6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride

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  • Identifiers

    CAS number
    83732-72-3

    Molecular formula
    C7H13Cl2N3O

    SMILES
    CNC1=C(C=CC(=N1)OC)N.Cl.Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Roasted 38.11%
    Odorless 37.01%
    Meaty 33.19%
    Nutty 29.86%
    Burnt 27.2%
    Savory 25.17%
    Fishy 24.1%
    Cheesy 23.02%
    Animal 22.53%
    Cooked 22.18%

     

    Flavor
    Bitter 44.32%
    Roasted 34.51%
    Fruity 29.52%
    Meaty 29.31%
    Mild 27.93%
    Odorless 24.74%
    Coffee 24.46%
    Musty 24.22%
    Roast 23.13%
    Potato 22.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.09 (weak acid)

    Molecular weight
    226.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    308°C

    Flash point

    • 152.1 ˚C est.

  • Synonyms

    • 6-Methoxy-N2-methylpyridine-2,3-diamine dihydrochloride
    • 3-Amino-2-Methylamino-6-Methoxypyridine dihydrochloride
    • 3-Amino-6-methoxy-2-(methylamino)pyridine dihydrochloride
    • 6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride
    • EINECS 280-622-9
    • 200C548F9J
    • HC BLUE NO. 7
    • 2,3-pyridinediamine, 6-methoxy-n2-methyl-, dihydrochloride
    • 2-Methylamino-3-amino-6-methoxypyridine dihydrochloride
    • 6-methoxy-2-methylamino-3-aminopyridine hcl
    • 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HYDROCHLORIDE
    • 2,3-PYRIDINEDIAMINE, 6-METHOXY-N2-METHYL-, HYDROCHLORIDE (1:2)
    • RefChem:543615
    • 6-METHOXY-2-METHYLAMINO-3-AMINOPYRIDINE HCL [INCI]
    • 83732-72-3
    • HC Blue 7
    • MFCD08543464
    • 3-AMINO-2-METHYLAMINO-6-METHOXYPYRIDINE 2HCL
    • 6-methoxy-2-N-methylpyridine-2,3-diamine;dihydrochloride
    • 3-Amino-6-methoxy-2-(methylamino)pyridine 2HCl
    • 3-Amino-6-methoxy-2-(methylamino)pyridine DiHCl
    • UNII-200C548F9J
    • SCHEMBL4602018
    • 6-Methoxy-N2-methylpyridine-2,3-diaminedihydrochloride
    • DTXSID80879796
    • GYLCRBBRGGGHBS-UHFFFAOYSA-N
    • SBB070576
    • AKOS015891760
    • AC-8152
    • AS-18096
    • NS00089421
    • 732A723
    • 6-METHOXY-N2-METHYLPYRIDINE-2,3-DIAMINE 2HCL
    • Q27253362
    • 6-methoxy-N2-methyl-pyridine-2,3-diamine;dihydrochloride
    • 6-Methoxy-N2-methylpyridine-2 pound not3-diamine Dihydrochloride
    • 6-Methoxy-N~2~-methylpyridine-2,3-diamine--hydrogen chloride (1/2)
    • 83732-72-3

  • Applications

    6-Methoxy-2-methylamino-3-aminopyridine dihydrochloride (CAS 83732-72-3) is primarily used in pharmaceutical research as a synthetic intermediate to access heteroaryl scaffolds in medicinal chemistry programs. It functions as a versatile building block for preparing pyridine-based compounds, supporting library design and lead diversification in drug discovery. In laboratory synthesis, it serves as a practical starting material for subsequent functionalization and derivatization. The dihydrochloride salt form provides improved aqueous solubility and handling, facilitating in vitro screening and library-generation workflows. Applications are therefore concentrated in pharmaceutical and medicinal chemistry contexts, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.75
    methanol 88.29
    isopropanol 32.72
    water 9.99
    ethyl acetate 16.12
    n-propanol 43.18
    acetone 30.89
    n-butanol 32.63
    acetonitrile 36.25
    DMF 111.14
    toluene 8.98
    isobutanol 27.06
    1,4-dioxane 72.66
    methyl acetate 22.01
    THF 92.43
    2-butanone 22.01
    n-pentanol 28.08
    sec-butanol 25.21
    n-hexane 0.34
    ethylene glycol 53.5
    NMP 83.94
    cyclohexane 1.41
    DMSO 242.11
    n-butyl acetate 11.05
    n-octanol 9.85
    chloroform 59.07
    n-propyl acetate 11.04
    acetic acid 179.43
    dichloromethane 82.25
    cyclohexanone 41.73
    propylene glycol 43.54
    isopropyl acetate 6.81
    DMAc 85.09
    2-ethoxyethanol 82.01
    isopentanol 22.5
    n-heptane 1.03
    ethyl formate 51.57
    1,2-dichloroethane 32.15
    n-hexanol 21.56
    2-methoxyethanol 148.88
    isobutyl acetate 6.68
    tetrachloromethane 10.61
    n-pentyl acetate 8.87
    transcutol 47.54
    n-heptanol 14.16
    ethylbenzene 3.99
    MIBK 7.66
    2-propoxyethanol 54.44
    tert-butanol 36.03
    MTBE 10.7
    2-butoxyethanol 33.87
    propionic acid 46.09
    o-xylene 7.5
    formic acid 190.1
    diethyl ether 8.02
    m-xylene 5.83
    p-xylene 6.19
    chlorobenzene 18.1
    dimethyl carbonate 12.66
    n-octane 0.55
    formamide 166.45
    cyclopentanone 57.54
    2-pentanone 12.89
    anisole 14.72
    cyclopentyl methyl ether 18.02
    gamma-butyrolactone 90.0
    1-methoxy-2-propanol 60.05
    pyridine 67.63
    3-pentanone 9.19
    furfural 150.52
    n-dodecane 0.55
    diethylene glycol 72.36
    diisopropyl ether 1.86
    tert-amyl alcohol 26.4
    acetylacetone 17.38
    n-hexadecane 0.63
    acetophenone 18.44
    methyl propionate 16.45
    isopentyl acetate 10.86
    trichloroethylene 69.28
    n-nonanol 9.4
    cyclohexanol 24.48
    benzyl alcohol 31.44
    2-ethylhexanol 11.63
    isooctanol 10.73
    dipropyl ether 6.89
    1,2-dichlorobenzene 17.88
    ethyl lactate 14.68
    propylene carbonate 51.3
    n-methylformamide 92.84
    2-pentanol 11.8
    n-pentane 0.55
    1-propoxy-2-propanol 26.9
    1-methoxy-2-propyl acetate 14.86
    2-(2-methoxypropoxy) propanol 21.49
    mesitylene 3.47
    ε-caprolactone 39.81
    p-cymene 4.94
    epichlorohydrin 89.76
    1,1,1-trichloroethane 20.56
    2-aminoethanol 72.45
    morpholine-4-carbaldehyde 84.05
    sulfolane 115.43
    2,2,4-trimethylpentane 0.63
    2-methyltetrahydrofuran 44.51
    n-hexyl acetate 10.8
    isooctane 0.33
    2-(2-butoxyethoxy)ethanol 30.7
    sec-butyl acetate 5.62
    tert-butyl acetate 7.67
    decalin 0.81
    glycerin 90.64
    diglyme 55.42
    acrylic acid 60.16
    isopropyl myristate 4.34
    n-butyric acid 59.67
    acetyl acetate 14.09
    di(2-ethylhexyl) phthalate 11.19
    ethyl propionate 8.65
    nitromethane 152.66
    1,2-diethoxyethane 11.86
    benzonitrile 32.52
    trioctyl phosphate 7.73
    1-bromopropane 10.9
    gamma-valerolactone 94.15
    n-decanol 7.03
    triethyl phosphate 9.95
    4-methyl-2-pentanol 6.39
    propionitrile 23.76
    vinylene carbonate 58.07
    1,1,2-trichlorotrifluoroethane 112.7
    DMS 9.4
    cumene 3.66
    2-octanol 7.17
    2-hexanone 11.19
    octyl acetate 7.2
    limonene 6.54
    1,2-dimethoxyethane 71.44
    ethyl orthosilicate 9.42
    tributyl phosphate 7.42
    diacetone alcohol 20.84
    N,N-dimethylaniline 11.54
    acrylonitrile 42.54
    aniline 29.94
    1,3-propanediol 86.46
    bromobenzene 14.69
    dibromomethane 36.09
    1,1,2,2-tetrachloroethane 48.67
    2-methyl-cyclohexyl acetate 11.71
    tetrabutyl urea 10.7
    diisobutyl methanol 5.5
    2-phenylethanol 25.39
    styrene 5.05
    dioctyl adipate 9.24
    dimethyl sulfate 30.95
    ethyl butyrate 11.22
    methyl lactate 26.1
    butyl lactate 12.58
    diethyl carbonate 9.81
    propanediol butyl ether 25.47
    triethyl orthoformate 10.45
    p-tert-butyltoluene 4.57
    methyl 4-tert-butylbenzoate 19.6
    morpholine 82.67
    tert-butylamine 13.53
    n-dodecanol 5.27
    dimethoxymethane 41.37
    ethylene carbonate 39.92
    cyrene 38.19
    2-ethoxyethyl acetate 14.51
    2-ethylhexyl acetate 7.81
    1,2,4-trichlorobenzene 24.42
    4-methylpyridine 42.78
    dibutyl ether 5.02
    2,6-dimethyl-4-heptanol 5.5
    DEF 26.2
    dimethyl isosorbide 36.93
    tetrachloroethylene 37.16
    eugenol 24.83
    triacetin 13.39
    span 80 22.11
    1,4-butanediol 42.23
    1,1-dichloroethane 20.9
    2-methyl-1-pentanol 20.5
    methyl formate 80.72
    2-methyl-1-butanol 23.61
    n-decane 0.79
    butyronitrile 27.7
    3,7-dimethyl-1-octanol 7.7
    1-chlorooctane 3.52
    1-chlorotetradecane 1.69
    n-nonane 0.66
    undecane 0.65
    tert-butylcyclohexane 0.69
    cyclooctane 0.53
    cyclopentanol 41.89
    tetrahydropyran 34.13
    tert-amyl methyl ether 8.78
    2,5,8-trioxanonane 42.18
    1-hexene 1.65
    2-isopropoxyethanol 35.99
    2,2,2-trifluoroethanol 67.35
    methyl butyrate 16.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction