHEMBL1144261
    • SCHEMBL31675833
    • AKOS024282452
    • FH66016
    • ST056255
    • DB-043140
    • 7-hydroxy-5-methyl-2-phenyl-chromen-4-one
    • NS00116346
    • 15235-99-1

  • Applications

    7-Hydroxy-5-methylflavone (CAS 15235-99-1) is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, while also serving as a scaffold for more complex flavonoid structures in research and development. Because of its polyphenolic nature, it is regarded as an important research reagent for flavone chemistry and as a precursor for new synthetic routes. In cosmetics and personal care, it is evaluated as an antioxidant and a potential stabilizer in formulations. In the materials arena, it is explored as a potential component for polymers, coatings, and inks, with the aim of enhancing optical stability and resistance to oxidation, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.94
    methanol 3.47
    isopropanol 3.06
    water 0.0
    ethyl acetate 7.19
    n-propanol 4.88
    acetone 15.42
    n-butanol 4.48
    acetonitrile 5.26
    DMF 95.77
    toluene 4.78
    isobutanol 4.06
    1,4-dioxane 40.95
    methyl acetate 12.97
    THF 142.92
    2-butanone 16.11
    n-pentanol 4.56
    sec-butanol 3.47
    n-hexane 0.04
    ethylene glycol 3.69
    NMP 103.58
    cyclohexane 0.06
    DMSO 201.25
    n-butyl acetate 11.2
    n-octanol 2.2
    chloroform 8.91
    n-propyl acetate 11.13
    acetic acid 17.47
    dichloromethane 13.92
    cyclohexanone 36.58
    propylene glycol 5.38
    isopropyl acetate 7.74
    DMAc 91.98
    2-ethoxyethanol 19.57
    isopentanol 6.17
    n-heptane 0.09
    ethyl formate 6.7
    1,2-dichloroethane 18.84
    n-hexanol 4.36
    2-methoxyethanol 43.22
    isobutyl acetate 9.1
    tetrachloromethane 0.32
    n-pentyl acetate 7.8
    transcutol 209.98
    n-heptanol 3.19
    ethylbenzene 1.8
    MIBK 11.84
    2-propoxyethanol 31.09
    tert-butanol 5.7
    MTBE 4.87
    2-butoxyethanol 15.47
    propionic acid 10.39
    o-xylene 2.24
    formic acid 6.11
    diethyl ether 3.42
    m-xylene 2.68
    p-xylene 2.72
    chlorobenzene 7.48
    dimethyl carbonate 12.82
    n-octane 0.05
    formamide 15.04
    cyclopentanone 75.31
    2-pentanone 11.61
    anisole 11.35
    cyclopentyl methyl ether 23.06
    gamma-butyrolactone 85.46
    1-methoxy-2-propanol 32.51
    pyridine 36.78
    3-pentanone 7.3
    furfural 66.83
    n-dodecane 0.13
    diethylene glycol 34.21
    diisopropyl ether 1.34
    tert-amyl alcohol 5.26
    acetylacetone 29.05
    n-hexadecane 0.16
    acetophenone 15.24
    methyl propionate 11.38
    isopentyl acetate 13.73
    trichloroethylene 45.54
    n-nonanol 2.73
    cyclohexanol 6.35
    benzyl alcohol 12.4
    2-ethylhexanol 4.26
    isooctanol 3.56
    dipropyl ether 5.6
    1,2-dichlorobenzene 7.11
    ethyl lactate 10.81
    propylene carbonate 28.24
    n-methylformamide 18.97
    2-pentanol 2.63
    n-pentane 0.03
    1-propoxy-2-propanol 22.17
    1-methoxy-2-propyl acetate 28.89
    2-(2-methoxypropoxy) propanol 31.05
    mesitylene 1.32
    ε-caprolactone 35.42
    p-cymene 2.4
    epichlorohydrin 129.41
    1,1,1-trichloroethane 5.31
    2-aminoethanol 6.87
    morpholine-4-carbaldehyde 106.71
    sulfolane 150.02
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 38.05
    n-hexyl acetate 9.98
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 38.84
    sec-butyl acetate 8.21
    tert-butyl acetate 14.1
    decalin 0.21
    glycerin 18.01
    diglyme 87.69
    acrylic acid 14.48
    isopropyl myristate 5.4
    n-butyric acid 11.76
    acetyl acetate 8.15
    di(2-ethylhexyl) phthalate 8.49
    ethyl propionate 9.57
    nitromethane 48.17
    1,2-diethoxyethane 27.52
    benzonitrile 12.51
    trioctyl phosphate 4.83
    1-bromopropane 3.68
    gamma-valerolactone 117.69
    n-decanol 2.32
    triethyl phosphate 9.01
    4-methyl-2-pentanol 3.13
    propionitrile 4.95
    vinylene carbonate 25.67
    1,1,2-trichlorotrifluoroethane 58.12
    DMS 21.26
    cumene 1.64
    2-octanol 1.95
    2-hexanone 12.06
    octyl acetate 6.44
    limonene 3.41
    1,2-dimethoxyethane 46.87
    ethyl orthosilicate 8.07
    tributyl phosphate 7.3
    diacetone alcohol 28.48
    N,N-dimethylaniline 8.13
    acrylonitrile 11.42
    aniline 12.01
    1,3-propanediol 12.36
    bromobenzene 5.9
    dibromomethane 5.82
    1,1,2,2-tetrachloroethane 29.22
    2-methyl-cyclohexyl acetate 12.66
    tetrabutyl urea 10.46
    diisobutyl methanol 3.8
    2-phenylethanol 12.63
    styrene 2.4
    dioctyl adipate 12.38
    dimethyl sulfate 36.88
    ethyl butyrate 9.96
    methyl lactate 16.66
    butyl lactate 11.67
    diethyl carbonate 7.75
    propanediol butyl ether 15.22
    triethyl orthoformate 10.98
    p-tert-butyltoluene 2.43
    methyl 4-tert-butylbenzoate 17.39
    morpholine 58.92
    tert-butylamine 2.19
    n-dodecanol 1.94
    dimethoxymethane 40.33
    ethylene carbonate 17.4
    cyrene 30.8
    2-ethoxyethyl acetate 21.3
    2-ethylhexyl acetate 10.0
    1,2,4-trichlorobenzene 12.5
    4-methylpyridine 27.65
    dibutyl ether 5.27
    2,6-dimethyl-4-heptanol 3.8
    DEF 21.57
    dimethyl isosorbide 61.83
    tetrachloroethylene 10.29
    eugenol 20.68
    triacetin 21.97
    span 80 19.59
    1,4-butanediol 4.56
    1,1-dichloroethane 5.7
    2-methyl-1-pentanol 6.37
    methyl formate 16.79
    2-methyl-1-butanol 5.26
    n-decane 0.18
    butyronitrile 5.11
    3,7-dimethyl-1-octanol 4.02
    1-chlorooctane 1.49
    1-chlorotetradecane 0.76
    n-nonane 0.12
    undecane 0.15
    tert-butylcyclohexane 0.23
    cyclooctane 0.03
    cyclopentanol 10.47
    tetrahydropyran 19.73
    tert-amyl methyl ether 5.37
    2,5,8-trioxanonane 59.67
    1-hexene 0.55
    2-isopropoxyethanol 14.21
    2,2,2-trifluoroethanol 6.76
    methyl butyrate 12.99

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction