4,4'-Methylenebis(2,6-di-tert-butylphenol)

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  • Identifiers

    CAS number
    118-82-1

    Molecular formula
    C29H44O2

    SMILES
    CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 48.95%
    Phenolic 44.29%
    Leathery 42.5%
    Dry 38.59%
    Musk 34.4%
    Vetiver 30.73%
    Animal 30.16%
    Camphoreous 29.86%
    Amber 29.56%
    Burnt 29.12%

     

    Flavor
    Phenolic 43.74%
    Camphor 42.67%
    Musty 36.99%
    Mild 33.19%
    Woody 26.4%
    Leather 23.99%
    Creosote 22.51%
    Medicinal 22.13%
    Thymol 21.98%
    Green pepper 21.53%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.8

    pKa est.
    7.01 (neutral)

    Molecular weight
    424.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    537°C

    Flash point

    • 191.04 ˚C est.

  • Synonyms

    • 118-82-1
    • 4,4'-METHYLENEBIS(2,6-DI-TERT-BUTYLPHENOL)
    • Ionox 220
    • Binox M
    • Antioxidant E 702
    • Ethyl 702
    • 4,4'-Methylenebis(2,6-di-t-butylphenol)
    • MB 1 (Antioxidant)
    • Ionox 220 antioxidant
    • LZ-MB 1
    • Etil 702
    • L 3MB1
    • E 702
    • Phenol, 4,4'-methylenebis[2,6-bis(1,1-dimethylethyl)-
    • Phenol, 4,4'-methylenebis(2,6-di-tert-butyl-
    • DTXSID7022411
    • VANLUBE DTB
    • Phenol, 4,4'-methylenebis(2,6-bis(1,1-dimethylethyl)-
    • NSC-30551
    • AGIDOL 23
    • ETHANOX 702
    • ETHANOX 4702
    • ETHYL 728
    • DTXCID702411
    • HITEC 4702
    • 37N5K66648
    • Phenol, 4,4'-methylenebis[2,6-di-tert-butyl-
    • H 301/92
    • 204-279-1
    • 4,4'-Methylenebis[2,6-Di-tert-butylphenol]
    • RefChem:506790
    • Bimox M
    • ANTIOXIDANT 702
    • 2,2',6,6'-Tetra-tert-butyl-4,4'-methylenediphenol
    • MFCD00008822
    • NSC 30551
    • Di(4-hydroxy-3,5-di-tert-butylphenyl)methane
    • 2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]phenol
    • 4,4-methylenebis(2,6-di-tert-butylphenol)
    • Bis(3,5-di-tert-butyl-4-hydroxyphenyl)methane
    • 3,3',5,5'-Tetra-tert-butyl-4,4'-dihydroxydiphenylmethane
    • 4,4'-methanediylbis(2,6-di-tert-butylphenol)
    • CAS-118-82-1
    • MB 1 (antioxidant) (VAN)
    • CCRIS 5836
    • ANTIOXIDANT 728
    • EINECS 204-279-1
    • BRN 1916919
    • 2,6-bis(tert-butyl)-4-{[3,5-bis(tert-butyl)-4-hydroxyphenyl]methyl}phenol
    • Binox-M
    • UNII-37N5K66648
    • bis-BHT
    • 4,4'-Methylenebis(2,6-bis(1,1-dimethylethyl)phenol)
    • ANTIOXIDANT 4426
    • EC 204-279-1
    • ANTIOXIDANT T 511
    • SCHEMBL39559
    • 4-06-00-06811 (Beilstein Handbook Reference)
    • BIDD:ER0322
    • orb1987312
    • SCHEMBL8514613
    • CHEMBL1795577
    • SCHEMBL14472045
    • CHEBI:34369
    • MDWVSAYEQPLWMX-UHFFFAOYSA-
    • MSK3124
    • BP_22
    • NSC30551
    • Tox21_201863
    • Tox21_303566
    • 2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxy-phenyl)methyl]phenol
    • SBB007948
    • STK709201
    • AKOS001063755
    • NCGC00249128-01
    • NCGC00249128-02
    • NCGC00257323-01
    • NCGC00259412-01
    • 2,2',6,6'-Tetra-tert-butylbisphenol F
    • AS-15298
    • ST029303
    • DB-041427
    • 4,4'-methyl enebis(2,6-di-t-butylphenol)
    • 4,4'-methylene-bis(2,6-di-t-butylphenol)
    • M0214
    • NS00001137
    • Phenol,4'-methylenebis[2,6-di-tert-butyl-
    • Di(3,5-di-tert-butyl-4-hydroxyphenyl)methane
    • 4,4'-methylene bis(2,6-di-tert-butylphenol)
    • 4,4'-methylene-bis(2,6-di-tert-butylphenol)
    • 4,4'-methylenebis (2,6-di-tert-butylphenol)
    • 4,4\'-Methylenebis(2,6-di-tert-butylphenol)
    • Bis(4-hydroxy-3,5-di-tert-butylphenyl)methane
    • F71321
    • 4,4'-methylene bis(2,6-di-tert-butyl phenol)
    • AB01317498-02
    • 4,4'-Methylenebis(2,6-di-tert-butylphenol), 98%
    • Phenol,4'-methylenebis[2,6-bis(1,1-dimethylethyl)-
    • Q27116023
    • Z56888647
    • 4,4'-Dihydroxy,3,3'-5,5'-tetra-t-butyldiphenylmethane
    • 4,4'-methanediylbis[2,6-bis(1,1-dimethylethyl)phenol]
    • 4,4'-Dihydroxy-3,3',5,5'-tetra-tert-butyldiphenylmethane
    • 4,4'-Dihydroxy-3,5,3',5'-tetra-tert-butyldiphenylmethane
    • Phenol, 4,4'-methylenebis 2,6-bis(1,1-dimethylethyl)-
    • 4-(3,5-di-tert-butyl-4-hydroxy-benzyl)-2,6-di-tert-butylphenol
    • 4 pound not4 inverted exclamation marka-Methylenebis(2 pound not6-di-tert-butylphenol)
    • InChI=1/C29H44O2/c1-26(2,3)20-14-18(15-21(24(20)30)27(4,5)6)13-19-16-22(28(7,8)9)25(31)23(17-19)29(10,11)12/h14-17,30-31H,13H2,1-12H3
    • 118-82-1

  • Applications

    4,4'-Methylenebis(2,6-di-tert-butylphenol) (CAS 118-82-1) is a hindered phenol antioxidant used primarily as a polymer stabilizer to prevent thermal-oxidative degradation in polyolefins and other plastics during processing and in service. It is commonly employed as a primary antioxidant in plastic formulations, often alongside phosphite stabilizers; it also serves as an antioxidant additive in lubricating oils and hydraulic fluids to extend oil life. In coatings and inks, it acts as a stabilizer against aging and yellowing, and it is used in rubber compounds to improve aging resistance. It may also be used as an antioxidant stabilizer in adhesive formulations to improve shelf life of the finished products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 74.01
    methanol 26.4
    isopropanol 84.04
    water 0.04
    ethyl acetate 132.72
    n-propanol 112.25
    acetone 150.51
    n-butanol 112.28
    acetonitrile 48.49
    DMF 238.72
    toluene 161.41
    isobutanol 103.2
    1,4-dioxane 230.07
    methyl acetate 104.25
    THF 753.47
    2-butanone 210.51
    n-pentanol 124.45
    sec-butanol 127.56
    n-hexane 55.49
    ethylene glycol 6.18
    NMP 360.14
    cyclohexane 34.24
    DMSO 133.66
    n-butyl acetate 190.17
    n-octanol 106.27
    chloroform 331.22
    n-propyl acetate 143.33
    acetic acid 55.48
    dichloromethane 221.55
    cyclohexanone 312.47
    propylene glycol 29.86
    isopropyl acetate 120.67
    DMAc 282.6
    2-ethoxyethanol 117.23
    isopentanol 99.07
    n-heptane 42.78
    ethyl formate 82.61
    1,2-dichloroethane 146.07
    n-hexanol 149.3
    2-methoxyethanol 116.55
    isobutyl acetate 141.51
    tetrachloromethane 48.45
    n-pentyl acetate 196.61
    transcutol 175.32
    n-heptanol 124.65
    ethylbenzene 114.58
    MIBK 140.36
    2-propoxyethanol 202.64
    tert-butanol 97.32
    MTBE 159.91
    2-butoxyethanol 184.66
    propionic acid 67.48
    o-xylene 92.17
    formic acid 10.53
    diethyl ether 145.97
    m-xylene 118.11
    p-xylene 146.42
    chlorobenzene 161.99
    dimethyl carbonate 63.09
    n-octane 22.7
    formamide 20.38
    cyclopentanone 451.08
    2-pentanone 193.74
    anisole 153.68
    cyclopentyl methyl ether 309.88
    gamma-butyrolactone 354.85
    1-methoxy-2-propanol 153.16
    pyridine 259.93
    3-pentanone 145.72
    furfural 226.28
    n-dodecane 11.84
    diethylene glycol 61.78
    diisopropyl ether 71.42
    tert-amyl alcohol 123.26
    acetylacetone 172.73
    n-hexadecane 13.54
    acetophenone 147.43
    methyl propionate 130.34
    isopentyl acetate 193.36
    trichloroethylene 308.48
    n-nonanol 106.66
    cyclohexanol 121.08
    benzyl alcohol 97.65
    2-ethylhexanol 127.39
    isooctanol 116.07
    dipropyl ether 169.73
    1,2-dichlorobenzene 136.1
    ethyl lactate 74.17
    propylene carbonate 196.07
    n-methylformamide 77.89
    2-pentanol 109.5
    n-pentane 36.9
    1-propoxy-2-propanol 198.66
    1-methoxy-2-propyl acetate 185.14
    2-(2-methoxypropoxy) propanol 130.2
    mesitylene 69.78
    ε-caprolactone 268.89
    p-cymene 80.47
    epichlorohydrin 383.2
    1,1,1-trichloroethane 190.44
    2-aminoethanol 31.09
    morpholine-4-carbaldehyde 267.0
    sulfolane 393.4
    2,2,4-trimethylpentane 23.65
    2-methyltetrahydrofuran 418.54
    n-hexyl acetate 224.36
    isooctane 17.18
    2-(2-butoxyethoxy)ethanol 159.46
    sec-butyl acetate 122.52
    tert-butyl acetate 155.29
    decalin 34.15
    glycerin 30.09
    diglyme 252.33
    acrylic acid 49.9
    isopropyl myristate 100.56
    n-butyric acid 119.69
    acetyl acetate 73.1
    di(2-ethylhexyl) phthalate 84.11
    ethyl propionate 127.64
    nitromethane 102.74
    1,2-diethoxyethane 150.82
    benzonitrile 102.23
    trioctyl phosphate 74.69
    1-bromopropane 164.13
    gamma-valerolactone 446.5
    n-decanol 75.6
    triethyl phosphate 78.26
    4-methyl-2-pentanol 73.67
    propionitrile 76.87
    vinylene carbonate 149.54
    1,1,2-trichlorotrifluoroethane 164.19
    DMS 110.91
    cumene 82.22
    2-octanol 111.34
    2-hexanone 195.74
    octyl acetate 125.32
    limonene 108.07
    1,2-dimethoxyethane 238.76
    ethyl orthosilicate 84.93
    tributyl phosphate 73.49
    diacetone alcohol 147.33
    N,N-dimethylaniline 140.79
    acrylonitrile 75.87
    aniline 111.94
    1,3-propanediol 51.8
    bromobenzene 180.04
    dibromomethane 175.76
    1,1,2,2-tetrachloroethane 277.24
    2-methyl-cyclohexyl acetate 157.78
    tetrabutyl urea 113.41
    diisobutyl methanol 72.18
    2-phenylethanol 140.72
    styrene 107.96
    dioctyl adipate 119.26
    dimethyl sulfate 107.1
    ethyl butyrate 149.67
    methyl lactate 70.84
    butyl lactate 145.44
    diethyl carbonate 78.85
    propanediol butyl ether 129.76
    triethyl orthoformate 133.68
    p-tert-butyltoluene 81.5
    methyl 4-tert-butylbenzoate 179.86
    morpholine 296.11
    tert-butylamine 70.83
    n-dodecanol 53.45
    dimethoxymethane 184.49
    ethylene carbonate 121.71
    cyrene 166.23
    2-ethoxyethyl acetate 177.97
    2-ethylhexyl acetate 181.13
    1,2,4-trichlorobenzene 157.43
    4-methylpyridine 272.38
    dibutyl ether 136.17
    2,6-dimethyl-4-heptanol 72.18
    DEF 192.35
    dimethyl isosorbide 265.02
    tetrachloroethylene 132.0
    eugenol 150.49
    triacetin 148.56
    span 80 146.26
    1,4-butanediol 31.54
    1,1-dichloroethane 179.36
    2-methyl-1-pentanol 118.68
    methyl formate 64.54
    2-methyl-1-butanol 121.98
    n-decane 26.53
    butyronitrile 106.15
    3,7-dimethyl-1-octanol 93.56
    1-chlorooctane 93.14
    1-chlorotetradecane 32.28
    n-nonane 26.04
    undecane 16.87
    tert-butylcyclohexane 35.98
    cyclooctane 19.77
    cyclopentanol 155.38
    tetrahydropyran 325.05
    tert-amyl methyl ether 155.96
    2,5,8-trioxanonane 163.84
    1-hexene 141.85
    2-isopropoxyethanol 113.11
    2,2,2-trifluoroethanol 20.99
    methyl butyrate 163.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction