4-Vinylpyridine

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  • Identifiers

    CAS number
    100-43-6

    Molecular formula
    C7H7N

    SMILES
    C=CC1=CC=NC=C1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Green 59.75%
    Herbal 57.28%
    Sweet 53.72%
    Nutty 51.1%
    Spicy 48.19%
    Pungent 40.24%
    Musty 37.14%
    Almond 36.16%
    Phenolic 35.9%
    Bitter 33.99%

     

    Flavor
    Sweet 45.54%
    Nutty 36.23%
    Cinnamon 32.06%
    Herbal 28.6%
    Oily 27.86%
    Woody 27.49%
    Spice 27.26%
    Green 27.05%
    Balsam 25.83%
    Warm 24.6%

     

    Odor impact est.
    High

    Odor threshold

    • AT ... CONCN ... /ABOVE 0.5 PPM 4-VINYLPYRIDINE HAS/ A VERY UNPLEASANT NAUSEATING ODOR. THE UNPLEASANT ODOR CAN BE TOLERATED @ CONCN THAT WILL PRODUCE ACUTE SYMPTOMS & IRRITATIONS.
    • ... ACCLIMATIZED INDIVIDUALS CAN READILY LEARN TO TOLERATE CONCN THAT WILL CAUSE ACUTE SYMPTOMS & IRRITATION. ... OLFACTORY FATIGUE OCCURS QUICKLY.
    • 1.16 mg/cu m (odor low); 1.94 mg/cu m (odor high).

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.59 (weak acid)

    Molecular weight
    105.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point

    • 65 °C @ 15 mm Hg

    Flash point

    • 54.78 ˚C est.

    Solubility expt.

    • Soluble in alcohol and chloroform; slightly soluble in ether
    • In water, 29,100 mg/l @ 20 °C

  • Synonyms

    • 4-VINYLPYRIDINE
    • 100-43-6
    • 4-Ethenylpyridine
    • Pyridine, 4-ethenyl-
    • Pyridine, 4-vinyl-
    • gamma-Vinylpyridine
    • I56G67XM8D
    • DTXSID0051499
    • NSC-18256
    • DTXCID4030047
    • RefChem:6770
    • 202-852-0
    • 684-212-4
    • .gamma.-Vinylpyridine
    • MFCD00006447
    • CHEMBL4550330
    • NSC18256
    • CCRIS 5240
    • HSDB 1509
    • 4-Vinylpyridine (stabilized with hydroquinone)
    • EINECS 202-852-0
    • NSC 18256
    • UNII-I56G67XM8D
    • 4-pyridylethylene
    • 4-vinyl-pyridine
    • 4-Vinyl pyridine
    • 2-(4-pyridyl)ethylene
    • 4-(1-ethenyl)pyridine
    • EC 202-852-0
    • SCHEMBL14867
    • SCHEMBL317543
    • SCHEMBL446651
    • SCHEMBL1781610
    • SCHEMBL4583853
    • 4-VINYLPYRIDINE [HSDB]
    • SCHEMBL12284753
    • SCHEMBL16289488
    • BB_SC-05441
    • Tox21_303844
    • BBL027584
    • BDBM50622834
    • STK802321
    • 4-Vinylpyridine (stabilized with HQ)
    • AKOS000119179
    • FV09698
    • NCGC00357114-01
    • CAS-100-43-6
    • FP180644
    • VS-08564
    • DB-012723
    • NS00003108
    • ST50409767
    • V0025
    • V0150
    • EN300-21304
    • 4-Vinylpyridine, 95%, stab. with hydroquinone
    • H58023
    • 4-Vinylpyridine, stabilized with 100ppm Hydroquinone
    • Poly(4-vinylpyridine),linear,150000-200000g/mol
    • Q13427555
    • F0001-0017
    • InChI=1/C7H7N/c1-2-7-3-5-8-6-4-7/h2-6H,1H
    • 4-Vinylpyridine, contains 100 ppm hydroquinone as inhibitor, 95%
    • 4-Ethenylpyridine; 2-(4-Pyridyl)ethylene; NSC 18256; ?-Vinylpyridine
    • 4-Vinylpyridine (stabilized with HQ)(Discontinued,See C4X-1254111)
    • 100-43-6

  • Applications

    4-Vinylpyridine (CAS 100-43-6) is mainly used as a monomer to prepare polymers and copolymers bearing pyridine groups, enabling ion-exchange resins and sorbent materials. Upon quaternization to form pyridinium sites, these materials can function as anion-exchange resins and serve in separation and water-purification processes. Polymers such as poly(4-vinylpyridine) and copolymers also provide supports for immobilized metal catalysts, leveraging the pyridine coordination to metals. In addition, the pyridine functionality is incorporated into coatings and adhesives to introduce metal-binding and adhesion-enhancing sites, and these monomers are used in functional membranes for ion-exchange and separation applications in water treatment and process separations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 316.63
    methanol 306.21
    isopropanol 159.09
    water 0.77
    ethyl acetate 700.45
    n-propanol 302.06
    acetone 275.84
    n-butanol 240.47
    acetonitrile 389.64
    DMF 522.02
    toluene 498.29
    isobutanol 151.1
    1,4-dioxane 914.81
    methyl acetate 471.32
    THF 547.3
    2-butanone 387.15
    n-pentanol 161.62
    sec-butanol 162.71
    n-hexane 25.13
    ethylene glycol 66.44
    NMP 363.7
    cyclohexane 59.33
    DMSO 581.27
    n-butyl acetate 343.93
    n-octanol 46.52
    chloroform 1123.15
    n-propyl acetate 200.71
    acetic acid 237.26
    dichloromethane 995.49
    cyclohexanone 476.91
    propylene glycol 70.15
    isopropyl acetate 196.77
    DMAc 442.75
    2-ethoxyethanol 210.69
    isopentanol 138.72
    n-heptane 40.86
    ethyl formate 255.68
    1,2-dichloroethane 667.87
    n-hexanol 214.15
    2-methoxyethanol 379.51
    isobutyl acetate 97.12
    tetrachloromethane 182.72
    n-pentyl acetate 112.04
    transcutol 781.22
    n-heptanol 60.51
    ethylbenzene 92.91
    MIBK 111.75
    2-propoxyethanol 310.4
    tert-butanol 146.41
    MTBE 198.63
    2-butoxyethanol 114.56
    propionic acid 298.18
    o-xylene 167.33
    formic acid 98.56
    diethyl ether 543.79
    m-xylene 184.33
    p-xylene 105.1
    chlorobenzene 404.04
    dimethyl carbonate 154.38
    n-octane 10.29
    formamide 163.42
    cyclopentanone 418.23
    2-pentanone 266.21
    anisole 192.87
    cyclopentyl methyl ether 361.43
    gamma-butyrolactone 526.48
    1-methoxy-2-propanol 231.14
    pyridine 1034.99
    3-pentanone 290.45
    furfural 506.91
    n-dodecane 7.13
    diethylene glycol 197.24
    diisopropyl ether 79.78
    tert-amyl alcohol 125.28
    acetylacetone 261.14
    n-hexadecane 8.38
    acetophenone 151.59
    methyl propionate 467.98
    isopentyl acetate 205.4
    trichloroethylene 1103.13
    n-nonanol 45.18
    cyclohexanol 180.66
    benzyl alcohol 136.07
    2-ethylhexanol 113.54
    isooctanol 45.37
    dipropyl ether 243.54
    1,2-dichlorobenzene 243.98
    ethyl lactate 59.85
    propylene carbonate 255.7
    n-methylformamide 317.29
    2-pentanol 127.85
    n-pentane 34.39
    1-propoxy-2-propanol 211.05
    1-methoxy-2-propyl acetate 266.6
    2-(2-methoxypropoxy) propanol 118.13
    mesitylene 80.93
    ε-caprolactone 406.09
    p-cymene 57.08
    epichlorohydrin 649.86
    1,1,1-trichloroethane 496.99
    2-aminoethanol 127.47
    morpholine-4-carbaldehyde 516.5
    sulfolane 425.34
    2,2,4-trimethylpentane 14.74
    2-methyltetrahydrofuran 489.05
    n-hexyl acetate 116.17
    isooctane 12.16
    2-(2-butoxyethoxy)ethanol 168.44
    sec-butyl acetate 107.37
    tert-butyl acetate 147.03
    decalin 23.91
    glycerin 102.19
    diglyme 355.96
    acrylic acid 227.05
    isopropyl myristate 46.5
    n-butyric acid 348.71
    acetyl acetate 252.79
    di(2-ethylhexyl) phthalate 43.85
    ethyl propionate 191.47
    nitromethane 524.85
    1,2-diethoxyethane 406.35
    benzonitrile 243.44
    trioctyl phosphate 29.85
    1-bromopropane 428.51
    gamma-valerolactone 589.21
    n-decanol 35.42
    triethyl phosphate 62.64
    4-methyl-2-pentanol 58.26
    propionitrile 374.48
    vinylene carbonate 274.45
    1,1,2-trichlorotrifluoroethane 343.08
    DMS 150.99
    cumene 43.8
    2-octanol 33.92
    2-hexanone 155.31
    octyl acetate 59.27
    limonene 92.36
    1,2-dimethoxyethane 338.07
    ethyl orthosilicate 65.82
    tributyl phosphate 43.59
    diacetone alcohol 129.06
    N,N-dimethylaniline 99.19
    acrylonitrile 420.84
    aniline 382.31
    1,3-propanediol 173.91
    bromobenzene 432.24
    dibromomethane 657.19
    1,1,2,2-tetrachloroethane 711.76
    2-methyl-cyclohexyl acetate 95.83
    tetrabutyl urea 57.66
    diisobutyl methanol 60.01
    2-phenylethanol 155.65
    styrene 163.96
    dioctyl adipate 67.26
    dimethyl sulfate 207.24
    ethyl butyrate 202.85
    methyl lactate 111.32
    butyl lactate 63.71
    diethyl carbonate 114.78
    propanediol butyl ether 66.13
    triethyl orthoformate 117.55
    p-tert-butyltoluene 55.14
    methyl 4-tert-butylbenzoate 88.15
    morpholine 893.84
    tert-butylamine 100.08
    n-dodecanol 29.12
    dimethoxymethane 362.05
    ethylene carbonate 250.28
    cyrene 89.37
    2-ethoxyethyl acetate 208.4
    2-ethylhexyl acetate 178.59
    1,2,4-trichlorobenzene 310.96
    4-methylpyridine 765.86
    dibutyl ether 109.73
    2,6-dimethyl-4-heptanol 60.01
    DEF 435.75
    dimethyl isosorbide 220.19
    tetrachloroethylene 516.35
    eugenol 87.92
    triacetin 114.46
    span 80 89.17
    1,4-butanediol 60.48
    1,1-dichloroethane 600.18
    2-methyl-1-pentanol 110.23
    methyl formate 204.66
    2-methyl-1-butanol 148.09
    n-decane 11.8
    butyronitrile 319.27
    3,7-dimethyl-1-octanol 56.79
    1-chlorooctane 48.04
    1-chlorotetradecane 20.32
    n-nonane 11.71
    undecane 8.84
    tert-butylcyclohexane 20.24
    cyclooctane 20.79
    cyclopentanol 160.99
    tetrahydropyran 726.92
    tert-amyl methyl ether 147.66
    2,5,8-trioxanonane 238.53
    1-hexene 107.8
    2-isopropoxyethanol 126.5
    2,2,2-trifluoroethanol 83.01
    methyl butyrate 217.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction