6-Ethyl-2,3-dimethylpyridine

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  • Identifiers

    CAS number
    1463-01-0

    Molecular formula
    C9H13N

    SMILES
    CCC1=NC(=C(C=C1)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 60.13%
    Earthy 59.3%
    Roasted 59.25%
    Green 58.84%
    Musty 47.75%
    Burnt 46.32%
    Animal 39.09%
    Herbal 38.71%
    Coffee 37.88%
    Vegetable 36.71%

     

    Flavor
    Nutty 62.18%
    Earthy 49.43%
    Roasted 49.08%
    Musty 41.4%
    Meaty 38.92%
    Potato 38.89%
    Green 36.63%
    Burnt 35.22%
    Hazelnut 35.01%
    Cocoa 34.67%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.07 (neutral)

    Molecular weight
    135.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    186°C

    Flash point

    • 55.32 ˚C est.

  • Synonyms

    • 6-Ethyl-2,3-dimethylpyridine
    • 1463-01-0
    • Pyridine, 6-ethyl-2,3-dimethyl-
    • EINECS 215-972-3
    • SCHEMBL10730430
    • SCHEMBL27997635
    • DTXSID00163346
    • NS00024785
    • 1463-01-0

  • Applications

    6-Ethyl-2,3-dimethylpyridine is commonly used as an intermediate in the synthesis of pharmaceutical and agrochemical active ingredients, providing a building block for the construction of complex heterocycles. In fragrance and flavor chemistry, it can serve as an odorant precursor or fragrance-building block, contributing characteristic notes depending on the substitution pattern. In materials and polymers, it is used as a precursor to pyridine-containing monomers and specialty polymers or additives for coatings and plastics. In industrial manufacturing, it may act as a ligand or starting material for catalyst systems in various processes, including cross-coupling and polymerization. Overall, its use is typically limited by regulatory and formulation constraints and is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 604.6
    methanol 521.86
    isopropanol 480.54
    water 1.25
    ethyl acetate 503.05
    n-propanol 567.71
    acetone 451.81
    n-butanol 558.55
    acetonitrile 492.58
    DMF 548.15
    toluene 597.17
    isobutanol 469.9
    1,4-dioxane 1005.46
    methyl acetate 513.18
    THF 1102.57
    2-butanone 601.62
    n-pentanol 450.8
    sec-butanol 538.45
    n-hexane 342.95
    ethylene glycol 73.46
    NMP 603.92
    cyclohexane 370.38
    DMSO 454.79
    n-butyl acetate 923.64
    n-octanol 436.75
    chloroform 2664.92
    n-propyl acetate 388.99
    acetic acid 268.42
    dichloromethane 2650.63
    cyclohexanone 857.37
    propylene glycol 114.27
    isopropyl acetate 313.84
    DMAc 547.03
    2-ethoxyethanol 364.62
    isopentanol 465.43
    n-heptane 354.28
    ethyl formate 432.41
    1,2-dichloroethane 1183.76
    n-hexanol 765.15
    2-methoxyethanol 444.34
    isobutyl acetate 306.17
    tetrachloromethane 710.69
    n-pentyl acetate 472.43
    transcutol 859.89
    n-heptanol 401.62
    ethylbenzene 411.04
    MIBK 327.95
    2-propoxyethanol 626.61
    tert-butanol 503.51
    MTBE 643.0
    2-butoxyethanol 435.92
    propionic acid 323.06
    o-xylene 394.34
    formic acid 80.75
    diethyl ether 751.15
    m-xylene 382.78
    p-xylene 535.0
    chlorobenzene 762.05
    dimethyl carbonate 165.46
    n-octane 158.27
    formamide 116.81
    cyclopentanone 790.6
    2-pentanone 474.96
    anisole 495.5
    cyclopentyl methyl ether 669.65
    gamma-butyrolactone 759.92
    1-methoxy-2-propanol 351.44
    pyridine 922.89
    3-pentanone 446.74
    furfural 712.1
    n-dodecane 115.67
    diethylene glycol 272.85
    diisopropyl ether 254.03
    tert-amyl alcohol 510.02
    acetylacetone 363.84
    n-hexadecane 126.36
    acetophenone 410.37
    methyl propionate 388.11
    isopentyl acetate 691.61
    trichloroethylene 1840.24
    n-nonanol 359.92
    cyclohexanol 493.09
    benzyl alcohol 365.15
    2-ethylhexanol 541.04
    isooctanol 312.67
    dipropyl ether 708.21
    1,2-dichlorobenzene 703.64
    ethyl lactate 164.42
    propylene carbonate 526.66
    n-methylformamide 295.24
    2-pentanol 395.08
    n-pentane 261.08
    1-propoxy-2-propanol 495.24
    1-methoxy-2-propyl acetate 420.1
    2-(2-methoxypropoxy) propanol 326.33
    mesitylene 258.51
    ε-caprolactone 679.39
    p-cymene 349.89
    epichlorohydrin 988.03
    1,1,1-trichloroethane 1221.33
    2-aminoethanol 181.68
    morpholine-4-carbaldehyde 606.49
    sulfolane 740.18
    2,2,4-trimethylpentane 140.91
    2-methyltetrahydrofuran 1005.44
    n-hexyl acetate 629.24
    isooctane 95.66
    2-(2-butoxyethoxy)ethanol 432.61
    sec-butyl acetate 285.15
    tert-butyl acetate 319.7
    decalin 183.13
    glycerin 125.45
    diglyme 746.91
    acrylic acid 231.37
    isopropyl myristate 276.58
    n-butyric acid 490.94
    acetyl acetate 298.03
    di(2-ethylhexyl) phthalate 232.86
    ethyl propionate 351.29
    nitromethane 357.59
    1,2-diethoxyethane 680.95
    benzonitrile 632.3
    trioctyl phosphate 183.85
    1-bromopropane 1056.26
    gamma-valerolactone 786.79
    n-decanol 277.54
    triethyl phosphate 225.67
    4-methyl-2-pentanol 227.44
    propionitrile 585.81
    vinylene carbonate 535.8
    1,1,2-trichlorotrifluoroethane 476.33
    DMS 356.52
    cumene 310.38
    2-octanol 323.08
    2-hexanone 486.73
    octyl acetate 344.15
    limonene 461.39
    1,2-dimethoxyethane 748.77
    ethyl orthosilicate 232.21
    tributyl phosphate 220.94
    diacetone alcohol 278.89
    N,N-dimethylaniline 411.71
    acrylonitrile 542.3
    aniline 470.3
    1,3-propanediol 257.42
    bromobenzene 937.46
    dibromomethane 1920.84
    1,1,2,2-tetrachloroethane 1427.89
    2-methyl-cyclohexyl acetate 392.28
    tetrabutyl urea 278.92
    diisobutyl methanol 261.99
    2-phenylethanol 487.84
    styrene 472.49
    dioctyl adipate 317.25
    dimethyl sulfate 211.88
    ethyl butyrate 556.92
    methyl lactate 148.29
    butyl lactate 280.0
    diethyl carbonate 354.71
    propanediol butyl ether 314.22
    triethyl orthoformate 351.44
    p-tert-butyltoluene 310.25
    methyl 4-tert-butylbenzoate 379.85
    morpholine 883.69
    tert-butylamine 437.26
    n-dodecanol 226.18
    dimethoxymethane 448.26
    ethylene carbonate 452.47
    cyrene 262.42
    2-ethoxyethyl acetate 465.59
    2-ethylhexyl acetate 635.56
    1,2,4-trichlorobenzene 700.74
    4-methylpyridine 935.53
    dibutyl ether 619.21
    2,6-dimethyl-4-heptanol 261.99
    DEF 556.98
    dimethyl isosorbide 549.89
    tetrachloroethylene 1052.25
    eugenol 346.22
    triacetin 363.6
    span 80 336.86
    1,4-butanediol 139.73
    1,1-dichloroethane 1260.16
    2-methyl-1-pentanol 430.88
    methyl formate 232.13
    2-methyl-1-butanol 485.59
    n-decane 181.09
    butyronitrile 711.11
    3,7-dimethyl-1-octanol 364.4
    1-chlorooctane 461.13
    1-chlorotetradecane 197.46
    n-nonane 202.78
    undecane 138.81
    tert-butylcyclohexane 189.18
    cyclooctane 153.77
    cyclopentanol 503.79
    tetrahydropyran 1068.11
    tert-amyl methyl ether 519.75
    2,5,8-trioxanonane 495.4
    1-hexene 684.32
    2-isopropoxyethanol 289.32
    2,2,2-trifluoroethanol 107.48
    methyl butyrate 475.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction