5-Butyl-2,3-dimethylpyrazine

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  • Identifiers

    CAS number
    15834-78-3

    Molecular formula
    C10H16N2

    SMILES
    CCCCC1=CN=C(C(=N1)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 61.22%
    Roasted 57.87%
    Earthy 53.8%
    Burnt 47.28%
    Musty 45.61%
    Hazelnut 43.09%
    Cocoa 42.45%
    Chocolate 35.26%
    Green 33.54%
    Potato 33.48%

     

    Flavor
    Earthy 54.26%
    Nutty 52.84%
    Roasted 50.18%
    Musty 44.07%
    Meaty 42.04%
    Potato 40.63%
    Green 39.21%
    Hazelnut 38.55%
    Burnt 37.02%
    Pepper 36.7%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    5.1 (weak acid)

    Molecular weight
    164.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    251°C

    Flash point

    • 97.38 ˚C est.

  • Synonyms

    • 5-Butyl-2,3-dimethylpyrazine
    • 15834-78-3
    • Pyrazine, 5-butyl-2,3-dimethyl-
    • 2,3-Dimethyl-5-butylpyrazine
    • SCHEMBL2616803
    • RYKQVGCVJZOAAN-UHFFFAOYSA-N
    • DB-085747
    • 15834-78-3

  • Applications

    5-Butyl-2,3-dimethylpyrazine (CAS 15834-78-3) is used in fragrance and flavor applications where it contributes warm, roasted, and nutty notes. In perfumery/fragrance it serves as an aroma ingredient, and in flavor formulation it may act as a flavoring agent under appropriate regulatory controls. It is also employed in cosmetics/personal care as a fragrance constituent in products such as creams, lotions, and cleansers. In household products such as detergents and air fresheners, it can provide distinctive scent profiles. In industrial manufacturing, it is often evaluated as a building block or intermediate for synthetic aroma systems, enabling the development of other flavor and fragrance compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 423.28
    methanol 448.91
    isopropanol 287.46
    water 0.73
    ethyl acetate 501.44
    n-propanol 357.85
    acetone 507.27
    n-butanol 417.84
    acetonitrile 310.36
    DMF 768.8
    toluene 409.15
    isobutanol 328.07
    1,4-dioxane 728.76
    methyl acetate 383.79
    THF 882.09
    2-butanone 466.11
    n-pentanol 304.4
    sec-butanol 316.56
    n-hexane 138.58
    ethylene glycol 69.01
    NMP 677.31
    cyclohexane 222.49
    DMSO 555.15
    n-butyl acetate 806.85
    n-octanol 191.33
    chloroform 2319.04
    n-propyl acetate 341.44
    acetic acid 439.53
    dichloromethane 1888.22
    cyclohexanone 969.23
    propylene glycol 103.07
    isopropyl acetate 336.09
    DMAc 678.24
    2-ethoxyethanol 306.55
    isopentanol 407.61
    n-heptane 85.36
    ethyl formate 384.22
    1,2-dichloroethane 1016.4
    n-hexanol 480.55
    2-methoxyethanol 498.33
    isobutyl acetate 274.76
    tetrachloromethane 456.83
    n-pentyl acetate 330.04
    transcutol 958.54
    n-heptanol 217.51
    ethylbenzene 228.55
    MIBK 274.82
    2-propoxyethanol 516.04
    tert-butanol 369.26
    MTBE 496.39
    2-butoxyethanol 311.9
    propionic acid 311.74
    o-xylene 264.37
    formic acid 119.53
    diethyl ether 468.55
    m-xylene 271.56
    p-xylene 322.02
    chlorobenzene 694.77
    dimethyl carbonate 165.56
    n-octane 42.28
    formamide 136.97
    cyclopentanone 853.36
    2-pentanone 411.88
    anisole 309.6
    cyclopentyl methyl ether 497.08
    gamma-butyrolactone 914.3
    1-methoxy-2-propanol 347.41
    pyridine 794.17
    3-pentanone 359.52
    furfural 857.57
    n-dodecane 34.7
    diethylene glycol 296.12
    diisopropyl ether 160.76
    tert-amyl alcohol 385.21
    acetylacetone 448.29
    n-hexadecane 40.02
    acetophenone 299.89
    methyl propionate 337.4
    isopentyl acetate 694.89
    trichloroethylene 1866.36
    n-nonanol 170.09
    cyclohexanol 429.66
    benzyl alcohol 288.16
    2-ethylhexanol 351.79
    isooctanol 178.97
    dipropyl ether 330.85
    1,2-dichlorobenzene 623.47
    ethyl lactate 144.3
    propylene carbonate 629.5
    n-methylformamide 277.52
    2-pentanol 272.23
    n-pentane 99.84
    1-propoxy-2-propanol 428.39
    1-methoxy-2-propyl acetate 440.97
    2-(2-methoxypropoxy) propanol 260.96
    mesitylene 177.74
    ε-caprolactone 712.69
    p-cymene 183.64
    epichlorohydrin 924.8
    1,1,1-trichloroethane 1012.16
    2-aminoethanol 148.21
    morpholine-4-carbaldehyde 619.32
    sulfolane 889.31
    2,2,4-trimethylpentane 72.02
    2-methyltetrahydrofuran 703.27
    n-hexyl acetate 403.9
    isooctane 44.42
    2-(2-butoxyethoxy)ethanol 339.88
    sec-butyl acetate 251.02
    tert-butyl acetate 327.8
    decalin 103.01
    glycerin 140.45
    diglyme 591.76
    acrylic acid 271.25
    isopropyl myristate 161.71
    n-butyric acid 607.47
    acetyl acetate 365.28
    di(2-ethylhexyl) phthalate 175.27
    ethyl propionate 281.11
    nitromethane 512.82
    1,2-diethoxyethane 525.79
    benzonitrile 510.69
    trioctyl phosphate 122.5
    1-bromopropane 698.3
    gamma-valerolactone 935.55
    n-decanol 132.08
    triethyl phosphate 177.67
    4-methyl-2-pentanol 182.42
    propionitrile 379.0
    vinylene carbonate 570.53
    1,1,2-trichlorotrifluoroethane 593.4
    DMS 296.21
    cumene 172.4
    2-octanol 157.23
    2-hexanone 370.59
    octyl acetate 204.21
    limonene 276.46
    1,2-dimethoxyethane 601.98
    ethyl orthosilicate 187.0
    tributyl phosphate 164.14
    diacetone alcohol 286.42
    N,N-dimethylaniline 246.59
    acrylonitrile 393.19
    aniline 427.5
    1,3-propanediol 264.59
    bromobenzene 818.18
    dibromomethane 1306.43
    1,1,2,2-tetrachloroethane 1627.32
    2-methyl-cyclohexyl acetate 297.62
    tetrabutyl urea 198.15
    diisobutyl methanol 175.59
    2-phenylethanol 364.5
    styrene 294.63
    dioctyl adipate 216.63
    dimethyl sulfate 261.88
    ethyl butyrate 395.9
    methyl lactate 155.3
    butyl lactate 246.25
    diethyl carbonate 263.62
    propanediol butyl ether 245.32
    triethyl orthoformate 277.98
    p-tert-butyltoluene 170.65
    methyl 4-tert-butylbenzoate 250.52
    morpholine 694.42
    tert-butylamine 296.4
    n-dodecanol 105.91
    dimethoxymethane 382.4
    ethylene carbonate 517.19
    cyrene 235.48
    2-ethoxyethyl acetate 356.62
    2-ethylhexyl acetate 560.95
    1,2,4-trichlorobenzene 611.94
    4-methylpyridine 825.09
    dibutyl ether 316.49
    2,6-dimethyl-4-heptanol 175.59
    DEF 531.2
    dimethyl isosorbide 476.37
    tetrachloroethylene 1122.39
    eugenol 274.74
    triacetin 273.87
    span 80 260.04
    1,4-butanediol 127.15
    1,1-dichloroethane 1019.99
    2-methyl-1-pentanol 338.62
    methyl formate 275.09
    2-methyl-1-butanol 401.55
    n-decane 56.29
    butyronitrile 478.51
    3,7-dimethyl-1-octanol 212.89
    1-chlorooctane 200.22
    1-chlorotetradecane 82.89
    n-nonane 56.83
    undecane 42.77
    tert-butylcyclohexane 92.41
    cyclooctane 69.69
    cyclopentanol 357.7
    tetrahydropyran 791.07
    tert-amyl methyl ether 373.22
    2,5,8-trioxanonane 396.65
    1-hexene 336.62
    2-isopropoxyethanol 234.58
    2,2,2-trifluoroethanol 156.31
    methyl butyrate 434.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction