6-Acetylaminocaproic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    57-08-9

    Molecular formula
    C8H15NO3

    SMILES
    CC(=O)NCCCCCC(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 48.73%
    Odorless 44.74%
    Savory 43.23%
    Cheesy 29.59%
    Fishy 26.94%
    Roasted 25.88%
    Cooked 23.99%
    Milky 19.98%
    Cooling 19.68%
    Sweet 19.22%

     

    Flavor
    Odorless 53.98%
    Sour 35.65%
    Cheese 32.82%
    Mild 29.19%
    Acidic 28.92%
    Fruity 27.41%
    Sweat 24.73%
    Fatty 22.85%
    Animal 22.09%
    Sulfury 21.83%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.83 (neutral)

    Molecular weight
    173.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    363°C

    Flash point

    • 172.96 ˚C est.

  • Synonyms

    • 6-(Acetylamino)hexanoic acid
    • 6-Acetylaminocaproic acid
    • epsilon-acetylaminocaproic acid
    • N-acetylamino-6-hexanoic acid
    • RefChem:109215
    • 6-Acetamidohexanoic acid
    • acexamic acid
    • 57-08-9
    • Hexanoic acid, 6-(acetylamino)-
    • 6-Acetamidocaproic acid
    • Plastenan
    • Acide acexamique
    • Acetaminocaproic acid
    • CY 153
    • Acemin
    • AEAH (base)
    • Acido acexamico
    • N-Acetyl-6-aminohexanoic acid
    • MFCD00004424
    • N-Acetyl-.epsilon.-aminocaproic acid
    • .epsilon.-Acetamidocaproic acid
    • HEXANOIC ACID, 6-ACETAMIDO-
    • NSC 12945
    • NSC-12945
    • 7IC4BO7D3R
    • DTXSID1045879
    • epsilon-Acetamidocaproic acid
    • CY-153
    • Acexamic Acid;6-Acetamidocaproic acid
    • Acexamic acid (INN)
    • NCGC00094990-01
    • ACEXAMIC ACID [INN]
    • DTXCID9025879
    • 6-Acetamidohexansaeure
    • 6-Acetamidohexanoicacid
    • 6-Acetylaminohexansaeure
    • 6-Acetymidohexanoic acid
    • Acidum acexamicum
    • CAS-57-08-9
    • Acide acexamique [INN-French]
    • Acido acexamico [INN-Spanish]
    • Acidum acexamicum [INN-Latin]
    • EINECS 200-310-8
    • 6-Acetamino hexanoic acid
    • 6-Acetylaminohexanoic acid
    • UNII-7IC4BO7D3R
    • acexamic-acid
    • Acexamic acid [INN:BAN:DCF]
    • acetamidocaproic acid
    • Spectrum_001280
    • 6-Acetaminocaproic acid
    • Spectrum2_000853
    • Spectrum3_000949
    • Spectrum4_001062
    • Spectrum5_001172
    • 6-acetamido hexanoic acid
    • WLN: QV5MV1
    • SCHEMBL24435
    • KBioGR_001384
    • KBioSS_001760
    • MLS002207271
    • DivK1c_000473
    • SPECTRUM1503045
    • SPBio_000865
    • ACEXAMIC ACID [MART.]
    • orb1310618
    • ACEXAMIC ACID [WHO-DD]
    • 6-Acetamidohexanoic acid, 99%
    • CHEMBL2105922
    • epsilon-N-acetylaminocaproic acid
    • HMS501H15
    • KBio1_000473
    • KBio2_001760
    • KBio2_004328
    • KBio2_006896
    • KBio3_002018
    • CHEBI:134808
    • NINDS_000473
    • HMS1922A17
    • HMS5083L07
    • Pharmakon1600-01503045
    • HY-B1259
    • NSC12945
    • Tox21_111377
    • CCG-40313
    • EBC-12516
    • MSK168265
    • NSC758219
    • s4534
    • SBB065849
    • AKOS000263977
    • Tox21_111377_1
    • CS-4812
    • NSC-758219
    • SB67369
    • IDI1_000473
    • NCGC00094990-02
    • NCGC00094990-04
    • SMR000059014
    • SY157627
    • SBI-0051755.P002
    • DB-053005
    • .EPSILON.-ACETAMIDOCAPROIC ACID [MI]
    • EU-0033936
    • NS00033640
    • ST50825044
    • EN300-17308
    • D07074
    • D83405
    • AB00052304_02
    • SR-01000872742
    • Q4727167
    • SR-01000872742-1
    • BRD-K72215350-001-06-5
    • Z56914861
    • 57-08-9

  • Applications

    6-Acetylaminocaproic acid is primarily used as a pharmaceutical intermediate and a protected amino acid derivative in synthetic chemistry. It serves as a building block for active pharmaceutical ingredients and drug candidates, and as an N-acyl protected form in peptide synthesis to enable selective coupling steps. It can act as a precursor to other N-acyl amino acid derivatives and other specialty chemicals, and in some cases is employed in polymer or materials chemistry as a starting point for amino-acid-containing polymers or as a chemical modifier for advanced materials. In industrial manufacturing, it is evaluated as a versatile intermediate for custom syntheses in fine chemicals and related formulation work, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 150.08
    methanol 376.63
    isopropanol 57.81
    water 64.96
    ethyl acetate 6.69
    n-propanol 80.12
    acetone 33.65
    n-butanol 48.63
    acetonitrile 7.96
    DMF 485.6
    toluene 1.13
    isobutanol 46.32
    1,4-dioxane 21.62
    methyl acetate 8.11
    THF 88.79
    2-butanone 15.3
    n-pentanol 33.38
    sec-butanol 38.06
    n-hexane 0.84
    ethylene glycol 170.8
    NMP 256.02
    cyclohexane 0.37
    DMSO 542.72
    n-butyl acetate 8.55
    n-octanol 8.82
    chloroform 5.41
    n-propyl acetate 6.97
    acetic acid 198.04
    dichloromethane 4.73
    cyclohexanone 42.19
    propylene glycol 186.78
    isopropyl acetate 6.42
    DMAc 303.68
    2-ethoxyethanol 107.72
    isopentanol 38.32
    n-heptane 0.36
    ethyl formate 23.39
    1,2-dichloroethane 4.44
    n-hexanol 20.15
    2-methoxyethanol 251.55
    isobutyl acetate 5.62
    tetrachloromethane 1.7
    n-pentyl acetate 6.01
    transcutol 160.57
    n-heptanol 8.9
    ethylbenzene 1.61
    MIBK 13.13
    2-propoxyethanol 64.85
    tert-butanol 68.33
    MTBE 9.81
    2-butoxyethanol 30.24
    propionic acid 86.25
    o-xylene 2.76
    formic acid 319.72
    diethyl ether 3.25
    m-xylene 2.32
    p-xylene 2.57
    chlorobenzene 2.22
    dimethyl carbonate 8.05
    n-octane 0.21
    formamide 250.9
    cyclopentanone 73.31
    2-pentanone 13.18
    anisole 7.74
    cyclopentyl methyl ether 16.61
    gamma-butyrolactone 84.16
    1-methoxy-2-propanol 114.54
    pyridine 11.66
    3-pentanone 7.17
    furfural 88.04
    n-dodecane 0.21
    diethylene glycol 105.75
    diisopropyl ether 1.63
    tert-amyl alcohol 47.1
    acetylacetone 22.93
    n-hexadecane 0.23
    acetophenone 13.33
    methyl propionate 10.54
    isopentyl acetate 11.18
    trichloroethylene 9.2
    n-nonanol 7.73
    cyclohexanol 25.95
    benzyl alcohol 20.2
    2-ethylhexanol 8.51
    isooctanol 7.25
    dipropyl ether 3.57
    1,2-dichlorobenzene 3.72
    ethyl lactate 16.28
    propylene carbonate 37.07
    n-methylformamide 190.15
    2-pentanol 16.19
    n-pentane 0.41
    1-propoxy-2-propanol 36.24
    1-methoxy-2-propyl acetate 17.41
    2-(2-methoxypropoxy) propanol 47.62
    mesitylene 2.02
    ε-caprolactone 40.7
    p-cymene 2.28
    epichlorohydrin 43.1
    1,1,1-trichloroethane 2.96
    2-aminoethanol 240.76
    morpholine-4-carbaldehyde 157.11
    sulfolane 175.65
    2,2,4-trimethylpentane 0.55
    2-methyltetrahydrofuran 29.39
    n-hexyl acetate 10.9
    isooctane 0.36
    2-(2-butoxyethoxy)ethanol 58.12
    sec-butyl acetate 4.94
    tert-butyl acetate 11.54
    decalin 0.59
    glycerin 283.62
    diglyme 80.03
    acrylic acid 92.44
    isopropyl myristate 4.21
    n-butyric acid 61.11
    acetyl acetate 6.82
    di(2-ethylhexyl) phthalate 12.64
    ethyl propionate 6.47
    nitromethane 121.55
    1,2-diethoxyethane 10.49
    benzonitrile 10.56
    trioctyl phosphate 7.29
    1-bromopropane 2.1
    gamma-valerolactone 127.01
    n-decanol 5.22
    triethyl phosphate 7.32
    4-methyl-2-pentanol 11.39
    propionitrile 8.79
    vinylene carbonate 30.88
    1,1,2-trichlorotrifluoroethane 89.23
    DMS 10.56
    cumene 2.26
    2-octanol 4.92
    2-hexanone 11.11
    octyl acetate 6.02
    limonene 3.02
    1,2-dimethoxyethane 87.94
    ethyl orthosilicate 6.68
    tributyl phosphate 9.27
    diacetone alcohol 46.64
    N,N-dimethylaniline 10.64
    acrylonitrile 16.42
    aniline 8.53
    1,3-propanediol 192.42
    bromobenzene 1.49
    dibromomethane 3.09
    1,1,2,2-tetrachloroethane 10.52
    2-methyl-cyclohexyl acetate 11.0
    tetrabutyl urea 15.55
    diisobutyl methanol 5.04
    2-phenylethanol 13.63
    styrene 1.62
    dioctyl adipate 10.44
    dimethyl sulfate 32.76
    ethyl butyrate 6.8
    methyl lactate 35.75
    butyl lactate 17.35
    diethyl carbonate 5.18
    propanediol butyl ether 58.6
    triethyl orthoformate 6.93
    p-tert-butyltoluene 2.24
    methyl 4-tert-butylbenzoate 21.77
    morpholine 54.81
    tert-butylamine 20.58
    n-dodecanol 3.58
    dimethoxymethane 47.93
    ethylene carbonate 21.3
    cyrene 54.67
    2-ethoxyethyl acetate 11.2
    2-ethylhexyl acetate 7.27
    1,2,4-trichlorobenzene 5.32
    4-methylpyridine 12.88
    dibutyl ether 3.86
    2,6-dimethyl-4-heptanol 5.04
    DEF 37.45
    dimethyl isosorbide 59.82
    tetrachloroethylene 8.77
    eugenol 28.21
    triacetin 17.65
    span 80 36.51
    1,4-butanediol 79.82
    1,1-dichloroethane 2.47
    2-methyl-1-pentanol 29.93
    methyl formate 82.43
    2-methyl-1-butanol 38.12
    n-decane 0.34
    butyronitrile 11.28
    3,7-dimethyl-1-octanol 9.11
    1-chlorooctane 1.62
    1-chlorotetradecane 0.72
    n-nonane 0.31
    undecane 0.26
    tert-butylcyclohexane 0.68
    cyclooctane 0.2
    cyclopentanol 51.82
    tetrahydropyran 11.1
    tert-amyl methyl ether 9.59
    2,5,8-trioxanonane 67.05
    1-hexene 2.77
    2-isopropoxyethanol 48.03
    2,2,2-trifluoroethanol 61.65
    methyl butyrate 13.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction