6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride

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  • Identifiers

    CAS number
    83732-72-3

    Molecular formula
    C7H13Cl2N3O

    SMILES
    CNC1=C(C=CC(=N1)OC)N.Cl.Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 63.33%
    Fishy 24.43%
    Roasted 22.12%
    Cheesy 21.42%
    Bitter 20.35%
    Musty 20.13%
    Ripe 19.5%
    Burnt 19.16%
    Nutty 18.7%
    Animal 18.23%

     

    Flavor
    Bitter 35.7%
    Roasted 28.66%
    Meaty 27.29%
    Sulfurous 25.66%
    Mild 25.59%
    Musty 24.53%
    Coffee 24.27%
    Fishy 23.44%
    Sulfur 22.66%
    Odorless 22.51%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -225614.6 (strong acid)

    Molecular weight
    226.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    333°C

    Flash point

    • 122.9 ˚C est.

  • Synonyms

    • 6-Methoxy-N2-methylpyridine-2,3-diamine dihydrochloride
    • 3-Amino-2-Methylamino-6-Methoxypyridine dihydrochloride
    • 3-Amino-6-methoxy-2-(methylamino)pyridine dihydrochloride
    • 6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride
    • EINECS 280-622-9
    • 200C548F9J
    • HC BLUE NO. 7
    • 2,3-pyridinediamine, 6-methoxy-n2-methyl-, dihydrochloride
    • 2-Methylamino-3-amino-6-methoxypyridine dihydrochloride
    • 6-methoxy-2-methylamino-3-aminopyridine hcl
    • 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HYDROCHLORIDE
    • 2,3-PYRIDINEDIAMINE, 6-METHOXY-N2-METHYL-, HYDROCHLORIDE (1:2)
    • RefChem:543615
    • 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL [INCI]
    • 83732-72-3
    • HC Blue 7
    • MFCD08543464
    • 3-AMINO-2-METHYLAMINO-6-METHOXYPYRIDINE 2HCL
    • 6-methoxy-2-N-methylpyridine-2,3-diamine;dihydrochloride
    • 3-Amino-6-methoxy-2-(methylamino)pyridine 2HCl
    • 3-Amino-6-methoxy-2-(methylamino)pyridine DiHCl
    • UNII-200C548F9J
    • SCHEMBL4602018
    • 6-Methoxy-N2-methylpyridine-2,3-diaminedihydrochloride
    • DTXSID80879796
    • GYLCRBBRGGGHBS-UHFFFAOYSA-N
    • SBB070576
    • AKOS015891760
    • AC-8152
    • AS-18096
    • NS00089421
    • 732A723
    • 6-METHOXY-N2-METHYLPYRIDINE-2,3-DIAMINE 2HCL
    • Q27253362
    • 6-methoxy-N2-methyl-pyridine-2,3-diamine;dihydrochloride
    • 6-Methoxy-N2-methylpyridine-2 pound not3-diamine Dihydrochloride
    • 6-Methoxy-N~2~-methylpyridine-2,3-diamine--hydrogen chloride (1/2)
    • 83732-72-3

  • Applications

    6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride (CAS 83732-72-3) is primarily used in pharmaceutical research as a synthetic intermediate to access heteroaryl scaffolds in medicinal chemistry programs. It functions as a versatile building block for preparing pyridine-based compounds, supporting library design and lead diversification in drug discovery. In laboratory synthesis, it serves as a practical starting material for subsequent functionalization and derivatization. The dihydrochloride salt form provides improved aqueous solubility and handling, facilitating in vitro screening and library-generation workflows. Applications are therefore concentrated in pharmaceutical and medicinal chemistry contexts, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.69
    methanol 242.92
    isopropanol 12.13
    water 1004.21
    ethyl acetate 0.71
    n-propanol 26.68
    acetone 1.27
    n-butanol 15.46
    acetonitrile 2.23
    DMF 113.02
    toluene 0.11
    isobutanol 9.4
    1,4-dioxane 9.31
    methyl acetate 0.91
    THF 8.11
    2-butanone 0.87
    n-pentanol 13.75
    sec-butanol 6.66
    n-hexane 0.18
    ethylene glycol 375.36
    NMP 92.06
    cyclohexane 0.27
    DMSO 187.93
    n-butyl acetate 1.01
    n-octanol 2.14
    chloroform 5.35
    n-propyl acetate 1.17
    acetic acid 83.82
    dichloromethane 10.92
    cyclohexanone 4.19
    propylene glycol 90.5
    isopropyl acetate 0.3
    DMAc 53.2
    2-ethoxyethanol 80.22
    isopentanol 5.64
    n-heptane 0.25
    ethyl formate 9.92
    1,2-dichloroethane 4.93
    n-hexanol 5.69
    2-methoxyethanol 190.14
    isobutyl acetate 0.63
    tetrachloromethane 1.83
    n-pentyl acetate 1.19
    transcutol 20.56
    n-heptanol 4.47
    ethylbenzene 0.24
    MIBK 0.39
    2-propoxyethanol 32.04
    tert-butanol 6.33
    MTBE 0.52
    2-butoxyethanol 18.85
    propionic acid 15.86
    o-xylene 0.3
    formic acid 784.41
    diethyl ether 0.88
    m-xylene 0.19
    p-xylene 0.34
    chlorobenzene 0.41
    dimethyl carbonate 1.57
    n-octane 0.14
    formamide 439.88
    cyclopentanone 5.23
    2-pentanone 0.66
    anisole 0.87
    cyclopentyl methyl ether 1.45
    gamma-butyrolactone 12.47
    1-methoxy-2-propanol 34.23
    pyridine 3.71
    3-pentanone 0.62
    furfural 36.85
    n-dodecane 0.08
    diethylene glycol 106.79
    diisopropyl ether 0.15
    tert-amyl alcohol 4.37
    acetylacetone 0.84
    n-hexadecane 0.09
    acetophenone 1.91
    methyl propionate 1.37
    isopentyl acetate 0.81
    trichloroethylene 5.03
    n-nonanol 2.11
    cyclohexanol 5.53
    benzyl alcohol 6.7
    2-ethylhexanol 2.11
    isooctanol 2.84
    dipropyl ether 1.07
    1,2-dichlorobenzene 0.91
    ethyl lactate 5.64
    propylene carbonate 6.03
    n-methylformamide 96.69
    2-pentanol 2.64
    n-pentane 0.21
    1-propoxy-2-propanol 9.63
    1-methoxy-2-propyl acetate 1.8
    2-(2-methoxypropoxy) propanol 8.35
    mesitylene 0.19
    ε-caprolactone 6.14
    p-cymene 0.42
    epichlorohydrin 12.7
    1,1,1-trichloroethane 0.66
    2-aminoethanol 234.11
    morpholine-4-carbaldehyde 66.74
    sulfolane 39.25
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 2.47
    n-hexyl acetate 1.21
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 13.7
    sec-butyl acetate 0.41
    tert-butyl acetate 0.32
    decalin 0.1
    glycerin 264.62
    diglyme 21.32
    acrylic acid 28.76
    isopropyl myristate 0.43
    n-butyric acid 11.99
    acetyl acetate 0.58
    di(2-ethylhexyl) phthalate 2.43
    ethyl propionate 0.98
    nitromethane 31.71
    1,2-diethoxyethane 1.79
    benzonitrile 2.35
    trioctyl phosphate 1.92
    1-bromopropane 1.28
    gamma-valerolactone 25.96
    n-decanol 1.53
    triethyl phosphate 1.76
    4-methyl-2-pentanol 1.01
    propionitrile 2.21
    vinylene carbonate 7.8
    1,1,2-trichlorotrifluoroethane 62.17
    DMS 1.21
    cumene 0.33
    2-octanol 1.69
    2-hexanone 1.1
    octyl acetate 0.85
    limonene 0.51
    1,2-dimethoxyethane 32.2
    ethyl orthosilicate 1.71
    tributyl phosphate 1.56
    diacetone alcohol 2.72
    N,N-dimethylaniline 1.6
    acrylonitrile 5.34
    aniline 1.64
    1,3-propanediol 163.18
    bromobenzene 0.25
    dibromomethane 4.11
    1,1,2,2-tetrachloroethane 5.73
    2-methyl-cyclohexyl acetate 1.52
    tetrabutyl urea 2.93
    diisobutyl methanol 0.78
    2-phenylethanol 4.51
    styrene 0.22
    dioctyl adipate 1.39
    dimethyl sulfate 6.94
    ethyl butyrate 1.13
    methyl lactate 9.78
    butyl lactate 4.65
    diethyl carbonate 1.14
    propanediol butyl ether 17.45
    triethyl orthoformate 1.74
    p-tert-butyltoluene 0.36
    methyl 4-tert-butylbenzoate 3.5
    morpholine 20.71
    tert-butylamine 2.17
    n-dodecanol 1.07
    dimethoxymethane 15.02
    ethylene carbonate 5.44
    cyrene 22.23
    2-ethoxyethyl acetate 1.99
    2-ethylhexyl acetate 0.69
    1,2,4-trichlorobenzene 1.26
    4-methylpyridine 1.76
    dibutyl ether 0.57
    2,6-dimethyl-4-heptanol 0.78
    DEF 5.81
    dimethyl isosorbide 10.97
    tetrachloroethylene 7.17
    eugenol 8.88
    triacetin 2.04
    span 80 8.97
    1,4-butanediol 96.58
    1,1-dichloroethane 0.88
    2-methyl-1-pentanol 5.53
    methyl formate 43.32
    2-methyl-1-butanol 6.63
    n-decane 0.13
    butyronitrile 2.6
    3,7-dimethyl-1-octanol 1.2
    1-chlorooctane 0.39
    1-chlorotetradecane 0.19
    n-nonane 0.12
    undecane 0.1
    tert-butylcyclohexane 0.07
    cyclooctane 0.12
    cyclopentanol 9.95
    tetrahydropyran 2.12
    tert-amyl methyl ether 0.62
    2,5,8-trioxanonane 15.41
    1-hexene 0.41
    2-isopropoxyethanol 18.9
    2,2,2-trifluoroethanol 58.01
    methyl butyrate 2.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction