6-tert-Butyl-m-cresol

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  • Identifiers

    CAS number
    88-60-8

    Molecular formula
    C11H16O

    SMILES
    CC1=CC(=C(C=C1)C(C)(C)C)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 72.62%
    Leathery 61.14%
    Woody 60.66%
    Medicinal 49.94%
    Spicy 49.83%
    Smoky 48.67%
    Dry 43.01%
    Animal 40.24%
    Burnt 35.97%
    Camphoreous 34.83%

     

    Flavor
    Phenolic 58.95%
    Camphor 45.68%
    Medicinal 38.81%
    Woody 37.74%
    Leather 34.65%
    Musty 33.75%
    Spice 27.67%
    Mild 26.44%
    Smoke 26.07%
    Smoky 25.68%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    9.75 (weak base)

    Molecular weight
    164.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 46 °C

    Boiling point

    • 224 °C AT 760 MM HG

    Flash point

    • 112.48 ˚C est.
    • 114 °C

    Solubility expt.

    • INSOL IN WATER; SOL IN ALCOHOL, ETHER, ACETONE, ORGANIC SOLVENTS

  • Synonyms

    • 6-tert-Butyl-m-cresol
    • 88-60-8
    • 2-tert-Butyl-5-methylphenol
    • 2-(tert-butyl)-5-methylphenol
    • 6-tert-Butyl-3-methylphenol
    • 5-Methyl-2-tert-butylphenol
    • Phenol, 2-(1,1-dimethylethyl)-5-methyl-
    • 3-Methyl-6-tert-butylphenol
    • m-Cresol, 6-tert-butyl-
    • 2-tert-butyl-5-methyl-phenol
    • 6-tert-Butyl-3-cresol
    • HSDB 5260
    • UNII-UXV32MJ2CA
    • 2-t-Butyl-5-methylphenol
    • EINECS 201-842-3
    • NSC 48467
    • BRN 1908225
    • DTXSID2026529
    • Phenol, 2-tert-butyl-5-methyl-
    • Benzene, 1-tert-butyl-2-hydroxy-4-methyl-
    • 2-(1,1-DIMETHYLETHYL)-5-METHYLPHENOL
    • MFCD00002308
    • NSC-48467
    • UXV32MJ2CA
    • 5-Methyl-2-(1,1-dimethylethyl)-phenol
    • DTXCID806529
    • EC 201-842-3
    • 4-06-00-03400 (Beilstein Handbook Reference)
    • 2-(1,1-DIMETHYLETHYL)-5-METHYLPHENOL [HSDB]
    • CAS-88-60-8
    • 6-t-butyl-m-cresol
    • 6tertButylmcresol
    • NSC48467
    • mCresol, 6tertbutyl
    • 6-t-butyl-3-cresol
    • 2tertButyl5methylphenol
    • 3Methyl6tertbutylphenol
    • 5Methyl2tertbutylphenol
    • 6tertButyl3methylphenol
    • 3-methyl-6-t-butylphenol
    • SCHEMBL180815
    • GTPL4111
    • CHEMBL1880057
    • Benzene, 1tertbutyl2hydroxy4methyl
    • Phenol,1-dimethylethyl)-5-methyl-
    • Tox21_201418
    • Tox21_300486
    • 2-tert-Butyl-5-methylphenol, 95%
    • Phenol, 2(1,1dimethylethyl)5methyl
    • AKOS000120129
    • NCGC00164216-01
    • NCGC00164216-02
    • NCGC00164216-03
    • NCGC00254288-01
    • NCGC00258969-01
    • BS-17803
    • FB158840
    • PD051571
    • DB-057088
    • B0718
    • CS-0037719
    • NS00003864
    • EN300-21368
    • W18665
    • Q27074017

  • Applications

    6-tert-Butyl-m-cresol (CAS 88-60-8) is primarily used as a hindered phenolic antioxidant and stabilizer in industrial formulations; in polymers and plastics it helps prevent thermo-oxidative degradation during processing and service, improving color stability and longevity; in lubricating oils and fuels it slows oxidation; in rubbers and rubber-based products it acts as a processing and long-term antioxidant; in coatings and inks it enhances oxidative stability of formulations; and in adhesives it can serve as a stabilizing additive where oxidation resistance is beneficial.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1246.47
    methanol 1555.84
    isopropanol 932.63
    water 0.71
    ethyl acetate 585.67
    n-propanol 908.64
    acetone 854.0
    n-butanol 828.65
    acetonitrile 1338.97
    DMF 894.69
    toluene 241.65
    isobutanol 576.13
    1,4-dioxane 1610.27
    methyl acetate 526.48
    THF 2678.39
    2-butanone 597.95
    n-pentanol 496.51
    sec-butanol 603.14
    n-hexane 307.35
    ethylene glycol 90.01
    NMP 510.56
    cyclohexane 329.42
    DMSO 421.1
    n-butyl acetate 579.91
    n-octanol 341.69
    chloroform 974.6
    n-propyl acetate 357.8
    acetic acid 437.14
    dichloromethane 728.97
    cyclohexanone 821.59
    propylene glycol 179.95
    isopropyl acetate 311.81
    DMAc 322.91
    2-ethoxyethanol 394.97
    isopentanol 515.59
    n-heptane 281.8
    ethyl formate 506.4
    1,2-dichloroethane 476.87
    n-hexanol 1029.7
    2-methoxyethanol 786.08
    isobutyl acetate 237.29
    tetrachloromethane 186.55
    n-pentyl acetate 259.96
    transcutol 664.25
    n-heptanol 365.67
    ethylbenzene 162.39
    MIBK 303.21
    2-propoxyethanol 877.3
    tert-butanol 903.58
    MTBE 630.73
    2-butoxyethanol 365.32
    propionic acid 352.78
    o-xylene 134.91
    formic acid 144.66
    diethyl ether 935.26
    m-xylene 186.14
    p-xylene 214.39
    chlorobenzene 300.82
    dimethyl carbonate 159.07
    n-octane 86.23
    formamide 237.64
    cyclopentanone 1018.75
    2-pentanone 583.57
    anisole 287.85
    cyclopentyl methyl ether 791.58
    gamma-butyrolactone 1013.29
    1-methoxy-2-propanol 639.96
    pyridine 603.7
    3-pentanone 347.69
    furfural 528.21
    n-dodecane 58.28
    diethylene glycol 381.7
    diisopropyl ether 236.82
    tert-amyl alcohol 526.19
    acetylacetone 388.19
    n-hexadecane 64.46
    acetophenone 194.89
    methyl propionate 394.89
    isopentyl acetate 433.59
    trichloroethylene 638.08
    n-nonanol 272.52
    cyclohexanol 574.23
    benzyl alcohol 206.93
    2-ethylhexanol 471.35
    isooctanol 252.16
    dipropyl ether 648.83
    1,2-dichlorobenzene 223.52
    ethyl lactate 146.01
    propylene carbonate 535.93
    n-methylformamide 574.2
    2-pentanol 519.82
    n-pentane 242.25
    1-propoxy-2-propanol 635.74
    1-methoxy-2-propyl acetate 376.82
    2-(2-methoxypropoxy) propanol 236.29
    mesitylene 131.29
    ε-caprolactone 593.72
    p-cymene 151.61
    epichlorohydrin 916.5
    1,1,1-trichloroethane 496.06
    2-aminoethanol 283.97
    morpholine-4-carbaldehyde 601.54
    sulfolane 611.33
    2,2,4-trimethylpentane 71.82
    2-methyltetrahydrofuran 1308.25
    n-hexyl acetate 409.86
    isooctane 81.38
    2-(2-butoxyethoxy)ethanol 371.63
    sec-butyl acetate 218.17
    tert-butyl acetate 332.72
    decalin 101.23
    glycerin 168.57
    diglyme 613.53
    acrylic acid 226.63
    isopropyl myristate 175.33
    n-butyric acid 611.39
    acetyl acetate 260.84
    di(2-ethylhexyl) phthalate 125.3
    ethyl propionate 305.13
    nitromethane 720.85
    1,2-diethoxyethane 443.6
    benzonitrile 342.05
    trioctyl phosphate 119.63
    1-bromopropane 496.52
    gamma-valerolactone 981.5
    n-decanol 214.91
    triethyl phosphate 142.7
    4-methyl-2-pentanol 259.9
    propionitrile 845.7
    vinylene carbonate 426.09
    1,1,2-trichlorotrifluoroethane 323.2
    DMS 193.03
    cumene 120.44
    2-octanol 246.93
    2-hexanone 409.01
    octyl acetate 218.34
    limonene 245.27
    1,2-dimethoxyethane 867.07
    ethyl orthosilicate 149.05
    tributyl phosphate 133.03
    diacetone alcohol 349.32
    N,N-dimethylaniline 177.64
    acrylonitrile 660.9
    aniline 281.16
    1,3-propanediol 442.6
    bromobenzene 283.99
    dibromomethane 586.72
    1,1,2,2-tetrachloroethane 538.2
    2-methyl-cyclohexyl acetate 277.45
    tetrabutyl urea 157.71
    diisobutyl methanol 240.38
    2-phenylethanol 322.85
    styrene 173.54
    dioctyl adipate 196.72
    dimethyl sulfate 151.63
    ethyl butyrate 355.87
    methyl lactate 162.22
    butyl lactate 197.35
    diethyl carbonate 219.79
    propanediol butyl ether 301.9
    triethyl orthoformate 252.0
    p-tert-butyltoluene 163.9
    methyl 4-tert-butylbenzoate 216.11
    morpholine 1706.94
    tert-butylamine 662.66
    n-dodecanol 167.13
    dimethoxymethane 768.88
    ethylene carbonate 407.57
    cyrene 214.43
    2-ethoxyethyl acetate 246.67
    2-ethylhexyl acetate 348.03
    1,2,4-trichlorobenzene 219.85
    4-methylpyridine 578.41
    dibutyl ether 381.65
    2,6-dimethyl-4-heptanol 240.38
    DEF 407.61
    dimethyl isosorbide 429.03
    tetrachloroethylene 330.85
    eugenol 201.86
    triacetin 202.2
    span 80 285.2
    1,4-butanediol 151.37
    1,1-dichloroethane 602.25
    2-methyl-1-pentanol 324.87
    methyl formate 445.1
    2-methyl-1-butanol 439.06
    n-decane 106.36
    butyronitrile 1028.88
    3,7-dimethyl-1-octanol 265.82
    1-chlorooctane 252.01
    1-chlorotetradecane 101.13
    n-nonane 114.64
    undecane 76.92
    tert-butylcyclohexane 104.3
    cyclooctane 114.29
    cyclopentanol 696.51
    tetrahydropyran 1670.44
    tert-amyl methyl ether 378.1
    2,5,8-trioxanonane 381.49
    1-hexene 560.02
    2-isopropoxyethanol 274.79
    2,2,2-trifluoroethanol 109.12
    methyl butyrate 393.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction