5'-Cytidylic acid

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  • Identifiers

    CAS number
    63-37-6

    Molecular formula
    C9H14N3O8P

    SMILES
    C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 90.08%
    Savory 18.52%
    Bitter 17.45%
    Milky 14.86%
    Cooked 14.76%
    Cooling 13.84%
    Clean 13.3%
    Meaty 13.01%
    Sweet 10.21%
    Dairy 10.04%

     

    Flavor
    Odorless 60.55%
    Bitter 52.11%
    Bland 29.57%
    Mild 29.53%
    Very mild 28.05%
    Sweet-like 24.05%
    Yeast 21.49%
    Formyl 19.67%
    Nitrile 19.38%
    Urine 19.35%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.4

    pKa est.
    6.24 (neutral)

    Molecular weight
    323.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2319°C

    Melting point expt.

    • 233 dec °C
    • 233 °C

    Flash point

    • 355.8 ˚C est.

  • Synonyms

    • 5'-CYTIDYLIC ACID
    • DTXSID50889322
    • 5'-CYTIDYLIC ACID (USP-RS)
    • 5'-CYTIDYLIC ACID [USP-RS]
    • RefChem:6771
    • DTXCID701028585
    • 200-556-6
    • 63-37-6
    • Cytidine 5'-monophosphate
    • Cytidine monophosphate
    • cytidylic acid
    • Cytidine-5'-monophosphate
    • 5'-CMP
    • cytidylate
    • Cytidine 5'-phosphate
    • CMP (nucleotide)
    • Cytidine 5'-phosphoric acid
    • Cytidine 5'-monophosphoric acid
    • ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
    • Cytidine 5'-(dihydrogenphosphate)
    • MFCD00006544
    • C9H14N3O8P
    • cytidine-P
    • cytidine-phosphate
    • CMP
    • Cytidine 3'-(dihydrogen phosphate)
    • 1beta-Ribofuranosylcytosine 5'-phosphate, d-
    • [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
    • C-5'-P
    • [(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
    • CHEMBL307679
    • {[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
    • CHEBI:17361
    • 5'-Cytidylic acid (8CI,9CI)
    • 5-Cmp
    • Cytidine, mono(dihydrogen phosphate) (ester)
    • F469818O25
    • 2(1H)-pyrimidinone, 4-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-
    • Cytidine-5' Monophosphate
    • cytidine-monophosphate
    • C5P
    • EINECS 200-556-6
    • BRN 0046982
    • 5-cytidylate
    • 5-Cytidylic acid
    • UNII-F469818O25
    • Cytidine mono(dihydrogen phosphate)
    • Cytidine 5'-monophosphate, free acid
    • cytidine mono phosphate
    • CytidylsA currencyure a
    • cytidine 5''-phosphate
    • Cytidine 5'-phosphorate
    • 5'-CYTIDYLICACID
    • Cytidine 5 -monophosphate
    • bmse000311
    • Epitope ID:196257
    • Cytidine 5'-monophosphorate
    • 3H-Cytidin-5'-monophosphat
    • SCHEMBL16189
    • 4-25-00-03673 (Beilstein Handbook Reference)
    • Cytidine 5a(2)-monophosphate
    • orb1297637
    • CYTIDYLIC ACID [WHO-DD]
    • CYTOSINE 5'-MONOPHOSPHATE
    • MSK6901
    • 5'-CYTIDYLIC ACID [FCC]
    • CYTIDINE-5''-MONOPHOSPHATE
    • Cytidine-5'-(dihydrogen phosphate)
    • HY-W009162R
    • Cytidine 5'-monophosphate free acid
    • BDBM50310540
    • s5374
    • Cytidine 5'-monophosphate (Standard)
    • AKOS015854843
    • AKOS015888565
    • Cytidine 5'-monophosphate (5'-CMP)
    • CCG-267735
    • CS-W009878
    • DB03403
    • EBC-145068
    • HY-W009162
    • NC02951
    • AC-32139
    • AS-56853
    • BP-58604
    • C25
    • SY030157
    • C1675
    • C00055
    • W18546
    • EN300-7376706
    • 006C544
    • A820633
    • Cyclazosin Impurity 1(Cytidine 5'-Monophosphate)
    • F047062
    • Q412622
    • Cytidine 5 inverted exclamation mark -Monophosphate
    • Q-101433
    • B755C4F3-3D29-45E0-9432-16F902ABCFE1
    • 4-Amino-1-(5-O-phosphono-?-D-ribofuranosyl)pyrimidin-2(1H)-on
    • 5'-Cytidylic acid; Cytidine monophosphate, Cytidine 5'-phosphate
    • 5'-Cytidylic acid, United States Pharmacopeia (USP) Reference Standard
    • Cytidine 5'-monophosphate, Sigma Grade, >=99% (HPLC), synthetic, powder
    • ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl dihydrogen phosphate
    • 293738-08-6
    • FN5
    • Phosphoric acid mono-[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
    • 63-37-6

  • Applications

    5'-Cytidylic acid, CAS 63-37-6, is a nucleotide monophosphate used as a reagent in biochemical and molecular biology contexts. It serves as a substrate for phosphorylation steps to generate other nucleotides (for example, CTP) and as a building block in nucleotide synthesis for cytidine derivatives in pharmaceutical research. It also functions as an analytical standard for quantifying CMP and related nucleotides in biological samples by HPLC/LC-MS, and as a reagent in enzyme assays and nucleic-acid research kits to probe kinases and nucleases. Finally, CMP can be viewed as an intermediate or precursor in nucleotide metabolism studies, including salvage pathway research, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.15
    methanol 0.62
    isopropanol 0.11
    water 51.54
    ethyl acetate 0.03
    n-propanol 0.11
    acetone 0.15
    n-butanol 0.1
    acetonitrile 0.09
    DMF 7.0
    toluene 0.03
    isobutanol 0.07
    1,4-dioxane 0.21
    methyl acetate 0.05
    THF 0.41
    2-butanone 0.09
    n-pentanol 0.06
    sec-butanol 0.1
    n-hexane 0.02
    ethylene glycol 2.08
    NMP 15.82
    cyclohexane 0.06
    DMSO 23.73
    n-butyl acetate 0.08
    n-octanol 0.08
    chloroform 0.02
    n-propyl acetate 0.04
    acetic acid 1.98
    dichloromethane 0.03
    cyclohexanone 0.36
    propylene glycol 1.43
    isopropyl acetate 0.03
    DMAc 6.72
    2-ethoxyethanol 1.07
    isopentanol 0.08
    n-heptane 0.08
    ethyl formate 0.13
    1,2-dichloroethane 0.03
    n-hexanol 0.14
    2-methoxyethanol 3.2
    isobutyl acetate 0.01
    tetrachloromethane 0.03
    n-pentyl acetate 0.06
    transcutol 0.84
    n-heptanol 0.17
    ethylbenzene 0.02
    MIBK 0.07
    2-propoxyethanol 1.25
    tert-butanol 0.17
    MTBE 0.04
    2-butoxyethanol 0.8
    propionic acid 0.28
    o-xylene 0.05
    formic acid 29.54
    diethyl ether 0.06
    m-xylene 0.03
    p-xylene 0.03
    chlorobenzene 0.01
    dimethyl carbonate 0.27
    n-octane 0.03
    formamide 21.84
    cyclopentanone 0.53
    2-pentanone 0.09
    anisole 0.03
    cyclopentyl methyl ether 0.24
    gamma-butyrolactone 0.59
    1-methoxy-2-propanol 1.66
    pyridine 0.19
    3-pentanone 0.1
    furfural 1.41
    n-dodecane 0.01
    diethylene glycol 3.79
    diisopropyl ether 0.03
    tert-amyl alcohol 0.16
    acetylacetone 0.18
    n-hexadecane 0.01
    acetophenone 0.1
    methyl propionate 0.1
    isopentyl acetate 0.06
    trichloroethylene 0.04
    n-nonanol 0.09
    cyclohexanol 0.23
    benzyl alcohol 0.09
    2-ethylhexanol 0.1
    isooctanol 0.1
    dipropyl ether 0.18
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.31
    propylene carbonate 0.26
    n-methylformamide 2.33
    2-pentanol 0.08
    n-pentane 0.02
    1-propoxy-2-propanol 0.8
    1-methoxy-2-propyl acetate 0.22
    2-(2-methoxypropoxy) propanol 0.64
    mesitylene 0.04
    ε-caprolactone 0.28
    p-cymene 0.05
    epichlorohydrin 0.16
    1,1,1-trichloroethane 0.01
    2-aminoethanol 1.5
    morpholine-4-carbaldehyde 5.01
    sulfolane 6.28
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.16
    n-hexyl acetate 0.05
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.78
    sec-butyl acetate 0.02
    tert-butyl acetate 0.07
    decalin 0.01
    glycerin 11.62
    diglyme 1.66
    acrylic acid 0.73
    isopropyl myristate 0.03
    n-butyric acid 0.21
    acetyl acetate 0.05
    di(2-ethylhexyl) phthalate 0.07
    ethyl propionate 0.05
    nitromethane 2.22
    1,2-diethoxyethane 0.1
    benzonitrile 0.05
    trioctyl phosphate 0.07
    1-bromopropane 0.02
    gamma-valerolactone 1.57
    n-decanol 0.07
    triethyl phosphate 0.16
    4-methyl-2-pentanol 0.05
    propionitrile 0.06
    vinylene carbonate 0.22
    1,1,2-trichlorotrifluoroethane 2.13
    DMS 0.07
    cumene 0.02
    2-octanol 0.09
    2-hexanone 0.06
    octyl acetate 0.04
    limonene 0.07
    1,2-dimethoxyethane 0.95
    ethyl orthosilicate 0.14
    tributyl phosphate 0.07
    diacetone alcohol 0.49
    N,N-dimethylaniline 0.1
    acrylonitrile 0.12
    aniline 0.09
    1,3-propanediol 1.03
    bromobenzene 0.01
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.06
    2-methyl-cyclohexyl acetate 0.1
    tetrabutyl urea 0.23
    diisobutyl methanol 0.07
    2-phenylethanol 0.13
    styrene 0.01
    dioctyl adipate 0.05
    dimethyl sulfate 1.41
    ethyl butyrate 0.11
    methyl lactate 1.06
    butyl lactate 0.25
    diethyl carbonate 0.08
    propanediol butyl ether 0.71
    triethyl orthoformate 0.18
    p-tert-butyltoluene 0.05
    methyl 4-tert-butylbenzoate 0.31
    morpholine 0.41
    tert-butylamine 0.07
    n-dodecanol 0.05
    dimethoxymethane 1.12
    ethylene carbonate 0.15
    cyrene 1.77
    2-ethoxyethyl acetate 0.09
    2-ethylhexyl acetate 0.06
    1,2,4-trichlorobenzene 0.02
    4-methylpyridine 0.1
    dibutyl ether 0.06
    2,6-dimethyl-4-heptanol 0.07
    DEF 0.55
    dimethyl isosorbide 1.21
    tetrachloroethylene 0.07
    eugenol 0.44
    triacetin 0.12
    span 80 0.43
    1,4-butanediol 0.43
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.05
    methyl formate 1.25
    2-methyl-1-butanol 0.09
    n-decane 0.02
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.05
    1-chlorooctane 0.03
    1-chlorotetradecane 0.01
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.03
    cyclopentanol 0.32
    tetrahydropyran 0.12
    tert-amyl methyl ether 0.07
    2,5,8-trioxanonane 1.37
    1-hexene 0.02
    2-isopropoxyethanol 0.34
    2,2,2-trifluoroethanol 2.69
    methyl butyrate 0.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction