5-Ethyl-2,4-dimethylthiazole

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  • Identifiers

    CAS number
    38205-61-7

    Molecular formula
    C7H11NS

    SMILES
    CCC1=C(N=C(S1)C)C

  • Odor profile

    Fragrance
    Nutty 82.43%
    Roasted 75.48%
    Meaty 65.6%
    Green 59.85%
    Earthy 58.51%
    Cocoa 55.24%
    Vegetable 54.55%
    Coffee 50.48%
    Hazelnut 49.14%
    Burnt 48.57%

     

    Flavor
    Nutty 71.76%
    Roasted 65.35%
    Earthy 49.91%
    Vegetable 47.18%
    Burnt 45.21%
    Coffee 44.64%
    Meaty 43.93%
    Roast 43.47%
    Cocoa 42.58%
    Potato 42.44%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    6.94 (neutral)

    Molecular weight
    141.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    182°C

    Flash point

    • 52.17 ˚C est.

  • Synonyms

    • 5-Ethyl-2,4-dimethylthiazole
    • 2,4-Dimethyl-5-ethylthiazole
    • Thiazole, 5-ethyl-2,4-dimethyl-
    • 5-Ethyl-2,4-dimethyl-1,3-thiazole
    • 38205-61-7
    • EINECS 253-827-6
    • 3836EZK8C1
    • UNII-3836EZK8C1
    • 5-Ethyl-2,4-dimethyl-Thiazole
    • DTXSID0068076
    • SCHEMBL755570
    • 2,4-dimethyl-5-ethyl thiazole
    • DTXCID8039457
    • CHEBI:193652
    • 5-Ethyl-2,4-dimethyl-1,3-thiazole #
    • NS00022128
    • 253-827-6

  • Applications

    5-Ethyl-2,4-dimethylthiazole (CAS 38205-61-7) is a thiazole derivative used as an odor-active ingredient and fragrance component in a range of industrial contexts; in practice, it is commonly evaluated as an odorant in perfumery and related fragrance formulations and may be considered for flavor/aroma applications at low levels. It may also be used as a fragrance ingredient in cosmetics and personal care products, and in household products such as cleaners and air fresheners to impart scent. Additionally, the compound can serve as an intermediate in organic synthesis for specialty chemicals and may be explored in coatings, paints, and inks as an odorant additive. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 575.89
    methanol 772.98
    isopropanol 413.14
    water 10.72
    ethyl acetate 568.42
    n-propanol 520.04
    acetone 733.78
    n-butanol 513.71
    acetonitrile 534.21
    DMF 1101.89
    toluene 648.31
    isobutanol 405.32
    1,4-dioxane 1306.66
    methyl acetate 555.95
    THF 1595.89
    2-butanone 661.64
    n-pentanol 356.54
    sec-butanol 420.83
    n-hexane 170.19
    ethylene glycol 210.69
    NMP 1323.19
    cyclohexane 259.72
    DMSO 872.22
    n-butyl acetate 430.01
    n-octanol 281.12
    chloroform 1755.15
    n-propyl acetate 324.77
    acetic acid 434.73
    dichloromethane 1552.31
    cyclohexanone 1139.73
    propylene glycol 226.42
    isopropyl acetate 397.72
    DMAc 886.44
    2-ethoxyethanol 570.59
    isopentanol 410.78
    n-heptane 132.1
    ethyl formate 356.37
    1,2-dichloroethane 917.68
    n-hexanol 477.93
    2-methoxyethanol 956.94
    isobutyl acetate 267.7
    tetrachloromethane 562.38
    n-pentyl acetate 381.97
    transcutol 946.7
    n-heptanol 275.01
    ethylbenzene 280.82
    MIBK 422.28
    2-propoxyethanol 809.83
    tert-butanol 482.08
    MTBE 586.65
    2-butoxyethanol 436.95
    propionic acid 367.93
    o-xylene 395.65
    formic acid 202.41
    diethyl ether 712.76
    m-xylene 455.07
    p-xylene 367.06
    chlorobenzene 770.66
    dimethyl carbonate 316.26
    n-octane 70.77
    formamide 270.82
    cyclopentanone 1256.23
    2-pentanone 604.14
    anisole 599.07
    cyclopentyl methyl ether 983.83
    gamma-butyrolactone 1175.38
    1-methoxy-2-propanol 716.57
    pyridine 937.46
    3-pentanone 534.26
    furfural 1080.06
    n-dodecane 56.13
    diethylene glycol 572.38
    diisopropyl ether 284.34
    tert-amyl alcohol 457.24
    acetylacetone 674.01
    n-hexadecane 64.38
    acetophenone 469.84
    methyl propionate 518.75
    isopentyl acetate 412.32
    trichloroethylene 1514.51
    n-nonanol 249.74
    cyclohexanol 558.88
    benzyl alcohol 405.64
    2-ethylhexanol 319.97
    isooctanol 228.46
    dipropyl ether 413.6
    1,2-dichlorobenzene 688.9
    ethyl lactate 193.17
    propylene carbonate 559.54
    n-methylformamide 507.23
    2-pentanol 368.91
    n-pentane 157.6
    1-propoxy-2-propanol 499.58
    1-methoxy-2-propyl acetate 480.55
    2-(2-methoxypropoxy) propanol 372.28
    mesitylene 319.82
    ε-caprolactone 845.59
    p-cymene 218.34
    epichlorohydrin 1249.2
    1,1,1-trichloroethane 1057.1
    2-aminoethanol 318.17
    morpholine-4-carbaldehyde 1257.89
    sulfolane 1383.2
    2,2,4-trimethylpentane 92.94
    2-methyltetrahydrofuran 1195.22
    n-hexyl acetate 525.19
    isooctane 76.71
    2-(2-butoxyethoxy)ethanol 468.35
    sec-butyl acetate 263.6
    tert-butyl acetate 464.68
    decalin 142.47
    glycerin 334.23
    diglyme 837.89
    acrylic acid 343.91
    isopropyl myristate 236.44
    n-butyric acid 487.83
    acetyl acetate 386.22
    di(2-ethylhexyl) phthalate 228.01
    ethyl propionate 336.02
    nitromethane 715.61
    1,2-diethoxyethane 481.97
    benzonitrile 545.59
    trioctyl phosphate 167.65
    1-bromopropane 661.33
    gamma-valerolactone 1387.73
    n-decanol 188.51
    triethyl phosphate 209.06
    4-methyl-2-pentanol 234.71
    propionitrile 496.76
    vinylene carbonate 564.59
    1,1,2-trichlorotrifluoroethane 744.91
    DMS 405.16
    cumene 217.43
    2-octanol 217.92
    2-hexanone 404.38
    octyl acetate 293.13
    limonene 336.81
    1,2-dimethoxyethane 895.93
    ethyl orthosilicate 207.88
    tributyl phosphate 196.21
    diacetone alcohol 442.54
    N,N-dimethylaniline 413.89
    acrylonitrile 526.75
    aniline 567.36
    1,3-propanediol 438.26
    bromobenzene 818.1
    dibromomethane 1126.19
    1,1,2,2-tetrachloroethane 1255.72
    2-methyl-cyclohexyl acetate 338.63
    tetrabutyl urea 248.35
    diisobutyl methanol 186.45
    2-phenylethanol 447.11
    styrene 369.79
    dioctyl adipate 281.85
    dimethyl sulfate 514.69
    ethyl butyrate 329.72
    methyl lactate 305.42
    butyl lactate 244.04
    diethyl carbonate 232.48
    propanediol butyl ether 321.86
    triethyl orthoformate 267.1
    p-tert-butyltoluene 234.0
    methyl 4-tert-butylbenzoate 433.36
    morpholine 1216.99
    tert-butylamine 362.08
    n-dodecanol 150.72
    dimethoxymethane 927.48
    ethylene carbonate 484.62
    cyrene 423.04
    2-ethoxyethyl acetate 475.4
    2-ethylhexyl acetate 365.24
    1,2,4-trichlorobenzene 814.96
    4-methylpyridine 992.05
    dibutyl ether 349.5
    2,6-dimethyl-4-heptanol 186.45
    DEF 666.52
    dimethyl isosorbide 680.59
    tetrachloroethylene 900.02
    eugenol 406.44
    triacetin 395.18
    span 80 358.41
    1,4-butanediol 223.91
    1,1-dichloroethane 926.51
    2-methyl-1-pentanol 328.08
    methyl formate 432.59
    2-methyl-1-butanol 430.12
    n-decane 87.08
    butyronitrile 508.17
    3,7-dimethyl-1-octanol 269.82
    1-chlorooctane 277.82
    1-chlorotetradecane 124.13
    n-nonane 91.9
    undecane 67.52
    tert-butylcyclohexane 136.96
    cyclooctane 125.88
    cyclopentanol 611.55
    tetrahydropyran 1094.36
    tert-amyl methyl ether 523.25
    2,5,8-trioxanonane 583.68
    1-hexene 330.97
    2-isopropoxyethanol 402.49
    2,2,2-trifluoroethanol 236.96
    methyl butyrate 390.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction