6,10-Dioxaspiro[4.5]decane, 8,8-dimethyl-7-(1-methylethyl)-

Overview IFRA Request a quote

  • Identifiers

    CAS number
    62406-73-9

    Molecular formula
    C13H24O2

    SMILES
    CC(C)C1C(COC2(O1)CCCC2)(C)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 70.38%
    Herbal 68.57%
    Camphoreous 52.81%
    Green 52.24%
    Fresh 50.32%
    Mint 49.76%
    Spicy 44.06%
    Earthy 40.3%
    Sweet 39.34%
    Cooling 37.83%

     

    Flavor
    Green 64.66%
    Earthy 44.52%
    Herbal 42.78%
    Minty 33.29%
    Earth 32.47%
    Spicy 32.11%
    Woody 29.31%
    Spice 28.92%
    Pepper 28.57%
    Camphor 27.99%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    8.03 (weak base)

    Molecular weight
    212.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    254°C

    Flash point

    • 86.44 ˚C est.

  • Synonyms

    • 7-isopropyl-8,8-dimethyl-6,10-dioxaspiro[4.5]decane
    • 6,10-Dioxaspiro[4.5]decane, 8,8-dimethyl-7-(1-methylethyl)-
    • DTXSID50866931
    • EC 424-030-2
    • NSC 39421
    • 8,8-dimethyl-7-isopropyl-6,10-dioxaspiro(4,5)decane
    • 6,10-Dioxaspiro(4.5)decane, 8,8-dimethyl-7-(1-methylethyl)-
    • 8,8-dimethyl-7-isopropyl-6,10-dioxaspiro[4,5]decane
    • 7-Isopropyl-8,8-dimethyl-6,10-dioxaspiro(4.5)decane
    • RefChem:538393
    • DTXCID80815159
    • 424-030-2
    • 62406-73-9
    • 6,10-Dioxaspiro[4.5]decane,8,8-dimethyl-7-(1-methylethyl)-
    • Opalal
    • NSC39421
    • 8,8-dimethyl-9-propan-2-yl-6,10-dioxaspiro[4.5]decane
    • SCHEMBL1474454
    • NKDJGNROVOPIGT-UHFFFAOYSA-N
    • 8,8-dimethyl-7-(propan-2-yl)-6,10-dioxaspiro[4.5]decane
    • NSC-39421
    • NS00123773
    • 62406-73-9

  • Applications

    6,10-Dioxaspiro[4.5]decane, 8,8-dimethyl-7-(1-methylethyl)- (CAS 62406-73-9) is primarily used as an intermediate in organic synthesis, chiefly as a carbonyl-protecting acetal owing to its dioxaspiro framework. Its acetal functionality enables protection of aldehydes/ketones in multi-step sequences and can be selectively deprotected to reveal carbonyl groups for subsequent transformations. The compound also serves as a building block for assembling more complex spirocyclic architectures, a feature valuable to pharmaceutical and specialty chemical R&D. Additionally, it can function as a versatile precursor for materials development, including specialized polymers or other functional platforms, enabling derivatization of the spiro-dioxaspiro core under appropriate conditions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 527.73
    methanol 531.14
    isopropanol 447.29
    water 2.74
    ethyl acetate 596.01
    n-propanol 528.81
    acetone 574.47
    n-butanol 539.38
    acetonitrile 439.59
    DMF 626.5
    toluene 832.51
    isobutanol 490.78
    1,4-dioxane 828.19
    methyl acetate 540.35
    THF 1314.69
    2-butanone 660.81
    n-pentanol 489.68
    sec-butanol 520.6
    n-hexane 198.37
    ethylene glycol 99.95
    NMP 806.1
    cyclohexane 308.48
    DMSO 440.58
    n-butyl acetate 879.66
    n-octanol 561.28
    chloroform 2978.04
    n-propyl acetate 611.16
    acetic acid 528.6
    dichloromethane 2156.41
    cyclohexanone 1162.63
    propylene glycol 170.06
    isopropyl acetate 513.91
    DMAc 677.09
    2-ethoxyethanol 505.16
    isopentanol 557.46
    n-heptane 227.33
    ethyl formate 486.11
    1,2-dichloroethane 930.67
    n-hexanol 695.98
    2-methoxyethanol 572.95
    isobutyl acetate 540.97
    tetrachloromethane 605.26
    n-pentyl acetate 723.54
    transcutol 999.63
    n-heptanol 497.57
    ethylbenzene 586.69
    MIBK 492.03
    2-propoxyethanol 687.75
    tert-butanol 479.84
    MTBE 579.58
    2-butoxyethanol 575.37
    propionic acid 458.38
    o-xylene 580.57
    formic acid 152.83
    diethyl ether 517.15
    m-xylene 612.6
    p-xylene 819.06
    chlorobenzene 884.66
    dimethyl carbonate 245.18
    n-octane 116.4
    formamide 175.64
    cyclopentanone 1061.03
    2-pentanone 609.98
    anisole 632.44
    cyclopentyl methyl ether 757.3
    gamma-butyrolactone 1095.93
    1-methoxy-2-propanol 485.46
    pyridine 944.78
    3-pentanone 500.91
    furfural 960.52
    n-dodecane 105.67
    diethylene glycol 367.87
    diisopropyl ether 285.13
    tert-amyl alcohol 523.05
    acetylacetone 593.41
    n-hexadecane 118.55
    acetophenone 672.53
    methyl propionate 459.78
    isopentyl acetate 849.81
    trichloroethylene 1902.87
    n-nonanol 480.45
    cyclohexanol 654.03
    benzyl alcohol 560.75
    2-ethylhexanol 551.16
    isooctanol 430.91
    dipropyl ether 525.97
    1,2-dichlorobenzene 868.42
    ethyl lactate 304.11
    propylene carbonate 855.8
    n-methylformamide 347.76
    2-pentanol 437.36
    n-pentane 179.39
    1-propoxy-2-propanol 561.19
    1-methoxy-2-propyl acetate 615.02
    2-(2-methoxypropoxy) propanol 479.45
    mesitylene 436.17
    ε-caprolactone 1090.38
    p-cymene 471.33
    epichlorohydrin 1128.48
    1,1,1-trichloroethane 1178.45
    2-aminoethanol 236.87
    morpholine-4-carbaldehyde 846.52
    sulfolane 986.45
    2,2,4-trimethylpentane 140.05
    2-methyltetrahydrofuran 1060.34
    n-hexyl acetate 949.57
    isooctane 106.73
    2-(2-butoxyethoxy)ethanol 549.73
    sec-butyl acetate 505.33
    tert-butyl acetate 519.09
    decalin 204.74
    glycerin 205.94
    diglyme 910.69
    acrylic acid 375.41
    isopropyl myristate 423.17
    n-butyric acid 688.85
    acetyl acetate 457.67
    di(2-ethylhexyl) phthalate 387.9
    ethyl propionate 507.4
    nitromethane 581.95
    1,2-diethoxyethane 555.8
    benzonitrile 865.71
    trioctyl phosphate 311.17
    1-bromopropane 802.47
    gamma-valerolactone 1226.5
    n-decanol 343.95
    triethyl phosphate 328.13
    4-methyl-2-pentanol 334.24
    propionitrile 537.54
    vinylene carbonate 837.56
    1,1,2-trichlorotrifluoroethane 746.1
    DMS 491.6
    cumene 436.09
    2-octanol 428.0
    2-hexanone 652.94
    octyl acetate 514.34
    limonene 545.43
    1,2-dimethoxyethane 815.36
    ethyl orthosilicate 326.01
    tributyl phosphate 347.95
    diacetone alcohol 430.09
    N,N-dimethylaniline 514.14
    acrylonitrile 554.07
    aniline 555.09
    1,3-propanediol 350.3
    bromobenzene 1096.91
    dibromomethane 1608.93
    1,1,2,2-tetrachloroethane 1580.0
    2-methyl-cyclohexyl acetate 606.65
    tetrabutyl urea 407.6
    diisobutyl methanol 313.02
    2-phenylethanol 639.93
    styrene 631.43
    dioctyl adipate 513.3
    dimethyl sulfate 309.44
    ethyl butyrate 633.12
    methyl lactate 259.3
    butyl lactate 488.23
    diethyl carbonate 440.7
    propanediol butyl ether 488.67
    triethyl orthoformate 478.78
    p-tert-butyltoluene 443.3
    methyl 4-tert-butylbenzoate 626.94
    morpholine 858.25
    tert-butylamine 410.07
    n-dodecanol 273.57
    dimethoxymethane 512.6
    ethylene carbonate 717.5
    cyrene 455.12
    2-ethoxyethyl acetate 654.44
    2-ethylhexyl acetate 777.71
    1,2,4-trichlorobenzene 974.19
    4-methylpyridine 1068.17
    dibutyl ether 563.26
    2,6-dimethyl-4-heptanol 313.02
    DEF 586.06
    dimethyl isosorbide 792.75
    tetrachloroethylene 1085.17
    eugenol 531.01
    triacetin 669.37
    span 80 525.8
    1,4-butanediol 213.35
    1,1-dichloroethane 1111.1
    2-methyl-1-pentanol 522.55
    methyl formate 323.67
    2-methyl-1-butanol 533.98
    n-decane 163.91
    butyronitrile 674.83
    3,7-dimethyl-1-octanol 507.39
    1-chlorooctane 476.06
    1-chlorotetradecane 214.32
    n-nonane 163.17
    undecane 125.79
    tert-butylcyclohexane 196.43
    cyclooctane 156.46
    cyclopentanol 614.79
    tetrahydropyran 950.67
    tert-amyl methyl ether 514.81
    2,5,8-trioxanonane 620.63
    1-hexene 471.1
    2-isopropoxyethanol 430.26
    2,2,2-trifluoroethanol 203.3
    methyl butyrate 700.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction