5-Ethyl-2-methyloxazole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    53833-29-7

    Molecular formula
    C6H9NO

    SMILES
    CCC1=CN=C(O1)C

    Safety labels

  • Odor profile

    Fragrance
    Green 79.36%
    Nutty 66.28%
    Roasted 62.69%
    Vegetable 54.77%
    Meaty 47.6%
    Earthy 46.72%
    Burnt 45.35%
    Musty 42.7%
    Cocoa 41.25%
    Hazelnut 35.79%

     

    Flavor
    Roasted 54.83%
    Nutty 50.01%
    Coffee 42.65%
    Burnt 41.44%
    Vegetable 37.71%
    Earthy 36.65%
    Green 31.28%
    Roast 29.83%
    Potato 29.37%
    Meaty 28.19%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.3 (neutral)

    Molecular weight
    111.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    165°C

    Flash point

    • 37.17 ˚C est.

  • Synonyms

    • 5-Ethyl-2-methyloxazole
    • 5-ethyl-2-methyl-1,3-oxazole
    • Oxazole, 5-ethyl-2-methyl-
    • 53833-29-7
    • Oxazole, 5-ethyl-2-methyl
    • WQJ2EAZ644
    • UNII-WQJ2EAZ644
    • 2-Methyl-5-athyloxazol
    • Oxazole, 2-methyl-5-ethyl
    • SCHEMBL2629342
    • SCHEMBL5540227
    • SCHEMBL5544423
    • SCHEMBL16836455
    • CHEBI:179312
    • KVHQALCDTOJIBP-UHFFFAOYSA-N
    • DTXSID501313942
    • 53833-29-7

  • Applications

    5-Ethyl-2-methyloxazole (CAS 53833-29-7) serves primarily as an organic synthesis intermediate and building block, enabling the preparation of oxazole-containing compounds for pharmaceutical and agrochemical development; it is evaluated as a precursor for fragrance and flavor ingredients, potentially contributing to odorant scaffolds in perfumery and to taste-active components in flavor formulations; in cosmetics and personal care, it can function as a synthetic intermediate for related active ingredients or fragrance components; and in general, its use is centered on industrial manufacturing as a versatile oxazole-building block suitable for further functionalization, subject to formulation needs and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 652.37
    methanol 1195.04
    isopropanol 499.53
    water 35.99
    ethyl acetate 309.09
    n-propanol 538.96
    acetone 493.59
    n-butanol 484.63
    acetonitrile 441.36
    DMF 1115.45
    toluene 229.86
    isobutanol 457.87
    1,4-dioxane 550.84
    methyl acetate 359.38
    THF 724.38
    2-butanone 424.56
    n-pentanol 338.71
    sec-butanol 489.62
    n-hexane 84.4
    ethylene glycol 329.93
    NMP 993.64
    cyclohexane 65.86
    DMSO 948.31
    n-butyl acetate 166.2
    n-octanol 190.09
    chloroform 1148.18
    n-propyl acetate 158.38
    acetic acid 521.92
    dichloromethane 1257.34
    cyclohexanone 513.98
    propylene glycol 356.26
    isopropyl acetate 208.35
    DMAc 949.43
    2-ethoxyethanol 483.03
    isopentanol 361.2
    n-heptane 37.5
    ethyl formate 265.12
    1,2-dichloroethane 596.12
    n-hexanol 251.6
    2-methoxyethanol 880.01
    isobutyl acetate 125.75
    tetrachloromethane 242.82
    n-pentyl acetate 180.61
    transcutol 729.21
    n-heptanol 150.23
    ethylbenzene 139.83
    MIBK 218.45
    2-propoxyethanol 435.34
    tert-butanol 468.42
    MTBE 401.38
    2-butoxyethanol 271.67
    propionic acid 405.23
    o-xylene 186.37
    formic acid 347.45
    diethyl ether 340.62
    m-xylene 173.09
    p-xylene 193.09
    chlorobenzene 358.48
    dimethyl carbonate 190.29
    n-octane 24.4
    formamide 355.23
    cyclopentanone 652.91
    2-pentanone 333.98
    anisole 302.36
    cyclopentyl methyl ether 374.58
    gamma-butyrolactone 684.71
    1-methoxy-2-propanol 632.35
    pyridine 484.85
    3-pentanone 285.99
    furfural 735.56
    n-dodecane 26.09
    diethylene glycol 376.45
    diisopropyl ether 117.59
    tert-amyl alcohol 459.86
    acetylacetone 409.75
    n-hexadecane 28.39
    acetophenone 258.3
    methyl propionate 316.08
    isopentyl acetate 168.58
    trichloroethylene 944.78
    n-nonanol 159.3
    cyclohexanol 338.81
    benzyl alcohol 280.84
    2-ethylhexanol 145.77
    isooctanol 129.87
    dipropyl ether 141.52
    1,2-dichlorobenzene 356.25
    ethyl lactate 146.44
    propylene carbonate 362.68
    n-methylformamide 542.66
    2-pentanol 305.95
    n-pentane 75.9
    1-propoxy-2-propanol 259.39
    1-methoxy-2-propyl acetate 199.36
    2-(2-methoxypropoxy) propanol 247.02
    mesitylene 115.58
    ε-caprolactone 445.93
    p-cymene 86.83
    epichlorohydrin 769.37
    1,1,1-trichloroethane 539.02
    2-aminoethanol 502.26
    morpholine-4-carbaldehyde 769.59
    sulfolane 938.31
    2,2,4-trimethylpentane 58.1
    2-methyltetrahydrofuran 544.9
    n-hexyl acetate 281.41
    isooctane 36.71
    2-(2-butoxyethoxy)ethanol 311.71
    sec-butyl acetate 127.42
    tert-butyl acetate 220.62
    decalin 59.38
    glycerin 480.12
    diglyme 502.5
    acrylic acid 400.98
    isopropyl myristate 112.15
    n-butyric acid 417.68
    acetyl acetate 227.34
    di(2-ethylhexyl) phthalate 135.4
    ethyl propionate 177.79
    nitromethane 680.37
    1,2-diethoxyethane 218.08
    benzonitrile 370.36
    trioctyl phosphate 91.85
    1-bromopropane 404.07
    gamma-valerolactone 740.28
    n-decanol 118.81
    triethyl phosphate 99.91
    4-methyl-2-pentanol 168.15
    propionitrile 383.22
    vinylene carbonate 368.2
    1,1,2-trichlorotrifluoroethane 586.24
    DMS 219.6
    cumene 120.66
    2-octanol 128.88
    2-hexanone 206.08
    octyl acetate 146.89
    limonene 120.78
    1,2-dimethoxyethane 584.3
    ethyl orthosilicate 96.45
    tributyl phosphate 110.33
    diacetone alcohol 278.55
    N,N-dimethylaniline 244.58
    acrylonitrile 484.07
    aniline 316.39
    1,3-propanediol 514.99
    bromobenzene 373.59
    dibromomethane 750.48
    1,1,2,2-tetrachloroethane 791.13
    2-methyl-cyclohexyl acetate 140.82
    tetrabutyl urea 148.31
    diisobutyl methanol 85.75
    2-phenylethanol 214.23
    styrene 172.16
    dioctyl adipate 148.69
    dimethyl sulfate 378.19
    ethyl butyrate 138.5
    methyl lactate 250.91
    butyl lactate 159.3
    diethyl carbonate 110.77
    propanediol butyl ether 277.56
    triethyl orthoformate 111.34
    p-tert-butyltoluene 89.74
    methyl 4-tert-butylbenzoate 242.85
    morpholine 587.51
    tert-butylamine 326.87
    n-dodecanol 92.02
    dimethoxymethane 525.92
    ethylene carbonate 278.12
    cyrene 257.58
    2-ethoxyethyl acetate 222.08
    2-ethylhexyl acetate 138.75
    1,2,4-trichlorobenzene 425.55
    4-methylpyridine 527.17
    dibutyl ether 170.61
    2,6-dimethyl-4-heptanol 85.75
    DEF 466.82
    dimethyl isosorbide 353.48
    tetrachloroethylene 545.61
    eugenol 248.56
    triacetin 236.47
    span 80 222.04
    1,4-butanediol 268.99
    1,1-dichloroethane 602.28
    2-methyl-1-pentanol 301.05
    methyl formate 390.52
    2-methyl-1-butanol 427.45
    n-decane 36.98
    butyronitrile 381.04
    3,7-dimethyl-1-octanol 172.21
    1-chlorooctane 129.95
    1-chlorotetradecane 61.91
    n-nonane 36.75
    undecane 30.06
    tert-butylcyclohexane 66.26
    cyclooctane 29.0
    cyclopentanol 438.53
    tetrahydropyran 431.43
    tert-amyl methyl ether 338.29
    2,5,8-trioxanonane 371.53
    1-hexene 192.13
    2-isopropoxyethanol 289.63
    2,2,2-trifluoroethanol 228.68
    methyl butyrate 241.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction