5-Ethyl-2,4-dimethyloxazole

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  • Identifiers

    CAS number
    33318-74-0

    Molecular formula
    C7H11NO

    SMILES
    CCC1=C(N=C(O1)C)C

    Safety labels

  • Odor profile

    Fragrance
    Green 76.66%
    Nutty 70.07%
    Roasted 67.62%
    Earthy 59.99%
    Vegetable 59.98%
    Musty 49.2%
    Burnt 48.6%
    Meaty 47.38%
    Cocoa 43.77%
    Hazelnut 42.25%

     

    Flavor
    Roasted 65.53%
    Nutty 58.19%
    Burnt 53.05%
    Earthy 47.51%
    Vegetable 44.65%
    Coffee 43.57%
    Roast 38.0%
    Meaty 37.7%
    Potato 37.45%
    Musty 35.37%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    6.5 (neutral)

    Molecular weight
    125.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    165°C

    Flash point

    • 41.24 ˚C est.

  • Synonyms

    • 5-Ethyl-2,4-dimethyloxazole
    • 5-ethyl-2,4-dimethyl-1,3-oxazole
    • 2,4-dimethyl-5-ethyloxazole
    • 33318-74-0
    • 5-ethyl-2,4-dimethyl-oxazole
    • SCHEMBL961927
    • Oxazole, 2,4-dimethyl-5-ethyl
    • CHEBI:193628
    • XOOCKFZHDAFKNK-UHFFFAOYSA-N
    • A955655SUV
    • DTXSID901309991
    • Oxazole, 5-ethyl-2,4-dimethyl-
    • 33318-74-0

  • Applications

    5-Ethyl-2,4-dimethyloxazole (CAS 33318-74-0) is primarily used as an intermediate and building block in the synthesis of heterocyclic compounds, especially in pharmaceutical and agrochemical development, where it provides a core scaffold for active ingredients and derivatives; it also serves as a precursor for oxazole-containing polymers and functional materials used in specialty coatings and electronics-related research. In fragrance chemistry, oxazole derivatives are evaluated for odor characteristics, and this compound may be considered for niche fragrance applications, subject to formulation constraints and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1849.4
    methanol 3249.24
    isopropanol 1274.76
    water 85.12
    ethyl acetate 926.85
    n-propanol 1646.81
    acetone 1128.45
    n-butanol 1456.97
    acetonitrile 1218.02
    DMF 2251.66
    toluene 789.34
    isobutanol 1317.21
    1,4-dioxane 1758.46
    methyl acetate 932.81
    THF 2193.15
    2-butanone 1102.36
    n-pentanol 1049.23
    sec-butanol 1348.96
    n-hexane 465.42
    ethylene glycol 770.38
    NMP 2217.81
    cyclohexane 411.74
    DMSO 2021.83
    n-butyl acetate 568.36
    n-octanol 556.54
    chloroform 3897.06
    n-propyl acetate 530.13
    acetic acid 1109.75
    dichloromethane 4564.7
    cyclohexanone 1475.24
    propylene glycol 723.24
    isopropyl acetate 600.83
    DMAc 1817.0
    2-ethoxyethanol 1424.7
    isopentanol 1088.39
    n-heptane 183.65
    ethyl formate 803.3
    1,2-dichloroethane 2178.51
    n-hexanol 810.53
    2-methoxyethanol 2348.36
    isobutyl acetate 401.54
    tetrachloromethane 1016.86
    n-pentyl acetate 563.68
    transcutol 1811.68
    n-heptanol 468.45
    ethylbenzene 504.71
    MIBK 653.9
    2-propoxyethanol 1330.22
    tert-butanol 1163.72
    MTBE 1254.55
    2-butoxyethanol 775.95
    propionic acid 921.73
    o-xylene 594.23
    formic acid 827.65
    diethyl ether 1354.94
    m-xylene 567.1
    p-xylene 663.75
    chlorobenzene 1120.56
    dimethyl carbonate 530.84
    n-octane 105.09
    formamide 912.76
    cyclopentanone 1691.94
    2-pentanone 964.82
    anisole 909.96
    cyclopentyl methyl ether 1317.35
    gamma-butyrolactone 1796.14
    1-methoxy-2-propanol 1578.17
    pyridine 1360.6
    3-pentanone 891.07
    furfural 1789.93
    n-dodecane 87.81
    diethylene glycol 1029.73
    diisopropyl ether 454.79
    tert-amyl alcohol 1229.67
    acetylacetone 916.31
    n-hexadecane 95.66
    acetophenone 691.3
    methyl propionate 879.02
    isopentyl acetate 558.59
    trichloroethylene 2988.91
    n-nonanol 466.73
    cyclohexanol 1123.75
    benzyl alcohol 767.72
    2-ethylhexanol 504.17
    isooctanol 391.96
    dipropyl ether 558.48
    1,2-dichlorobenzene 1115.8
    ethyl lactate 361.69
    propylene carbonate 940.07
    n-methylformamide 1345.25
    2-pentanol 910.89
    n-pentane 391.28
    1-propoxy-2-propanol 751.37
    1-methoxy-2-propyl acetate 561.25
    2-(2-methoxypropoxy) propanol 538.2
    mesitylene 392.77
    ε-caprolactone 1286.42
    p-cymene 285.44
    epichlorohydrin 2322.76
    1,1,1-trichloroethane 1727.86
    2-aminoethanol 1239.87
    morpholine-4-carbaldehyde 1894.56
    sulfolane 2114.1
    2,2,4-trimethylpentane 238.08
    2-methyltetrahydrofuran 1797.58
    n-hexyl acetate 837.04
    isooctane 145.19
    2-(2-butoxyethoxy)ethanol 765.19
    sec-butyl acetate 405.07
    tert-butyl acetate 664.21
    decalin 254.13
    glycerin 949.31
    diglyme 1393.73
    acrylic acid 856.71
    isopropyl myristate 297.84
    n-butyric acid 1153.47
    acetyl acetate 575.31
    di(2-ethylhexyl) phthalate 320.5
    ethyl propionate 608.25
    nitromethane 1542.12
    1,2-diethoxyethane 720.87
    benzonitrile 989.27
    trioctyl phosphate 235.14
    1-bromopropane 1598.9
    gamma-valerolactone 1960.1
    n-decanol 326.96
    triethyl phosphate 268.73
    4-methyl-2-pentanol 500.98
    propionitrile 1154.25
    vinylene carbonate 978.14
    1,1,2-trichlorotrifluoroethane 1424.7
    DMS 615.82
    cumene 406.94
    2-octanol 398.33
    2-hexanone 638.18
    octyl acetate 385.07
    limonene 412.2
    1,2-dimethoxyethane 1856.99
    ethyl orthosilicate 285.4
    tributyl phosphate 290.59
    diacetone alcohol 677.26
    N,N-dimethylaniline 723.22
    acrylonitrile 1307.77
    aniline 921.48
    1,3-propanediol 1340.87
    bromobenzene 1191.14
    dibromomethane 3007.4
    1,1,2,2-tetrachloroethane 2492.21
    2-methyl-cyclohexyl acetate 422.58
    tetrabutyl urea 385.81
    diisobutyl methanol 267.69
    2-phenylethanol 642.09
    styrene 590.3
    dioctyl adipate 379.32
    dimethyl sulfate 850.45
    ethyl butyrate 456.39
    methyl lactate 539.17
    butyl lactate 414.02
    diethyl carbonate 341.39
    propanediol butyl ether 654.98
    triethyl orthoformate 349.06
    p-tert-butyltoluene 289.04
    methyl 4-tert-butylbenzoate 642.31
    morpholine 1876.38
    tert-butylamine 966.72
    n-dodecanol 242.66
    dimethoxymethane 1623.38
    ethylene carbonate 817.72
    cyrene 574.28
    2-ethoxyethyl acetate 668.91
    2-ethylhexyl acetate 484.88
    1,2,4-trichlorobenzene 1210.94
    4-methylpyridine 1570.95
    dibutyl ether 580.58
    2,6-dimethyl-4-heptanol 267.69
    DEF 1256.14
    dimethyl isosorbide 834.96
    tetrachloroethylene 1916.24
    eugenol 632.0
    triacetin 550.08
    span 80 473.1
    1,4-butanediol 726.77
    1,1-dichloroethane 1886.14
    2-methyl-1-pentanol 959.51
    methyl formate 1035.96
    2-methyl-1-butanol 1288.31
    n-decane 137.77
    butyronitrile 1240.35
    3,7-dimethyl-1-octanol 490.15
    1-chlorooctane 458.24
    1-chlorotetradecane 183.13
    n-nonane 148.64
    undecane 104.05
    tert-butylcyclohexane 260.49
    cyclooctane 175.36
    cyclopentanol 1245.0
    tetrahydropyran 1571.61
    tert-amyl methyl ether 1092.71
    2,5,8-trioxanonane 848.83
    1-hexene 807.26
    2-isopropoxyethanol 857.05
    2,2,2-trifluoroethanol 536.28
    methyl butyrate 767.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction