5-Ethyl-2-thiophenecarboxaldehyde

Overview IFRA Request a quote

  • Identifiers

    CAS number
    36880-33-8

    Molecular formula
    C7H8OS

    SMILES
    CCC1=CC=C(S1)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 85.92%
    Nutty 51.97%
    Caramellic 51.62%
    Sweet 43.44%
    Almond 43.34%
    Cherry 39.56%
    Burnt 35.02%
    Roasted 33.93%
    Spicy 33.59%
    Coffee 31.02%

     

    Flavor
    Woody 51.07%
    Sweet 47.8%
    Almond 42.36%
    Sulfur 35.47%
    Spicy 34.44%
    Nutty 32.27%
    Caramel 32.01%
    Fatty 31.18%
    Spice 30.41%
    Oily 28.82%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.22 (neutral)

    Molecular weight
    140.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    227°C

    Flash point

    • 79.44 ˚C est.

  • Synonyms

    • 5-Ethylthiophene-2-carbaldehyde
    • 36880-33-8
    • 5-Ethyl-2-thiophenecarboxaldehyde
    • 2-Thiophenecarboxaldehyde, 5-ethyl-
    • 5-ethyl-2-thiophenecarbaldehyde
    • 5-ethyl-2-thiophene carboxaldehyde
    • EINECS 253-252-0
    • MFCD00143457
    • 8I907X809K
    • DTXSID2068004
    • 5-ethyl-thiophene-2-carbaldehyde
    • 2-Ethyl-5-formylthiophene
    • UNII-8I907X809K
    • BIDD:GT0099
    • SCHEMBL158329
    • DTXCID7039252
    • 5-Ethylthiophene-2-carboxaldehyde
    • 5-ethyl-thiophene-2-carboxaldehyde
    • BBL040916
    • GEO-01381
    • STK400128
    • XH1310
    • AKOS000304486
    • AT16722
    • SB66977
    • 5-Ethyl-2-thiophenecarboxaldehyde, 98%
    • AS-60625
    • SY061865
    • CS-0099746
    • NS00022111
    • EN300-56842
    • Q27270576
    • Z385369988
    • 253-252-0

  • Applications

    Chemical name: 5-Ethyl-2-thiophenecarboxaldehyde; CAS number: 36880-33-8. In industry, it is used as a synthetic intermediate for the preparation of heteroaryl thiophene-based compounds in pharmaceutical and agrochemical research; it also serves as a fragrance ingredient or aroma-building block in perfumery; it can function as a reactive aldehyde for crosslinking and as a building block in polymer formulations, coatings, and adhesives; it provides a precursor for specialty dyes and pigments; and it is evaluated for potential use in thiophene-based electronic materials such as organic semiconductors or OLED components.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 260.56
    methanol 201.29
    isopropanol 166.22
    water 0.8
    ethyl acetate 796.33
    n-propanol 202.73
    acetone 1072.65
    n-butanol 178.51
    acetonitrile 609.49
    DMF 1328.25
    toluene 386.95
    isobutanol 137.41
    1,4-dioxane 986.32
    methyl acetate 823.96
    THF 1346.11
    2-butanone 843.06
    n-pentanol 118.48
    sec-butanol 148.53
    n-hexane 9.27
    ethylene glycol 76.81
    NMP 1142.24
    cyclohexane 30.5
    DMSO 1112.83
    n-butyl acetate 374.47
    n-octanol 82.16
    chloroform 1373.33
    n-propyl acetate 349.27
    acetic acid 291.99
    dichloromethane 1773.95
    cyclohexanone 1016.46
    propylene glycol 80.39
    isopropyl acetate 362.18
    DMAc 629.25
    2-ethoxyethanol 273.76
    isopentanol 155.37
    n-heptane 17.72
    ethyl formate 409.74
    1,2-dichloroethane 1250.39
    n-hexanol 175.33
    2-methoxyethanol 474.41
    isobutyl acetate 209.46
    tetrachloromethane 189.66
    n-pentyl acetate 206.25
    transcutol 965.66
    n-heptanol 81.93
    ethylbenzene 129.79
    MIBK 304.41
    2-propoxyethanol 377.86
    tert-butanol 223.61
    MTBE 298.08
    2-butoxyethanol 201.61
    propionic acid 281.68
    o-xylene 178.25
    formic acid 99.43
    diethyl ether 402.18
    m-xylene 224.91
    p-xylene 168.25
    chlorobenzene 609.95
    dimethyl carbonate 302.63
    n-octane 9.3
    formamide 273.58
    cyclopentanone 1502.93
    2-pentanone 630.6
    anisole 363.44
    cyclopentyl methyl ether 496.08
    gamma-butyrolactone 1486.5
    1-methoxy-2-propanol 367.28
    pyridine 971.52
    3-pentanone 491.24
    furfural 1143.9
    n-dodecane 10.17
    diethylene glycol 315.29
    diisopropyl ether 105.65
    tert-amyl alcohol 178.13
    acetylacetone 804.15
    n-hexadecane 12.27
    acetophenone 334.42
    methyl propionate 610.45
    isopentyl acetate 305.3
    trichloroethylene 2354.35
    n-nonanol 76.59
    cyclohexanol 211.76
    benzyl alcohol 231.73
    2-ethylhexanol 107.67
    isooctanol 72.26
    dipropyl ether 156.75
    1,2-dichlorobenzene 484.34
    ethyl lactate 131.17
    propylene carbonate 647.13
    n-methylformamide 583.39
    2-pentanol 125.64
    n-pentane 12.22
    1-propoxy-2-propanol 241.67
    1-methoxy-2-propyl acetate 414.86
    2-(2-methoxypropoxy) propanol 215.45
    mesitylene 131.16
    ε-caprolactone 740.63
    p-cymene 88.96
    epichlorohydrin 1696.99
    1,1,1-trichloroethane 976.04
    2-aminoethanol 120.57
    morpholine-4-carbaldehyde 1007.16
    sulfolane 1265.35
    2,2,4-trimethylpentane 13.78
    2-methyltetrahydrofuran 891.14
    n-hexyl acetate 268.94
    isooctane 13.84
    2-(2-butoxyethoxy)ethanol 289.41
    sec-butyl acetate 222.38
    tert-butyl acetate 399.25
    decalin 25.31
    glycerin 140.58
    diglyme 595.75
    acrylic acid 272.26
    isopropyl myristate 108.83
    n-butyric acid 341.32
    acetyl acetate 414.04
    di(2-ethylhexyl) phthalate 105.01
    ethyl propionate 300.98
    nitromethane 1092.68
    1,2-diethoxyethane 366.87
    benzonitrile 431.49
    trioctyl phosphate 71.87
    1-bromopropane 424.49
    gamma-valerolactone 1436.23
    n-decanol 59.58
    triethyl phosphate 118.82
    4-methyl-2-pentanol 83.72
    propionitrile 391.96
    vinylene carbonate 620.45
    1,1,2-trichlorotrifluoroethane 601.42
    DMS 347.7
    cumene 79.35
    2-octanol 62.28
    2-hexanone 323.1
    octyl acetate 130.75
    limonene 127.7
    1,2-dimethoxyethane 530.42
    ethyl orthosilicate 112.26
    tributyl phosphate 94.72
    diacetone alcohol 365.57
    N,N-dimethylaniline 187.28
    acrylonitrile 610.13
    aniline 348.16
    1,3-propanediol 195.52
    bromobenzene 698.39
    dibromomethane 958.1
    1,1,2,2-tetrachloroethane 1209.55
    2-methyl-cyclohexyl acetate 184.18
    tetrabutyl urea 126.99
    diisobutyl methanol 81.03
    2-phenylethanol 251.3
    styrene 199.5
    dioctyl adipate 149.52
    dimethyl sulfate 518.48
    ethyl butyrate 234.37
    methyl lactate 196.12
    butyl lactate 142.19
    diethyl carbonate 161.36
    propanediol butyl ether 168.9
    triethyl orthoformate 152.33
    p-tert-butyltoluene 91.81
    methyl 4-tert-butylbenzoate 228.6
    morpholine 930.8
    tert-butylamine 118.21
    n-dodecanol 47.71
    dimethoxymethane 624.29
    ethylene carbonate 479.69
    cyrene 277.32
    2-ethoxyethyl acetate 372.18
    2-ethylhexyl acetate 236.94
    1,2,4-trichlorobenzene 570.45
    4-methylpyridine 893.39
    dibutyl ether 134.23
    2,6-dimethyl-4-heptanol 81.03
    DEF 594.27
    dimethyl isosorbide 444.56
    tetrachloroethylene 703.06
    eugenol 231.0
    triacetin 276.06
    span 80 175.81
    1,4-butanediol 75.54
    1,1-dichloroethane 1093.99
    2-methyl-1-pentanol 113.4
    methyl formate 515.51
    2-methyl-1-butanol 136.01
    n-decane 14.66
    butyronitrile 364.04
    3,7-dimethyl-1-octanol 96.76
    1-chlorooctane 80.49
    1-chlorotetradecane 35.46
    n-nonane 13.4
    undecane 12.04
    tert-butylcyclohexane 23.38
    cyclooctane 12.76
    cyclopentanol 272.29
    tetrahydropyran 752.42
    tert-amyl methyl ether 213.85
    2,5,8-trioxanonane 386.24
    1-hexene 59.94
    2-isopropoxyethanol 205.66
    2,2,2-trifluoroethanol 166.1
    methyl butyrate 387.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction