5-Ethoxythiazole

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  • Identifiers

    CAS number
    25115-63-3

    Molecular formula
    C5H7NOS

    SMILES
    CCOC1=CN=CS1

    Safety labels

  • Odor profile

    Fragrance
    Nutty 66.96%
    Roasted 60.63%
    Green 55.59%
    Meaty 53.86%
    Sweet 51.04%
    Vegetable 50.17%
    Sulfurous 47.01%
    Coffee 46.33%
    Burnt 45.71%
    Earthy 40.95%

     

    Flavor
    Sweet 57.53%
    Nutty 47.83%
    Green 45.13%
    Fruity 44.13%
    Earthy 39.97%
    Coffee 33.77%
    Vegetable 28.77%
    Musty 27.4%
    Fruit 25.88%
    Roasted 24.73%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.27 (neutral)

    Molecular weight
    129.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    200°C

    Flash point

    • 58.01 ˚C est.

  • Synonyms

    • 5-Ethoxythiazole
    • Thiazole, 5-ethoxy-
    • 5-Ethoxy-1,3-thiazole
    • RefChem:102531
    • CAYSHAOATVWHSR-UHFFFAOYSA-N
    • 5-ethoxy thiazole
    • 25115-63-3
    • 5-Ethoxy-1,3-thiazole #
    • SCHEMBL9209356
    • SCHEMBL11579261
    • 25115-63-3

  • Applications

    5-Ethoxythiazole (CAS 25115-63-3) is primarily used as an organic synthesis intermediate, serving as a building block for the preparation of more complex heterocyclic compounds in pharmaceutical and agrochemical development. It also functions as a precursor in the synthesis of specialty dyes and pigments, and as a starting material for functionalized thiazole derivatives in polymers and coatings chemistry. In industry and research, it may be evaluated for applications in solvent systems or formulation studies to explore reactivity, solubility, and compatibility across drug, crop protection, and material science contexts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 132.61
    methanol 222.53
    isopropanol 94.65
    water 3.53
    ethyl acetate 233.66
    n-propanol 101.3
    acetone 414.68
    n-butanol 100.28
    acetonitrile 299.01
    DMF 851.67
    toluene 142.32
    isobutanol 85.36
    1,4-dioxane 495.7
    methyl acetate 248.15
    THF 476.48
    2-butanone 255.27
    n-pentanol 93.85
    sec-butanol 89.25
    n-hexane 20.52
    ethylene glycol 115.13
    NMP 739.88
    cyclohexane 36.37
    DMSO 1147.08
    n-butyl acetate 157.62
    n-octanol 74.9
    chloroform 528.91
    n-propyl acetate 164.8
    acetic acid 246.48
    dichloromethane 613.7
    cyclohexanone 391.67
    propylene glycol 77.58
    isopropyl acetate 140.0
    DMAc 674.97
    2-ethoxyethanol 266.98
    isopentanol 91.95
    n-heptane 27.38
    ethyl formate 179.09
    1,2-dichloroethane 427.56
    n-hexanol 98.31
    2-methoxyethanol 402.55
    isobutyl acetate 111.68
    tetrachloromethane 134.14
    n-pentyl acetate 115.31
    transcutol 536.25
    n-heptanol 58.84
    ethylbenzene 83.01
    MIBK 142.54
    2-propoxyethanol 250.62
    tert-butanol 132.32
    MTBE 146.17
    2-butoxyethanol 140.21
    propionic acid 144.27
    o-xylene 121.08
    formic acid 120.05
    diethyl ether 168.27
    m-xylene 120.67
    p-xylene 115.22
    chlorobenzene 260.07
    dimethyl carbonate 171.0
    n-octane 14.15
    formamide 166.94
    cyclopentanone 483.99
    2-pentanone 211.77
    anisole 229.46
    cyclopentyl methyl ether 229.01
    gamma-butyrolactone 501.1
    1-methoxy-2-propanol 254.7
    pyridine 389.66
    3-pentanone 197.94
    furfural 639.44
    n-dodecane 16.54
    diethylene glycol 299.23
    diisopropyl ether 70.17
    tert-amyl alcohol 114.76
    acetylacetone 363.51
    n-hexadecane 19.01
    acetophenone 233.98
    methyl propionate 217.26
    isopentyl acetate 134.55
    trichloroethylene 747.65
    n-nonanol 69.89
    cyclohexanol 122.83
    benzyl alcohol 165.15
    2-ethylhexanol 82.36
    isooctanol 55.11
    dipropyl ether 120.08
    1,2-dichlorobenzene 274.1
    ethyl lactate 118.85
    propylene carbonate 246.81
    n-methylformamide 290.34
    2-pentanol 70.55
    n-pentane 20.15
    1-propoxy-2-propanol 170.5
    1-methoxy-2-propyl acetate 195.65
    2-(2-methoxypropoxy) propanol 178.63
    mesitylene 90.83
    ε-caprolactone 296.25
    p-cymene 75.97
    epichlorohydrin 537.51
    1,1,1-trichloroethane 390.71
    2-aminoethanol 116.64
    morpholine-4-carbaldehyde 785.86
    sulfolane 811.91
    2,2,4-trimethylpentane 21.09
    2-methyltetrahydrofuran 280.52
    n-hexyl acetate 144.59
    isooctane 16.39
    2-(2-butoxyethoxy)ethanol 218.79
    sec-butyl acetate 110.38
    tert-butyl acetate 164.48
    decalin 33.44
    glycerin 177.83
    diglyme 442.59
    acrylic acid 182.03
    isopropyl myristate 82.36
    n-butyric acid 163.52
    acetyl acetate 216.64
    di(2-ethylhexyl) phthalate 93.59
    ethyl propionate 153.28
    nitromethane 598.2
    1,2-diethoxyethane 202.05
    benzonitrile 264.95
    trioctyl phosphate 64.02
    1-bromopropane 170.76
    gamma-valerolactone 602.68
    n-decanol 58.13
    triethyl phosphate 98.33
    4-methyl-2-pentanol 55.96
    propionitrile 192.09
    vinylene carbonate 276.9
    1,1,2-trichlorotrifluoroethane 454.78
    DMS 191.99
    cumene 69.98
    2-octanol 49.54
    2-hexanone 162.23
    octyl acetate 99.41
    limonene 104.82
    1,2-dimethoxyethane 481.61
    ethyl orthosilicate 92.35
    tributyl phosphate 78.5
    diacetone alcohol 181.55
    N,N-dimethylaniline 169.05
    acrylonitrile 277.68
    aniline 174.09
    1,3-propanediol 150.67
    bromobenzene 289.87
    dibromomethane 366.77
    1,1,2,2-tetrachloroethane 564.83
    2-methyl-cyclohexyl acetate 127.74
    tetrabutyl urea 121.64
    diisobutyl methanol 62.36
    2-phenylethanol 149.67
    styrene 121.75
    dioctyl adipate 121.83
    dimethyl sulfate 366.03
    ethyl butyrate 145.87
    methyl lactate 164.65
    butyl lactate 98.59
    diethyl carbonate 117.77
    propanediol butyl ether 134.69
    triethyl orthoformate 113.03
    p-tert-butyltoluene 73.48
    methyl 4-tert-butylbenzoate 180.82
    morpholine 404.59
    tert-butylamine 84.34
    n-dodecanol 50.63
    dimethoxymethane 413.76
    ethylene carbonate 212.54
    cyrene 228.74
    2-ethoxyethyl acetate 174.27
    2-ethylhexyl acetate 116.95
    1,2,4-trichlorobenzene 323.0
    4-methylpyridine 350.09
    dibutyl ether 103.71
    2,6-dimethyl-4-heptanol 62.36
    DEF 347.51
    dimethyl isosorbide 318.92
    tetrachloroethylene 367.35
    eugenol 193.43
    triacetin 194.35
    span 80 152.0
    1,4-butanediol 93.46
    1,1-dichloroethane 324.64
    2-methyl-1-pentanol 88.43
    methyl formate 266.42
    2-methyl-1-butanol 89.06
    n-decane 21.97
    butyronitrile 171.86
    3,7-dimethyl-1-octanol 79.37
    1-chlorooctane 74.16
    1-chlorotetradecane 42.78
    n-nonane 20.6
    undecane 18.51
    tert-butylcyclohexane 30.92
    cyclooctane 19.54
    cyclopentanol 143.73
    tetrahydropyran 245.36
    tert-amyl methyl ether 129.95
    2,5,8-trioxanonane 334.92
    1-hexene 56.93
    2-isopropoxyethanol 183.15
    2,2,2-trifluoroethanol 125.22
    methyl butyrate 199.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction