5-(1-Hydroxyethyl)oxolan-2-one

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  • Identifiers

    CAS number
    27610-27-1

    Molecular formula
    C6H10O3

    SMILES
    CC(C1CCC(=O)O1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Caramellic 54.92%
    Buttery 52.7%
    Creamy 40.07%
    Sweet 39.21%
    Nutty 36.02%
    Milky 34.48%
    Odorless 31.43%
    Lactonic 30.44%
    Fatty 27.49%
    Dairy 27.07%

     

    Flavor
    Sweet 54.21%
    Caramel 44.48%
    Buttery 34.34%
    Fatty 29.42%
    Fruity 29.07%
    Bitter 27.9%
    Odorless 27.29%
    Creamy 26.13%
    Bread 25.66%
    Oily 24.35%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.94 (neutral)

    Molecular weight
    130.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    302°C

    Flash point

    • 111.93 ˚C est.

  • Synonyms

    • 5-(1-hydroxyethyl)oxolan-2-one
    • SOLEROLE
    • 27610-27-1
    • DTXSID40974453
    • RefChem:528996
    • DTXCID101401880
    • 830-829-0
    • Sherry lactone
    • 58957-60-1
    • 4,5-Dihydroxyhexanoic Acid gamma-Lactone; Dihydro-5-(1-hydroxyethyl)-2(3H)-furanone;
    • EINECS 261-520-3
    • 5-Hydroxyhexan-4-olid
    • 5-Hydroxy-4-hexanolide
    • SCHEMBL14233902
    • CHEBI:173518
    • KBLZKAKKJPDYKJ-UHFFFAOYSA-N
    • CBA61027
    • 2,3,6-Trideoxy-1,4-hexonolactone
    • NS00055706
    • EN300-333347
    • (R*,S*)-(1)-Dihydro-5-(1-hydroxyethyl)-3H-furan-2-one
    • 27610-27-1

  • Applications

    5-(1-Hydroxyethyl)oxolan-2-one, CAS 27610-27-1, is primarily employed as an intermediate in organic synthesis for the manufacture of pharmaceuticals and specialty chemicals, and serves as a precursor for certain polymers and resins; it may function as a solvent or processing aid in coatings, inks, and adhesives; it may be evaluated as a lactone-building block for polymerization and could be explored as a fragrance intermediate or in cosmetic formulations; and it may appear in cleaning formulations as a solvent or additive, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 608.22
    methanol 1219.31
    isopropanol 374.25
    water 313.86
    ethyl acetate 83.83
    n-propanol 326.09
    acetone 232.49
    n-butanol 235.11
    acetonitrile 237.22
    DMF 668.52
    toluene 20.52
    isobutanol 206.35
    1,4-dioxane 254.72
    methyl acetate 105.5
    THF 275.69
    2-butanone 98.85
    n-pentanol 155.11
    sec-butanol 193.18
    n-hexane 2.72
    ethylene glycol 406.3
    NMP 272.19
    cyclohexane 2.67
    DMSO 681.6
    n-butyl acetate 49.85
    n-octanol 56.58
    chloroform 160.0
    n-propyl acetate 46.68
    acetic acid 653.04
    dichloromethane 210.68
    cyclohexanone 111.07
    propylene glycol 264.42
    isopropyl acetate 51.33
    DMAc 399.39
    2-ethoxyethanol 390.3
    isopentanol 184.18
    n-heptane 2.65
    ethyl formate 155.0
    1,2-dichloroethane 96.57
    n-hexanol 92.17
    2-methoxyethanol 664.99
    isobutyl acetate 32.54
    tetrachloromethane 19.97
    n-pentyl acetate 38.3
    transcutol 559.63
    n-heptanol 48.21
    ethylbenzene 14.32
    MIBK 67.57
    2-propoxyethanol 236.59
    tert-butanol 323.73
    MTBE 96.76
    2-butoxyethanol 123.64
    propionic acid 220.53
    o-xylene 22.19
    formic acid 993.21
    diethyl ether 66.21
    m-xylene 23.91
    p-xylene 21.34
    chlorobenzene 41.94
    dimethyl carbonate 47.2
    n-octane 2.06
    formamide 771.55
    cyclopentanone 165.71
    2-pentanone 83.97
    anisole 66.1
    cyclopentyl methyl ether 73.67
    gamma-butyrolactone 238.52
    1-methoxy-2-propanol 363.62
    pyridine 110.95
    3-pentanone 39.97
    furfural 286.88
    n-dodecane 2.81
    diethylene glycol 338.98
    diisopropyl ether 19.37
    tert-amyl alcohol 201.22
    acetylacetone 121.38
    n-hexadecane 3.02
    acetophenone 68.0
    methyl propionate 69.89
    isopentyl acetate 50.44
    trichloroethylene 162.8
    n-nonanol 48.08
    cyclohexanol 91.83
    benzyl alcohol 91.81
    2-ethylhexanol 40.91
    isooctanol 38.61
    dipropyl ether 26.18
    1,2-dichlorobenzene 45.07
    ethyl lactate 56.98
    propylene carbonate 119.89
    n-methylformamide 457.42
    2-pentanol 107.92
    n-pentane 3.64
    1-propoxy-2-propanol 118.59
    1-methoxy-2-propyl acetate 74.67
    2-(2-methoxypropoxy) propanol 123.15
    mesitylene 16.71
    ε-caprolactone 109.58
    p-cymene 14.73
    epichlorohydrin 225.01
    1,1,1-trichloroethane 53.23
    2-aminoethanol 484.03
    morpholine-4-carbaldehyde 369.67
    sulfolane 238.01
    2,2,4-trimethylpentane 3.61
    2-methyltetrahydrofuran 131.99
    n-hexyl acetate 60.92
    isooctane 3.28
    2-(2-butoxyethoxy)ethanol 170.97
    sec-butyl acetate 33.04
    tert-butyl acetate 64.74
    decalin 3.54
    glycerin 390.87
    diglyme 282.16
    acrylic acid 234.74
    isopropyl myristate 27.12
    n-butyric acid 213.87
    acetyl acetate 70.39
    di(2-ethylhexyl) phthalate 39.19
    ethyl propionate 39.32
    nitromethane 583.23
    1,2-diethoxyethane 89.42
    benzonitrile 90.03
    trioctyl phosphate 27.68
    1-bromopropane 42.81
    gamma-valerolactone 274.18
    n-decanol 35.89
    triethyl phosphate 28.93
    4-methyl-2-pentanol 68.19
    propionitrile 118.09
    vinylene carbonate 128.37
    1,1,2-trichlorotrifluoroethane 220.8
    DMS 53.89
    cumene 14.55
    2-octanol 32.82
    2-hexanone 52.96
    octyl acetate 35.23
    limonene 18.69
    1,2-dimethoxyethane 340.21
    ethyl orthosilicate 27.46
    tributyl phosphate 32.94
    diacetone alcohol 128.66
    N,N-dimethylaniline 52.2
    acrylonitrile 176.15
    aniline 69.57
    1,3-propanediol 458.98
    bromobenzene 33.02
    dibromomethane 96.15
    1,1,2,2-tetrachloroethane 111.58
    2-methyl-cyclohexyl acetate 37.87
    tetrabutyl urea 44.58
    diisobutyl methanol 27.68
    2-phenylethanol 68.15
    styrene 18.2
    dioctyl adipate 42.64
    dimethyl sulfate 104.13
    ethyl butyrate 37.93
    methyl lactate 93.84
    butyl lactate 48.8
    diethyl carbonate 32.02
    propanediol butyl ether 141.81
    triethyl orthoformate 33.24
    p-tert-butyltoluene 14.7
    methyl 4-tert-butylbenzoate 69.99
    morpholine 283.66
    tert-butylamine 142.23
    n-dodecanol 26.79
    dimethoxymethane 237.08
    ethylene carbonate 96.1
    cyrene 113.8
    2-ethoxyethyl acetate 66.28
    2-ethylhexyl acetate 34.41
    1,2,4-trichlorobenzene 53.11
    4-methylpyridine 113.92
    dibutyl ether 33.34
    2,6-dimethyl-4-heptanol 27.68
    DEF 125.94
    dimethyl isosorbide 146.57
    tetrachloroethylene 82.37
    eugenol 86.11
    triacetin 72.15
    span 80 85.28
    1,4-butanediol 238.0
    1,1-dichloroethane 77.52
    2-methyl-1-pentanol 118.83
    methyl formate 303.51
    2-methyl-1-butanol 158.41
    n-decane 4.17
    butyronitrile 129.97
    3,7-dimethyl-1-octanol 53.47
    1-chlorooctane 17.76
    1-chlorotetradecane 8.4
    n-nonane 3.67
    undecane 3.29
    tert-butylcyclohexane 4.04
    cyclooctane 1.63
    cyclopentanol 134.48
    tetrahydropyran 96.49
    tert-amyl methyl ether 64.92
    2,5,8-trioxanonane 207.4
    1-hexene 14.07
    2-isopropoxyethanol 198.27
    2,2,2-trifluoroethanol 245.74
    methyl butyrate 63.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction