6-Hydroxyflavanone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    4250-77-5

    Molecular formula
    C15H12O3

    SMILES
    C1C(OC2=C(C1=O)C=C(C=C2)O)C3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 61.03%
    Phenolic 51.43%
    Vanilla 44.63%
    Spicy 43.23%
    Coumarinic 42.69%
    Coconut 36.43%
    Balsamic 34.39%
    Aromatic 30.95%
    Hay 30.93%
    Powdery 30.66%

     

    Flavor
    Bitter 92.27%
    Tonka 24.15%
    Herbal 22.11%
    Lovage 20.81%
    Sweet 20.52%
    Naphthalic 19.53%
    Cedarleaf 19.15%
    Parsley 18.98%
    Balsam 18.91%
    Nitrile 18.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    9.58 (weak base)

    Molecular weight
    240.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    457°C

    Flash point

    • 199.51 ˚C est.

  • Synonyms

    • 6-Hydroxyflavanone
    • 4250-77-5
    • 6-hydroxy-2-phenylchroman-4-one
    • 6-hydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
    • Flavanone, 6-hydroxy-
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-2-phenyl-
    • 1F174812MP
    • DTXSID1022429
    • CHEBI:34471
    • RefChem:543429
    • GlyTouCan:G63995JW
    • (+-)-6-Hydroxyflavanone
    • DTXCID202429
    • G63995JW
    • 624-472-8
    • (+/-)-6-Hydroxyflavanone
    • 6-hydroxy-2-phenyl-2,3-dihydrochromen-4-one
    • MFCD00017485
    • UNII-1F174812MP
    • 6-hydroxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • 6-hydroxy-2-phenyl-chroman-4-one
    • CHEMBL195033
    • 6-Hydroxy-Flavanone
    • Maybridge3_000570
    • 6-Hydroxyflavanone, 99%
    • bmse000985
    • Oprea1_761592
    • (2R)-6-hydroxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • SCHEMBL126598
    • orb1684824
    • XYHWPQUEOOBIOW-UHFFFAOYSA-
    • HMS1432J20
    • BDBM50296861
    • NSC804064
    • AKOS015856201
    • CCG-233325
    • EBC-616703
    • FH66053
    • HY-W028263
    • NSC-804064
    • IDI1_011957
    • AS-60586
    • PD182938
    • SY049325
    • DB-050919
    • CS-0072287
    • H1027
    • NS00126793
    • ST50307519
    • A12518
    • Q27116092
    • 6-Hydroxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
    • F0001-1180
    • InChI=1/C15H12O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-8,15-16H,9H2
    • 4250-77-5

  • Applications

    6-Hydroxyflavanone (CAS 4250-77-5) is primarily used as a synthetic intermediate and building block in flavonoid-related chemistry. In industrial and pharmaceutical contexts it serves as a scaffold for the preparation of flavonoid derivatives and other pharmaceutical intermediates. In fragrance and flavor chemistry, it is explored as a precursor to aroma compounds and related specialty chemicals. In cosmetics and personal care research, it may be evaluated as a potential starting material for cosmetic actives or pigment-related intermediates. In academic and pilot-scale settings, it functions as a versatile reagent for method development and the synthesis of more complex heterocyclic structures.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.48
    methanol 23.04
    isopropanol 14.08
    water 0.11
    ethyl acetate 46.94
    n-propanol 12.17
    acetone 24.7
    n-butanol 11.14
    acetonitrile 70.08
    DMF 35.29
    toluene 8.32
    isobutanol 9.14
    1,4-dioxane 140.59
    methyl acetate 64.8
    THF 136.0
    2-butanone 45.45
    n-pentanol 13.64
    sec-butanol 9.85
    n-hexane 0.06
    ethylene glycol 13.24
    NMP 10.19
    cyclohexane 0.18
    DMSO 143.06
    n-butyl acetate 28.28
    n-octanol 7.71
    chloroform 39.81
    n-propyl acetate 35.13
    acetic acid 31.55
    dichloromethane 40.52
    cyclohexanone 32.75
    propylene glycol 11.47
    isopropyl acetate 30.01
    DMAc 113.99
    2-ethoxyethanol 70.96
    isopentanol 15.78
    n-heptane 0.46
    ethyl formate 27.52
    1,2-dichloroethane 39.0
    n-hexanol 12.42
    2-methoxyethanol 91.84
    isobutyl acetate 25.29
    tetrachloromethane 1.77
    n-pentyl acetate 14.49
    transcutol 324.93
    n-heptanol 8.06
    ethylbenzene 7.84
    MIBK 27.12
    2-propoxyethanol 63.19
    tert-butanol 25.8
    MTBE 17.79
    2-butoxyethanol 28.96
    propionic acid 19.65
    o-xylene 7.9
    formic acid 16.6
    diethyl ether 14.47
    m-xylene 6.89
    p-xylene 10.24
    chlorobenzene 13.69
    dimethyl carbonate 37.26
    n-octane 0.34
    formamide 49.8
    cyclopentanone 34.08
    2-pentanone 25.69
    anisole 44.82
    cyclopentyl methyl ether 19.0
    gamma-butyrolactone 51.88
    1-methoxy-2-propanol 57.07
    pyridine 56.73
    3-pentanone 26.38
    furfural 66.51
    n-dodecane 0.75
    diethylene glycol 73.9
    diisopropyl ether 5.81
    tert-amyl alcohol 15.66
    acetylacetone 64.92
    n-hexadecane 0.9
    acetophenone 39.55
    methyl propionate 39.88
    isopentyl acetate 31.01
    trichloroethylene 84.07
    n-nonanol 9.41
    cyclohexanol 9.93
    benzyl alcohol 28.49
    2-ethylhexanol 11.02
    isooctanol 8.49
    dipropyl ether 17.04
    1,2-dichlorobenzene 17.13
    ethyl lactate 23.45
    propylene carbonate 28.6
    n-methylformamide 27.37
    2-pentanol 8.15
    n-pentane 0.06
    1-propoxy-2-propanol 37.54
    1-methoxy-2-propyl acetate 53.28
    2-(2-methoxypropoxy) propanol 54.22
    mesitylene 5.11
    ε-caprolactone 32.41
    p-cymene 8.29
    epichlorohydrin 114.06
    1,1,1-trichloroethane 19.76
    2-aminoethanol 17.14
    morpholine-4-carbaldehyde 77.04
    sulfolane 48.68
    2,2,4-trimethylpentane 0.35
    2-methyltetrahydrofuran 31.11
    n-hexyl acetate 21.58
    isooctane 0.34
    2-(2-butoxyethoxy)ethanol 72.72
    sec-butyl acetate 26.19
    tert-butyl acetate 35.39
    decalin 0.72
    glycerin 28.27
    diglyme 165.63
    acrylic acid 21.32
    isopropyl myristate 14.77
    n-butyric acid 25.05
    acetyl acetate 41.36
    di(2-ethylhexyl) phthalate 15.44
    ethyl propionate 33.72
    nitromethane 100.25
    1,2-diethoxyethane 74.95
    benzonitrile 36.12
    trioctyl phosphate 9.57
    1-bromopropane 7.22
    gamma-valerolactone 71.83
    n-decanol 8.16
    triethyl phosphate 21.29
    4-methyl-2-pentanol 8.95
    propionitrile 43.34
    vinylene carbonate 36.37
    1,1,2-trichlorotrifluoroethane 58.27
    DMS 39.15
    cumene 6.79
    2-octanol 5.37
    2-hexanone 30.38
    octyl acetate 15.64
    limonene 8.34
    1,2-dimethoxyethane 149.75
    ethyl orthosilicate 19.51
    tributyl phosphate 14.1
    diacetone alcohol 45.73
    N,N-dimethylaniline 23.6
    acrylonitrile 65.96
    aniline 18.99
    1,3-propanediol 32.23
    bromobenzene 13.01
    dibromomethane 13.86
    1,1,2,2-tetrachloroethane 54.32
    2-methyl-cyclohexyl acetate 25.48
    tetrabutyl urea 20.09
    diisobutyl methanol 10.15
    2-phenylethanol 27.03
    styrene 9.81
    dioctyl adipate 24.44
    dimethyl sulfate 44.98
    ethyl butyrate 28.15
    methyl lactate 28.16
    butyl lactate 16.92
    diethyl carbonate 26.74
    propanediol butyl ether 26.37
    triethyl orthoformate 25.16
    p-tert-butyltoluene 7.6
    methyl 4-tert-butylbenzoate 30.89
    morpholine 104.36
    tert-butylamine 8.27
    n-dodecanol 7.12
    dimethoxymethane 92.95
    ethylene carbonate 31.42
    cyrene 36.8
    2-ethoxyethyl acetate 39.31
    2-ethylhexyl acetate 22.43
    1,2,4-trichlorobenzene 23.59
    4-methylpyridine 30.89
    dibutyl ether 18.23
    2,6-dimethyl-4-heptanol 10.15
    DEF 30.1
    dimethyl isosorbide 84.96
    tetrachloroethylene 26.72
    eugenol 35.23
    triacetin 42.46
    span 80 26.09
    1,4-butanediol 14.26
    1,1-dichloroethane 18.42
    2-methyl-1-pentanol 15.62
    methyl formate 28.84
    2-methyl-1-butanol 10.66
    n-decane 1.01
    butyronitrile 24.16
    3,7-dimethyl-1-octanol 12.56
    1-chlorooctane 5.35
    1-chlorotetradecane 3.41
    n-nonane 0.7
    undecane 0.86
    tert-butylcyclohexane 0.76
    cyclooctane 0.13
    cyclopentanol 9.04
    tetrahydropyran 39.58
    tert-amyl methyl ether 14.14
    2,5,8-trioxanonane 121.75
    1-hexene 0.88
    2-isopropoxyethanol 45.3
    2,2,2-trifluoroethanol 16.77
    methyl butyrate 35.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction