6-Methoxyflavone

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  • Identifiers

    CAS number
    26964-24-9

    Molecular formula
    C16H12O3

    SMILES
    COC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 73.36%
    Floral 52.12%
    Powdery 44.89%
    Fruity 44.68%
    Coumarinic 42.66%
    Phenolic 40.93%
    Vanilla 40.13%
    Balsamic 35.27%
    Hay 31.77%
    Aromatic 31.41%

     

    Flavor
    Bitter 90.11%
    Balsam 27.38%
    Sweet 24.74%
    Tonka 24.38%
    Very strong 19.74%
    Tarragon 19.59%
    Moth ball 19.52%
    Lovage 19.51%
    Naphthelene 19.41%
    Indole 19.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    6.64 (neutral)

    Molecular weight
    252.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    439°C

    Flash point

    • 171.86 ˚C est.

  • Synonyms

    • 6-Methoxyflavone
    • 26964-24-9
    • 6-methoxy-2-phenylchromen-4-one
    • 4H-1-Benzopyran-4-one, 6-methoxy-2-phenyl-
    • QAX7R06N2Q
    • DTXSID50181459
    • RefChem:104948
    • DTXCID10103950
    • 248-144-5
    • 6-Methoxy-2-phenyl-4H-chromen-4-one
    • MFCD00017322
    • 6-Methoxy-2-phenyl-4H-1-benzopyran-4-one
    • Flavone, 6-methoxy-
    • 6-Methoxy-2-phenyl-chromen-4-one
    • CHEMBL137586
    • 6-Methoxy-2-phenyl-4-benzopyrone
    • BRN 0218520
    • EINECS 248-144-5
    • Maybridge4_001878
    • 6-Methoxyflavone, 99%
    • 4H-1-Benzopyran-4-one,6-methoxy-2-phenyl-
    • UNII-QAX7R06N2Q
    • METHOXYFLAVONE, 6-
    • Oprea1_826922
    • 5-18-02-00257 (Beilstein Handbook Reference)
    • MLS002473406
    • BIDD:ER0437
    • SCHEMBL312059
    • MEGxp0_001705
    • orb1297129
    • SCHEMBL30799564
    • ACon1_000249
    • CHEBI:193017
    • HMS1526F08
    • BDBM50081946
    • LMPK12110100
    • STL561017
    • AKOS002246841
    • CCG-250451
    • DS-9912
    • EBC-605442
    • FM66838
    • HY-W097625
    • NCGC00177162-01
    • NCGC00177162-02
    • PD158872
    • SMR001397497
    • SY049346
    • DB-047071
    • CS-0166748
    • M1346
    • NS00015827
    • ST50207139
    • D81756
    • F498978
    • BRD-K41667702-001-02-9
    • 26964-24-9

  • Applications

    6-Methoxyflavone (CAS 26964-24-9) is primarily used as a synthetic intermediate and core scaffold for flavonoid derivatives in pharmaceutical and medicinal chemistry research, supporting route development and structure–activity relationship studies. In cosmetics and personal care, the compound is investigated for antioxidant activity and may be considered for inclusion in skin-care formulations under appropriate regulatory and formulation limits. In coatings and polymer systems, it has been evaluated as a UV-absorbing additive or stabilizer to improve photochemical stability of films and plastics. As a flavone, it serves as a versatile building block for synthesizing other flavonoid derivatives and is occasionally explored as a fragrance-related intermediate in flavor/fragrance research.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.39
    methanol 2.39
    isopropanol 1.53
    water 0.0
    ethyl acetate 10.68
    n-propanol 2.47
    acetone 7.24
    n-butanol 2.07
    acetonitrile 9.35
    DMF 16.47
    toluene 8.9
    isobutanol 1.89
    1,4-dioxane 36.78
    methyl acetate 17.7
    THF 58.35
    2-butanone 12.63
    n-pentanol 2.3
    sec-butanol 1.94
    n-hexane 0.06
    ethylene glycol 1.97
    NMP 10.38
    cyclohexane 0.19
    DMSO 33.23
    n-butyl acetate 7.16
    n-octanol 1.29
    chloroform 44.0
    n-propyl acetate 9.22
    acetic acid 10.76
    dichloromethane 91.79
    cyclohexanone 15.66
    propylene glycol 1.47
    isopropyl acetate 7.38
    DMAc 40.53
    2-ethoxyethanol 11.89
    isopentanol 2.67
    n-heptane 0.23
    ethyl formate 6.18
    1,2-dichloroethane 57.65
    n-hexanol 2.34
    2-methoxyethanol 16.17
    isobutyl acetate 7.27
    tetrachloromethane 1.08
    n-pentyl acetate 4.62
    transcutol 89.15
    n-heptanol 1.66
    ethylbenzene 5.68
    MIBK 6.49
    2-propoxyethanol 11.91
    tert-butanol 2.94
    MTBE 4.34
    2-butoxyethanol 7.46
    propionic acid 5.48
    o-xylene 4.9
    formic acid 3.93
    diethyl ether 5.33
    m-xylene 3.72
    p-xylene 6.85
    chlorobenzene 11.63
    dimethyl carbonate 9.83
    n-octane 0.16
    formamide 12.39
    cyclopentanone 21.03
    2-pentanone 6.1
    anisole 17.78
    cyclopentyl methyl ether 9.33
    gamma-butyrolactone 30.18
    1-methoxy-2-propanol 8.48
    pyridine 53.97
    3-pentanone 7.23
    furfural 39.46
    n-dodecane 0.25
    diethylene glycol 13.31
    diisopropyl ether 1.83
    tert-amyl alcohol 2.76
    acetylacetone 17.72
    n-hexadecane 0.3
    acetophenone 17.36
    methyl propionate 9.9
    isopentyl acetate 9.5
    trichloroethylene 110.65
    n-nonanol 1.79
    cyclohexanol 3.04
    benzyl alcohol 10.95
    2-ethylhexanol 2.78
    isooctanol 1.99
    dipropyl ether 5.91
    1,2-dichlorobenzene 12.95
    ethyl lactate 4.79
    propylene carbonate 11.91
    n-methylformamide 8.13
    2-pentanol 1.31
    n-pentane 0.05
    1-propoxy-2-propanol 7.29
    1-methoxy-2-propyl acetate 15.72
    2-(2-methoxypropoxy) propanol 16.3
    mesitylene 2.2
    ε-caprolactone 15.76
    p-cymene 3.88
    epichlorohydrin 88.13
    1,1,1-trichloroethane 13.32
    2-aminoethanol 2.79
    morpholine-4-carbaldehyde 32.89
    sulfolane 28.21
    2,2,4-trimethylpentane 0.17
    2-methyltetrahydrofuran 17.11
    n-hexyl acetate 5.43
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 18.76
    sec-butyl acetate 7.93
    tert-butyl acetate 10.09
    decalin 0.47
    glycerin 4.9
    diglyme 56.02
    acrylic acid 8.01
    isopropyl myristate 4.27
    n-butyric acid 6.18
    acetyl acetate 12.22
    di(2-ethylhexyl) phthalate 5.42
    ethyl propionate 9.64
    nitromethane 31.84
    1,2-diethoxyethane 22.45
    benzonitrile 13.14
    trioctyl phosphate 2.55
    1-bromopropane 9.0
    gamma-valerolactone 37.54
    n-decanol 1.61
    triethyl phosphate 8.05
    4-methyl-2-pentanol 1.57
    propionitrile 8.4
    vinylene carbonate 14.74
    1,1,2-trichlorotrifluoroethane 29.88
    DMS 14.79
    cumene 3.81
    2-octanol 1.04
    2-hexanone 8.07
    octyl acetate 4.09
    limonene 3.55
    1,2-dimethoxyethane 36.6
    ethyl orthosilicate 7.8
    tributyl phosphate 4.12
    diacetone alcohol 10.6
    N,N-dimethylaniline 10.27
    acrylonitrile 16.76
    aniline 10.86
    1,3-propanediol 4.98
    bromobenzene 12.76
    dibromomethane 30.68
    1,1,2,2-tetrachloroethane 53.21
    2-methyl-cyclohexyl acetate 10.51
    tetrabutyl urea 5.9
    diisobutyl methanol 2.94
    2-phenylethanol 9.92
    styrene 7.38
    dioctyl adipate 8.64
    dimethyl sulfate 16.22
    ethyl butyrate 9.1
    methyl lactate 5.37
    butyl lactate 4.57
    diethyl carbonate 8.97
    propanediol butyl ether 4.75
    triethyl orthoformate 9.03
    p-tert-butyltoluene 3.24
    methyl 4-tert-butylbenzoate 13.2
    morpholine 32.89
    tert-butylamine 1.39
    n-dodecanol 1.49
    dimethoxymethane 21.02
    ethylene carbonate 10.55
    cyrene 13.03
    2-ethoxyethyl acetate 13.58
    2-ethylhexyl acetate 7.45
    1,2,4-trichlorobenzene 19.08
    4-methylpyridine 23.04
    dibutyl ether 5.5
    2,6-dimethyl-4-heptanol 2.94
    DEF 10.74
    dimethyl isosorbide 37.4
    tetrachloroethylene 28.74
    eugenol 13.6
    triacetin 13.83
    span 80 8.44
    1,4-butanediol 2.05
    1,1-dichloroethane 14.17
    2-methyl-1-pentanol 3.82
    methyl formate 8.6
    2-methyl-1-butanol 2.49
    n-decane 0.33
    butyronitrile 5.37
    3,7-dimethyl-1-octanol 2.71
    1-chlorooctane 1.7
    1-chlorotetradecane 1.07
    n-nonane 0.23
    undecane 0.28
    tert-butylcyclohexane 0.39
    cyclooctane 0.08
    cyclopentanol 3.23
    tetrahydropyran 15.37
    tert-amyl methyl ether 4.26
    2,5,8-trioxanonane 40.73
    1-hexene 0.85
    2-isopropoxyethanol 8.55
    2,2,2-trifluoroethanol 4.52
    methyl butyrate 10.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction