5-Ethyl-2-methylpyridine

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  • Identifiers

    CAS number
    104-90-5

    Molecular formula
    C8H11N

    SMILES
    CCC1=CN=C(C=C1)C

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 74.87%
    Nutty 63.49%
    Roasted 63.03%
    Earthy 56.63%
    Fishy 48.94%
    Fatty 47.37%
    Musty 44.33%
    Burnt 42.59%
    Vegetable 40.0%
    Animal 39.12%

     

    Flavor
    Nutty 69.22%
    Earthy 51.89%
    Roasted 50.82%
    Woody 40.76%
    Musty 40.14%
    Potato 39.98%
    Spicy 37.59%
    Meaty 36.84%
    Coffee 32.94%
    Cocoa 31.71%

     

    Odor impact est.
    High

    Odor threshold

    • 0.03 mg/cu m (odor low); 94.1 mg/cu m (odor high)

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    6.0 (weak acid)

    Molecular weight
    121.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • -94.5 °F (USCG, 1999)
    • -70.3 °C (freezing point)
    • -70.9 °C
    • -70 °C

    Boiling point

    • 352 °F at 760 mmHg (USCG, 1999)
    • 177.8 °C @ 747 mm Hg
    • 172.00 to 175.00 °C. @ 760.00 mm Hg
    • 178.3 °C

    Flash point

    • 52.22 ˚C est.
    • 155 °F (USCG, 1999)
    • 68 °C
    • 155 °F, 68 °C (OPEN CUP)
    • 68 °C o.c.

    Solubility expt.

    • Sol in alc, ether, benzene, dilute acids, concn sulfuric acid
    • Very soluble in acetone
    • In water, 1.2 g/100 ml @ 29 °C
    • 12 mg/mL at 20 °C
    • Solubility in water, g/l at 20 °C: 12 (moderate)
    • Slightly soluble in water and fat
    • Soluble (in ethanol)

  • Synonyms

    • 5-Ethyl-2-methylpyridine
    • 104-90-5
    • 5-Ethyl-2-picoline
    • Aldehydine
    • 2-METHYL-5-ETHYLPYRIDINE
    • Pyridine, 5-ethyl-2-methyl-
    • Aldehydkollidin
    • Aldehydecollidine
    • 2-Picoline, 5-ethyl-
    • 5-Ethyl-2-methyl-pyridine
    • 2,5-Aldehydine
    • 3-Ethyl-6-methylpyridine
    • 6-Methyl-3-ethylpyridine
    • Collidine, aldehydecollidine
    • 5-Ethyl-alpha-picoline
    • FEMA No. 3546
    • HSDB 5137
    • UNII-WG205CGK3Y
    • 5-Ethyl-2-methyl pyridine
    • NSC 1984
    • EINECS 203-250-0
    • UN2300
    • 5-Ethyl-a-picoline
    • BRN 0109269
    • Methyl ethyl pyridine
    • DTXSID7021861
    • AI3-19225
    • NSC-1984
    • 5-Ethyl-.alpha.-picoline
    • WG205CGK3Y
    • DTXCID901861
    • FEMA 3546
    • EC 203-250-0
    • 5-ETHYL-2-PICOLINE [MI]
    • 5-20-06-00086 (Beilstein Handbook Reference)
    • ETHYL-2-METHYLPYRIDINE, 5-
    • MFCD00006344
    • UN 2300
    • 2-METHYL-5-ETHYLPYRIDINE [HSDB]
    • 5-ETHYL-2-METHYLPYRIDINE [FHFI]
    • 5-Ethyl-2-methylpyridine, >=96%
    • aldehyde-collidine
    • MEP (VAN)
    • 5-?Ethyl-?2-?methylpyridine(5-Ethyl-2-picoline)
    • 5-ETHYL-2-METHYLPYRIDINE (2-METHYL-5-PYRINE)
    • 5-ETHYL-2-METHYLPYRIDINE {2-METHYL-5-PYRINE}
    • 2-Methyl-5-ethyl pyridine
    • 5Ethyl2picoline
    • 2,5Aldehydine
    • 5Ethylalphapicoline
    • 2Picoline, 5ethyl
    • 3Ethyl6methylpyridine
    • 5Ethyl2methylpyridine
    • 6Methyl3ethylpyridine
    • Pyridine, 5ethyl2methyl
    • PICOLINE, ETHYL-
    • 5-Ethyl-2-methylpyridine (5-Ethyl-2-picoline)
    • pyridine, 5-ethyl-2-methyl
    • SCHEMBL24448
    • WLN: T6NJ B1 E2
    • pyridine, 3-ethyl-6-methyl-
    • 2-Methyl-5-ethylpyridine MEP
    • CHEMBL227181
    • DTXCID30285141
    • NSC1984
    • CHEBI:179423
    • Tox21_303710
    • AKOS000120418
    • AC-5961
    • FE23106
    • NCGC00357258-01
    • CAS-104-90-5
    • DB-002462
    • E0142
    • NS00019931
    • 2-Methyl-5-ethylpyridine;5-Ethyl-2-picoline
    • EN300-20453
    • 5-Ethyl-2-methylpyridine(5-Ethyl-2-picoline)
    • D88165
    • 2-Methyl-5-ethylpyridine [UN2300] [Poison]
    • AC-907/25014214
    • Q27292618
    • F0001-0092
    • 5-Ethyl-2-methylpyridine, Lonza quality, >=96.0% (GC)
    • 203-250-0
    • 897-629-3

  • Applications

    5-Ethyl-2-methylpyridine (CAS 104-90-5) is a substituted pyridine that is primarily used as an organic synthesis intermediate in the pharmaceutical and agrochemical sectors, serving as a building block for small-molecule drug and crop-protection candidates. It also functions as a precursor for dyes and pigment chemistry. In the fragrance and flavor industries, such pyridine derivatives are evaluated as odorants or intermediates for fragrance compounds. In industrial manufacturing, it can act as a solvent or reagent and as a precursor to more complex pyridine-containing compounds used in specialty chemicals and catalysis. In polymer chemistry, it may be used as a ligand precursor or as a functionalizing agent for pyridine-containing polymers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 416.89
    methanol 240.54
    isopropanol 346.03
    water 0.77
    ethyl acetate 346.54
    n-propanol 375.01
    acetone 319.34
    n-butanol 371.75
    acetonitrile 489.06
    DMF 369.61
    toluene 370.38
    isobutanol 295.7
    1,4-dioxane 655.24
    methyl acetate 331.95
    THF 643.94
    2-butanone 391.76
    n-pentanol 255.87
    sec-butanol 338.96
    n-hexane 133.18
    ethylene glycol 50.76
    NMP 328.34
    cyclohexane 198.24
    DMSO 395.59
    n-butyl acetate 536.21
    n-octanol 204.28
    chloroform 1991.67
    n-propyl acetate 221.15
    acetic acid 275.73
    dichloromethane 1690.88
    cyclohexanone 568.19
    propylene glycol 98.64
    isopropyl acetate 181.58
    DMAc 312.83
    2-ethoxyethanol 191.93
    isopentanol 283.48
    n-heptane 164.05
    ethyl formate 308.35
    1,2-dichloroethane 683.67
    n-hexanol 488.39
    2-methoxyethanol 287.48
    isobutyl acetate 149.54
    tetrachloromethane 391.96
    n-pentyl acetate 215.44
    transcutol 612.99
    n-heptanol 200.86
    ethylbenzene 173.96
    MIBK 166.89
    2-propoxyethanol 382.05
    tert-butanol 350.63
    MTBE 303.03
    2-butoxyethanol 229.31
    propionic acid 275.7
    o-xylene 203.53
    formic acid 57.27
    diethyl ether 361.45
    m-xylene 205.21
    p-xylene 231.96
    chlorobenzene 479.03
    dimethyl carbonate 98.68
    n-octane 53.29
    formamide 89.91
    cyclopentanone 489.67
    2-pentanone 301.66
    anisole 240.37
    cyclopentyl methyl ether 361.27
    gamma-butyrolactone 500.92
    1-methoxy-2-propanol 243.92
    pyridine 739.71
    3-pentanone 258.16
    furfural 498.24
    n-dodecane 42.87
    diethylene glycol 183.06
    diisopropyl ether 112.39
    tert-amyl alcohol 309.63
    acetylacetone 231.86
    n-hexadecane 47.35
    acetophenone 204.81
    methyl propionate 252.97
    isopentyl acetate 363.97
    trichloroethylene 1182.72
    n-nonanol 166.25
    cyclohexanol 320.89
    benzyl alcohol 199.29
    2-ethylhexanol 327.65
    isooctanol 142.52
    dipropyl ether 370.83
    1,2-dichlorobenzene 383.8
    ethyl lactate 93.05
    propylene carbonate 351.46
    n-methylformamide 199.98
    2-pentanol 237.74
    n-pentane 118.65
    1-propoxy-2-propanol 326.18
    1-methoxy-2-propyl acetate 254.69
    2-(2-methoxypropoxy) propanol 193.06
    mesitylene 123.75
    ε-caprolactone 426.71
    p-cymene 156.4
    epichlorohydrin 599.82
    1,1,1-trichloroethane 776.78
    2-aminoethanol 128.79
    morpholine-4-carbaldehyde 342.57
    sulfolane 444.85
    2,2,4-trimethylpentane 56.07
    2-methyltetrahydrofuran 587.39
    n-hexyl acetate 292.46
    isooctane 39.06
    2-(2-butoxyethoxy)ethanol 256.28
    sec-butyl acetate 139.16
    tert-butyl acetate 176.91
    decalin 77.47
    glycerin 102.39
    diglyme 426.87
    acrylic acid 205.62
    isopropyl myristate 124.39
    n-butyric acid 430.97
    acetyl acetate 198.9
    di(2-ethylhexyl) phthalate 117.23
    ethyl propionate 183.35
    nitromethane 349.47
    1,2-diethoxyethane 351.36
    benzonitrile 401.4
    trioctyl phosphate 87.99
    1-bromopropane 586.22
    gamma-valerolactone 485.18
    n-decanol 128.36
    triethyl phosphate 115.68
    4-methyl-2-pentanol 125.67
    propionitrile 472.01
    vinylene carbonate 370.07
    1,1,2-trichlorotrifluoroethane 329.48
    DMS 167.56
    cumene 125.82
    2-octanol 141.22
    2-hexanone 244.2
    octyl acetate 162.35
    limonene 228.47
    1,2-dimethoxyethane 385.15
    ethyl orthosilicate 120.45
    tributyl phosphate 106.45
    diacetone alcohol 177.47
    N,N-dimethylaniline 177.0
    acrylonitrile 460.43
    aniline 347.6
    1,3-propanediol 184.77
    bromobenzene 561.92
    dibromomethane 1245.21
    1,1,2,2-tetrachloroethane 902.15
    2-methyl-cyclohexyl acetate 196.68
    tetrabutyl urea 138.04
    diisobutyl methanol 143.8
    2-phenylethanol 260.27
    styrene 229.32
    dioctyl adipate 157.17
    dimethyl sulfate 132.59
    ethyl butyrate 304.1
    methyl lactate 100.09
    butyl lactate 144.29
    diethyl carbonate 190.6
    propanediol butyl ether 169.76
    triethyl orthoformate 189.78
    p-tert-butyltoluene 141.05
    methyl 4-tert-butylbenzoate 190.5
    morpholine 636.32
    tert-butylamine 278.07
    n-dodecanol 104.36
    dimethoxymethane 237.21
    ethylene carbonate 312.82
    cyrene 146.42
    2-ethoxyethyl acetate 229.54
    2-ethylhexyl acetate 313.92
    1,2,4-trichlorobenzene 389.3
    4-methylpyridine 647.56
    dibutyl ether 293.79
    2,6-dimethyl-4-heptanol 143.8
    DEF 321.65
    dimethyl isosorbide 303.77
    tetrachloroethylene 613.35
    eugenol 176.92
    triacetin 194.34
    span 80 196.49
    1,4-butanediol 84.47
    1,1-dichloroethane 825.6
    2-methyl-1-pentanol 234.56
    methyl formate 156.18
    2-methyl-1-butanol 287.62
    n-decane 66.97
    butyronitrile 541.51
    3,7-dimethyl-1-octanol 175.82
    1-chlorooctane 191.8
    1-chlorotetradecane 80.56
    n-nonane 73.46
    undecane 51.69
    tert-butylcyclohexane 74.69
    cyclooctane 64.19
    cyclopentanol 320.39
    tetrahydropyran 693.74
    tert-amyl methyl ether 225.88
    2,5,8-trioxanonane 306.21
    1-hexene 320.11
    2-isopropoxyethanol 148.77
    2,2,2-trifluoroethanol 86.26
    methyl butyrate 264.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction