6-Methoxyflavanone

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  • Identifiers

    CAS number
    3034-04-6

    Molecular formula
    C16H14O3

    SMILES
    COC1=CC2=C(C=C1)OC(CC2=O)C3=CC=CC=C3

    Safety labels

  • Odor profile

    Fragrance
    Sweet 76.52%
    Floral 52.22%
    Coumarinic 48.19%
    Vanilla 46.79%
    Spicy 44.55%
    Herbal 41.34%
    Powdery 40.81%
    Hay 39.81%
    Aromatic 37.11%
    Phenolic 36.96%

     

    Flavor
    Bitter 84.31%
    Herbal 35.41%
    Balsam 30.21%
    Sweet 29.71%
    Tonka 27.91%
    Lovage 20.87%
    Naphthalic 19.88%
    Coconut 19.77%
    Parsley 19.47%
    Tarragon 19.42%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    7.16 (neutral)

    Molecular weight
    254.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    426°C

    Flash point

    • 175.28 ˚C est.

  • Synonyms

    • 6-Methoxyflavanone
    • 3034-04-6
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-6-methoxy-2-phenyl-
    • 6-methoxy-2-phenyl-2,3-dihydrochromen-4-one
    • NSC-50184
    • 6CS44YN4Y5
    • 2,3-Dihydro-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
    • RefChem:104947
    • 6-methoxy-2-phenylchroman-4-one
    • 6-Methoxy-2-phenyl-chroman-4-one
    • NSC50184
    • 6-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • MLS002667344
    • CHEMBL476292
    • Flavanone, 6-methoxy-
    • Oprea1_206352
    • (2S)-6-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • SCHEMBL126192
    • MEGxp0_001702
    • orb1683384
    • ACon1_000173
    • CHEBI:230836
    • DTXSID701369258
    • HMS3079K20
    • HY-N8852
    • BDBM50296860
    • NSC 50184
    • AKOS015851685
    • CCG-250432
    • EBC-470101
    • FM67337
    • NCGC00180811-01
    • AS-69581
    • PD210358
    • SMR001557111
    • DB-047764
    • CS-0149188
    • M1403
    • NS00038718
    • ST50307518
    • D91496
    • 6-Methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
    • 6-Methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one #
    • BRD-A89936123-001-01-6
    • NCGC00180811-02!6-methoxy-2-phenyl-2,3-dihydrochromen-4-one
    • 3034-04-6

  • Applications

    6-Methoxyflavanone (CAS 3034-04-6) is primarily used as a synthetic intermediate and building block in flavonoid-type chemistry. In pharmaceutical and agrochemical R&D, it serves as a starting point for preparing flavanone- and chromanone-derived compounds and related pharmacophores. In fragrance and flavor applications, it may be evaluated as a fragrance or aroma intermediate due to its aromatic framework and methoxy substituent. In cosmetics and personal care, it can be explored as a cosmetic ingredient or fragrance component within formulation limits. In academic and industrial organic synthesis, it is used as a reagent or reference material to study reaction pathways and assemble more complex flavonoid derivatives. All uses are typical for methoxy-substituted flavanones and are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.15
    methanol 16.94
    isopropanol 8.52
    water 0.07
    ethyl acetate 100.38
    n-propanol 10.25
    acetone 31.73
    n-butanol 9.48
    acetonitrile 115.21
    DMF 41.35
    toluene 45.79
    isobutanol 7.34
    1,4-dioxane 247.68
    methyl acetate 111.61
    THF 170.69
    2-butanone 56.53
    n-pentanol 10.65
    sec-butanol 7.36
    n-hexane 0.36
    ethylene glycol 10.43
    NMP 29.39
    cyclohexane 2.15
    DMSO 127.84
    n-butyl acetate 36.89
    n-octanol 7.33
    chloroform 332.92
    n-propyl acetate 51.6
    acetic acid 53.29
    dichloromethane 453.71
    cyclohexanone 60.02
    propylene glycol 7.68
    isopropyl acetate 45.75
    DMAc 116.55
    2-ethoxyethanol 60.63
    isopentanol 11.64
    n-heptane 1.52
    ethyl formate 47.04
    1,2-dichloroethane 239.31
    n-hexanol 10.34
    2-methoxyethanol 72.23
    isobutyl acetate 32.48
    tetrachloromethane 13.06
    n-pentyl acetate 19.36
    transcutol 323.22
    n-heptanol 6.95
    ethylbenzene 23.46
    MIBK 28.68
    2-propoxyethanol 51.46
    tert-butanol 16.41
    MTBE 20.0
    2-butoxyethanol 26.69
    propionic acid 27.02
    o-xylene 25.68
    formic acid 21.19
    diethyl ether 32.68
    m-xylene 20.91
    p-xylene 27.65
    chlorobenzene 71.53
    dimethyl carbonate 59.24
    n-octane 0.93
    formamide 61.47
    cyclopentanone 69.36
    2-pentanone 30.63
    anisole 80.88
    cyclopentyl methyl ether 40.55
    gamma-butyrolactone 114.54
    1-methoxy-2-propanol 39.31
    pyridine 181.78
    3-pentanone 44.04
    furfural 143.22
    n-dodecane 1.36
    diethylene glycol 58.32
    diisopropyl ether 9.9
    tert-amyl alcohol 10.96
    acetylacetone 93.94
    n-hexadecane 1.69
    acetophenone 74.19
    methyl propionate 68.01
    isopentyl acetate 38.95
    trichloroethylene 460.25
    n-nonanol 9.23
    cyclohexanol 14.46
    benzyl alcohol 43.63
    2-ethylhexanol 11.21
    isooctanol 7.58
    dipropyl ether 24.94
    1,2-dichlorobenzene 71.08
    ethyl lactate 25.84
    propylene carbonate 60.4
    n-methylformamide 33.86
    2-pentanol 6.89
    n-pentane 0.31
    1-propoxy-2-propanol 29.88
    1-methoxy-2-propyl acetate 67.88
    2-(2-methoxypropoxy) propanol 55.91
    mesitylene 12.56
    ε-caprolactone 63.8
    p-cymene 15.05
    epichlorohydrin 261.88
    1,1,1-trichloroethane 106.8
    2-aminoethanol 12.99
    morpholine-4-carbaldehyde 122.62
    sulfolane 95.02
    2,2,4-trimethylpentane 0.75
    2-methyltetrahydrofuran 59.49
    n-hexyl acetate 27.58
    isooctane 0.6
    2-(2-butoxyethoxy)ethanol 68.58
    sec-butyl acetate 37.22
    tert-butyl acetate 44.26
    decalin 2.63
    glycerin 21.79
    diglyme 194.69
    acrylic acid 35.5
    isopropyl myristate 19.02
    n-butyric acid 33.65
    acetyl acetate 101.43
    di(2-ethylhexyl) phthalate 21.03
    ethyl propionate 55.59
    nitromethane 176.73
    1,2-diethoxyethane 96.74
    benzonitrile 72.94
    trioctyl phosphate 11.07
    1-bromopropane 42.69
    gamma-valerolactone 113.22
    n-decanol 8.12
    triethyl phosphate 34.02
    4-methyl-2-pentanol 7.2
    propionitrile 63.21
    vinylene carbonate 81.5
    1,1,2-trichlorotrifluoroethane 113.81
    DMS 64.33
    cumene 14.67
    2-octanol 4.5
    2-hexanone 35.82
    octyl acetate 19.69
    limonene 15.83
    1,2-dimethoxyethane 161.91
    ethyl orthosilicate 30.24
    tributyl phosphate 17.85
    diacetone alcohol 40.91
    N,N-dimethylaniline 40.08
    acrylonitrile 112.83
    aniline 50.29
    1,3-propanediol 21.98
    bromobenzene 84.7
    dibromomethane 182.39
    1,1,2,2-tetrachloroethane 245.85
    2-methyl-cyclohexyl acetate 40.78
    tetrabutyl urea 23.49
    diisobutyl methanol 10.41
    2-phenylethanol 36.75
    styrene 34.3
    dioctyl adipate 35.58
    dimethyl sulfate 76.05
    ethyl butyrate 45.87
    methyl lactate 30.14
    butyl lactate 17.73
    diethyl carbonate 46.92
    propanediol butyl ether 19.03
    triethyl orthoformate 38.88
    p-tert-butyltoluene 13.15
    methyl 4-tert-butylbenzoate 45.28
    morpholine 159.22
    tert-butylamine 7.29
    n-dodecanol 7.47
    dimethoxymethane 96.33
    ethylene carbonate 66.05
    cyrene 50.15
    2-ethoxyethyl acetate 58.65
    2-ethylhexyl acetate 31.56
    1,2,4-trichlorobenzene 90.77
    4-methylpyridine 81.49
    dibutyl ether 23.4
    2,6-dimethyl-4-heptanol 10.41
    DEF 45.08
    dimethyl isosorbide 115.25
    tetrachloroethylene 134.73
    eugenol 44.84
    triacetin 67.35
    span 80 28.7
    1,4-butanediol 10.44
    1,1-dichloroethane 108.07
    2-methyl-1-pentanol 12.8
    methyl formate 39.8
    2-methyl-1-butanol 8.81
    n-decane 1.92
    butyronitrile 35.97
    3,7-dimethyl-1-octanol 12.58
    1-chlorooctane 9.15
    1-chlorotetradecane 5.6
    n-nonane 1.47
    undecane 1.57
    tert-butylcyclohexane 2.01
    cyclooctane 0.97
    cyclopentanol 12.67
    tetrahydropyran 78.11
    tert-amyl methyl ether 16.25
    2,5,8-trioxanonane 145.5
    1-hexene 3.01
    2-isopropoxyethanol 39.1
    2,2,2-trifluoroethanol 29.52
    methyl butyrate 55.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction