6-Methyl-2-pyridylmethanol

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  • Identifiers

    CAS number
    1122-71-0

    Molecular formula
    C7H9NO

    SMILES
    CC1=NC(=CC=C1)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 49.26%
    Roasted 44.55%
    Green 43.2%
    Earthy 37.99%
    Animal 36.69%
    Musty 35.24%
    Burnt 32.96%
    Sweet 31.93%
    Almond 31.57%
    Fishy 30.79%

     

    Flavor
    Sweet 43.16%
    Bitter 40.18%
    Coffee 40.09%
    Roasted 36.1%
    Musty 34.81%
    Fatty 32.68%
    Nutty 32.44%
    Chocolate 31.94%
    Almond 30.11%
    Caramel 28.96%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    6.25 (neutral)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    218°C

    Flash point

    • 101.95 ˚C est.

  • Synonyms

    • 6-Methyl-2-pyridinemethanol
    • 2-Pyridinemethanol, 6-methyl-
    • 6-Methyl-2-pyridylmethanol
    • EINECS 214-358-2
    • AI3-52476
    • DTXSID90149952
    • NSC 66528
    • 6Methyl2pyridylmethanol
    • RefChem:543856
    • 2Pyridinemethanol, 6methyl
    • DTXCID4072443
    • 214-358-2
    • 1122-71-0
    • (6-Methylpyridin-2-yl)methanol
    • (6-methyl-2-pyridyl)methanol
    • MFCD00023520
    • 2-Hydroxymethyl-6-methylpyridine
    • 6-methylpyridine-2-methanol
    • NSC-66528
    • (6-methyl-2-pyridyl)methan-1-ol
    • 6-Hydroxymethyl-2-picoline
    • 2-methyl-6-pyridinemethanol
    • 2-(Hydroxymethyl)-6-methylpyridine
    • NSC66528
    • KLM9RS9ZWN
    • 6-methyl-2-pyridylcarbinol
    • 6-methyl-2-pyridyl methanol
    • 6-methylpyridin-2-ylmethanol
    • 6-methyl-2-pyridine methanol
    • 6-methyl-pyridine-2-methanol
    • SCHEMBL116463
    • SCHEMBL243243
    • orb3030258
    • SCHEMBL1633023
    • SCHEMBL5604290
    • (6-methyl-2-pyridinyl)methanol
    • SCHEMBL18322711
    • SCHEMBL29687394
    • (6-methylpyridine-2-yl)methanol
    • 6-Methyl-2-hydroxymethylpyridine
    • CHEBI:167736
    • (6-methyl-pyridin-2-yl)-methanol
    • 6-Methyl-2-pyridinemethanol, 98%
    • BBL103457
    • CL0232
    • pyridine, 2-hydroxymethyl-6-methyl-
    • SBB065460
    • STL557267
    • AKOS009159390
    • AC-1927
    • CS-W008058
    • FG-0476
    • SB52404
    • SDCCGMLS-0066210.P001
    • BP-20351
    • SY004267
    • DB-012786
    • DB-359608
    • M1282
    • NS00015806
    • ST51038614
    • EN300-112685
    • 122M710
    • F092614
    • Z397587486
    • InChI=1/C7H9NO/c1-6-3-2-4-7(5-9)8-6/h2-4,9H,5H2,1H
    • 1122-71-0

  • Applications

    6-Methyl-2-pyridylmethanol (CAS 1122-71-0) is primarily used as an intermediate in pharmaceutical synthesis and in the production of agrochemicals, serving as a versatile building block to incorporate a 2-pyridyl moiety into target molecules. It also functions as a precursor for the synthesis of heterocyclic compounds and medicinal chemistry scaffolds, and can be used as a ligand or precursor in catalytic or coordination chemistry with metal centers. In addition, it may be employed as a platform intermediate for further functionalization and for producing specialty-chemical intermediates. Exact usage depends on formulation goals and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 389.4
    methanol 554.85
    isopropanol 229.48
    water 16.68
    ethyl acetate 166.82
    n-propanol 297.66
    acetone 300.68
    n-butanol 208.99
    acetonitrile 238.56
    DMF 489.71
    toluene 88.62
    isobutanol 168.21
    1,4-dioxane 660.89
    methyl acetate 175.02
    THF 531.9
    2-butanone 192.36
    n-pentanol 135.84
    sec-butanol 154.96
    n-hexane 11.78
    ethylene glycol 181.77
    NMP 363.38
    cyclohexane 10.51
    DMSO 938.93
    n-butyl acetate 125.2
    n-octanol 68.52
    chloroform 327.0
    n-propyl acetate 87.59
    acetic acid 255.59
    dichloromethane 374.48
    cyclohexanone 269.98
    propylene glycol 118.67
    isopropyl acetate 74.47
    DMAc 268.94
    2-ethoxyethanol 232.67
    isopentanol 132.86
    n-heptane 15.94
    ethyl formate 158.05
    1,2-dichloroethane 248.33
    n-hexanol 171.38
    2-methoxyethanol 420.25
    isobutyl acetate 56.53
    tetrachloromethane 62.42
    n-pentyl acetate 63.82
    transcutol 347.64
    n-heptanol 75.09
    ethylbenzene 30.93
    MIBK 82.12
    2-propoxyethanol 280.88
    tert-butanol 226.91
    MTBE 141.24
    2-butoxyethanol 133.09
    propionic acid 195.32
    o-xylene 50.2
    formic acid 224.74
    diethyl ether 164.41
    m-xylene 60.71
    p-xylene 38.22
    chlorobenzene 115.39
    dimethyl carbonate 63.5
    n-octane 7.0
    formamide 226.46
    cyclopentanone 356.57
    2-pentanone 148.36
    anisole 87.91
    cyclopentyl methyl ether 193.35
    gamma-butyrolactone 415.04
    1-methoxy-2-propanol 236.03
    pyridine 238.56
    3-pentanone 109.4
    furfural 341.78
    n-dodecane 6.41
    diethylene glycol 265.37
    diisopropyl ether 37.0
    tert-amyl alcohol 152.39
    acetylacetone 147.39
    n-hexadecane 7.04
    acetophenone 77.12
    methyl propionate 141.11
    isopentyl acetate 94.5
    trichloroethylene 338.85
    n-nonanol 56.93
    cyclohexanol 132.55
    benzyl alcohol 84.68
    2-ethylhexanol 82.89
    isooctanol 58.39
    dipropyl ether 85.25
    1,2-dichlorobenzene 87.47
    ethyl lactate 58.24
    propylene carbonate 169.88
    n-methylformamide 311.71
    2-pentanol 104.75
    n-pentane 12.77
    1-propoxy-2-propanol 163.08
    1-methoxy-2-propyl acetate 105.13
    2-(2-methoxypropoxy) propanol 99.44
    mesitylene 36.96
    ε-caprolactone 214.06
    p-cymene 34.49
    epichlorohydrin 430.66
    1,1,1-trichloroethane 153.26
    2-aminoethanol 242.68
    morpholine-4-carbaldehyde 392.03
    sulfolane 479.25
    2,2,4-trimethylpentane 10.25
    2-methyltetrahydrofuran 300.48
    n-hexyl acetate 85.1
    isooctane 8.64
    2-(2-butoxyethoxy)ethanol 143.12
    sec-butyl acetate 48.51
    tert-butyl acetate 81.83
    decalin 10.19
    glycerin 193.56
    diglyme 249.37
    acrylic acid 172.04
    isopropyl myristate 36.49
    n-butyric acid 212.66
    acetyl acetate 79.67
    di(2-ethylhexyl) phthalate 40.36
    ethyl propionate 71.44
    nitromethane 412.67
    1,2-diethoxyethane 119.15
    benzonitrile 115.52
    trioctyl phosphate 36.4
    1-bromopropane 144.44
    gamma-valerolactone 434.89
    n-decanol 43.83
    triethyl phosphate 41.95
    4-methyl-2-pentanol 59.14
    propionitrile 183.11
    vinylene carbonate 165.67
    1,1,2-trichlorotrifluoroethane 219.15
    DMS 65.89
    cumene 27.84
    2-octanol 48.27
    2-hexanone 94.24
    octyl acetate 48.63
    limonene 48.58
    1,2-dimethoxyethane 287.46
    ethyl orthosilicate 40.5
    tributyl phosphate 39.74
    diacetone alcohol 127.74
    N,N-dimethylaniline 61.37
    acrylonitrile 219.09
    aniline 127.52
    1,3-propanediol 258.58
    bromobenzene 104.58
    dibromomethane 250.99
    1,1,2,2-tetrachloroethane 235.33
    2-methyl-cyclohexyl acetate 58.42
    tetrabutyl urea 53.25
    diisobutyl methanol 47.69
    2-phenylethanol 93.83
    styrene 40.67
    dioctyl adipate 48.29
    dimethyl sulfate 123.04
    ethyl butyrate 75.99
    methyl lactate 91.95
    butyl lactate 59.95
    diethyl carbonate 48.34
    propanediol butyl ether 104.13
    triethyl orthoformate 51.8
    p-tert-butyltoluene 34.78
    methyl 4-tert-butylbenzoate 75.14
    morpholine 520.78
    tert-butylamine 123.33
    n-dodecanol 34.54
    dimethoxymethane 262.84
    ethylene carbonate 140.11
    cyrene 96.77
    2-ethoxyethyl acetate 88.39
    2-ethylhexyl acetate 69.83
    1,2,4-trichlorobenzene 100.03
    4-methylpyridine 224.97
    dibutyl ether 58.96
    2,6-dimethyl-4-heptanol 47.69
    DEF 183.05
    dimethyl isosorbide 153.37
    tetrachloroethylene 165.82
    eugenol 85.56
    triacetin 66.14
    span 80 83.49
    1,4-butanediol 124.25
    1,1-dichloroethane 206.04
    2-methyl-1-pentanol 102.41
    methyl formate 251.97
    2-methyl-1-butanol 137.79
    n-decane 9.86
    butyronitrile 174.24
    3,7-dimethyl-1-octanol 59.7
    1-chlorooctane 40.4
    1-chlorotetradecane 17.14
    n-nonane 9.78
    undecane 7.72
    tert-butylcyclohexane 12.55
    cyclooctane 5.8
    cyclopentanol 170.06
    tetrahydropyran 328.38
    tert-amyl methyl ether 94.41
    2,5,8-trioxanonane 172.59
    1-hexene 46.81
    2-isopropoxyethanol 134.39
    2,2,2-trifluoroethanol 111.16
    methyl butyrate 102.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction