4,4'-Dichlorodiphenyl sulfone

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  • Identifiers

    CAS number
    80-07-9

    Molecular formula
    C12H8Cl2O2S

    SMILES
    C1=CC(=CC=C1S(=O)(=O)C2=CC=C(C=C2)Cl)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 44.7%
    Bitter 32.13%
    Burnt 27.93%
    Phenolic 24.67%
    Sulfurous 24.6%
    Cooked 24.38%
    Meaty 22.75%
    Roasted 22.42%
    Almond 21.75%
    Floral 20.28%

     

    Flavor
    Bitter 74.83%
    Odorless 26.67%
    Nitrile 21.68%
    Very strong 19.57%
    Indole 19.33%
    Bread crust 18.97%
    Mild 18.81%
    Taco 18.8%
    Moth ball 18.64%
    Urine 18.56%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    7.84 (neutral)

    Molecular weight
    287.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 293 to 298 °F (NTP, 1992)
    • 147.9 °C

    Boiling point

    • Sublimes (NTP, 1992)
    • 250 °C at 10 mm Hg

    Flash point

    • 213.02 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Soluble in ethanol and chloroform.
    • Slightly soluble in water

  • Synonyms

    • 4,4'-DICHLORODIPHENYL SULFONE
    • 80-07-9
    • Bis(4-chlorophenyl) sulfone
    • p,p'-Dichlorodiphenyl sulfone
    • Benzene, 1,1'-sulfonylbis[4-chloro-
    • Bis(p-chlorophenyl) sulfone
    • 4-Chlorophenyl sulfone
    • 1,1'-Sulfonylbis(4-chlorobenzene)
    • Sulfone, bis(p-chlorophenyl)
    • p-Chlorophenyl sulfone
    • Di-p-chlorophenyl sulfone
    • 4,4'-Dichlorodiphenyl sulphone
    • 4-Chloro-1-(4-chlorophenylsulfonyl)benzene
    • Benzene, 1,1'-sulfonylbis(4-chloro-
    • DTXSID9024986
    • NSC-23899
    • DTXCID004986
    • 5U49794253
    • 4,4-dichlorophenylsulfone
    • bis(para-chlorophenyl)sulfone
    • RefChem:506637
    • 201-247-9
    • 4,4'-sulfonylbis(chlorobenzene)
    • 4,4'-Dichlorodiphenylsulfone
    • MFCD00000619
    • 1-chloro-4-(4-chlorophenyl)sulfonylbenzene
    • Bis(4-chlorophenyl)sulphone
    • NSC 23899
    • bis(4-chlorophenyl)sulfone
    • 1-chloro-4-(4-chlorobenzenesulfonyl)benzene
    • NCGC00090750-04
    • WLN: GR DSWR DG
    • Bis(4-chlorophenyl) sulphone
    • Benzene,1'-sulfonylbis[4-chloro-
    • 4-chloro-1-[(4-chlorophenyl)sulfonyl]benzene
    • HSDB 5233
    • EINECS 201-247-9
    • BRN 2052955
    • AI3-01386
    • AI3-02901
    • CCRIS 8813
    • UNII-5U49794253
    • 1-chloro-4-(4-chlorophenyl)sulfonyl-benzene
    • EC 201-247-9
    • SCHEMBL22742
    • 4,4-Dichlorodiphenyl Sulfone
    • MLS001065613
    • SCHEMBL2122579
    • CHEMBL1334784
    • NSC7207
    • HMS3039H07
    • MSK14238
    • NSC-7207
    • NSC23899
    • NSC38759
    • NSC50730
    • Bis(4-chlorophenyl) sulfone, 98%
    • Tox21_400008
    • BBL000098
    • NSC-38759
    • NSC-50730
    • SBB059046
    • STK279748
    • AKOS001053313
    • EBC-618301
    • FB34591
    • CAS-80-07-9
    • NCGC00090750-01
    • NCGC00090750-02
    • NCGC00090750-03
    • NCGC00090750-05
    • DS-13151
    • SMR000568488
    • MSK14238-1000
    • DB-056405
    • B0810
    • CS-0071002
    • NS00003990
    • ST45133164
    • 1-Chloro-4-[(4-chlorophenyl)sulfonyl]benzene
    • 4,4'-DICHLORODIPHENYL SULFONE [HSDB]
    • 1-chloro-4-[(4-chlorobenzene)sulfonyl]benzene
    • D71229
    • EN300-100311
    • 1-Chloro-4-[(4-chlorophenyl)sulfonyl]benzene #
    • AE-848/30709029
    • F358022
    • Q4637049
    • Z56858060
    • F0701-0150
    • 4,4'-Dichlorodiphenyl Sulfone 100 microg/mL in Acetonitrile
    • 4,4'-Dichlorodiphenyl sulfone Solution in Methanol, 1000?g/mL
    • InChI=1/C12H8Cl2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8
    • 80-07-9

  • Applications

    4,4'-Dichlorodiphenyl sulfone (CAS 80-07-9) is predominantly used as a difunctional monomer to synthesize polysulfone and related poly(arylsulfone) resins by nucleophilic aromatic substitution with bisphenols. Polymers derived from this monomer offer high thermal stability, chemical resistance, and mechanical strength, enabling applications in high-temperature engineering plastics, membranes for water treatment and gas separation, electronics packaging and insulating materials, and protective coatings and adhesives in industrial manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.66
    methanol 1.35
    isopropanol 3.92
    water 0.01
    ethyl acetate 104.22
    n-propanol 5.95
    acetone 153.67
    n-butanol 5.6
    acetonitrile 49.19
    DMF 460.89
    toluene 49.35
    isobutanol 4.8
    1,4-dioxane 113.16
    methyl acetate 157.4
    THF 198.62
    2-butanone 248.05
    n-pentanol 9.09
    sec-butanol 16.73
    n-hexane 0.91
    ethylene glycol 1.44
    NMP 370.32
    cyclohexane 2.6
    DMSO 63.73
    n-butyl acetate 105.69
    n-octanol 12.35
    chloroform 181.46
    n-propyl acetate 93.03
    acetic acid 26.34
    dichloromethane 132.92
    cyclohexanone 318.01
    propylene glycol 4.57
    isopropyl acetate 88.11
    DMAc 550.21
    2-ethoxyethanol 31.76
    isopentanol 7.42
    n-heptane 3.46
    ethyl formate 60.25
    1,2-dichloroethane 79.95
    n-hexanol 13.86
    2-methoxyethanol 31.68
    isobutyl acetate 45.14
    tetrachloromethane 10.04
    n-pentyl acetate 66.16
    transcutol 163.07
    n-heptanol 10.95
    ethylbenzene 36.1
    MIBK 63.17
    2-propoxyethanol 43.82
    tert-butanol 9.71
    MTBE 48.85
    2-butoxyethanol 33.19
    propionic acid 28.97
    o-xylene 41.57
    formic acid 6.76
    diethyl ether 30.0
    m-xylene 30.56
    p-xylene 48.1
    chlorobenzene 72.5
    dimethyl carbonate 78.37
    n-octane 1.86
    formamide 42.96
    cyclopentanone 383.51
    2-pentanone 114.07
    anisole 125.03
    cyclopentyl methyl ether 81.01
    gamma-butyrolactone 334.53
    1-methoxy-2-propanol 33.71
    pyridine 188.91
    3-pentanone 140.57
    furfural 324.0
    n-dodecane 1.9
    diethylene glycol 22.53
    diisopropyl ether 16.57
    tert-amyl alcohol 23.64
    acetylacetone 256.67
    n-hexadecane 2.35
    acetophenone 164.38
    methyl propionate 105.58
    isopentyl acetate 82.69
    trichloroethylene 360.08
    n-nonanol 14.4
    cyclohexanol 20.79
    benzyl alcohol 50.71
    2-ethylhexanol 19.4
    isooctanol 11.11
    dipropyl ether 41.4
    1,2-dichlorobenzene 82.17
    ethyl lactate 44.67
    propylene carbonate 173.74
    n-methylformamide 80.81
    2-pentanol 9.39
    n-pentane 0.66
    1-propoxy-2-propanol 48.45
    1-methoxy-2-propyl acetate 136.91
    2-(2-methoxypropoxy) propanol 75.04
    mesitylene 20.72
    ε-caprolactone 232.28
    p-cymene 29.61
    epichlorohydrin 251.77
    1,1,1-trichloroethane 97.45
    2-aminoethanol 3.72
    morpholine-4-carbaldehyde 355.5
    sulfolane 298.96
    2,2,4-trimethylpentane 2.21
    2-methyltetrahydrofuran 132.62
    n-hexyl acetate 71.34
    isooctane 1.14
    2-(2-butoxyethoxy)ethanol 67.34
    sec-butyl acetate 76.42
    tert-butyl acetate 106.1
    decalin 3.63
    glycerin 9.47
    diglyme 176.98
    acrylic acid 37.02
    isopropyl myristate 38.93
    n-butyric acid 31.43
    acetyl acetate 107.03
    di(2-ethylhexyl) phthalate 31.07
    ethyl propionate 91.27
    nitromethane 229.68
    1,2-diethoxyethane 103.17
    benzonitrile 109.45
    trioctyl phosphate 20.86
    1-bromopropane 32.1
    gamma-valerolactone 459.45
    n-decanol 12.02
    triethyl phosphate 51.56
    4-methyl-2-pentanol 8.19
    propionitrile 36.37
    vinylene carbonate 178.84
    1,1,2-trichlorotrifluoroethane 163.66
    DMS 119.6
    cumene 21.43
    2-octanol 12.25
    2-hexanone 107.5
    octyl acetate 42.83
    limonene 41.35
    1,2-dimethoxyethane 143.37
    ethyl orthosilicate 43.71
    tributyl phosphate 32.94
    diacetone alcohol 80.31
    N,N-dimethylaniline 79.78
    acrylonitrile 76.95
    aniline 43.02
    1,3-propanediol 5.85
    bromobenzene 77.05
    dibromomethane 59.74
    1,1,2,2-tetrachloroethane 214.62
    2-methyl-cyclohexyl acetate 80.86
    tetrabutyl urea 54.07
    diisobutyl methanol 16.36
    2-phenylethanol 51.94
    styrene 46.41
    dioctyl adipate 63.12
    dimethyl sulfate 155.7
    ethyl butyrate 101.54
    methyl lactate 52.67
    butyl lactate 49.3
    diethyl carbonate 65.03
    propanediol butyl ether 30.84
    triethyl orthoformate 68.9
    p-tert-butyltoluene 28.17
    methyl 4-tert-butylbenzoate 84.41
    morpholine 105.15
    tert-butylamine 5.93
    n-dodecanol 10.01
    dimethoxymethane 109.1
    ethylene carbonate 111.35
    cyrene 112.31
    2-ethoxyethyl acetate 112.08
    2-ethylhexyl acetate 76.42
    1,2,4-trichlorobenzene 108.7
    4-methylpyridine 193.31
    dibutyl ether 36.96
    2,6-dimethyl-4-heptanol 16.36
    DEF 203.59
    dimethyl isosorbide 182.02
    tetrachloroethylene 103.65
    eugenol 85.04
    triacetin 123.85
    span 80 53.38
    1,4-butanediol 4.32
    1,1-dichloroethane 74.05
    2-methyl-1-pentanol 13.91
    methyl formate 91.54
    2-methyl-1-butanol 9.43
    n-decane 3.03
    butyronitrile 30.48
    3,7-dimethyl-1-octanol 17.01
    1-chlorooctane 14.06
    1-chlorotetradecane 7.14
    n-nonane 2.48
    undecane 2.34
    tert-butylcyclohexane 3.23
    cyclooctane 1.4
    cyclopentanol 26.29
    tetrahydropyran 85.33
    tert-amyl methyl ether 59.29
    2,5,8-trioxanonane 128.38
    1-hexene 8.11
    2-isopropoxyethanol 30.92
    2,2,2-trifluoroethanol 26.52
    methyl butyrate 123.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction