6-Hydroxyethyl sorbitol

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  • Identifiers

    CAS number
    110204-70-1

    Molecular formula
    C8H18O7

    SMILES
    C(COC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.75%
    Sweet 44.45%
    Alcoholic 28.42%
    Buttery 18.19%
    Fishy 17.94%
    Clean 17.09%
    Caramellic 16.33%
    Oily 16.31%
    Cooling 15.51%
    Ethereal 14.23%

     

    Flavor
    Odorless 72.07%
    Sweet 60.22%
    Sweet-like 34.71%
    Very mild 24.39%
    Very slight 22.88%
    Bland 21.6%
    Mild 21.11%
    Cauliflower 20.01%
    Yeast 19.43%
    Bitter 19.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.8

    pKa est.
    5.13 (weak acid)

    Molecular weight
    226.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    997°C

    Flash point

    • 250.4 ˚C est.

  • Synonyms

    • 6-Hydroxyethyl sorbitol
    • TRQ60PZ09D
    • 110204-70-1
    • UNII-TRQ60PZ09D
    • D-Glucitol, 6-O-(2-hydroxyethyl)-
    • RefChem:104780
    • (2R,3R,4R,5S)-6-(2-hydroxyethoxy)hexane-1,2,3,4,5-pentol
    • SCHEMBL10709
    • SCHEMBL1161497
    • DTXSID001021388
    • Q27290233
    • 110204-70-1

  • Applications

    6-Hydroxyethyl sorbitol (CAS 110204-70-1) is commonly used as a humectant and processing aid in cosmetics and personal care formulations, helping to retain moisture and improve texture. It also serves as a polyol intermediate and plasticizer in polymer and coating formulations, enabling flexibility and processing of adhesives, coatings, and inks. In industrial manufacturing, it can function as a viscous agent and stabilizer in cleaning and household products, and as a reactive diluent or coupling component in certain polymer systems. Additionally, it may be evaluated as an excipient or formulation aid in pharmaceutical formulations, subject to regulatory approvals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.07
    methanol 33.41
    isopropanol 1.15
    water 1711.3
    ethyl acetate 0.5
    n-propanol 2.39
    acetone 0.63
    n-butanol 1.37
    acetonitrile 0.64
    DMF 183.72
    toluene 0.14
    isobutanol 1.08
    1,4-dioxane 3.67
    methyl acetate 0.54
    THF 1.95
    2-butanone 0.6
    n-pentanol 0.51
    sec-butanol 1.43
    n-hexane 0.05
    ethylene glycol 245.21
    NMP 135.76
    cyclohexane 0.53
    DMSO 429.91
    n-butyl acetate 0.36
    n-octanol 0.78
    chloroform 0.13
    n-propyl acetate 0.26
    acetic acid 24.81
    dichloromethane 0.19
    cyclohexanone 2.56
    propylene glycol 74.06
    isopropyl acetate 0.36
    DMAc 80.02
    2-ethoxyethanol 13.29
    isopentanol 0.87
    n-heptane 0.33
    ethyl formate 0.93
    1,2-dichloroethane 0.33
    n-hexanol 1.02
    2-methoxyethanol 58.41
    isobutyl acetate 0.13
    tetrachloromethane 0.14
    n-pentyl acetate 0.38
    transcutol 17.38
    n-heptanol 1.09
    ethylbenzene 0.12
    MIBK 0.44
    2-propoxyethanol 8.02
    tert-butanol 1.8
    MTBE 0.37
    2-butoxyethanol 4.69
    propionic acid 7.93
    o-xylene 0.4
    formic acid 557.32
    diethyl ether 0.32
    m-xylene 0.24
    p-xylene 0.14
    chlorobenzene 0.08
    dimethyl carbonate 3.36
    n-octane 0.14
    formamide 319.11
    cyclopentanone 3.31
    2-pentanone 0.53
    anisole 0.35
    cyclopentyl methyl ether 1.72
    gamma-butyrolactone 6.42
    1-methoxy-2-propanol 22.89
    pyridine 1.08
    3-pentanone 0.84
    furfural 9.66
    n-dodecane 0.07
    diethylene glycol 45.7
    diisopropyl ether 0.18
    tert-amyl alcohol 2.07
    acetylacetone 1.65
    n-hexadecane 0.08
    acetophenone 0.89
    methyl propionate 1.84
    isopentyl acetate 0.31
    trichloroethylene 0.38
    n-nonanol 0.74
    cyclohexanol 3.61
    benzyl alcohol 1.32
    2-ethylhexanol 0.64
    isooctanol 0.8
    dipropyl ether 0.67
    1,2-dichlorobenzene 0.16
    ethyl lactate 3.21
    propylene carbonate 2.42
    n-methylformamide 57.11
    2-pentanol 0.77
    n-pentane 0.1
    1-propoxy-2-propanol 4.86
    1-methoxy-2-propyl acetate 2.04
    2-(2-methoxypropoxy) propanol 5.95
    mesitylene 0.3
    ε-caprolactone 3.56
    p-cymene 0.35
    epichlorohydrin 1.63
    1,1,1-trichloroethane 0.09
    2-aminoethanol 104.8
    morpholine-4-carbaldehyde 74.93
    sulfolane 63.15
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 1.02
    n-hexyl acetate 0.53
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 7.6
    sec-butyl acetate 0.18
    tert-butyl acetate 0.62
    decalin 0.12
    glycerin 352.19
    diglyme 13.29
    acrylic acid 19.69
    isopropyl myristate 0.24
    n-butyric acid 3.72
    acetyl acetate 0.62
    di(2-ethylhexyl) phthalate 0.71
    ethyl propionate 0.45
    nitromethane 17.02
    1,2-diethoxyethane 0.86
    benzonitrile 0.38
    trioctyl phosphate 0.66
    1-bromopropane 0.1
    gamma-valerolactone 13.22
    n-decanol 0.56
    triethyl phosphate 1.03
    4-methyl-2-pentanol 0.48
    propionitrile 0.47
    vinylene carbonate 2.54
    1,1,2-trichlorotrifluoroethane 28.01
    DMS 1.19
    cumene 0.14
    2-octanol 0.57
    2-hexanone 0.23
    octyl acetate 0.39
    limonene 0.61
    1,2-dimethoxyethane 5.28
    ethyl orthosilicate 0.88
    tributyl phosphate 0.57
    diacetone alcohol 4.62
    N,N-dimethylaniline 0.88
    acrylonitrile 1.28
    aniline 0.78
    1,3-propanediol 44.97
    bromobenzene 0.06
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.69
    2-methyl-cyclohexyl acetate 0.65
    tetrabutyl urea 1.36
    diisobutyl methanol 0.6
    2-phenylethanol 1.16
    styrene 0.09
    dioctyl adipate 0.63
    dimethyl sulfate 17.08
    ethyl butyrate 0.53
    methyl lactate 17.92
    butyl lactate 1.94
    diethyl carbonate 0.42
    propanediol butyl ether 8.89
    triethyl orthoformate 0.86
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 2.61
    morpholine 7.92
    tert-butylamine 0.65
    n-dodecanol 0.44
    dimethoxymethane 10.9
    ethylene carbonate 1.75
    cyrene 17.79
    2-ethoxyethyl acetate 0.77
    2-ethylhexyl acetate 0.27
    1,2,4-trichlorobenzene 0.26
    4-methylpyridine 0.57
    dibutyl ether 0.3
    2,6-dimethyl-4-heptanol 0.6
    DEF 7.81
    dimethyl isosorbide 8.81
    tetrachloroethylene 0.83
    eugenol 3.36
    triacetin 1.89
    span 80 6.37
    1,4-butanediol 13.84
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.43
    methyl formate 16.56
    2-methyl-1-butanol 1.14
    n-decane 0.13
    butyronitrile 0.28
    3,7-dimethyl-1-octanol 0.57
    1-chlorooctane 0.19
    1-chlorotetradecane 0.1
    n-nonane 0.13
    undecane 0.09
    tert-butylcyclohexane 0.06
    cyclooctane 0.33
    cyclopentanol 3.9
    tetrahydropyran 1.08
    tert-amyl methyl ether 0.74
    2,5,8-trioxanonane 12.73
    1-hexene 0.06
    2-isopropoxyethanol 3.88
    2,2,2-trifluoroethanol 39.66
    methyl butyrate 0.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction