6-Hydroxy-2-naphthoic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    16712-64-4

    Molecular formula
    C11H8O3

    SMILES
    C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 69.83%
    Balsamic 39.54%
    Odorless 38.35%
    Medicinal 35.78%
    Animal 35.37%
    Nutty 34.25%
    Burnt 30.89%
    Aromatic 29.85%
    Bitter 29.04%
    Sweet 28.14%

     

    Flavor
    Phenolic 54.15%
    Nutty 44.27%
    Bitter 42.95%
    Mild 40.74%
    Balsam 38.42%
    Odorless 37.29%
    Faint 35.22%
    Balsamic 30.3%
    Honey 26.53%
    Urine 26.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    8.32 (weak base)

    Molecular weight
    188.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    424°C

    Flash point

    • 208.51 ˚C est.

  • Synonyms

    • 6-Hydroxy-2-naphthoic acid
    • 16712-64-4
    • 2-Naphthalenecarboxylic acid, 6-hydroxy-
    • 6-Hydroxy-2-naphthalenecarboxylic acid
    • 6-Carboxy-2-naphthol
    • 2-Naphthoic acid, 6-hydroxy-
    • 2-Hydroxynaphthalene-6-carboxylic acid
    • 6-Hydroxy-beta-naphthoic acid
    • NSC 148862
    • EINECS 240-759-7
    • NSC 689433
    • DTXSID3029312
    • 72XA858I6P
    • NSC-148862
    • NSC-689433
    • 2-Napthalenecarboxylic acid, 6-hydroxy-
    • DTXCID609312
    • EC 240-759-7
    • HYDROXY-2-NAPHTHOIC ACID, 6-
    • RefChem:543375
    • 240-759-7
    • 6-hydroxynaphthalene-2-carboxylic acid
    • MFCD00060070
    • 2-hydroxy-6-naphthoic acid
    • 6-Hydroxy-naphthalene-2-carboxylic acid
    • 6-hydroxy-2-naphtoic acid
    • CHEMBL278950
    • NSC689433
    • 94857-18-8
    • 2-Naphthol-6-carboxylic Acid
    • UNII-72XA858I6P
    • HNCA
    • 6-Hydroxy-2-napthoic acid
    • 6-hydroxy 2-naphthoic acid
    • SCHEMBL44327
    • 2-hydroxy-6-carboxynaphthalene
    • 6-hydroxy-2-carboxynaphthalene
    • SCHEMBL1804447
    • SCHEMBL7068212
    • SCHEMBL29357264
    • CHEBI:193581
    • 6-Hydroxy-2-naphthoic acid, 98%
    • 6-hydroxyl-2-naphthaleneformic acid
    • ALBB-028467
    • Tox21_200732
    • BDBM50057339
    • GEO-01537
    • NSC148862
    • SBB008594
    • AKOS001213537
    • 6-HYDROXY-2-CARBOXYLNAPHTHALENE
    • AC-9509
    • CS-W016817
    • EBC-612573
    • FH00099
    • FS-1340
    • PB47354
    • 2-hydroxy-naphthalene-6-carboxylic acid
    • 6-Hydroxy-2-naphthalene carboxylic acid
    • NCGC00248815-01
    • NCGC00258286-01
    • SY014339
    • CAS-16712-64-4
    • DB-000262
    • H0612
    • NS00008375
    • ST50406037
    • EN300-24140
    • P16614
    • 712H644
    • F013602
    • Q27266105
    • F0001-0611
    • 6-Hydroxy-2-naphthalenecarboxylic acid 100 microg/mL in Acetonitrile
    • 16712-64-4

  • Applications

    6-Hydroxy-2-naphthoic acid is primarily used as an intermediate in the synthesis of dyes and pigments based on naphthoic frameworks, supporting colorants for textiles, inks, and coatings. It also serves as a building block in synthetic routes to pharmaceutical and agrochemical compounds. Additionally, it is used as a precursor for specialty polymer additives and light-stabilizing agents incorporated into plastics and coatings. It may be evaluated as a dye intermediate for coatings and inks formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 57.27
    methanol 61.47
    isopropanol 35.88
    water 0.11
    ethyl acetate 23.51
    n-propanol 35.23
    acetone 75.93
    n-butanol 32.47
    acetonitrile 12.27
    DMF 125.16
    toluene 3.2
    isobutanol 17.77
    1,4-dioxane 53.89
    methyl acetate 26.98
    THF 212.1
    2-butanone 41.82
    n-pentanol 30.98
    sec-butanol 22.08
    n-hexane 0.08
    ethylene glycol 19.01
    NMP 29.19
    cyclohexane 0.03
    DMSO 74.06
    n-butyl acetate 29.6
    n-octanol 22.6
    chloroform 0.35
    n-propyl acetate 25.42
    acetic acid 20.69
    dichloromethane 0.71
    cyclohexanone 21.48
    propylene glycol 18.09
    isopropyl acetate 27.13
    DMAc 73.63
    2-ethoxyethanol 120.09
    isopentanol 30.4
    n-heptane 0.55
    ethyl formate 15.03
    1,2-dichloroethane 2.18
    n-hexanol 31.61
    2-methoxyethanol 155.84
    isobutyl acetate 14.78
    tetrachloromethane 0.14
    n-pentyl acetate 28.18
    transcutol 166.54
    n-heptanol 27.93
    ethylbenzene 3.66
    MIBK 36.79
    2-propoxyethanol 117.75
    tert-butanol 61.38
    MTBE 22.99
    2-butoxyethanol 74.45
    propionic acid 11.51
    o-xylene 3.25
    formic acid 21.63
    diethyl ether 17.19
    m-xylene 5.62
    p-xylene 3.74
    chlorobenzene 1.73
    dimethyl carbonate 16.04
    n-octane 0.58
    formamide 71.17
    cyclopentanone 58.16
    2-pentanone 44.04
    anisole 23.07
    cyclopentyl methyl ether 27.0
    gamma-butyrolactone 57.71
    1-methoxy-2-propanol 118.37
    pyridine 15.32
    3-pentanone 13.04
    furfural 36.14
    n-dodecane 1.11
    diethylene glycol 88.5
    diisopropyl ether 6.39
    tert-amyl alcohol 33.13
    acetylacetone 49.06
    n-hexadecane 1.2
    acetophenone 20.58
    methyl propionate 22.8
    isopentyl acetate 28.38
    trichloroethylene 4.08
    n-nonanol 23.93
    cyclohexanol 8.08
    benzyl alcohol 20.55
    2-ethylhexanol 16.45
    isooctanol 22.46
    dipropyl ether 22.94
    1,2-dichlorobenzene 2.19
    ethyl lactate 19.88
    propylene carbonate 20.83
    n-methylformamide 53.79
    2-pentanol 20.87
    n-pentane 0.07
    1-propoxy-2-propanol 73.69
    1-methoxy-2-propyl acetate 52.04
    2-(2-methoxypropoxy) propanol 53.44
    mesitylene 3.97
    ε-caprolactone 25.63
    p-cymene 6.33
    epichlorohydrin 73.1
    1,1,1-trichloroethane 1.43
    2-aminoethanol 35.14
    morpholine-4-carbaldehyde 64.07
    sulfolane 45.92
    2,2,4-trimethylpentane 0.27
    2-methyltetrahydrofuran 45.84
    n-hexyl acetate 31.31
    isooctane 0.57
    2-(2-butoxyethoxy)ethanol 96.14
    sec-butyl acetate 19.21
    tert-butyl acetate 43.67
    decalin 0.27
    glycerin 38.82
    diglyme 130.47
    acrylic acid 9.99
    isopropyl myristate 17.66
    n-butyric acid 22.07
    acetyl acetate 12.08
    di(2-ethylhexyl) phthalate 13.86
    ethyl propionate 19.84
    nitromethane 50.78
    1,2-diethoxyethane 67.08
    benzonitrile 10.13
    trioctyl phosphate 12.92
    1-bromopropane 1.06
    gamma-valerolactone 80.01
    n-decanol 20.09
    triethyl phosphate 12.09
    4-methyl-2-pentanol 17.65
    propionitrile 11.18
    vinylene carbonate 13.8
    1,1,2-trichlorotrifluoroethane 26.14
    DMS 17.91
    cumene 4.13
    2-octanol 18.96
    2-hexanone 33.25
    octyl acetate 23.74
    limonene 6.23
    1,2-dimethoxyethane 119.74
    ethyl orthosilicate 12.55
    tributyl phosphate 13.49
    diacetone alcohol 78.65
    N,N-dimethylaniline 17.29
    acrylonitrile 15.56
    aniline 7.51
    1,3-propanediol 60.23
    bromobenzene 1.09
    dibromomethane 0.29
    1,1,2,2-tetrachloroethane 3.7
    2-methyl-cyclohexyl acetate 18.65
    tetrabutyl urea 23.58
    diisobutyl methanol 15.43
    2-phenylethanol 26.19
    styrene 3.15
    dioctyl adipate 21.94
    dimethyl sulfate 19.33
    ethyl butyrate 23.68
    methyl lactate 23.82
    butyl lactate 24.45
    diethyl carbonate 13.05
    propanediol butyl ether 48.91
    triethyl orthoformate 18.16
    p-tert-butyltoluene 6.79
    methyl 4-tert-butylbenzoate 36.67
    morpholine 71.33
    tert-butylamine 16.45
    n-dodecanol 15.3
    dimethoxymethane 107.52
    ethylene carbonate 11.44
    cyrene 40.01
    2-ethoxyethyl acetate 44.77
    2-ethylhexyl acetate 18.28
    1,2,4-trichlorobenzene 3.28
    4-methylpyridine 16.17
    dibutyl ether 23.58
    2,6-dimethyl-4-heptanol 15.43
    DEF 31.55
    dimethyl isosorbide 93.95
    tetrachloroethylene 1.78
    eugenol 42.88
    triacetin 28.41
    span 80 34.74
    1,4-butanediol 25.03
    1,1-dichloroethane 1.38
    2-methyl-1-pentanol 23.64
    methyl formate 35.77
    2-methyl-1-butanol 20.29
    n-decane 1.41
    butyronitrile 14.85
    3,7-dimethyl-1-octanol 18.86
    1-chlorooctane 6.94
    1-chlorotetradecane 3.66
    n-nonane 0.99
    undecane 1.26
    tert-butylcyclohexane 0.58
    cyclooctane 0.06
    cyclopentanol 14.64
    tetrahydropyran 18.65
    tert-amyl methyl ether 19.72
    2,5,8-trioxanonane 101.16
    1-hexene 1.17
    2-isopropoxyethanol 72.29
    2,2,2-trifluoroethanol 8.35
    methyl butyrate 24.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction