4H-1,3,5-Dithiazine, dihydro-2,4,5,6-tetramethyl-

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  • Identifiers

    CAS number
    37434-57-4

    Molecular formula
    C7H15NS2

    SMILES
    CC1N(C(SC(S1)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Meaty 81.35%
    Roasted 72.66%
    Nutty 63.11%
    Sulfurous 56.92%
    Beefy 50.21%
    Cooked 46.76%
    Savory 38.43%
    Onion 37.96%
    Cocoa 34.11%
    Burnt 33.06%

     

    Flavor
    Sulfurous 48.14%
    Roasted 41.79%
    Meaty 35.45%
    Vegetable 31.09%
    Green 28.22%
    Cocoa 25.55%
    Onion 24.71%
    Sulfury 24.42%
    Alliaceous 24.19%
    Bouillon 23.18%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    4.85 (weak acid)

    Molecular weight
    177.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    226°C

    Flash point

    • 82.82 ˚C est.

  • Synonyms

    • 37434-57-4
    • 4H-1,3,5-Dithiazine, dihydro-2,4,5,6-tetramethyl-
    • DTXSID40885676
    • RefChem:527305
    • DTXCID801025041
    • 1,2,4,6-Tetramethylthialdine
    • 2,4,5,6-tetramethyl-1,3,5-dithiazinane
    • Dihydro-2,4,5,6-tetramethyl-4H-1,3,5-dithiazine
    • SCHEMBL11821311
    • AZHPCHPZVNDJKI-UHFFFAOYSA-N
    • DB-286745
    • 37434-57-4

  • Applications

    4H-1,3,5-Dithiazine, dihydro-2,4,5,6-tetramethyl- (CAS 37434-57-4) is primarily used as a synthetic building block in organic chemistry, often as an intermediate for constructing heterocyclic frameworks. In practice, it is commonly evaluated as a precursor in pharmaceutical and agrochemical development. It also serves as a starting material or functional component in specialty polymers and materials, where the heterocyclic core supports incorporation of ligands or other active groups. Additionally, the compound is studied for potential use in catalysis or polymerization as a ligand or reactive modifier, and in research contexts as a scaffold for advanced electronic materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 168.78
    methanol 217.05
    isopropanol 122.98
    water 11.03
    ethyl acetate 293.71
    n-propanol 153.96
    acetone 301.12
    n-butanol 136.09
    acetonitrile 241.84
    DMF 319.9
    toluene 206.43
    isobutanol 111.9
    1,4-dioxane 490.54
    methyl acetate 282.36
    THF 600.51
    2-butanone 265.0
    n-pentanol 87.89
    sec-butanol 118.52
    n-hexane 12.27
    ethylene glycol 83.09
    NMP 515.05
    cyclohexane 48.16
    DMSO 379.1
    n-butyl acetate 257.4
    n-octanol 94.99
    chloroform 842.47
    n-propyl acetate 153.71
    acetic acid 315.99
    dichloromethane 652.22
    cyclohexanone 504.38
    propylene glycol 90.79
    isopropyl acetate 174.97
    DMAc 307.6
    2-ethoxyethanol 187.22
    isopentanol 102.0
    n-heptane 28.32
    ethyl formate 218.3
    1,2-dichloroethane 340.74
    n-hexanol 154.72
    2-methoxyethanol 299.61
    isobutyl acetate 110.87
    tetrachloromethane 255.49
    n-pentyl acetate 175.36
    transcutol 386.75
    n-heptanol 102.57
    ethylbenzene 74.49
    MIBK 131.84
    2-propoxyethanol 291.62
    tert-butanol 148.87
    MTBE 141.2
    2-butoxyethanol 179.09
    propionic acid 214.46
    o-xylene 142.31
    formic acid 136.66
    diethyl ether 166.77
    m-xylene 143.09
    p-xylene 101.61
    chlorobenzene 334.38
    dimethyl carbonate 118.4
    n-octane 13.92
    formamide 164.41
    cyclopentanone 590.67
    2-pentanone 210.52
    anisole 180.82
    cyclopentyl methyl ether 298.14
    gamma-butyrolactone 689.95
    1-methoxy-2-propanol 217.43
    pyridine 397.34
    3-pentanone 199.35
    furfural 665.76
    n-dodecane 12.56
    diethylene glycol 250.12
    diisopropyl ether 70.99
    tert-amyl alcohol 130.41
    acetylacetone 295.32
    n-hexadecane 14.88
    acetophenone 189.96
    methyl propionate 219.69
    isopentyl acetate 218.46
    trichloroethylene 724.79
    n-nonanol 86.47
    cyclohexanol 202.46
    benzyl alcohol 148.91
    2-ethylhexanol 113.5
    isooctanol 85.44
    dipropyl ether 142.84
    1,2-dichlorobenzene 323.0
    ethyl lactate 99.71
    propylene carbonate 390.37
    n-methylformamide 228.39
    2-pentanol 95.04
    n-pentane 19.78
    1-propoxy-2-propanol 225.16
    1-methoxy-2-propyl acetate 259.97
    2-(2-methoxypropoxy) propanol 161.29
    mesitylene 99.24
    ε-caprolactone 433.37
    p-cymene 94.59
    epichlorohydrin 559.74
    1,1,1-trichloroethane 523.31
    2-aminoethanol 118.81
    morpholine-4-carbaldehyde 474.78
    sulfolane 764.88
    2,2,4-trimethylpentane 17.99
    2-methyltetrahydrofuran 420.33
    n-hexyl acetate 203.64
    isooctane 13.26
    2-(2-butoxyethoxy)ethanol 190.7
    sec-butyl acetate 112.46
    tert-butyl acetate 188.89
    decalin 25.15
    glycerin 154.69
    diglyme 343.5
    acrylic acid 218.79
    isopropyl myristate 95.67
    n-butyric acid 272.02
    acetyl acetate 262.37
    di(2-ethylhexyl) phthalate 98.74
    ethyl propionate 137.06
    nitromethane 517.32
    1,2-diethoxyethane 195.17
    benzonitrile 248.96
    trioctyl phosphate 76.76
    1-bromopropane 186.09
    gamma-valerolactone 740.97
    n-decanol 66.37
    triethyl phosphate 116.41
    4-methyl-2-pentanol 65.07
    propionitrile 190.4
    vinylene carbonate 405.97
    1,1,2-trichlorotrifluoroethane 408.24
    DMS 179.22
    cumene 61.24
    2-octanol 72.98
    2-hexanone 137.86
    octyl acetate 119.61
    limonene 132.98
    1,2-dimethoxyethane 246.25
    ethyl orthosilicate 109.92
    tributyl phosphate 89.79
    diacetone alcohol 178.67
    N,N-dimethylaniline 119.1
    acrylonitrile 234.57
    aniline 234.61
    1,3-propanediol 157.06
    bromobenzene 340.16
    dibromomethane 417.25
    1,1,2,2-tetrachloroethane 531.96
    2-methyl-cyclohexyl acetate 169.61
    tetrabutyl urea 105.83
    diisobutyl methanol 82.09
    2-phenylethanol 179.47
    styrene 100.08
    dioctyl adipate 130.08
    dimethyl sulfate 209.51
    ethyl butyrate 183.81
    methyl lactate 143.22
    butyl lactate 136.13
    diethyl carbonate 138.51
    propanediol butyl ether 144.3
    triethyl orthoformate 154.29
    p-tert-butyltoluene 97.89
    methyl 4-tert-butylbenzoate 189.1
    morpholine 407.81
    tert-butylamine 90.95
    n-dodecanol 53.87
    dimethoxymethane 228.55
    ethylene carbonate 340.59
    cyrene 201.93
    2-ethoxyethyl acetate 236.96
    2-ethylhexyl acetate 200.96
    1,2,4-trichlorobenzene 388.25
    4-methylpyridine 374.93
    dibutyl ether 104.02
    2,6-dimethyl-4-heptanol 82.09
    DEF 229.57
    dimethyl isosorbide 320.85
    tetrachloroethylene 397.34
    eugenol 170.22
    triacetin 210.42
    span 80 161.36
    1,4-butanediol 74.98
    1,1-dichloroethane 380.54
    2-methyl-1-pentanol 78.68
    methyl formate 224.4
    2-methyl-1-butanol 107.01
    n-decane 21.06
    butyronitrile 179.17
    3,7-dimethyl-1-octanol 93.01
    1-chlorooctane 84.6
    1-chlorotetradecane 38.69
    n-nonane 19.77
    undecane 15.66
    tert-butylcyclohexane 23.64
    cyclooctane 22.63
    cyclopentanol 230.88
    tetrahydropyran 354.77
    tert-amyl methyl ether 131.16
    2,5,8-trioxanonane 258.67
    1-hexene 40.91
    2-isopropoxyethanol 134.65
    2,2,2-trifluoroethanol 204.79
    methyl butyrate 167.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction