5-Ethyl-2-methyl-4-propylthiazole

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  • Identifiers

    CAS number
    4276-67-9

    Molecular formula
    C9H15NS

    SMILES
    CCCC1=C(SC(=N1)C)CC

    Safety labels

  • Odor profile

    Fragrance
    Green 84.44%
    Nutty 62.91%
    Vegetable 57.19%
    Roasted 55.75%
    Fruity 54.96%
    Earthy 49.25%
    Meaty 45.04%
    Burnt 34.14%
    Cocoa 33.5%
    Tropical 33.47%

     

    Flavor
    Green 68.43%
    Nutty 57.32%
    Earthy 54.02%
    Roasted 50.88%
    Vegetable 46.43%
    Meaty 41.02%
    Pepper 35.22%
    Burnt 34.9%
    Raw 34.19%
    Potato 34.02%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    7.7 (neutral)

    Molecular weight
    169.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    212°C

    Flash point

    • 71.22 ˚C est.

  • Synonyms

    • 5-Ethyl-2-methyl-4-propylthiazole
    • 5-Ethyl-2-methyl-4-propyl-1,3-thiazole
    • Thiazole, 5-ethyl-2-methyl-4-propyl-
    • 4276-67-9
    • FG4NAZ6C2F
    • SCHEMBL15897986
    • YTFYPHBAFRPICF-UHFFFAOYSA-N
    • DTXSID801298921
    • 5-Ethyl-2-methyl-4-propyl-Thiazole
    • 5-Ethyl-2-methyl-4-propyl-1,3-thiazole #
    • 4276-67-9

  • Applications

    5-Ethyl-2-methyl-4-propylthiazole (CAS 4276-67-9) is used as an odorant in perfumery and flavor applications, contributing distinctive notes to fragrances, cosmetics, and household products such as air fresheners and cleaners. It is commonly evaluated as a fragrance component or aroma compound in personal care formulations. In industrial manufacturing, the compound serves as an intermediate or building block for the synthesis of more complex heterocyclic chemicals used in specialty formulations. Use is typically subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 400.41
    methanol 358.01
    isopropanol 396.21
    water 0.52
    ethyl acetate 613.45
    n-propanol 443.01
    acetone 1021.02
    n-butanol 469.45
    acetonitrile 538.73
    DMF 1416.47
    toluene 932.25
    isobutanol 426.26
    1,4-dioxane 1434.15
    methyl acetate 649.9
    THF 2245.69
    2-butanone 840.85
    n-pentanol 418.44
    sec-butanol 467.33
    n-hexane 240.62
    ethylene glycol 90.21
    NMP 1607.92
    cyclohexane 485.06
    DMSO 1065.54
    n-butyl acetate 930.64
    n-octanol 479.37
    chloroform 2700.9
    n-propyl acetate 564.23
    acetic acid 360.88
    dichloromethane 2355.32
    cyclohexanone 1828.96
    propylene glycol 157.53
    isopropyl acetate 457.84
    DMAc 984.22
    2-ethoxyethanol 398.61
    isopentanol 458.03
    n-heptane 280.53
    ethyl formate 463.79
    1,2-dichloroethane 1331.04
    n-hexanol 724.84
    2-methoxyethanol 563.33
    isobutyl acetate 461.27
    tetrachloromethane 687.92
    n-pentyl acetate 657.19
    transcutol 825.7
    n-heptanol 381.85
    ethylbenzene 522.28
    MIBK 522.93
    2-propoxyethanol 729.83
    tert-butanol 521.18
    MTBE 667.31
    2-butoxyethanol 447.25
    propionic acid 358.36
    o-xylene 560.73
    formic acid 60.28
    diethyl ether 687.35
    m-xylene 637.03
    p-xylene 734.73
    chlorobenzene 1248.52
    dimethyl carbonate 337.84
    n-octane 143.71
    formamide 102.62
    cyclopentanone 1947.17
    2-pentanone 745.12
    anisole 715.9
    cyclopentyl methyl ether 1107.51
    gamma-butyrolactone 1729.34
    1-methoxy-2-propanol 513.06
    pyridine 1413.27
    3-pentanone 629.68
    furfural 1284.99
    n-dodecane 121.15
    diethylene glycol 394.36
    diisopropyl ether 309.76
    tert-amyl alcohol 509.18
    acetylacetone 843.44
    n-hexadecane 141.01
    acetophenone 684.35
    methyl propionate 534.45
    isopentyl acetate 787.94
    trichloroethylene 2466.89
    n-nonanol 403.36
    cyclohexanol 751.56
    benzyl alcohol 542.91
    2-ethylhexanol 551.89
    isooctanol 329.61
    dipropyl ether 647.33
    1,2-dichlorobenzene 1061.46
    ethyl lactate 262.77
    propylene carbonate 1016.18
    n-methylformamide 397.44
    2-pentanol 369.81
    n-pentane 205.47
    1-propoxy-2-propanol 576.85
    1-methoxy-2-propyl acetate 683.96
    2-(2-methoxypropoxy) propanol 477.61
    mesitylene 445.68
    ε-caprolactone 1231.91
    p-cymene 422.94
    epichlorohydrin 1562.57
    1,1,1-trichloroethane 1687.39
    2-aminoethanol 169.04
    morpholine-4-carbaldehyde 1345.19
    sulfolane 1935.45
    2,2,4-trimethylpentane 128.27
    2-methyltetrahydrofuran 1544.59
    n-hexyl acetate 928.45
    isooctane 103.91
    2-(2-butoxyethoxy)ethanol 555.15
    sec-butyl acetate 387.79
    tert-butyl acetate 568.74
    decalin 246.56
    glycerin 198.26
    diglyme 947.4
    acrylic acid 314.09
    isopropyl myristate 447.48
    n-butyric acid 546.67
    acetyl acetate 475.29
    di(2-ethylhexyl) phthalate 379.09
    ethyl propionate 471.22
    nitromethane 672.5
    1,2-diethoxyethane 649.52
    benzonitrile 950.79
    trioctyl phosphate 303.99
    1-bromopropane 990.99
    gamma-valerolactone 1701.78
    n-decanol 321.22
    triethyl phosphate 321.56
    4-methyl-2-pentanol 268.5
    propionitrile 559.12
    vinylene carbonate 940.73
    1,1,2-trichlorotrifluoroethane 808.25
    DMS 650.31
    cumene 368.89
    2-octanol 376.73
    2-hexanone 647.27
    octyl acetate 528.03
    limonene 644.88
    1,2-dimethoxyethane 937.13
    ethyl orthosilicate 305.4
    tributyl phosphate 344.74
    diacetone alcohol 508.59
    N,N-dimethylaniline 565.02
    acrylonitrile 603.56
    aniline 637.29
    1,3-propanediol 278.94
    bromobenzene 1543.38
    dibromomethane 1708.8
    1,1,2,2-tetrachloroethane 1954.83
    2-methyl-cyclohexyl acetate 618.96
    tetrabutyl urea 484.77
    diisobutyl methanol 310.17
    2-phenylethanol 639.92
    styrene 665.36
    dioctyl adipate 526.18
    dimethyl sulfate 544.42
    ethyl butyrate 585.63
    methyl lactate 268.09
    butyl lactate 426.23
    diethyl carbonate 416.65
    propanediol butyl ether 426.32
    triethyl orthoformate 428.47
    p-tert-butyltoluene 414.0
    methyl 4-tert-butylbenzoate 621.83
    morpholine 1255.39
    tert-butylamine 397.17
    n-dodecanol 268.75
    dimethoxymethane 811.72
    ethylene carbonate 792.61
    cyrene 569.36
    2-ethoxyethyl acetate 664.49
    2-ethylhexyl acetate 721.19
    1,2,4-trichlorobenzene 1175.0
    4-methylpyridine 1490.49
    dibutyl ether 654.96
    2,6-dimethyl-4-heptanol 310.17
    DEF 778.01
    dimethyl isosorbide 952.75
    tetrachloroethylene 1289.14
    eugenol 568.66
    triacetin 642.52
    span 80 541.36
    1,4-butanediol 174.5
    1,1-dichloroethane 1445.66
    2-methyl-1-pentanol 432.27
    methyl formate 411.28
    2-methyl-1-butanol 458.82
    n-decane 187.07
    butyronitrile 698.91
    3,7-dimethyl-1-octanol 431.99
    1-chlorooctane 533.89
    1-chlorotetradecane 245.24
    n-nonane 202.24
    undecane 144.71
    tert-butylcyclohexane 213.13
    cyclooctane 204.14
    cyclopentanol 782.27
    tetrahydropyran 1539.06
    tert-amyl methyl ether 566.03
    2,5,8-trioxanonane 739.39
    1-hexene 549.92
    2-isopropoxyethanol 345.44
    2,2,2-trifluoroethanol 155.06
    methyl butyrate 638.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction