5-Amino-2-methylphenol

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  • Identifiers

    CAS number
    2835-95-2

    Molecular formula
    C7H9NO

    SMILES
    CC1=C(C=C(C=C1)N)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 70.55%
    Smoky 46.62%
    Medicinal 41.77%
    Sweet 40.96%
    Burnt 40.1%
    Animal 35.81%
    Meaty 33.9%
    Musty 31.77%
    Spicy 30.3%
    Leathery 29.82%

     

    Flavor
    Phenolic 66.02%
    Medicinal 44.49%
    Mild 37.28%
    Sweet 36.81%
    Meaty 35.18%
    Phenol 31.3%
    Smoke 29.36%
    Smoky 28.68%
    Musty 27.49%
    Bitter 27.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    7.23 (neutral)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    285°C

    Melting point expt.

    • 320 to 347 °F (sublimes) (NTP, 1992)
    • 161 °C

    Flash point

    • 127.42 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 70 °F (NTP, 1992)
    • In water, 2,427 mg/L @ 25 °C /Estimated/

  • Synonyms

    • 5-Amino-2-methylphenol
    • 5-Amino-o-cresol
    • 2835-95-2
    • 4-Amino-2-hydroxytoluene
    • 3-Hydroxy-4-methylaniline
    • Phenol, 5-amino-2-methyl-
    • 6-Methyl-3-aminophenol
    • 2-methyl-5-aminophenol
    • 4-Amino-2-hydroxy-1-methylbenzene
    • UBB8XEB10B
    • DTXSID9024489
    • 3-HYDROXY-P-TOLUIDINE
    • DTXCID204489
    • 1-methyl-2-hydroxy-4-aminobenzene
    • RefChem:913242
    • 220-618-6
    • 2-Hydroxy-p-toluidine
    • 3-AMINO-6-METHYLPHENOL
    • 5-Amino-2-Methyl Phenol
    • 2635-98-5
    • MFCD00043922
    • 5-amino-2-methyl-phenol
    • NCGC00090702-02
    • HSDB 7152
    • CCRIS 4582
    • EINECS 220-618-6
    • UNII-UBB8XEB10B
    • BRN 2802317
    • 5-amino cresol
    • 3-hydroxy4-methylaniline
    • 2-hydroxy-4-aminotoluene
    • 3-amino-6-methyl phenol
    • 5-amino 2-methyl phenol
    • 3-hydroxy-4-methyl aniline
    • 3-hydroxy-4-methyl-aniline
    • 5A2MP
    • SCHEMBL93860
    • MLS001055501
    • SCHEMBL2995201
    • SCHEMBL8411530
    • 5-Amino-2-methylphenol, 97%
    • CHEMBL1446372
    • SCHEMBL10972850
    • SCHEMBL29670126
    • 5-AMINO-O-CRESOL [HSDB]
    • HMS3039M03
    • Tox21_400033
    • MSK000393
    • AKOS009159063
    • AC-7842
    • CS-W016574
    • EBC-151123
    • FA00831
    • PS-3000
    • NCGC00090702-01
    • NCGC00090702-03
    • SMR001227188
    • SY007529
    • CAS-2835-95-2
    • DB-032383
    • A0925
    • NS00006552
    • ST51038071
    • EN300-84103
    • A15450
    • D70142
    • F078747
    • Q27290997
    • F0001-0895
    • Z944939438
    • 5-Amino-o-cresol;3-Hydroxy-4-methylaniline;4-Amino-2-hydroxytoluene
    • InChI=1/C7H9NO/c1-5-2-3-6(8)4-7(5)9/h2-4,9H,8H2,1H
    • 2835-95-2

  • Applications

    5-Amino-2-methylphenol (CAS 2835-95-2) is primarily employed as an intermediate in the synthesis of azo and other dyes and pigments, providing aromatic amine and phenol functionality for color development; it serves as a building block in polymer and coating/ink formulations where color and reactivity are required; it may be used as a precursor for cosmetic colorants and hair-dye components in personal care products; it can function as an intermediate in the manufacture of pharmaceutical and agrochemical compounds; and it is sometimes evaluated for use in specialty adhesives or resin systems where amine/phenol groups enable cross-linking.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 232.78
    methanol 300.13
    isopropanol 179.4
    water 13.1
    ethyl acetate 173.07
    n-propanol 155.14
    acetone 456.26
    n-butanol 116.14
    acetonitrile 221.95
    DMF 283.58
    toluene 9.61
    isobutanol 91.84
    1,4-dioxane 304.41
    methyl acetate 205.8
    THF 899.81
    2-butanone 266.01
    n-pentanol 86.05
    sec-butanol 97.17
    n-hexane 3.01
    ethylene glycol 55.25
    NMP 142.3
    cyclohexane 1.06
    DMSO 400.55
    n-butyl acetate 55.28
    n-octanol 45.56
    chloroform 43.58
    n-propyl acetate 61.64
    acetic acid 184.13
    dichloromethane 30.28
    cyclohexanone 128.45
    propylene glycol 66.56
    isopropyl acetate 70.33
    DMAc 218.49
    2-ethoxyethanol 142.95
    isopentanol 86.37
    n-heptane 4.64
    ethyl formate 108.53
    1,2-dichloroethane 27.34
    n-hexanol 108.8
    2-methoxyethanol 244.51
    isobutyl acetate 36.89
    tetrachloromethane 15.78
    n-pentyl acetate 38.08
    transcutol 127.5
    n-heptanol 63.16
    ethylbenzene 7.45
    MIBK 83.08
    2-propoxyethanol 186.55
    tert-butanol 190.9
    MTBE 112.32
    2-butoxyethanol 109.47
    propionic acid 137.32
    o-xylene 10.1
    formic acid 135.19
    diethyl ether 86.92
    m-xylene 15.14
    p-xylene 11.42
    chlorobenzene 17.06
    dimethyl carbonate 64.06
    n-octane 2.5
    formamide 189.02
    cyclopentanone 342.23
    2-pentanone 180.54
    anisole 38.53
    cyclopentyl methyl ether 137.21
    gamma-butyrolactone 331.24
    1-methoxy-2-propanol 186.97
    pyridine 64.35
    3-pentanone 86.23
    furfural 135.92
    n-dodecane 2.06
    diethylene glycol 135.66
    diisopropyl ether 20.86
    tert-amyl alcohol 111.55
    acetylacetone 150.68
    n-hexadecane 2.21
    acetophenone 33.9
    methyl propionate 131.03
    isopentyl acetate 44.11
    trichloroethylene 59.72
    n-nonanol 37.99
    cyclohexanol 46.57
    benzyl alcohol 35.46
    2-ethylhexanol 43.98
    isooctanol 46.47
    dipropyl ether 43.16
    1,2-dichlorobenzene 16.66
    ethyl lactate 36.25
    propylene carbonate 105.04
    n-methylformamide 234.21
    2-pentanol 67.97
    n-pentane 2.15
    1-propoxy-2-propanol 104.67
    1-methoxy-2-propyl acetate 70.0
    2-(2-methoxypropoxy) propanol 59.06
    mesitylene 10.56
    ε-caprolactone 92.21
    p-cymene 10.18
    epichlorohydrin 242.23
    1,1,1-trichloroethane 43.27
    2-aminoethanol 107.64
    morpholine-4-carbaldehyde 161.02
    sulfolane 244.06
    2,2,4-trimethylpentane 2.82
    2-methyltetrahydrofuran 274.25
    n-hexyl acetate 51.21
    isooctane 3.33
    2-(2-butoxyethoxy)ethanol 88.55
    sec-butyl acetate 33.67
    tert-butyl acetate 76.28
    decalin 2.01
    glycerin 111.44
    diglyme 146.63
    acrylic acid 97.63
    isopropyl myristate 19.33
    n-butyric acid 149.47
    acetyl acetate 64.57
    di(2-ethylhexyl) phthalate 20.98
    ethyl propionate 51.06
    nitromethane 428.06
    1,2-diethoxyethane 48.49
    benzonitrile 30.78
    trioctyl phosphate 20.01
    1-bromopropane 15.41
    gamma-valerolactone 271.36
    n-decanol 27.56
    triethyl phosphate 21.05
    4-methyl-2-pentanol 46.62
    propionitrile 99.86
    vinylene carbonate 77.15
    1,1,2-trichlorotrifluoroethane 111.72
    DMS 33.25
    cumene 8.51
    2-octanol 36.46
    2-hexanone 86.58
    octyl acetate 28.17
    limonene 14.72
    1,2-dimethoxyethane 206.89
    ethyl orthosilicate 20.44
    tributyl phosphate 19.0
    diacetone alcohol 115.62
    N,N-dimethylaniline 27.84
    acrylonitrile 111.19
    aniline 32.47
    1,3-propanediol 152.25
    bromobenzene 11.41
    dibromomethane 18.83
    1,1,2,2-tetrachloroethane 48.9
    2-methyl-cyclohexyl acetate 31.33
    tetrabutyl urea 25.67
    diisobutyl methanol 26.05
    2-phenylethanol 51.61
    styrene 7.39
    dioctyl adipate 23.23
    dimethyl sulfate 94.57
    ethyl butyrate 38.0
    methyl lactate 67.88
    butyl lactate 35.34
    diethyl carbonate 23.46
    propanediol butyl ether 61.01
    triethyl orthoformate 26.87
    p-tert-butyltoluene 11.22
    methyl 4-tert-butylbenzoate 46.47
    morpholine 265.41
    tert-butylamine 68.22
    n-dodecanol 20.1
    dimethoxymethane 205.46
    ethylene carbonate 67.51
    cyrene 60.49
    2-ethoxyethyl acetate 48.51
    2-ethylhexyl acetate 29.85
    1,2,4-trichlorobenzene 20.07
    4-methylpyridine 61.24
    dibutyl ether 25.91
    2,6-dimethyl-4-heptanol 26.05
    DEF 96.6
    dimethyl isosorbide 86.89
    tetrachloroethylene 35.33
    eugenol 50.6
    triacetin 35.97
    span 80 53.14
    1,4-butanediol 57.18
    1,1-dichloroethane 42.0
    2-methyl-1-pentanol 60.41
    methyl formate 190.88
    2-methyl-1-butanol 72.54
    n-decane 3.55
    butyronitrile 98.78
    3,7-dimethyl-1-octanol 34.23
    1-chlorooctane 16.22
    1-chlorotetradecane 5.69
    n-nonane 3.34
    undecane 2.61
    tert-butylcyclohexane 3.42
    cyclooctane 0.89
    cyclopentanol 102.79
    tetrahydropyran 161.07
    tert-amyl methyl ether 59.97
    2,5,8-trioxanonane 99.88
    1-hexene 13.99
    2-isopropoxyethanol 93.57
    2,2,2-trifluoroethanol 83.23
    methyl butyrate 69.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction