4,4-Dimethyl oxazolidine

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  • Identifiers

    CAS number
    51200-87-4

    Molecular formula
    C5H11NO

    SMILES
    CC1(COCN1)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 35.19%
    Fishy 34.54%
    Sweet 33.75%
    Roasted 32.1%
    Musty 32.05%
    Mint 31.6%
    Earthy 30.42%
    Woody 27.45%
    Cooling 26.06%
    Meaty 24.54%

     

    Flavor
    Green 41.41%
    Earthy 36.57%
    Vegetable 28.56%
    Roasted 28.39%
    Minty 28.15%
    Herbal 28.05%
    Musty 26.57%
    Spicy 25.43%
    Earth 24.95%
    Caramel 24.24%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.27 (neutral)

    Molecular weight
    101.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point

    • 100.9 °C

    Flash point

    • 36.68 ˚C est.
    • 49 °C (120 °F) - closed cup

    Solubility expt.

    • Miscible with water in all proportions
    • Miscible with methanol, ethanol, propanol and acetone

  • Synonyms

    • 4,4-DIMETHYLOXAZOLIDINE
    • 51200-87-4
    • 4,4-Dimethyl-1,3-oxazolidine
    • Oxazolidine A
    • Dimethyl oxazolidine
    • Oxadine A
    • Oxazolidine, 4,4-dimethyl-
    • Oxaban A
    • Zoldine ZA
    • Nuosept 101
    • Caswell No. 374AB
    • Oxaban-A
    • 4,4-dimethyl oxazolidine
    • Truptan OX-I
    • Nuosept 166
    • Nuospet 101
    • EINECS 257-048-2
    • EPA Pesticide Chemical Code 114801
    • UNII-96J42P99ZA
    • BRN 0969276
    • CCRIS 9305
    • DTXSID0032314
    • TRUPTAN OX
    • 96J42P99ZA
    • DTXCID8012314
    • HSDB 8295
    • 4,4-dimethyl-1-oxa-3-azacyclopentane
    • RefChem:507364
    • Oxazolidine, 4,4dimethyl
    • 4,4Dimethyl1,3oxazolidine
    • DIMETHYL OXAZOLIDINE [INCI]
    • 257-048-2
    • Dimethyloxazolidine
    • MFCD00154171
    • Oxazolidine,4,4-dimethyl-
    • 4,4-dimethyl-oxazolidine
    • Cosan 101 (Salt/Mix)
    • SCHEMBL113032
    • SCHEMBL449273
    • SCHEMBL5891845
    • Amine CS-1135 (Salt/Mix)
    • CHEMBL3560963
    • Bioban CS-1135 (Salt/Mix)
    • STR04936
    • Tox21_303770
    • MSK161249
    • SBB059841
    • AKOS006229298
    • FD10630
    • SB74496
    • NCGC00357063-01
    • SY122482
    • CAS-51200-87-4
    • DB-008361
    • NS00010285
    • ST50411180
    • EN300-199741
    • 200D874
    • F860002
    • Q16801494
    • F0001-1335
    • InChI=1/C5H11NO/c1-5(2)3-7-4-6-5/h6H,3-4H2,1-2H
    • 51200-87-4

  • Applications

    4,4-Dimethyl oxazolidine (CAS 51200-87-4) is primarily used as an intermediate in the synthesis of specialty chemicals and as a building block for advanced polymer and coating formulations. In epoxy systems, it is commonly treated as a latent curing-agent precursor, enabling controlled cure initiation and improved adhesion in coatings and adhesives. It can also serve as a processing additive or co-solvent in certain industrial formulations, depending on formulation needs. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 681.81
    methanol 1046.81
    isopropanol 406.8
    water 766.77
    ethyl acetate 213.08
    n-propanol 452.38
    acetone 228.67
    n-butanol 354.35
    acetonitrile 289.56
    DMF 467.22
    toluene 44.78
    isobutanol 269.92
    1,4-dioxane 230.32
    methyl acetate 237.06
    THF 288.82
    2-butanone 186.91
    n-pentanol 158.41
    sec-butanol 314.17
    n-hexane 10.64
    ethylene glycol 506.46
    NMP 356.68
    cyclohexane 16.18
    DMSO 233.36
    n-butyl acetate 83.5
    n-octanol 97.06
    chloroform 628.37
    n-propyl acetate 73.56
    acetic acid 1169.41
    dichloromethane 364.98
    cyclohexanone 166.15
    propylene glycol 566.22
    isopropyl acetate 102.39
    DMAc 426.12
    2-ethoxyethanol 301.01
    isopentanol 192.45
    n-heptane 15.97
    ethyl formate 206.99
    1,2-dichloroethane 133.64
    n-hexanol 172.37
    2-methoxyethanol 649.38
    isobutyl acetate 43.9
    tetrachloromethane 154.35
    n-pentyl acetate 66.32
    transcutol 430.85
    n-heptanol 124.32
    ethylbenzene 18.31
    MIBK 70.2
    2-propoxyethanol 310.91
    tert-butanol 295.05
    MTBE 120.65
    2-butoxyethanol 229.25
    propionic acid 557.09
    o-xylene 40.39
    formic acid 1168.91
    diethyl ether 125.01
    m-xylene 39.97
    p-xylene 29.24
    chlorobenzene 75.67
    dimethyl carbonate 101.09
    n-octane 7.3
    formamide 797.59
    cyclopentanone 233.61
    2-pentanone 131.96
    anisole 63.48
    cyclopentyl methyl ether 137.77
    gamma-butyrolactone 321.4
    1-methoxy-2-propanol 404.24
    pyridine 186.56
    3-pentanone 109.81
    furfural 314.48
    n-dodecane 6.01
    diethylene glycol 327.63
    diisopropyl ether 34.61
    tert-amyl alcohol 245.92
    acetylacetone 122.07
    n-hexadecane 6.18
    acetophenone 65.46
    methyl propionate 193.48
    isopentyl acetate 64.78
    trichloroethylene 324.19
    n-nonanol 83.84
    cyclohexanol 182.96
    benzyl alcohol 98.83
    2-ethylhexanol 82.24
    isooctanol 80.18
    dipropyl ether 60.92
    1,2-dichlorobenzene 75.7
    ethyl lactate 86.42
    propylene carbonate 194.28
    n-methylformamide 501.79
    2-pentanol 195.56
    n-pentane 20.79
    1-propoxy-2-propanol 204.14
    1-methoxy-2-propyl acetate 105.37
    2-(2-methoxypropoxy) propanol 126.12
    mesitylene 23.8
    ε-caprolactone 184.1
    p-cymene 26.06
    epichlorohydrin 239.73
    1,1,1-trichloroethane 188.55
    2-aminoethanol 731.84
    morpholine-4-carbaldehyde 345.65
    sulfolane 234.07
    2,2,4-trimethylpentane 14.35
    2-methyltetrahydrofuran 213.82
    n-hexyl acetate 87.31
    isooctane 7.82
    2-(2-butoxyethoxy)ethanol 185.27
    sec-butyl acetate 49.81
    tert-butyl acetate 79.36
    decalin 7.43
    glycerin 688.48
    diglyme 275.59
    acrylic acid 549.77
    isopropyl myristate 29.76
    n-butyric acid 488.93
    acetyl acetate 141.05
    di(2-ethylhexyl) phthalate 44.84
    ethyl propionate 73.93
    nitromethane 698.37
    1,2-diethoxyethane 84.9
    benzonitrile 88.08
    trioctyl phosphate 33.24
    1-bromopropane 84.88
    gamma-valerolactone 303.91
    n-decanol 58.74
    triethyl phosphate 39.27
    4-methyl-2-pentanol 89.54
    propionitrile 192.76
    vinylene carbonate 190.0
    1,1,2-trichlorotrifluoroethane 446.94
    DMS 64.72
    cumene 17.65
    2-octanol 62.01
    2-hexanone 59.97
    octyl acetate 49.66
    limonene 38.01
    1,2-dimethoxyethane 188.72
    ethyl orthosilicate 39.77
    tributyl phosphate 35.05
    diacetone alcohol 145.09
    N,N-dimethylaniline 49.49
    acrylonitrile 243.44
    aniline 163.98
    1,3-propanediol 553.95
    bromobenzene 57.51
    dibromomethane 225.74
    1,1,2,2-tetrachloroethane 281.52
    2-methyl-cyclohexyl acetate 48.73
    tetrabutyl urea 44.4
    diisobutyl methanol 37.78
    2-phenylethanol 101.46
    styrene 23.02
    dioctyl adipate 44.2
    dimethyl sulfate 130.89
    ethyl butyrate 66.6
    methyl lactate 214.44
    butyl lactate 83.48
    diethyl carbonate 47.68
    propanediol butyl ether 197.49
    triethyl orthoformate 54.86
    p-tert-butyltoluene 27.39
    methyl 4-tert-butylbenzoate 85.68
    morpholine 331.59
    tert-butylamine 173.03
    n-dodecanol 42.0
    dimethoxymethane 201.65
    ethylene carbonate 148.82
    cyrene 109.17
    2-ethoxyethyl acetate 96.58
    2-ethylhexyl acetate 50.79
    1,2,4-trichlorobenzene 103.39
    4-methylpyridine 150.38
    dibutyl ether 42.24
    2,6-dimethyl-4-heptanol 37.78
    DEF 202.22
    dimethyl isosorbide 133.54
    tetrachloroethylene 239.77
    eugenol 103.63
    triacetin 94.5
    span 80 133.83
    1,4-butanediol 219.86
    1,1-dichloroethane 217.34
    2-methyl-1-pentanol 103.51
    methyl formate 303.3
    2-methyl-1-butanol 226.11
    n-decane 10.22
    butyronitrile 175.92
    3,7-dimethyl-1-octanol 69.43
    1-chlorooctane 33.45
    1-chlorotetradecane 12.65
    n-nonane 9.57
    undecane 7.48
    tert-butylcyclohexane 8.92
    cyclooctane 7.36
    cyclopentanol 244.11
    tetrahydropyran 165.04
    tert-amyl methyl ether 107.94
    2,5,8-trioxanonane 172.67
    1-hexene 30.09
    2-isopropoxyethanol 174.26
    2,2,2-trifluoroethanol 661.78
    methyl butyrate 91.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction