5-Ethyl-2-methoxyphenol

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  • Identifiers

    CAS number
    2785-88-8

    Molecular formula
    C9H12O2

    SMILES
    CCC1=CC(=C(C=C1)OC)O

  • Odor profile

    Fragrance
    Phenolic 86.2%
    Spicy 80.08%
    Smoky 74.35%
    Woody 63.93%
    Sweet 63.19%
    Medicinal 57.55%
    Vanilla 54.44%
    Clove 52.25%
    Burnt 48.8%
    Leathery 42.69%

     

    Flavor
    Phenolic 75.48%
    Spicy 62.1%
    Spice 59.77%
    Smoky 59.3%
    Medicinal 54.41%
    Clove 52.95%
    Woody 51.97%
    Bacon 49.52%
    Smoke 45.28%
    Vanilla 42.62%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    9.22 (weak base)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    234°C

    Flash point

    • 102.57 ˚C est.

  • Synonyms

    • 5-ethyl-2-methoxyphenol
    • 2785-88-8
    • Locustol
    • Phenol, 5-ethyl-2-methoxy-
    • 2-Methoxy-5-ethylphenol
    • G8V5WHB17K
    • UNII-G8V5WHB17K
    • MFCD16997738
    • 5-ETHYLGUAIACOL
    • 5-ethyl-2-methoxy-phenol
    • GUAIACOL, 5-ETHYL-
    • SCHEMBL109505
    • DTXSID50182163
    • CAWZFQGJUGEKFU-UHFFFAOYSA-N
    • AKOS024259699
    • MB23985
    • AS-50226
    • CS-0134143
    • O11426
    • A819219
    • Q27278942

  • Applications

    5-Ethyl-2-methoxyphenol (CAS 2785-88-8) is primarily used as an intermediate and fragrance-related ingredient in industrial chemistry. In perfumery and cosmetics, it may serve as a fragrance note or odorant, contributing a woody, resinous character to formulations. It is commonly evaluated as an intermediate for the synthesis of specialty chemicals, including dyes, pigments, and pharmaceutical or agrochemical intermediates. In household cleaning products, it may be employed as a fragrance component to impart aroma. In coatings, inks, and polymer formulations, it can act as a reactive building block or precursor for functionalized materials. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1075.4
    methanol 1538.87
    isopropanol 530.22
    water 1.71
    ethyl acetate 813.5
    n-propanol 764.7
    acetone 685.21
    n-butanol 558.46
    acetonitrile 997.33
    DMF 702.65
    toluene 127.62
    isobutanol 397.04
    1,4-dioxane 1862.05
    methyl acetate 744.69
    THF 1068.42
    2-butanone 450.77
    n-pentanol 294.78
    sec-butanol 366.49
    n-hexane 23.2
    ethylene glycol 306.65
    NMP 284.88
    cyclohexane 82.11
    DMSO 938.9
    n-butyl acetate 410.72
    n-octanol 123.17
    chloroform 1159.21
    n-propyl acetate 351.51
    acetic acid 960.92
    dichloromethane 1272.99
    cyclohexanone 559.29
    propylene glycol 206.01
    isopropyl acetate 305.4
    DMAc 288.49
    2-ethoxyethanol 594.71
    isopentanol 368.63
    n-heptane 27.76
    ethyl formate 576.15
    1,2-dichloroethane 948.57
    n-hexanol 363.25
    2-methoxyethanol 1289.4
    isobutyl acetate 174.96
    tetrachloromethane 188.17
    n-pentyl acetate 166.65
    transcutol 1111.66
    n-heptanol 138.07
    ethylbenzene 76.44
    MIBK 197.75
    2-propoxyethanol 608.49
    tert-butanol 847.16
    MTBE 553.53
    2-butoxyethanol 272.27
    propionic acid 529.28
    o-xylene 85.54
    formic acid 443.97
    diethyl ether 849.41
    m-xylene 87.64
    p-xylene 90.52
    chlorobenzene 285.51
    dimethyl carbonate 197.36
    n-octane 14.61
    formamide 812.79
    cyclopentanone 562.55
    2-pentanone 362.61
    anisole 237.17
    cyclopentyl methyl ether 311.22
    gamma-butyrolactone 789.62
    1-methoxy-2-propanol 557.13
    pyridine 653.64
    3-pentanone 260.99
    furfural 668.06
    n-dodecane 13.1
    diethylene glycol 559.2
    diisopropyl ether 114.81
    tert-amyl alcohol 444.94
    acetylacetone 408.4
    n-hexadecane 14.92
    acetophenone 178.05
    methyl propionate 432.24
    isopentyl acetate 294.05
    trichloroethylene 1263.17
    n-nonanol 110.04
    cyclohexanol 323.93
    benzyl alcohol 193.51
    2-ethylhexanol 161.08
    isooctanol 107.45
    dipropyl ether 201.33
    1,2-dichlorobenzene 241.61
    ethyl lactate 130.55
    propylene carbonate 388.6
    n-methylformamide 626.66
    2-pentanol 244.99
    n-pentane 32.36
    1-propoxy-2-propanol 301.68
    1-methoxy-2-propyl acetate 291.39
    2-(2-methoxypropoxy) propanol 214.34
    mesitylene 66.75
    ε-caprolactone 462.21
    p-cymene 62.56
    epichlorohydrin 1061.6
    1,1,1-trichloroethane 659.14
    2-aminoethanol 491.79
    morpholine-4-carbaldehyde 594.11
    sulfolane 642.94
    2,2,4-trimethylpentane 21.63
    2-methyltetrahydrofuran 600.14
    n-hexyl acetate 221.78
    isooctane 20.18
    2-(2-butoxyethoxy)ethanol 331.28
    sec-butyl acetate 173.91
    tert-butyl acetate 308.15
    decalin 29.05
    glycerin 326.45
    diglyme 675.67
    acrylic acid 456.95
    isopropyl myristate 86.68
    n-butyric acid 716.73
    acetyl acetate 406.88
    di(2-ethylhexyl) phthalate 81.04
    ethyl propionate 255.74
    nitromethane 1333.68
    1,2-diethoxyethane 420.34
    benzonitrile 249.62
    trioctyl phosphate 65.17
    1-bromopropane 391.15
    gamma-valerolactone 788.82
    n-decanol 85.02
    triethyl phosphate 100.94
    4-methyl-2-pentanol 130.75
    propionitrile 633.91
    vinylene carbonate 449.74
    1,1,2-trichlorotrifluoroethane 580.83
    DMS 197.67
    cumene 59.55
    2-octanol 87.29
    2-hexanone 256.72
    octyl acetate 111.96
    limonene 91.45
    1,2-dimethoxyethane 941.74
    ethyl orthosilicate 102.05
    tributyl phosphate 79.46
    diacetone alcohol 315.22
    N,N-dimethylaniline 117.68
    acrylonitrile 714.03
    aniline 249.14
    1,3-propanediol 715.73
    bromobenzene 266.88
    dibromomethane 761.37
    1,1,2,2-tetrachloroethane 861.84
    2-methyl-cyclohexyl acetate 144.67
    tetrabutyl urea 91.12
    diisobutyl methanol 97.34
    2-phenylethanol 209.03
    styrene 110.22
    dioctyl adipate 118.9
    dimethyl sulfate 213.45
    ethyl butyrate 240.32
    methyl lactate 183.77
    butyl lactate 118.78
    diethyl carbonate 174.47
    propanediol butyl ether 190.66
    triethyl orthoformate 154.95
    p-tert-butyltoluene 63.05
    methyl 4-tert-butylbenzoate 150.85
    morpholine 1681.55
    tert-butylamine 433.45
    n-dodecanol 66.34
    dimethoxymethane 658.04
    ethylene carbonate 402.52
    cyrene 182.38
    2-ethoxyethyl acetate 273.71
    2-ethylhexyl acetate 204.36
    1,2,4-trichlorobenzene 251.35
    4-methylpyridine 380.08
    dibutyl ether 150.39
    2,6-dimethyl-4-heptanol 97.34
    DEF 346.45
    dimethyl isosorbide 326.27
    tetrachloroethylene 637.02
    eugenol 173.1
    triacetin 187.02
    span 80 169.53
    1,4-butanediol 197.56
    1,1-dichloroethane 725.61
    2-methyl-1-pentanol 216.86
    methyl formate 584.19
    2-methyl-1-butanol 312.4
    n-decane 20.82
    butyronitrile 537.55
    3,7-dimethyl-1-octanol 110.51
    1-chlorooctane 81.71
    1-chlorotetradecane 36.59
    n-nonane 19.5
    undecane 16.06
    tert-butylcyclohexane 26.96
    cyclooctane 22.61
    cyclopentanol 308.21
    tetrahydropyran 1123.4
    tert-amyl methyl ether 264.26
    2,5,8-trioxanonane 410.6
    1-hexene 89.28
    2-isopropoxyethanol 327.39
    2,2,2-trifluoroethanol 267.07
    methyl butyrate 337.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction