5-Methoxy-2-methylthiazole

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  • Identifiers

    CAS number
    38205-64-0

    Molecular formula
    C5H7NOS

    SMILES
    CC1=NC=C(S1)OC

  • Odor profile

    Fragrance
    Green 79.34%
    Vegetable 63.23%
    Sulfurous 60.44%
    Nutty 59.27%
    Meaty 54.7%
    Roasted 51.03%
    Earthy 38.71%
    Alliaceous 36.67%
    Burnt 35.3%
    Cocoa 35.19%

     

    Flavor
    Nutty 54.58%
    Roasted 48.67%
    Coffee 40.24%
    Burnt 34.01%
    Earthy 33.62%
    Vegetable 32.65%
    Potato 29.42%
    Green 28.65%
    Cocoa 28.2%
    Meaty 27.15%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    5.62 (weak acid)

    Molecular weight
    129.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    185°C

    Flash point

    • 57.54 ˚C est.

    Solubility expt.

    • Insoluble in water; Soluble in organic solvents
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 5-Methoxy-2-methylthiazole
    • 2-Methyl-5-methoxythiazole
    • 38205-64-0
    • 5-methoxy-2-methyl-1,3-thiazole
    • Thiazole, 5-methoxy-2-methyl-
    • FEMA 3192
    • FEMA No. 3192
    • BRN 1209888
    • UNII-154Z60090O
    • 154Z60090O
    • DTXSID5068077
    • METHYL-5-METHOXYTHIAZOLE, 2-
    • 2-METHYL-5-METHOXYTHIAZOLE [FHFI]
    • 5-Methoxy-2-methyl-Thiazole
    • SCHEMBL3506762
    • DTXCID3039458
    • CHEBI:185906
    • 5-Methoxy-2-methylthiazole, 9CI
    • AKOS006272284
    • DB-069649
    • CS-0308014
    • NS00122907
    • EN300-105089
    • Q27251691

  • Applications

    5-Methoxy-2-methylthiazole (CAS 38205-64-0) is primarily used as an odor-active compound in fragrance and flavor formulations, serving as a fragrance ingredient or aroma intermediate. It is commonly evaluated as a building block in organic synthesis for thiazole-containing compounds, supporting development in pharmaceutical and agrochemical research. In cosmetics and personal care, it may function as a scent component within formulations. In household products and air fresheners, it can contribute characteristic note profiles. In industrial manufacturing, it is employed as an intermediate for the synthesis of specialty chemicals and functionalized polymers. It may also be used as a precursor or building block in polymers/plastics applications where thiazole motifs are desirable.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 236.94
    methanol 346.88
    isopropanol 210.19
    water 35.74
    ethyl acetate 301.82
    n-propanol 207.31
    acetone 604.72
    n-butanol 171.9
    acetonitrile 432.1
    DMF 1059.88
    toluene 163.44
    isobutanol 164.42
    1,4-dioxane 578.97
    methyl acetate 378.06
    THF 597.59
    2-butanone 364.78
    n-pentanol 121.09
    sec-butanol 201.89
    n-hexane 16.09
    ethylene glycol 215.14
    NMP 660.82
    cyclohexane 33.43
    DMSO 921.97
    n-butyl acetate 118.84
    n-octanol 88.46
    chloroform 698.36
    n-propyl acetate 148.79
    acetic acid 342.8
    dichloromethane 598.96
    cyclohexanone 397.81
    propylene glycol 229.71
    isopropyl acetate 182.44
    DMAc 705.24
    2-ethoxyethanol 323.71
    isopentanol 133.42
    n-heptane 20.52
    ethyl formate 240.02
    1,2-dichloroethane 354.25
    n-hexanol 114.14
    2-methoxyethanol 604.6
    isobutyl acetate 102.88
    tetrachloromethane 177.24
    n-pentyl acetate 104.19
    transcutol 391.25
    n-heptanol 76.92
    ethylbenzene 79.05
    MIBK 171.98
    2-propoxyethanol 274.82
    tert-butanol 279.72
    MTBE 208.41
    2-butoxyethanol 157.51
    propionic acid 233.29
    o-xylene 128.61
    formic acid 238.14
    diethyl ether 200.33
    m-xylene 127.56
    p-xylene 123.58
    chlorobenzene 241.57
    dimethyl carbonate 226.04
    n-octane 12.83
    formamide 362.34
    cyclopentanone 550.69
    2-pentanone 263.77
    anisole 254.89
    cyclopentyl methyl ether 270.91
    gamma-butyrolactone 550.38
    1-methoxy-2-propanol 444.31
    pyridine 348.64
    3-pentanone 232.46
    furfural 623.93
    n-dodecane 14.66
    diethylene glycol 315.08
    diisopropyl ether 78.0
    tert-amyl alcohol 216.34
    acetylacetone 424.62
    n-hexadecane 16.59
    acetophenone 221.07
    methyl propionate 293.9
    isopentyl acetate 109.39
    trichloroethylene 731.75
    n-nonanol 81.27
    cyclohexanol 200.99
    benzyl alcohol 186.01
    2-ethylhexanol 78.64
    isooctanol 66.54
    dipropyl ether 96.97
    1,2-dichlorobenzene 231.67
    ethyl lactate 132.79
    propylene carbonate 275.26
    n-methylformamide 460.06
    2-pentanol 133.0
    n-pentane 21.94
    1-propoxy-2-propanol 184.47
    1-methoxy-2-propyl acetate 190.23
    2-(2-methoxypropoxy) propanol 169.97
    mesitylene 85.85
    ε-caprolactone 301.99
    p-cymene 61.26
    epichlorohydrin 563.97
    1,1,1-trichloroethane 498.86
    2-aminoethanol 245.37
    morpholine-4-carbaldehyde 704.96
    sulfolane 738.94
    2,2,4-trimethylpentane 20.31
    2-methyltetrahydrofuran 364.87
    n-hexyl acetate 144.19
    isooctane 15.14
    2-(2-butoxyethoxy)ethanol 199.53
    sec-butyl acetate 106.31
    tert-butyl acetate 209.46
    decalin 26.29
    glycerin 376.77
    diglyme 377.61
    acrylic acid 258.76
    isopropyl myristate 75.07
    n-butyric acid 228.95
    acetyl acetate 241.1
    di(2-ethylhexyl) phthalate 75.03
    ethyl propionate 151.73
    nitromethane 834.97
    1,2-diethoxyethane 151.82
    benzonitrile 216.09
    trioctyl phosphate 58.25
    1-bromopropane 172.16
    gamma-valerolactone 681.68
    n-decanol 66.13
    triethyl phosphate 86.31
    4-methyl-2-pentanol 83.85
    propionitrile 246.18
    vinylene carbonate 294.38
    1,1,2-trichlorotrifluoroethane 532.28
    DMS 174.35
    cumene 61.37
    2-octanol 68.16
    2-hexanone 161.52
    octyl acetate 95.18
    limonene 88.84
    1,2-dimethoxyethane 459.68
    ethyl orthosilicate 80.89
    tributyl phosphate 64.58
    diacetone alcohol 267.88
    N,N-dimethylaniline 168.47
    acrylonitrile 347.65
    aniline 233.64
    1,3-propanediol 283.93
    bromobenzene 238.29
    dibromomethane 361.71
    1,1,2,2-tetrachloroethane 576.7
    2-methyl-cyclohexyl acetate 110.45
    tetrabutyl urea 89.1
    diisobutyl methanol 59.44
    2-phenylethanol 151.17
    styrene 107.46
    dioctyl adipate 102.46
    dimethyl sulfate 429.47
    ethyl butyrate 111.89
    methyl lactate 230.79
    butyl lactate 98.81
    diethyl carbonate 93.35
    propanediol butyl ether 159.81
    triethyl orthoformate 93.73
    p-tert-butyltoluene 65.07
    methyl 4-tert-butylbenzoate 175.64
    morpholine 480.0
    tert-butylamine 150.52
    n-dodecanol 55.16
    dimethoxymethane 497.03
    ethylene carbonate 223.88
    cyrene 238.07
    2-ethoxyethyl acetate 156.6
    2-ethylhexyl acetate 93.44
    1,2,4-trichlorobenzene 307.89
    4-methylpyridine 357.91
    dibutyl ether 87.1
    2,6-dimethyl-4-heptanol 59.44
    DEF 341.07
    dimethyl isosorbide 274.34
    tetrachloroethylene 389.93
    eugenol 182.62
    triacetin 185.7
    span 80 144.05
    1,4-butanediol 147.53
    1,1-dichloroethane 417.32
    2-methyl-1-pentanol 104.53
    methyl formate 423.69
    2-methyl-1-butanol 136.27
    n-decane 20.55
    butyronitrile 194.68
    3,7-dimethyl-1-octanol 81.84
    1-chlorooctane 70.27
    1-chlorotetradecane 37.39
    n-nonane 19.52
    undecane 16.97
    tert-butylcyclohexane 26.01
    cyclooctane 16.71
    cyclopentanol 244.54
    tetrahydropyran 306.27
    tert-amyl methyl ether 172.75
    2,5,8-trioxanonane 284.68
    1-hexene 53.68
    2-isopropoxyethanol 217.1
    2,2,2-trifluoroethanol 233.05
    methyl butyrate 189.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction