6,7-Dihydro-2,6-dimethyl-5H-cyclopentapyrazine

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  • Identifiers

    CAS number
    61928-63-0

    Molecular formula
    C9H12N2

    SMILES
    CC1CC2=NC=C(N=C2C1)C

    Safety labels

  • Odor profile

    Fragrance
    Roasted 77.7%
    Nutty 76.29%
    Earthy 59.24%
    Burnt 52.87%
    Coffee 52.75%
    Hazelnut 50.63%
    Musty 50.09%
    Cocoa 48.74%
    Potato 44.04%
    Popcorn 40.09%

     

    Flavor
    Roasted 53.75%
    Earthy 46.39%
    Nutty 42.25%
    Potato 40.63%
    Musty 40.2%
    Coffee 39.56%
    Cocoa 36.96%
    Roast 36.85%
    Peanut 32.11%
    Bitter 31.34%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    5.12 (weak acid)

    Molecular weight
    148.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    261°C

    Flash point

    • 89.1 ˚C est.

  • Synonyms

    • 6,7-Dihydro-2,6-dimethyl-5H-cyclopentapyrazine
    • 61928-63-0
    • RefChem:103813
    • 2,6-dimethyl-6,7-dihydro-5H-cyclopenta[b]pyrazine
    • CHEBI:193668
    • FKMPZHRHBYPYIZ-UHFFFAOYSA-N
    • DTXSID301249024
    • 2,6-dimethyl-6,7-dihydro-5H-cyclopentapyrazine
    • 3,6-dimethyl-6,7-dihydro-5H-cyclopenta[b]pyrazine
    • 61928-63-0

  • Applications

    For 6,7-Dihydro-2,6-dimethyl-5H-cyclopentapyrazine (CAS 61928-63-0), as a versatile heterocyclic scaffold, it is principally used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, enabling access to heterocyclic drug-like and biologically active derivatives. It also serves as a building block for functionalized derivatives in research and development programs. In addition, the compound may be employed as a precursor to materials and additives in polymers/plastics, coatings/inks, and related industries, where its heterocyclic core supports further modification. In electronics-related applications, its cyclopentapyrazine scaffold can be explored for organic semiconductor or other advanced materials purposes, subject to formulation and regulatory constraints. Real-world use is governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 110.92
    methanol 134.08
    isopropanol 80.97
    water 2.13
    ethyl acetate 108.73
    n-propanol 99.73
    acetone 143.76
    n-butanol 93.12
    acetonitrile 122.96
    DMF 217.09
    toluene 115.59
    isobutanol 90.58
    1,4-dioxane 210.22
    methyl acetate 120.36
    THF 318.54
    2-butanone 132.59
    n-pentanol 87.01
    sec-butanol 91.11
    n-hexane 23.71
    ethylene glycol 51.12
    NMP 265.88
    cyclohexane 44.62
    DMSO 164.94
    n-butyl acetate 158.94
    n-octanol 105.72
    chloroform 546.15
    n-propyl acetate 89.22
    acetic acid 147.39
    dichloromethane 434.1
    cyclohexanone 239.27
    propylene glycol 76.73
    isopropyl acetate 78.0
    DMAc 187.62
    2-ethoxyethanol 94.12
    isopentanol 92.26
    n-heptane 38.72
    ethyl formate 114.93
    1,2-dichloroethane 189.75
    n-hexanol 165.21
    2-methoxyethanol 140.87
    isobutyl acetate 76.15
    tetrachloromethane 99.21
    n-pentyl acetate 104.14
    transcutol 290.18
    n-heptanol 89.95
    ethylbenzene 76.11
    MIBK 85.44
    2-propoxyethanol 185.51
    tert-butanol 89.52
    MTBE 91.93
    2-butoxyethanol 121.34
    propionic acid 126.16
    o-xylene 93.03
    formic acid 49.99
    diethyl ether 83.29
    m-xylene 98.2
    p-xylene 106.43
    chlorobenzene 183.79
    dimethyl carbonate 67.54
    n-octane 19.92
    formamide 52.99
    cyclopentanone 279.89
    2-pentanone 104.79
    anisole 113.78
    cyclopentyl methyl ether 155.21
    gamma-butyrolactone 298.12
    1-methoxy-2-propanol 121.37
    pyridine 228.06
    3-pentanone 99.93
    furfural 308.55
    n-dodecane 22.73
    diethylene glycol 151.12
    diisopropyl ether 39.67
    tert-amyl alcohol 94.08
    acetylacetone 127.61
    n-hexadecane 24.58
    acetophenone 121.45
    methyl propionate 103.83
    isopentyl acetate 142.69
    trichloroethylene 392.39
    n-nonanol 89.3
    cyclohexanol 115.92
    benzyl alcohol 108.94
    2-ethylhexanol 113.38
    isooctanol 76.35
    dipropyl ether 102.21
    1,2-dichlorobenzene 179.63
    ethyl lactate 73.81
    propylene carbonate 221.95
    n-methylformamide 104.85
    2-pentanol 68.56
    n-pentane 24.25
    1-propoxy-2-propanol 145.3
    1-methoxy-2-propyl acetate 137.65
    2-(2-methoxypropoxy) propanol 145.03
    mesitylene 66.89
    ε-caprolactone 204.63
    p-cymene 82.39
    epichlorohydrin 267.54
    1,1,1-trichloroethane 206.02
    2-aminoethanol 81.91
    morpholine-4-carbaldehyde 228.9
    sulfolane 321.06
    2,2,4-trimethylpentane 21.07
    2-methyltetrahydrofuran 210.02
    n-hexyl acetate 156.91
    isooctane 15.4
    2-(2-butoxyethoxy)ethanol 163.37
    sec-butyl acetate 65.91
    tert-butyl acetate 80.63
    decalin 29.84
    glycerin 92.66
    diglyme 223.62
    acrylic acid 127.04
    isopropyl myristate 78.24
    n-butyric acid 143.66
    acetyl acetate 88.9
    di(2-ethylhexyl) phthalate 100.68
    ethyl propionate 80.16
    nitromethane 177.69
    1,2-diethoxyethane 115.62
    benzonitrile 186.25
    trioctyl phosphate 73.91
    1-bromopropane 140.69
    gamma-valerolactone 288.42
    n-decanol 77.53
    triethyl phosphate 69.26
    4-methyl-2-pentanol 56.42
    propionitrile 114.36
    vinylene carbonate 227.66
    1,1,2-trichlorotrifluoroethane 191.04
    DMS 129.88
    cumene 66.88
    2-octanol 71.39
    2-hexanone 93.4
    octyl acetate 104.43
    limonene 101.88
    1,2-dimethoxyethane 147.35
    ethyl orthosilicate 62.51
    tributyl phosphate 82.04
    diacetone alcohol 97.83
    N,N-dimethylaniline 99.7
    acrylonitrile 142.5
    aniline 120.73
    1,3-propanediol 86.54
    bromobenzene 207.29
    dibromomethane 297.38
    1,1,2,2-tetrachloroethane 303.11
    2-methyl-cyclohexyl acetate 112.52
    tetrabutyl urea 100.99
    diisobutyl methanol 65.07
    2-phenylethanol 151.17
    styrene 86.41
    dioctyl adipate 112.1
    dimethyl sulfate 104.68
    ethyl butyrate 106.63
    methyl lactate 81.89
    butyl lactate 97.24
    diethyl carbonate 85.91
    propanediol butyl ether 136.19
    triethyl orthoformate 81.53
    p-tert-butyltoluene 73.87
    methyl 4-tert-butylbenzoate 137.46
    morpholine 182.26
    tert-butylamine 71.94
    n-dodecanol 67.97
    dimethoxymethane 127.52
    ethylene carbonate 171.38
    cyrene 136.23
    2-ethoxyethyl acetate 122.68
    2-ethylhexyl acetate 122.56
    1,2,4-trichlorobenzene 213.11
    4-methylpyridine 208.31
    dibutyl ether 98.24
    2,6-dimethyl-4-heptanol 65.07
    DEF 119.87
    dimethyl isosorbide 220.51
    tetrachloroethylene 209.22
    eugenol 141.0
    triacetin 142.13
    span 80 146.95
    1,4-butanediol 60.45
    1,1-dichloroethane 202.86
    2-methyl-1-pentanol 88.59
    methyl formate 109.66
    2-methyl-1-butanol 94.03
    n-decane 29.64
    butyronitrile 122.04
    3,7-dimethyl-1-octanol 99.17
    1-chlorooctane 84.86
    1-chlorotetradecane 46.93
    n-nonane 28.87
    undecane 25.33
    tert-butylcyclohexane 28.01
    cyclooctane 20.31
    cyclopentanol 140.15
    tetrahydropyran 184.27
    tert-amyl methyl ether 85.03
    2,5,8-trioxanonane 190.7
    1-hexene 64.17
    2-isopropoxyethanol 78.87
    2,2,2-trifluoroethanol 69.93
    methyl butyrate 107.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction