6,7-Dihydroxyflavone

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  • Identifiers

    CAS number
    38183-04-9

    Molecular formula
    C15H10O4

    SMILES
    C1=CC=C(C=C1)C2=CC(=O)C3=CC(=C(C=C3O2)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 55.28%
    Odorless 46.03%
    Burnt 43.25%
    Medicinal 25.93%
    Spicy 25.59%
    Fruity 25.27%
    Smoky 25.18%
    Balsamic 25.05%
    Bitter 23.65%
    Vanilla 23.44%

     

    Flavor
    Bitter 94.14%
    Very strong 20.31%
    Indole 19.8%
    Nitrile 19.71%
    Curry 19.59%
    Lovage 19.51%
    Moth ball 19.48%
    Naphthalic 19.35%
    Cedarleaf 19.25%
    Naphthelene 19.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    8.86 (weak base)

    Molecular weight
    254.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    579°C

    Flash point

    • 204.27 ˚C est.

  • Synonyms

    • 6,7-dihydroxyflavone
    • 38183-04-9
    • 6,7-dihydroxy-2-phenylchromen-4-one
    • 4H-1-Benzopyran-4-one, 6,7-dihydroxy-2-phenyl-
    • P6R86H59XS
    • DTXSID60191569
    • RefChem:538677
    • DTXCID50114060
    • 6,7-dihydroxy-2-phenyl-4H-chromen-4-one
    • 6,7-Dihydroxy-2-phenyl-chromen-4-one
    • MFCD00016947
    • UNII-P6R86H59XS
    • CHEMBL300814
    • 6,7-DIHYDROXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE
    • SR-05000002250
    • 6,7-ihydroxyflavone
    • 6,7-dihydroxy flavone
    • 6,?7-?Dihydroxyflavone
    • DivK1c_000421
    • SCHEMBL980197
    • SPECTRUM1500718
    • orb1683409
    • SCHEMBL29678059
    • HMS501F03
    • KBio1_000421
    • GSAOUZGPXSGVRS-UHFFFAOYSA-N
    • NINDS_000421
    • BDBM50077318
    • MSK158896
    • AKOS024283483
    • CCG-208431
    • FD65892
    • FS-6828
    • IDI1_000421
    • NCGC00096018-01
    • NCGC00096018-02
    • DA-06282
    • ST069294
    • 6,7-bis(oxidanyl)-2-phenyl-chromen-4-one
    • CS-0094411
    • NS00006964
    • SR-05000002250-2
    • SR-05000002250-3
    • 6,7-Dihydroxyflavone6,7-Dihydroxy-2-phenyl-chromen-4-one; 4H-1-Benzopyran-4-one, 6,7-dihydroxy-2-phenyl-; 6,7-dihydroxy-2-phenyl-4H-chromen-4-one
    • 38183-04-9

  • Applications

    6,7-Dihydroxyflavone (CAS 38183-04-9) is commonly regarded as a flavonoid scaffold and is investigated as a building block in chemical synthesis and related research. In cosmetics and personal care, it may serve as an antioxidant ingredient and could function as a natural colorant or formulation aid. In the polymer and plastics sector it is evaluated as an antioxidant stabilizer and has potential as a UV-protective additive to enhance the durability of coatings and molded products. In coatings, inks, and surface finishes, it may be used as a natural dye and light-stabilizing additive for polymer systems. In pharmaceutical and flavonoid research, it is commonly used as a core structure for the synthesis of flavonoid derivatives and as a reference compound in structure-activity studies. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.73
    methanol 2.33
    isopropanol 3.0
    water 0.01
    ethyl acetate 2.06
    n-propanol 3.86
    acetone 3.88
    n-butanol 3.01
    acetonitrile 1.67
    DMF 19.18
    toluene 0.32
    isobutanol 2.29
    1,4-dioxane 10.88
    methyl acetate 5.26
    THF 41.75
    2-butanone 8.88
    n-pentanol 2.14
    sec-butanol 4.31
    n-hexane 0.0
    ethylene glycol 4.42
    NMP 4.81
    cyclohexane 0.0
    DMSO 51.21
    n-butyl acetate 2.48
    n-octanol 0.73
    chloroform 0.01
    n-propyl acetate 2.6
    acetic acid 5.47
    dichloromethane 0.03
    cyclohexanone 4.76
    propylene glycol 4.74
    isopropyl acetate 2.85
    DMAc 48.27
    2-ethoxyethanol 16.68
    isopentanol 3.57
    n-heptane 0.01
    ethyl formate 1.6
    1,2-dichloroethane 0.18
    n-hexanol 1.41
    2-methoxyethanol 36.92
    isobutyl acetate 1.71
    tetrachloromethane 0.01
    n-pentyl acetate 2.11
    transcutol 91.8
    n-heptanol 1.17
    ethylbenzene 0.31
    MIBK 3.71
    2-propoxyethanol 13.85
    tert-butanol 5.49
    MTBE 3.21
    2-butoxyethanol 7.83
    propionic acid 3.4
    o-xylene 0.4
    formic acid 4.12
    diethyl ether 1.16
    m-xylene 0.27
    p-xylene 0.38
    chlorobenzene 0.15
    dimethyl carbonate 3.56
    n-octane 0.01
    formamide 14.26
    cyclopentanone 7.87
    2-pentanone 3.15
    anisole 3.88
    cyclopentyl methyl ether 3.19
    gamma-butyrolactone 9.87
    1-methoxy-2-propanol 22.37
    pyridine 6.68
    3-pentanone 2.01
    furfural 9.89
    n-dodecane 0.03
    diethylene glycol 18.38
    diisopropyl ether 0.41
    tert-amyl alcohol 6.02
    acetylacetone 7.85
    n-hexadecane 0.03
    acetophenone 4.16
    methyl propionate 3.19
    isopentyl acetate 3.69
    trichloroethylene 0.32
    n-nonanol 1.04
    cyclohexanol 2.02
    benzyl alcohol 3.95
    2-ethylhexanol 1.35
    isooctanol 1.34
    dipropyl ether 1.78
    1,2-dichlorobenzene 0.27
    ethyl lactate 3.56
    propylene carbonate 3.14
    n-methylformamide 6.94
    2-pentanol 1.87
    n-pentane 0.0
    1-propoxy-2-propanol 9.67
    1-methoxy-2-propyl acetate 9.14
    2-(2-methoxypropoxy) propanol 15.01
    mesitylene 0.2
    ε-caprolactone 5.61
    p-cymene 0.6
    epichlorohydrin 18.05
    1,1,1-trichloroethane 0.06
    2-aminoethanol 6.94
    morpholine-4-carbaldehyde 18.2
    sulfolane 13.62
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 8.4
    n-hexyl acetate 2.48
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 20.39
    sec-butyl acetate 2.58
    tert-butyl acetate 6.29
    decalin 0.02
    glycerin 14.47
    diglyme 41.76
    acrylic acid 3.99
    isopropyl myristate 1.81
    n-butyric acid 3.47
    acetyl acetate 2.01
    di(2-ethylhexyl) phthalate 2.4
    ethyl propionate 2.5
    nitromethane 13.18
    1,2-diethoxyethane 11.4
    benzonitrile 1.94
    trioctyl phosphate 1.32
    1-bromopropane 0.06
    gamma-valerolactone 19.83
    n-decanol 0.92
    triethyl phosphate 2.62
    4-methyl-2-pentanol 1.71
    propionitrile 2.08
    vinylene carbonate 2.61
    1,1,2-trichlorotrifluoroethane 10.2
    DMS 4.45
    cumene 0.33
    2-octanol 0.71
    2-hexanone 3.32
    octyl acetate 1.88
    limonene 0.58
    1,2-dimethoxyethane 29.52
    ethyl orthosilicate 2.63
    tributyl phosphate 1.81
    diacetone alcohol 15.39
    N,N-dimethylaniline 2.53
    acrylonitrile 3.68
    aniline 2.33
    1,3-propanediol 12.3
    bromobenzene 0.08
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.32
    2-methyl-cyclohexyl acetate 3.0
    tetrabutyl urea 3.08
    diisobutyl methanol 1.71
    2-phenylethanol 3.85
    styrene 0.32
    dioctyl adipate 3.49
    dimethyl sulfate 7.18
    ethyl butyrate 2.58
    methyl lactate 6.72
    butyl lactate 3.39
    diethyl carbonate 2.08
    propanediol butyl ether 7.18
    triethyl orthoformate 3.58
    p-tert-butyltoluene 0.65
    methyl 4-tert-butylbenzoate 6.12
    morpholine 19.43
    tert-butylamine 1.24
    n-dodecanol 0.78
    dimethoxymethane 17.79
    ethylene carbonate 1.91
    cyrene 9.35
    2-ethoxyethyl acetate 6.8
    2-ethylhexyl acetate 2.42
    1,2,4-trichlorobenzene 0.67
    4-methylpyridine 3.43
    dibutyl ether 1.88
    2,6-dimethyl-4-heptanol 1.71
    DEF 5.93
    dimethyl isosorbide 22.92
    tetrachloroethylene 0.17
    eugenol 7.31
    triacetin 6.05
    span 80 6.72
    1,4-butanediol 3.06
    1,1-dichloroethane 0.04
    2-methyl-1-pentanol 3.31
    methyl formate 4.16
    2-methyl-1-butanol 3.63
    n-decane 0.03
    butyronitrile 1.65
    3,7-dimethyl-1-octanol 1.53
    1-chlorooctane 0.21
    1-chlorotetradecane 0.16
    n-nonane 0.02
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.0
    cyclopentanol 2.52
    tetrahydropyran 3.97
    tert-amyl methyl ether 3.48
    2,5,8-trioxanonane 30.37
    1-hexene 0.03
    2-isopropoxyethanol 10.21
    2,2,2-trifluoroethanol 1.75
    methyl butyrate 3.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction