5-Methyloxolan-3-one

Overview IFRA Request a quote

  • Identifiers

    CAS number
    34003-72-0

    Molecular formula
    C5H8O2

    SMILES
    CC1CC(=O)CO1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 80.34%
    Caramellic 70.79%
    Nutty 56.24%
    Buttery 53.11%
    Burnt 47.18%
    Coumarinic 46.6%
    Hay 42.78%
    Roasted 42.26%
    Ethereal 37.18%
    Solvent 36.61%

     

    Flavor
    Sweet 70.73%
    Caramel 54.19%
    Nutty 47.82%
    Tobacco 40.98%
    Woody 39.19%
    Herbal 36.56%
    Bread 30.65%
    Coconut 29.77%
    Minty 29.72%
    Musty 29.04%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.12 (neutral)

    Molecular weight
    100.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    160°C

    Flash point

    • 49.01 ˚C est.

  • Synonyms

    • 5-methyloxolan-3-one
    • 34003-72-0
    • 3(2H)-Furanone, dihydro-5-methyl-
    • 5-Methyldihydro-3(2H)-furanone
    • DIHYDRO-5-METHYL-3(2H)-FURANONE
    • 5-methyldihydrofuran-3(2H)-one
    • 5-methyl tetrahydrofuran-3-one
    • SCHEMBL4951040
    • DTXSID50334423
    • 3(2H)-Furanone, 4,5-dihydro-5-methyl
    • EN300-262297
    • 821-771-7

  • Applications

    5-Methyloxolan-3-one is principally used as an intermediate in organic synthesis, enabling access to more complex cyclic ketones and lactone-derived motifs. It is commonly evaluated as a building block for pharmaceutical and agrochemical research, supporting routes to heterocyclic scaffolds. In fragrance and flavor chemistry, it can serve as a precursor to aroma compounds or as a scaffold for developing new fragrance ingredients. In polymer and materials science, it is explored as a specialty lactone intermediate for routes to functionalized polymers and coatings. In general industrial manufacturing, it may function as a precursor in synthesis steps that require a methyl-substituted oxolane lactone motif, with processing and regulatory considerations governed by local requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 626.76
    methanol 966.89
    isopropanol 395.59
    water 394.04
    ethyl acetate 173.75
    n-propanol 342.47
    acetone 416.24
    n-butanol 231.96
    acetonitrile 461.0
    DMF 685.45
    toluene 31.93
    isobutanol 206.06
    1,4-dioxane 402.19
    methyl acetate 254.71
    THF 309.31
    2-butanone 197.74
    n-pentanol 119.79
    sec-butanol 251.56
    n-hexane 6.66
    ethylene glycol 543.9
    NMP 440.13
    cyclohexane 11.73
    DMSO 428.1
    n-butyl acetate 49.17
    n-octanol 80.12
    chloroform 665.01
    n-propyl acetate 61.72
    acetic acid 1355.23
    dichloromethane 462.57
    cyclohexanone 172.17
    propylene glycol 489.45
    isopropyl acetate 74.54
    DMAc 511.17
    2-ethoxyethanol 313.97
    isopentanol 137.96
    n-heptane 7.0
    ethyl formate 138.06
    1,2-dichloroethane 163.51
    n-hexanol 99.08
    2-methoxyethanol 653.68
    isobutyl acetate 38.27
    tetrachloromethane 75.05
    n-pentyl acetate 47.05
    transcutol 765.89
    n-heptanol 59.31
    ethylbenzene 19.64
    MIBK 63.91
    2-propoxyethanol 241.21
    tert-butanol 325.18
    MTBE 100.15
    2-butoxyethanol 142.81
    propionic acid 463.67
    o-xylene 35.99
    formic acid 999.8
    diethyl ether 109.85
    m-xylene 32.71
    p-xylene 33.69
    chlorobenzene 74.81
    dimethyl carbonate 87.17
    n-octane 3.61
    formamide 845.92
    cyclopentanone 249.38
    2-pentanone 115.63
    anisole 90.6
    cyclopentyl methyl ether 104.25
    gamma-butyrolactone 332.51
    1-methoxy-2-propanol 408.59
    pyridine 212.01
    3-pentanone 93.85
    furfural 361.33
    n-dodecane 4.61
    diethylene glycol 375.24
    diisopropyl ether 24.41
    tert-amyl alcohol 213.5
    acetylacetone 159.04
    n-hexadecane 4.85
    acetophenone 88.33
    methyl propionate 151.03
    isopentyl acetate 45.44
    trichloroethylene 402.08
    n-nonanol 66.16
    cyclohexanol 153.72
    benzyl alcohol 108.2
    2-ethylhexanol 47.0
    isooctanol 44.75
    dipropyl ether 40.23
    1,2-dichlorobenzene 82.06
    ethyl lactate 77.63
    propylene carbonate 164.48
    n-methylformamide 480.24
    2-pentanol 125.18
    n-pentane 9.37
    1-propoxy-2-propanol 142.38
    1-methoxy-2-propyl acetate 88.31
    2-(2-methoxypropoxy) propanol 162.95
    mesitylene 21.18
    ε-caprolactone 173.08
    p-cymene 20.66
    epichlorohydrin 293.63
    1,1,1-trichloroethane 183.06
    2-aminoethanol 598.41
    morpholine-4-carbaldehyde 458.71
    sulfolane 283.48
    2,2,4-trimethylpentane 7.5
    2-methyltetrahydrofuran 195.29
    n-hexyl acetate 92.19
    isooctane 4.82
    2-(2-butoxyethoxy)ethanol 220.51
    sec-butyl acetate 41.98
    tert-butyl acetate 70.75
    decalin 7.25
    glycerin 622.36
    diglyme 337.3
    acrylic acid 540.32
    isopropyl myristate 35.29
    n-butyric acid 313.59
    acetyl acetate 136.51
    di(2-ethylhexyl) phthalate 48.74
    ethyl propionate 66.49
    nitromethane 1078.17
    1,2-diethoxyethane 101.59
    benzonitrile 111.68
    trioctyl phosphate 31.87
    1-bromopropane 73.54
    gamma-valerolactone 371.19
    n-decanol 47.04
    triethyl phosphate 35.24
    4-methyl-2-pentanol 62.89
    propionitrile 196.79
    vinylene carbonate 180.11
    1,1,2-trichlorotrifluoroethane 425.63
    DMS 88.02
    cumene 19.73
    2-octanol 40.5
    2-hexanone 62.59
    octyl acetate 50.7
    limonene 30.59
    1,2-dimethoxyethane 274.75
    ethyl orthosilicate 33.22
    tributyl phosphate 38.39
    diacetone alcohol 146.15
    N,N-dimethylaniline 64.37
    acrylonitrile 297.96
    aniline 126.75
    1,3-propanediol 476.1
    bromobenzene 58.05
    dibromomethane 237.26
    1,1,2,2-tetrachloroethane 296.21
    2-methyl-cyclohexyl acetate 46.07
    tetrabutyl urea 50.28
    diisobutyl methanol 28.78
    2-phenylethanol 84.89
    styrene 26.01
    dioctyl adipate 60.04
    dimethyl sulfate 141.31
    ethyl butyrate 46.29
    methyl lactate 165.99
    butyl lactate 63.86
    diethyl carbonate 41.53
    propanediol butyl ether 196.61
    triethyl orthoformate 39.93
    p-tert-butyltoluene 19.91
    methyl 4-tert-butylbenzoate 94.68
    morpholine 434.51
    tert-butylamine 155.56
    n-dodecanol 35.44
    dimethoxymethane 239.92
    ethylene carbonate 127.76
    cyrene 136.58
    2-ethoxyethyl acetate 84.55
    2-ethylhexyl acetate 33.68
    1,2,4-trichlorobenzene 113.98
    4-methylpyridine 156.44
    dibutyl ether 43.69
    2,6-dimethyl-4-heptanol 28.78
    DEF 178.68
    dimethyl isosorbide 170.73
    tetrachloroethylene 207.94
    eugenol 110.23
    triacetin 125.4
    span 80 139.9
    1,4-butanediol 204.26
    1,1-dichloroethane 232.12
    2-methyl-1-pentanol 87.84
    methyl formate 284.58
    2-methyl-1-butanol 150.48
    n-decane 7.05
    butyronitrile 141.56
    3,7-dimethyl-1-octanol 65.18
    1-chlorooctane 28.78
    1-chlorotetradecane 12.6
    n-nonane 6.31
    undecane 5.53
    tert-butylcyclohexane 7.68
    cyclooctane 3.98
    cyclopentanol 209.06
    tetrahydropyran 181.27
    tert-amyl methyl ether 75.77
    2,5,8-trioxanonane 253.83
    1-hexene 23.31
    2-isopropoxyethanol 165.99
    2,2,2-trifluoroethanol 556.75
    methyl butyrate 80.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction