4,4'-Dihydroxybiphenyl

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  • Identifiers

    CAS number
    92-88-6

    Molecular formula
    C12H10O2

    SMILES
    C1=CC(=CC=C1C2=CC=C(C=C2)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 86.79%
    Medicinal 63.59%
    Smoky 42.99%
    Animal 41.98%
    Leathery 36.7%
    Burnt 35.97%
    Spicy 32.76%
    Musty 32.58%
    Woody 32.37%
    Sweet 32.1%

     

    Flavor
    Phenolic 63.89%
    Bitter 44.08%
    Medicinal 40.93%
    Phenol 33.67%
    Medical 32.13%
    Fecal 27.44%
    Smoke 27.31%
    Plastic 27.27%
    Animal 24.48%
    Chemical 23.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    10.52 (weak base)

    Molecular weight
    186.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    365°C

    Flash point

    • 182.94 ˚C est.

  • Synonyms

    • 4,4'-Dihydroxybiphenyl
    • 92-88-6
    • 4,4'-BIPHENOL
    • 4,4'-Biphenyldiol
    • [1,1'-Biphenyl]-4,4'-diol
    • Biphenyl-4,4'-diol
    • p,p'-Biphenol
    • p,p'-Diphenol
    • 4,4'-dihydroxydiphenyl
    • Antioxidant DOD
    • 4,4'-Dioxydiphenyl
    • 4,4'-Bisphenol
    • p,p'-Dihydroxybiphenyl
    • ASM DOD
    • (1,1'-Biphenyl)-4,4'-diol
    • Dihydroxybiphenyl
    • DTXSID1029120
    • NSC-8711
    • DTXCID709120
    • GM-W06
    • GM-W07
    • R8994A0904
    • CHEBI:34367
    • 4,4'-diphenyldiol
    • 44'BP cpd
    • RefChem:506655
    • 202-200-5
    • 4-(4-hydroxyphenyl)phenol
    • 4,4'-Diphenol
    • p-Dihydroxydiphenyl
    • para,para'-Biphenol
    • 4,4-Biphenol
    • 4,4'-Dioxydiphenol
    • USAF DO-30
    • DOD
    • Phenol p-(p-hydroxyphenyl)-
    • 4,4-Dihydroxybiphenyl
    • 4,4'-Dihydroxy-1,1'-biphenyl
    • 4,4'-Dihydroxy-biphenyl
    • NSC 8711
    • MFCD00002348
    • 4,4`-dihydroxybiphenyl
    • CHEMBL76398
    • 4,4'-DIHYDROXYDIPHENYL-D8 (RINGS-D8)
    • CCRIS 2981
    • EINECS 202-200-5
    • BRN 1908886
    • AI3-16055
    • p,p''-biphenol
    • UNII-R8994A0904
    • 4,4'biphenol
    • 4,4-dioxydiphenyl
    • 4,4''-biphenol
    • 4,4''-Biphenyldiol
    • 4,4''-dioxydiphenyl
    • 4,4'-Diol-biphenyl
    • 4,4'-Hydroxybiphenyl
    • 4,4'-Dihydroxybipheny
    • biphenyl-4,4''-diol
    • biphenyl-4,4\'-diol
    • p,p''-dihydroxybiphenyl
    • 4,4''-Dihydroxybiphenyl
    • 4,4'-Dihydroxy biphenyl
    • WLN: QR DR DQ
    • 4,4'-bis-hydroxybiphenyl
    • [1,4'-diol
    • EC 202-200-5
    • Oprea1_514666
    • SCHEMBL15632
    • 4-06-00-06651 (Beilstein Handbook Reference)
    • BIDD:ER0226
    • 1,1'-biphenyl-4,4'-diol
    • Phenol, p-(p-hydroxyphenyl)-
    • orb3026016
    • orb3029249
    • SCHEMBL4823334
    • SCHEMBL5686870
    • 4,4'-Dihydroxybiphenyl, 97%
    • 4,4'-Dihydroxydiphenyl (DOD)
    • SCHEMBL14677847
    • NSC8711
    • Tox21_200469
    • [1,1''-biphenyl]-4,4''-diol
    • BDBM50121958
    • MSK002072
    • SBB058730
    • STK365601
    • AKOS005442497
    • AC-7327
    • CS-W016905
    • EBC-152349
    • FD10896
    • HY-W016189
    • CAS-92-88-6
    • NCGC00248640-01
    • NCGC00248640-02
    • NCGC00258023-01
    • AS-14303
    • B0464
    • NS00002875
    • ST50406744
    • D77801
    • AB01334799-02
    • EN300-4290281
    • F078954
    • Q2168450
    • W-100267
    • 4,4'-Dihydroxybiphenyl, Vetec(TM) reagent grade, 97%
    • F0001-2226
    • Z1255423443
    • 4HB
    • 92-88-6

  • Applications

    4,4'-Dihydroxybiphenyl (CAS 92-88-6) is primarily used as a difunctional diol building block in polymer synthesis and related industrial chemistry. In polymers/plastics, it serves as a diol monomer for constructing rigid polyesters, polyurethanes, and epoxy networks; in coatings and inks, it can act as a crosslinking component or reactive intermediate for UV-curable formulations; in electronics and specialty polymers, it is explored as a precursor for high-temperature resistant materials and liquid-crystal polymers; in adhesives, it is used as a diol crosslinker to improve network properties; and it also functions as a building block for certain specialty dyes and pigments in some chemical programs. Use is typically subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 25.17
    methanol 38.17
    isopropanol 13.1
    water 0.21
    ethyl acetate 68.77
    n-propanol 23.73
    acetone 56.56
    n-butanol 14.8
    acetonitrile 35.38
    DMF 95.31
    toluene 3.6
    isobutanol 8.2
    1,4-dioxane 76.17
    methyl acetate 68.54
    THF 188.55
    2-butanone 82.84
    n-pentanol 12.45
    sec-butanol 18.07
    n-hexane 0.18
    ethylene glycol 15.46
    NMP 75.52
    cyclohexane 0.12
    DMSO 196.18
    n-butyl acetate 32.61
    n-octanol 4.88
    chloroform 3.62
    n-propyl acetate 33.47
    acetic acid 32.97
    dichloromethane 3.08
    cyclohexanone 40.7
    propylene glycol 23.74
    isopropyl acetate 37.77
    DMAc 174.25
    2-ethoxyethanol 72.13
    isopentanol 14.23
    n-heptane 0.51
    ethyl formate 21.93
    1,2-dichloroethane 9.14
    n-hexanol 12.38
    2-methoxyethanol 97.89
    isobutyl acetate 14.77
    tetrachloromethane 1.4
    n-pentyl acetate 14.56
    transcutol 366.2
    n-heptanol 6.64
    ethylbenzene 4.14
    MIBK 24.47
    2-propoxyethanol 57.13
    tert-butanol 25.88
    MTBE 37.08
    2-butoxyethanol 30.17
    propionic acid 36.79
    o-xylene 4.68
    formic acid 26.75
    diethyl ether 36.82
    m-xylene 3.63
    p-xylene 3.85
    chlorobenzene 4.23
    dimethyl carbonate 37.5
    n-octane 0.19
    formamide 135.93
    cyclopentanone 111.57
    2-pentanone 43.82
    anisole 36.77
    cyclopentyl methyl ether 32.53
    gamma-butyrolactone 149.02
    1-methoxy-2-propanol 66.91
    pyridine 38.23
    3-pentanone 42.88
    furfural 88.3
    n-dodecane 0.21
    diethylene glycol 55.39
    diisopropyl ether 9.79
    tert-amyl alcohol 31.81
    acetylacetone 74.1
    n-hexadecane 0.24
    acetophenone 32.61
    methyl propionate 65.78
    isopentyl acetate 29.37
    trichloroethylene 19.68
    n-nonanol 5.3
    cyclohexanol 8.25
    benzyl alcohol 19.59
    2-ethylhexanol 10.23
    isooctanol 5.96
    dipropyl ether 22.18
    1,2-dichlorobenzene 7.18
    ethyl lactate 25.21
    propylene carbonate 47.6
    n-methylformamide 68.05
    2-pentanol 11.05
    n-pentane 0.14
    1-propoxy-2-propanol 42.41
    1-methoxy-2-propyl acetate 60.7
    2-(2-methoxypropoxy) propanol 58.49
    mesitylene 3.03
    ε-caprolactone 48.14
    p-cymene 5.23
    epichlorohydrin 124.18
    1,1,1-trichloroethane 7.45
    2-aminoethanol 32.93
    morpholine-4-carbaldehyde 96.76
    sulfolane 147.36
    2,2,4-trimethylpentane 0.76
    2-methyltetrahydrofuran 68.99
    n-hexyl acetate 19.17
    isooctane 0.47
    2-(2-butoxyethoxy)ethanol 71.37
    sec-butyl acetate 26.91
    tert-butyl acetate 52.63
    decalin 0.58
    glycerin 48.42
    diglyme 154.47
    acrylic acid 36.07
    isopropyl myristate 9.43
    n-butyric acid 31.27
    acetyl acetate 32.65
    di(2-ethylhexyl) phthalate 11.42
    ethyl propionate 38.42
    nitromethane 141.02
    1,2-diethoxyethane 65.87
    benzonitrile 13.99
    trioctyl phosphate 7.1
    1-bromopropane 2.59
    gamma-valerolactone 117.06
    n-decanol 4.07
    triethyl phosphate 21.96
    4-methyl-2-pentanol 9.01
    propionitrile 27.05
    vinylene carbonate 33.84
    1,1,2-trichlorotrifluoroethane 88.15
    DMS 40.14
    cumene 4.24
    2-octanol 3.8
    2-hexanone 27.85
    octyl acetate 10.4
    limonene 6.04
    1,2-dimethoxyethane 105.83
    ethyl orthosilicate 21.38
    tributyl phosphate 11.16
    diacetone alcohol 63.37
    N,N-dimethylaniline 21.03
    acrylonitrile 39.02
    aniline 13.94
    1,3-propanediol 36.09
    bromobenzene 2.89
    dibromomethane 1.48
    1,1,2,2-tetrachloroethane 21.22
    2-methyl-cyclohexyl acetate 24.35
    tetrabutyl urea 13.32
    diisobutyl methanol 8.77
    2-phenylethanol 19.76
    styrene 4.15
    dioctyl adipate 19.6
    dimethyl sulfate 77.84
    ethyl butyrate 33.79
    methyl lactate 40.91
    butyl lactate 20.47
    diethyl carbonate 27.39
    propanediol butyl ether 31.13
    triethyl orthoformate 29.21
    p-tert-butyltoluene 5.6
    methyl 4-tert-butylbenzoate 30.53
    morpholine 97.14
    tert-butylamine 11.06
    n-dodecanol 3.13
    dimethoxymethane 89.41
    ethylene carbonate 26.73
    cyrene 45.44
    2-ethoxyethyl acetate 42.23
    2-ethylhexyl acetate 22.94
    1,2,4-trichlorobenzene 12.58
    4-methylpyridine 20.84
    dibutyl ether 11.97
    2,6-dimethyl-4-heptanol 8.77
    DEF 47.94
    dimethyl isosorbide 95.45
    tetrachloroethylene 13.1
    eugenol 30.82
    triacetin 40.35
    span 80 30.0
    1,4-butanediol 11.64
    1,1-dichloroethane 3.89
    2-methyl-1-pentanol 15.47
    methyl formate 39.55
    2-methyl-1-butanol 13.99
    n-decane 0.33
    butyronitrile 15.04
    3,7-dimethyl-1-octanol 8.09
    1-chlorooctane 2.1
    1-chlorotetradecane 0.96
    n-nonane 0.25
    undecane 0.26
    tert-butylcyclohexane 0.85
    cyclooctane 0.12
    cyclopentanol 13.07
    tetrahydropyran 36.41
    tert-amyl methyl ether 35.44
    2,5,8-trioxanonane 102.0
    1-hexene 1.49
    2-isopropoxyethanol 44.44
    2,2,2-trifluoroethanol 19.63
    methyl butyrate 35.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction