5alpha-Androstan-17beta-ol

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  • Identifiers

    CAS number
    1225-43-0

    Molecular formula
    C19H32O

    SMILES
    C[C@]12CCCC[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 71.56%
    Sweet 48.67%
    Amber 46.74%
    Sandalwood 45.3%
    Musk 43.38%
    Balsamic 41.81%
    Dry 41.47%
    Clean 37.75%
    Cedar 36.54%
    Animal 32.45%

     

    Flavor
    Earthy 40.69%
    Sweet 35.63%
    Woody 28.41%
    Earth 27.65%
    Dry 26.11%
    Spicy 26.1%
    Camphor 26.0%
    Fir needle 25.81%
    Beet 25.53%
    Herb 25.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.9

    pKa est.
    7.96 (neutral)

    Molecular weight
    276.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    400°C

    Flash point

    • 179.22 ˚C est.

  • Synonyms

    • 5alpha-Androstan-17beta-ol
    • 1225-43-0
    • 5.alpha.-Androstan-17.beta.-ol
    • Androstan-17-ol, (5alpha,17beta)-
    • I5JL49BERK
    • 17.beta.-Hydroxy-5.alpha.-androstane
    • CHEMBL371356
    • Androstan-17-ol, (5.alpha.,17.beta.)-
    • (5R,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
    • NSC-36058
    • Androstan-17-ol #
    • UNII-I5JL49BERK
    • 17beta-Hydroxy-5alpha-androstane
    • NSC 36058
    • 17-beta-HYDROXY-5-alpha-ANDROSTANE
    • SCHEMBL716358
    • DTXSID8036493
    • 17beta-hydroxy-5alpha-Androstan
    • Androstan-17-ol,17.beta.)-
    • CHEBI:34462
    • NSC36058
    • BDBM50410518
    • MFCD03225418
    • AKOS025146290
    • F95582
    • (5.ALPHA.,17.BETA.)-ANDROSTAN-17-OL
    • Q27116085
    • (5R,8R,10S,13S,17S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-ol
    • 1225-43-0

  • Applications

    5alpha-Androstan-17beta-ol (CAS 1225-43-0) is a steroidal alcohol that is commonly used as an intermediate and building block in steroid synthesis. In pharmaceuticals and related fine chemicals, it serves as an intermediate for the preparation of steroid hormones and various derivatives; in industrial chemical manufacturing, it can function as a precursor for high-value steroid compounds and downstream products; in research and development, it is used for synthetic studies and process evaluation; in cosmetics and personal care, it may be employed as a precursor to steroid-derived actives in regulated formulations; and in analytical laboratories, it can be used as a reference material or standard for steroid analyses.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1150.37
    methanol 731.18
    isopropanol 1283.11
    water 2.64
    ethyl acetate 1643.54
    n-propanol 1308.59
    acetone 2306.11
    n-butanol 1376.66
    acetonitrile 1137.14
    DMF 2149.44
    toluene 1282.0
    isobutanol 739.27
    1,4-dioxane 2755.65
    methyl acetate 851.14
    THF 4571.67
    2-butanone 1238.0
    n-pentanol 188.73
    sec-butanol 331.97
    n-hexane 40.31
    ethylene glycol 50.25
    NMP 238.92
    cyclohexane 225.35
    DMSO 498.28
    n-butyl acetate 864.26
    n-octanol 96.21
    chloroform 1671.75
    n-propyl acetate 444.7
    acetic acid 265.4
    dichloromethane 1363.57
    cyclohexanone 1369.0
    propylene glycol 59.76
    isopropyl acetate 1381.42
    DMAc 487.48
    2-ethoxyethanol 390.72
    isopentanol 867.76
    n-heptane 52.95
    ethyl formate 578.73
    1,2-dichloroethane 1085.5
    n-hexanol 420.14
    2-methoxyethanol 1367.18
    isobutyl acetate 359.46
    tetrachloromethane 352.71
    n-pentyl acetate 385.48
    transcutol 1865.6
    n-heptanol 168.08
    ethylbenzene 236.73
    MIBK 945.47
    2-propoxyethanol 924.7
    tert-butanol 1010.01
    MTBE 1559.79
    2-butoxyethanol 432.36
    propionic acid 297.4
    o-xylene 411.27
    formic acid 81.24
    diethyl ether 2716.0
    m-xylene 726.35
    p-xylene 267.46
    chlorobenzene 722.74
    dimethyl carbonate 375.43
    n-octane 17.39
    formamide 246.29
    cyclopentanone 1598.23
    2-pentanone 1613.33
    anisole 491.18
    cyclopentyl methyl ether 1318.24
    gamma-butyrolactone 1258.97
    1-methoxy-2-propanol 1067.66
    pyridine 1679.81
    3-pentanone 830.39
    furfural 751.55
    n-dodecane 10.0
    diethylene glycol 380.47
    diisopropyl ether 596.65
    tert-amyl alcohol 240.88
    acetylacetone 1428.61
    n-hexadecane 12.62
    acetophenone 288.11
    methyl propionate 888.61
    isopentyl acetate 835.28
    trichloroethylene 1393.82
    n-nonanol 101.55
    cyclohexanol 496.51
    benzyl alcohol 231.56
    2-ethylhexanol 200.38
    isooctanol 143.06
    dipropyl ether 683.48
    1,2-dichlorobenzene 482.93
    ethyl lactate 131.9
    propylene carbonate 550.97
    n-methylformamide 902.06
    2-pentanol 529.41
    n-pentane 127.25
    1-propoxy-2-propanol 620.18
    1-methoxy-2-propyl acetate 938.21
    2-(2-methoxypropoxy) propanol 264.28
    mesitylene 442.11
    ε-caprolactone 829.07
    p-cymene 159.94
    epichlorohydrin 1528.38
    1,1,1-trichloroethane 925.09
    2-aminoethanol 183.09
    morpholine-4-carbaldehyde 657.37
    sulfolane 562.88
    2,2,4-trimethylpentane 33.51
    2-methyltetrahydrofuran 1479.35
    n-hexyl acetate 366.13
    isooctane 59.32
    2-(2-butoxyethoxy)ethanol 469.9
    sec-butyl acetate 358.99
    tert-butyl acetate 1149.9
    decalin 44.22
    glycerin 107.3
    diglyme 1133.62
    acrylic acid 186.85
    isopropyl myristate 148.06
    n-butyric acid 898.6
    acetyl acetate 721.22
    di(2-ethylhexyl) phthalate 113.11
    ethyl propionate 444.0
    nitromethane 798.4
    1,2-diethoxyethane 1079.62
    benzonitrile 514.66
    trioctyl phosphate 84.28
    1-bromopropane 788.06
    gamma-valerolactone 1753.12
    n-decanol 72.85
    triethyl phosphate 161.44
    4-methyl-2-pentanol 352.93
    propionitrile 1333.21
    vinylene carbonate 573.93
    1,1,2-trichlorotrifluoroethane 375.65
    DMS 320.29
    cumene 138.17
    2-octanol 83.91
    2-hexanone 313.28
    octyl acetate 156.32
    limonene 181.35
    1,2-dimethoxyethane 1216.98
    ethyl orthosilicate 180.0
    tributyl phosphate 108.02
    diacetone alcohol 553.08
    N,N-dimethylaniline 223.97
    acrylonitrile 1104.32
    aniline 850.47
    1,3-propanediol 705.18
    bromobenzene 797.65
    dibromomethane 968.0
    1,1,2,2-tetrachloroethane 897.82
    2-methyl-cyclohexyl acetate 248.66
    tetrabutyl urea 117.33
    diisobutyl methanol 193.37
    2-phenylethanol 356.89
    styrene 310.59
    dioctyl adipate 164.62
    dimethyl sulfate 286.65
    ethyl butyrate 538.95
    methyl lactate 204.27
    butyl lactate 223.26
    diethyl carbonate 303.5
    propanediol butyl ether 200.09
    triethyl orthoformate 365.4
    p-tert-butyltoluene 177.97
    methyl 4-tert-butylbenzoate 298.02
    morpholine 2470.71
    tert-butylamine 736.67
    n-dodecanol 53.67
    dimethoxymethane 2528.64
    ethylene carbonate 634.32
    cyrene 157.15
    2-ethoxyethyl acetate 607.84
    2-ethylhexyl acetate 516.49
    1,2,4-trichlorobenzene 452.76
    4-methylpyridine 1463.35
    dibutyl ether 298.06
    2,6-dimethyl-4-heptanol 193.37
    DEF 783.7
    dimethyl isosorbide 493.98
    tetrachloroethylene 689.1
    eugenol 244.01
    triacetin 318.17
    span 80 190.41
    1,4-butanediol 68.15
    1,1-dichloroethane 1195.84
    2-methyl-1-pentanol 139.56
    methyl formate 503.05
    2-methyl-1-butanol 454.33
    n-decane 20.88
    butyronitrile 1559.58
    3,7-dimethyl-1-octanol 147.62
    1-chlorooctane 87.07
    1-chlorotetradecane 30.89
    n-nonane 18.98
    undecane 13.68
    tert-butylcyclohexane 37.32
    cyclooctane 79.74
    cyclopentanol 453.87
    tetrahydropyran 3006.68
    tert-amyl methyl ether 431.23
    2,5,8-trioxanonane 524.68
    1-hexene 142.27
    2-isopropoxyethanol 254.46
    2,2,2-trifluoroethanol 129.24
    methyl butyrate 487.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction