4,8-Dimethylquinoline

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  • Identifiers

    CAS number
    13362-80-6

    Molecular formula
    C11H11N

    SMILES
    CC1=C2C(=CC=C1)C(=CC=N2)C

    Safety labels

  • Odor profile

    Fragrance
    Animal 61.99%
    Floral 51.42%
    Sweet 51.24%
    Leathery 49.98%
    Tobacco 49.29%
    Earthy 48.32%
    Herbal 42.63%
    Nutty 42.17%
    Musty 41.47%
    Green 40.97%

     

    Flavor
    Nutty 32.9%
    Fecal 31.84%
    Leather 29.7%
    Tobacco 29.33%
    Roasted 29.12%
    Phenolic 29.01%
    Coffee 28.97%
    Bitter 28.84%
    Musty 28.72%
    Medicinal 27.78%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    4.78 (weak acid)

    Molecular weight
    157.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    276°C

    Flash point

    • 112.31 ˚C est.

  • Synonyms

    • 4,8-Dimethylquinoline
    • 13362-80-6
    • Quinoline, 4,8-dimethyl-
    • 90Z5HA71DP
    • DTXSID60928211
    • RefChem:1069596
    • DTXCID301356982
    • Quinoline, dimethyl-
    • 28351-04-4
    • UNII-90Z5HA71DP
    • 4,8-dimethyl-quinoline
    • 4,8-Dimethylquinoline #
    • SCHEMBL2607397
    • SCHEMBL3861841
    • AKOS006370715
    • SB68007
    • Q27271353
    • 13362-80-6

  • Applications

    4,8-Dimethylquinoline (CAS 13362-80-6) is used as an organic synthesis intermediate, providing a quinoline scaffold for downstream building blocks. It is commonly evaluated as a precursor for the production of dyes and pigments and as a starting material for pharmaceutical and agrochemical candidates. It can also serve as a ligand framework or catalyst modifier in synthetic chemistry, and is explored as a building block for materials in organic electronics, including luminescent or charge-transport applications. In polymer chemistry, it may be used to introduce quinoline functionalities into specialty polymers, with use governed by formulation requirements and regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 143.13
    methanol 99.95
    isopropanol 134.74
    water 0.48
    ethyl acetate 545.09
    n-propanol 168.05
    acetone 597.66
    n-butanol 174.03
    acetonitrile 430.1
    DMF 628.86
    toluene 446.19
    isobutanol 152.7
    1,4-dioxane 1558.88
    methyl acetate 486.79
    THF 1488.67
    2-butanone 537.83
    n-pentanol 185.29
    sec-butanol 148.97
    n-hexane 164.86
    ethylene glycol 20.85
    NMP 544.11
    cyclohexane 140.77
    DMSO 515.08
    n-butyl acetate 801.79
    n-octanol 184.21
    chloroform 1247.54
    n-propyl acetate 528.18
    acetic acid 146.23
    dichloromethane 1614.56
    cyclohexanone 885.31
    propylene glycol 17.8
    isopropyl acetate 331.55
    DMAc 352.28
    2-ethoxyethanol 254.73
    isopentanol 173.25
    n-heptane 126.32
    ethyl formate 334.6
    1,2-dichloroethane 1307.26
    n-hexanol 318.05
    2-methoxyethanol 273.3
    isobutyl acetate 377.25
    tetrachloromethane 298.6
    n-pentyl acetate 391.13
    transcutol 681.89
    n-heptanol 183.3
    ethylbenzene 308.91
    MIBK 327.14
    2-propoxyethanol 440.51
    tert-butanol 193.96
    MTBE 358.26
    2-butoxyethanol 264.79
    propionic acid 149.7
    o-xylene 258.99
    formic acid 28.43
    diethyl ether 689.01
    m-xylene 314.1
    p-xylene 386.11
    chlorobenzene 491.03
    dimethyl carbonate 219.68
    n-octane 77.26
    formamide 71.69
    cyclopentanone 1080.92
    2-pentanone 495.7
    anisole 419.77
    cyclopentyl methyl ether 777.81
    gamma-butyrolactone 1118.11
    1-methoxy-2-propanol 217.25
    pyridine 830.56
    3-pentanone 462.62
    furfural 638.62
    n-dodecane 43.95
    diethylene glycol 188.11
    diisopropyl ether 213.31
    tert-amyl alcohol 177.58
    acetylacetone 502.42
    n-hexadecane 52.55
    acetophenone 350.23
    methyl propionate 428.62
    isopentyl acetate 537.53
    trichloroethylene 1697.86
    n-nonanol 159.33
    cyclohexanol 224.65
    benzyl alcohol 216.71
    2-ethylhexanol 250.25
    isooctanol 157.73
    dipropyl ether 512.59
    1,2-dichlorobenzene 398.64
    ethyl lactate 131.35
    propylene carbonate 512.19
    n-methylformamide 264.04
    2-pentanol 153.49
    n-pentane 92.75
    1-propoxy-2-propanol 308.59
    1-methoxy-2-propyl acetate 403.46
    2-(2-methoxypropoxy) propanol 184.07
    mesitylene 203.72
    ε-caprolactone 692.0
    p-cymene 178.16
    epichlorohydrin 1381.2
    1,1,1-trichloroethane 868.95
    2-aminoethanol 44.27
    morpholine-4-carbaldehyde 719.58
    sulfolane 899.36
    2,2,4-trimethylpentane 47.69
    2-methyltetrahydrofuran 992.31
    n-hexyl acetate 461.73
    isooctane 45.48
    2-(2-butoxyethoxy)ethanol 284.38
    sec-butyl acetate 311.36
    tert-butyl acetate 346.0
    decalin 97.66
    glycerin 32.97
    diglyme 625.23
    acrylic acid 124.45
    isopropyl myristate 181.09
    n-butyric acid 239.16
    acetyl acetate 276.17
    di(2-ethylhexyl) phthalate 119.53
    ethyl propionate 412.71
    nitromethane 470.93
    1,2-diethoxyethane 606.86
    benzonitrile 363.53
    trioctyl phosphate 105.15
    1-bromopropane 668.27
    gamma-valerolactone 1068.64
    n-decanol 128.28
    triethyl phosphate 158.78
    4-methyl-2-pentanol 107.72
    propionitrile 367.79
    vinylene carbonate 470.98
    1,1,2-trichlorotrifluoroethane 342.36
    DMS 373.4
    cumene 206.84
    2-octanol 153.75
    2-hexanone 526.52
    octyl acetate 219.18
    limonene 239.69
    1,2-dimethoxyethane 843.14
    ethyl orthosilicate 157.21
    tributyl phosphate 136.16
    diacetone alcohol 249.18
    N,N-dimethylaniline 279.26
    acrylonitrile 395.86
    aniline 266.94
    1,3-propanediol 94.7
    bromobenzene 603.96
    dibromomethane 1100.44
    1,1,2,2-tetrachloroethane 1049.73
    2-methyl-cyclohexyl acetate 273.25
    tetrabutyl urea 176.17
    diisobutyl methanol 143.35
    2-phenylethanol 273.51
    styrene 334.0
    dioctyl adipate 197.93
    dimethyl sulfate 283.42
    ethyl butyrate 431.35
    methyl lactate 95.71
    butyl lactate 172.98
    diethyl carbonate 246.83
    propanediol butyl ether 148.95
    triethyl orthoformate 242.13
    p-tert-butyltoluene 168.45
    methyl 4-tert-butylbenzoate 238.54
    morpholine 1003.67
    tert-butylamine 153.01
    n-dodecanol 104.14
    dimethoxymethane 621.68
    ethylene carbonate 460.67
    cyrene 195.22
    2-ethoxyethyl acetate 428.32
    2-ethylhexyl acetate 494.28
    1,2,4-trichlorobenzene 407.94
    4-methylpyridine 749.21
    dibutyl ether 415.06
    2,6-dimethyl-4-heptanol 143.35
    DEF 530.03
    dimethyl isosorbide 401.99
    tetrachloroethylene 768.49
    eugenol 222.26
    triacetin 263.58
    span 80 158.33
    1,4-butanediol 56.81
    1,1-dichloroethane 856.76
    2-methyl-1-pentanol 175.54
    methyl formate 282.91
    2-methyl-1-butanol 169.55
    n-decane 77.8
    butyronitrile 377.98
    3,7-dimethyl-1-octanol 151.56
    1-chlorooctane 254.44
    1-chlorotetradecane 95.9
    n-nonane 85.27
    undecane 57.61
    tert-butylcyclohexane 95.67
    cyclooctane 71.09
    cyclopentanol 256.93
    tetrahydropyran 1092.0
    tert-amyl methyl ether 292.67
    2,5,8-trioxanonane 347.96
    1-hexene 391.62
    2-isopropoxyethanol 229.15
    2,2,2-trifluoroethanol 79.01
    methyl butyrate 526.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction