(6E,10E,14E)-16-Hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one

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  • Identifiers

    CAS number
    67880-32-4

    Molecular formula
    C20H32O2

    SMILES
    CC(=CC(=O)C/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 84.27%
    Rose 64.67%
    Sweet 62.92%
    Fruity 62.33%
    Waxy 51.6%
    Woody 51.53%
    Citrus 48.31%
    Fresh 46.3%
    Balsamic 37.38%
    Green 37.17%

     

    Flavor
    Floral 65.89%
    Sweet 48.01%
    Waxy 44.11%
    Green 43.73%
    Citrus 40.97%
    Fruity 36.23%
    Rose 35.52%
    Orange 33.74%
    Herbal 33.29%
    Woody 32.7%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.5

    pKa est.
    8.55 (weak base)

    Molecular weight
    304.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    390°C

    Flash point

    • 176.87 ˚C est.

  • Synonyms

    • Eleganolone
    • 67880-32-4
    • (6E,10E,14E)-16-hydroxy-2,6,10,14-tetramethylhexadeca-2,6,10,14-tetraen-4-one
    • DTXSID701139176
    • 2,6,10,14-Hexadecatetraen-4-one, 16-hydroxy-2,6,10,14-tetramethyl-, (E,E,E)-
    • (6E,10E,14E)-16-Hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one
    • RefChem:906255
    • DTXCID401570799
    • BRN 1968009
    • (E,E,E)-16-Hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one
    • CHEMBL444409
    • SCHEMBL31305336
    • SCHEMBL31305337
    • 67880-32-4

  • Applications

    The chemical (6E,10E,14E)-16-Hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one (CAS 67880-32-4) is used as an odorant and fragrance intermediate in perfumery and is commonly evaluated for cosmetics and personal care formulations as a fragrance ingredient. It may also be employed in household products such as air fresheners and cleaners as a fragrance additive, and in industrial manufacturing as a specialty chemical intermediate for synthesis. In coatings and inks it can serve as an odorant/fragrance additive to impart scent in surface finishes, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 192.1
    methanol 177.42
    isopropanol 89.92
    water 0.06
    ethyl acetate 102.44
    n-propanol 143.92
    acetone 96.35
    n-butanol 146.04
    acetonitrile 28.06
    DMF 99.65
    toluene 54.78
    isobutanol 84.76
    1,4-dioxane 271.23
    methyl acetate 60.71
    THF 544.94
    2-butanone 113.75
    n-pentanol 129.78
    sec-butanol 112.57
    n-hexane 24.62
    ethylene glycol 4.25
    NMP 136.09
    cyclohexane 30.12
    DMSO 107.0
    n-butyl acetate 105.7
    n-octanol 56.52
    chloroform 206.97
    n-propyl acetate 101.2
    acetic acid 57.98
    dichloromethane 159.52
    cyclohexanone 192.59
    propylene glycol 21.52
    isopropyl acetate 79.55
    DMAc 177.99
    2-ethoxyethanol 163.48
    isopentanol 115.62
    n-heptane 16.15
    ethyl formate 48.52
    1,2-dichloroethane 106.15
    n-hexanol 132.74
    2-methoxyethanol 178.65
    isobutyl acetate 84.32
    tetrachloromethane 25.95
    n-pentyl acetate 85.56
    transcutol 588.87
    n-heptanol 68.83
    ethylbenzene 47.47
    MIBK 92.38
    2-propoxyethanol 207.58
    tert-butanol 128.06
    MTBE 134.93
    2-butoxyethanol 137.99
    propionic acid 42.65
    o-xylene 39.44
    formic acid 14.8
    diethyl ether 159.29
    m-xylene 45.73
    p-xylene 55.14
    chlorobenzene 60.14
    dimethyl carbonate 17.86
    n-octane 5.98
    formamide 19.35
    cyclopentanone 172.73
    2-pentanone 112.35
    anisole 100.87
    cyclopentyl methyl ether 170.06
    gamma-butyrolactone 133.56
    1-methoxy-2-propanol 148.96
    pyridine 119.24
    3-pentanone 78.54
    furfural 109.21
    n-dodecane 3.85
    diethylene glycol 69.85
    diisopropyl ether 43.38
    tert-amyl alcohol 122.52
    acetylacetone 93.7
    n-hexadecane 4.43
    acetophenone 91.64
    methyl propionate 63.71
    isopentyl acetate 111.34
    trichloroethylene 169.32
    n-nonanol 58.45
    cyclohexanol 104.32
    benzyl alcohol 74.03
    2-ethylhexanol 84.46
    isooctanol 59.89
    dipropyl ether 119.84
    1,2-dichlorobenzene 60.45
    ethyl lactate 44.35
    propylene carbonate 78.69
    n-methylformamide 37.06
    2-pentanol 85.31
    n-pentane 15.18
    1-propoxy-2-propanol 167.72
    1-methoxy-2-propyl acetate 124.32
    2-(2-methoxypropoxy) propanol 141.5
    mesitylene 33.06
    ε-caprolactone 162.3
    p-cymene 35.49
    epichlorohydrin 199.34
    1,1,1-trichloroethane 89.95
    2-aminoethanol 29.05
    morpholine-4-carbaldehyde 164.89
    sulfolane 146.99
    2,2,4-trimethylpentane 10.88
    2-methyltetrahydrofuran 280.52
    n-hexyl acetate 113.47
    isooctane 7.75
    2-(2-butoxyethoxy)ethanol 196.17
    sec-butyl acetate 88.51
    tert-butyl acetate 105.94
    decalin 17.19
    glycerin 25.33
    diglyme 313.99
    acrylic acid 23.83
    isopropyl myristate 48.12
    n-butyric acid 107.79
    acetyl acetate 47.17
    di(2-ethylhexyl) phthalate 47.61
    ethyl propionate 83.73
    nitromethane 63.25
    1,2-diethoxyethane 181.5
    benzonitrile 55.05
    trioctyl phosphate 31.6
    1-bromopropane 88.48
    gamma-valerolactone 249.25
    n-decanol 40.37
    triethyl phosphate 51.98
    4-methyl-2-pentanol 57.87
    propionitrile 44.07
    vinylene carbonate 59.55
    1,1,2-trichlorotrifluoroethane 103.9
    DMS 51.38
    cumene 37.82
    2-octanol 44.55
    2-hexanone 119.85
    octyl acetate 60.08
    limonene 57.32
    1,2-dimethoxyethane 300.25
    ethyl orthosilicate 61.44
    tributyl phosphate 38.38
    diacetone alcohol 118.78
    N,N-dimethylaniline 79.5
    acrylonitrile 31.98
    aniline 59.31
    1,3-propanediol 65.85
    bromobenzene 54.25
    dibromomethane 118.18
    1,1,2,2-tetrachloroethane 167.84
    2-methyl-cyclohexyl acetate 110.99
    tetrabutyl urea 55.36
    diisobutyl methanol 45.15
    2-phenylethanol 90.14
    styrene 47.3
    dioctyl adipate 75.52
    dimethyl sulfate 27.53
    ethyl butyrate 105.02
    methyl lactate 29.61
    butyl lactate 70.72
    diethyl carbonate 55.71
    propanediol butyl ether 99.78
    triethyl orthoformate 95.36
    p-tert-butyltoluene 34.36
    methyl 4-tert-butylbenzoate 98.33
    morpholine 364.88
    tert-butylamine 83.44
    n-dodecanol 28.52
    dimethoxymethane 118.43
    ethylene carbonate 53.39
    cyrene 108.29
    2-ethoxyethyl acetate 115.02
    2-ethylhexyl acetate 92.21
    1,2,4-trichlorobenzene 70.29
    4-methylpyridine 116.61
    dibutyl ether 88.57
    2,6-dimethyl-4-heptanol 45.15
    DEF 112.49
    dimethyl isosorbide 226.29
    tetrachloroethylene 94.55
    eugenol 95.47
    triacetin 101.76
    span 80 129.16
    1,4-butanediol 27.19
    1,1-dichloroethane 86.63
    2-methyl-1-pentanol 122.34
    methyl formate 23.27
    2-methyl-1-butanol 109.48
    n-decane 8.91
    butyronitrile 75.75
    3,7-dimethyl-1-octanol 59.7
    1-chlorooctane 39.54
    1-chlorotetradecane 12.7
    n-nonane 8.18
    undecane 5.46
    tert-butylcyclohexane 17.46
    cyclooctane 9.38
    cyclopentanol 80.05
    tetrahydropyran 340.12
    tert-amyl methyl ether 109.54
    2,5,8-trioxanonane 209.36
    1-hexene 79.53
    2-isopropoxyethanol 124.65
    2,2,2-trifluoroethanol 11.78
    methyl butyrate 111.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction