5-Methoxysalicylic Acid

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  • Identifiers

    CAS number
    2612-02-4

    Molecular formula
    C8H8O4

    SMILES
    COC1=CC(=C(C=C1)O)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 66.65%
    Sweet 62.41%
    Vanilla 52.02%
    Balsamic 43.71%
    Aromatic 36.84%
    Odorless 34.9%
    Spicy 34.2%
    Powdery 33.89%
    Medicinal 33.45%
    Creamy 31.58%

     

    Flavor
    Phenolic 51.8%
    Odorless 40.79%
    Mild 39.73%
    Faint 34.07%
    Sweet 30.81%
    Nutty 30.2%
    Balsamic 26.86%
    Powdery 26.78%
    Creamy 25.3%
    Sour 23.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    7.1 (neutral)

    Molecular weight
    168.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    321°C

    Melting point expt.

    • 142 - 146 °C

    Flash point

    • 159.28 ˚C est.

    Solubility expt.

    • 9 mg/mL

  • Synonyms

    • 5-Methoxysalicylic acid
    • 2-Hydroxy-5-methoxybenzoic acid
    • 2612-02-4
    • Benzoic acid, 2-hydroxy-5-methoxy-
    • 5-Methoxy-2-hydroxybenzoic acid
    • NSC-2579
    • 4EQ4PA4ASH
    • DTXSID0062551
    • CHEBI:89830
    • RefChem:103076
    • Bee Venom Wart Remover Cream
    • DTXCID5037448
    • 220-037-8
    • 6-hydroxy-m-anisic acid
    • MFCD00002459
    • Acid5-methoxysalicylic
    • 5-o-METHYL GENTISIC ACID
    • m-Anisic acid, 6-hydroxy-
    • 2-hydroxy-5-methoxy-benzoic acid
    • 5-MeOSA
    • 6-hydroxy-3-anisic acid
    • 2-Hydroxy-5-methoxybenzoicAcid
    • 5-Methoxysalicylate
    • 6-hydroxy-m-Anisate
    • 6-Methoxy-m-anisate
    • 5-methoxysalicyclic acid
    • 6-methoxy-m-anisic acid
    • 5-methoxy-salicylic acid
    • 2-hydroxy-5-methoxybenzoate
    • 5-Methoxy-2-hydroxybenzoate
    • SCHEMBL128781
    • CHEMBL452949
    • orb1301406
    • SCHEMBL1803304
    • SCHEMBL6856233
    • 2-hydroxy 5-methoxybenzoic acid
    • 5-methoxy-2-hydroxobenzoic acid
    • SCHEMBL29431885
    • 2-hydroxyl-5-methoxybenzoic acid
    • MSK2684
    • NSC2579
    • BB_SC-07209
    • NSC 2579
    • EINECS 220-037-8
    • 2-hydroxy-5-(methyloxy)benzoic acid
    • BBL012998
    • s6319
    • SBB058327
    • STK522179
    • AKOS000121285
    • AC-2987
    • CS-W007856
    • EBC-152300
    • FH71120
    • HY-W007856
    • 2-Hydroxy-5-methoxybenzoic acid, 98%
    • AC-16957
    • AS-14602
    • PD123981
    • SY003499
    • AI3-24048
    • DB-046840
    • M1254
    • NS00014758
    • ST50406567
    • EN300-21328
    • I12079
    • F218970
    • Q15410212
    • 5-Methoxysalicylic acid 2-Hydroxy-5-methoxybenzoic acid
    • Z104495362
    • InChI=1/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11
    • 2612-02-4

  • Applications

    5-Methoxysalicylic Acid (CAS 2612-02-4) is primarily used as an organic-synthesis intermediate and a building block for downstream salicylate derivatives, supporting routes to specialty aromatic compounds. It may serve in pharmaceutical development as a precursor to salicylate-based intermediates and related API candidates. In perfumery and cosmetics, it is often evaluated as a fragrance-building material or as a precursor to aroma-active derivatives. In coatings and inks, it can function as a precursor to colorants or resin modifiers. In polymer chemistry, it may be employed to introduce salicylic functionality into polymers or to prepare functionalized monomers for specialty resins. Use is typically formulation- and regulation-dependent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 83.44
    methanol 161.1
    isopropanol 60.74
    water 2.46
    ethyl acetate 27.74
    n-propanol 58.87
    acetone 119.57
    n-butanol 45.9
    acetonitrile 48.23
    DMF 344.97
    toluene 2.6
    isobutanol 35.48
    1,4-dioxane 113.31
    methyl acetate 65.92
    THF 274.81
    2-butanone 61.16
    n-pentanol 28.79
    sec-butanol 34.85
    n-hexane 0.42
    ethylene glycol 58.61
    NMP 214.3
    cyclohexane 0.68
    DMSO 415.0
    n-butyl acetate 14.67
    n-octanol 15.01
    chloroform 4.18
    n-propyl acetate 19.58
    acetic acid 53.77
    dichloromethane 15.22
    cyclohexanone 55.86
    propylene glycol 45.8
    isopropyl acetate 15.54
    DMAc 273.88
    2-ethoxyethanol 87.61
    isopentanol 37.02
    n-heptane 1.29
    ethyl formate 42.15
    1,2-dichloroethane 17.14
    n-hexanol 21.75
    2-methoxyethanol 202.75
    isobutyl acetate 9.64
    tetrachloromethane 1.54
    n-pentyl acetate 11.6
    transcutol 72.78
    n-heptanol 15.02
    ethylbenzene 3.54
    MIBK 21.09
    2-propoxyethanol 69.94
    tert-butanol 103.49
    MTBE 27.92
    2-butoxyethanol 37.47
    propionic acid 35.08
    o-xylene 5.49
    formic acid 72.21
    diethyl ether 17.25
    m-xylene 4.37
    p-xylene 5.65
    chlorobenzene 4.43
    dimethyl carbonate 34.13
    n-octane 0.69
    formamide 192.76
    cyclopentanone 130.24
    2-pentanone 37.12
    anisole 25.26
    cyclopentyl methyl ether 38.94
    gamma-butyrolactone 153.6
    1-methoxy-2-propanol 100.65
    pyridine 29.22
    3-pentanone 22.75
    furfural 92.78
    n-dodecane 0.98
    diethylene glycol 87.46
    diisopropyl ether 4.93
    tert-amyl alcohol 59.31
    acetylacetone 46.73
    n-hexadecane 1.06
    acetophenone 26.16
    methyl propionate 41.36
    isopentyl acetate 15.46
    trichloroethylene 19.83
    n-nonanol 14.93
    cyclohexanol 23.87
    benzyl alcohol 25.06
    2-ethylhexanol 13.02
    isooctanol 13.04
    dipropyl ether 13.32
    1,2-dichlorobenzene 7.34
    ethyl lactate 19.79
    propylene carbonate 49.65
    n-methylformamide 165.83
    2-pentanol 19.62
    n-pentane 0.48
    1-propoxy-2-propanol 34.82
    1-methoxy-2-propyl acetate 29.94
    2-(2-methoxypropoxy) propanol 39.74
    mesitylene 4.07
    ε-caprolactone 48.69
    p-cymene 5.57
    epichlorohydrin 149.89
    1,1,1-trichloroethane 8.56
    2-aminoethanol 84.04
    morpholine-4-carbaldehyde 168.06
    sulfolane 175.71
    2,2,4-trimethylpentane 0.73
    2-methyltetrahydrofuran 95.29
    n-hexyl acetate 17.89
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 49.08
    sec-butyl acetate 11.12
    tert-butyl acetate 23.89
    decalin 1.02
    glycerin 79.37
    diglyme 93.32
    acrylic acid 32.43
    isopropyl myristate 9.42
    n-butyric acid 33.12
    acetyl acetate 19.14
    di(2-ethylhexyl) phthalate 12.96
    ethyl propionate 19.1
    nitromethane 167.46
    1,2-diethoxyethane 22.89
    benzonitrile 17.42
    trioctyl phosphate 10.66
    1-bromopropane 5.69
    gamma-valerolactone 142.09
    n-decanol 12.7
    triethyl phosphate 15.44
    4-methyl-2-pentanol 12.68
    propionitrile 32.24
    vinylene carbonate 37.32
    1,1,2-trichlorotrifluoroethane 65.91
    DMS 19.88
    cumene 4.08
    2-octanol 8.86
    2-hexanone 23.61
    octyl acetate 13.67
    limonene 7.64
    1,2-dimethoxyethane 132.97
    ethyl orthosilicate 13.79
    tributyl phosphate 10.35
    diacetone alcohol 53.63
    N,N-dimethylaniline 22.11
    acrylonitrile 46.82
    aniline 13.21
    1,3-propanediol 100.37
    bromobenzene 3.32
    dibromomethane 6.12
    1,1,2,2-tetrachloroethane 14.99
    2-methyl-cyclohexyl acetate 18.22
    tetrabutyl urea 20.1
    diisobutyl methanol 8.96
    2-phenylethanol 23.41
    styrene 3.52
    dioctyl adipate 16.75
    dimethyl sulfate 68.58
    ethyl butyrate 15.6
    methyl lactate 36.76
    butyl lactate 12.85
    diethyl carbonate 13.67
    propanediol butyl ether 27.38
    triethyl orthoformate 13.86
    p-tert-butyltoluene 5.51
    methyl 4-tert-butylbenzoate 30.71
    morpholine 130.44
    tert-butylamine 31.88
    n-dodecanol 10.09
    dimethoxymethane 141.19
    ethylene carbonate 32.87
    cyrene 62.6
    2-ethoxyethyl acetate 20.96
    2-ethylhexyl acetate 11.02
    1,2,4-trichlorobenzene 10.63
    4-methylpyridine 29.49
    dibutyl ether 10.61
    2,6-dimethyl-4-heptanol 8.96
    DEF 57.71
    dimethyl isosorbide 80.22
    tetrachloroethylene 8.64
    eugenol 30.83
    triacetin 22.41
    span 80 27.53
    1,4-butanediol 40.07
    1,1-dichloroethane 8.1
    2-methyl-1-pentanol 23.54
    methyl formate 127.21
    2-methyl-1-butanol 31.37
    n-decane 1.26
    butyronitrile 26.04
    3,7-dimethyl-1-octanol 13.32
    1-chlorooctane 4.87
    1-chlorotetradecane 2.94
    n-nonane 1.0
    undecane 1.11
    tert-butylcyclohexane 1.02
    cyclooctane 0.47
    cyclopentanol 48.27
    tetrahydropyran 41.44
    tert-amyl methyl ether 22.32
    2,5,8-trioxanonane 77.66
    1-hexene 2.04
    2-isopropoxyethanol 48.54
    2,2,2-trifluoroethanol 33.5
    methyl butyrate 27.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction